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ES2161726T3 - Formas amorfas monoesfericas de derivados de insulina. - Google Patents

Formas amorfas monoesfericas de derivados de insulina.

Info

Publication number
ES2161726T3
ES2161726T3 ES94106196T ES94106196T ES2161726T3 ES 2161726 T3 ES2161726 T3 ES 2161726T3 ES 94106196 T ES94106196 T ES 94106196T ES 94106196 T ES94106196 T ES 94106196T ES 2161726 T3 ES2161726 T3 ES 2161726T3
Authority
ES
Spain
Prior art keywords
monospheric
amorphes
insulin derivatives
water
propanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94106196T
Other languages
English (en)
Inventor
Rainer Dr Obermeier
Walter Sabel
Peter Deil
Karl Dr Geisen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2161726T3 publication Critical patent/ES2161726T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA EL TRATAMIENTO DE UNA FORMA MONOESFERICA AMORFA DE DERIVADOS DE INSULINA, DONDE EL DERIVADO DE INSULINA SE DISUELVE EN UNA MEZCLA AMORTIGUADORA N-PROPANOL EN UN PH DESDE 4,5 HASTA 6,5, SE AJUSTA EN UN CONTENIDO EN NPROPANOL DE MAS DEL 13 % CON RESPECTO AL AGUA Y LA SOLUCION OBTENIDA SE DILUYE A CONTINUACION CON AGUA.
ES94106196T 1993-04-27 1994-04-21 Formas amorfas monoesfericas de derivados de insulina. Expired - Lifetime ES2161726T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4313702 1993-04-27

Publications (1)

Publication Number Publication Date
ES2161726T3 true ES2161726T3 (es) 2001-12-16

Family

ID=6486458

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94106196T Expired - Lifetime ES2161726T3 (es) 1993-04-27 1994-04-21 Formas amorfas monoesfericas de derivados de insulina.

Country Status (8)

Country Link
US (1) US5466666A (es)
EP (1) EP0622376B1 (es)
JP (1) JP3532956B2 (es)
AT (1) ATE203998T1 (es)
DE (1) DE59409816D1 (es)
DK (1) DK0622376T3 (es)
ES (1) ES2161726T3 (es)
GR (1) GR3036840T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19903125B4 (de) * 1999-01-27 2006-01-05 Sanofi-Aventis Deutschland Gmbh Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga
CZ2004710A3 (cs) * 2001-12-20 2005-02-16 Eli Lilly And Company Inzulínová sloučenina s protrahovaným účinkem
BRPI0409600A (pt) * 2003-04-29 2006-04-18 Lilly Co Eli análogo de insulina, composição, método de tratamento de hiperglicemia, e, análogo de pró-insulina
RU2495131C2 (ru) * 2008-02-19 2013-10-10 Байокон Лимитид Способ получения рекомбинантного инсулина гларгина
PL239062B1 (pl) * 2016-01-22 2021-11-02 Inst Biotechnologii I Antybiotykow Sposób wytwarzania insuliny i jej pochodnych

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE4012818A1 (de) * 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
EP0347781B1 (de) * 1988-06-23 1994-02-16 Hoechst Aktiengesellschaft Mini-Proinsulin, seine Herstellung und Verwendung
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
GR1005153B (el) * 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.

Also Published As

Publication number Publication date
US5466666A (en) 1995-11-14
EP0622376A1 (de) 1994-11-02
EP0622376B1 (de) 2001-08-08
GR3036840T3 (en) 2002-01-31
JP3532956B2 (ja) 2004-05-31
DE59409816D1 (de) 2001-09-13
DK0622376T3 (da) 2001-11-12
ATE203998T1 (de) 2001-08-15
JPH06321990A (ja) 1994-11-22

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