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ES2161655B1 - Procedimiento para determinar la capacidad invasiva y metastasica de un tumor epitelial mediante el uso de snail. - Google Patents

Procedimiento para determinar la capacidad invasiva y metastasica de un tumor epitelial mediante el uso de snail.

Info

Publication number
ES2161655B1
ES2161655B1 ES200002074A ES200002074A ES2161655B1 ES 2161655 B1 ES2161655 B1 ES 2161655B1 ES 200002074 A ES200002074 A ES 200002074A ES 200002074 A ES200002074 A ES 200002074A ES 2161655 B1 ES2161655 B1 ES 2161655B1
Authority
ES
Spain
Prior art keywords
snail
capacity
invasive
metastassic
epitelial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200002074A
Other languages
English (en)
Other versions
ES2161655A1 (es
Inventor
Toledano M Angela Nieto
Garcia Amparo Cano
Castro M Isabel Rodrigo
Annamaria Locascio
Del Barrio Marta Garcia
Fernandez De Valderrama Blanco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Autonoma de Madrid
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Autonoma de Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8309058&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2161655(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Consejo Superior de Investigaciones Cientificas CSIC, Universidad Autonoma de Madrid filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Publication of ES2161655A1 publication Critical patent/ES2161655A1/es
Application granted granted Critical
Publication of ES2161655B1 publication Critical patent/ES2161655B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedimiento para determinar la capacidad invasiva y metastásica de un tumor epitelial mediante el uso de Snail. El procedimiento consiste en la determinación de la presencia de un marcador pronóstico, Snail, en la muestra biológica obtenida de dicho tumor, y la comparación de la presencia de este marcador pronóstico con la ausencia del mismo en una muestra control, y en donde dicha presencia es indicativa de capacidad invasiva y metastásica de dicho tumor epitelial.
ES200002074A 1999-07-01 1999-07-01 Procedimiento para determinar la capacidad invasiva y metastasica de un tumor epitelial mediante el uso de snail. Expired - Fee Related ES2161655B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901466A ES2161612B1 (es) 1999-07-01 1999-07-01 Procedimiento para identificar un compuesto que inhiba la funcion represora de snail.

Publications (2)

Publication Number Publication Date
ES2161655A1 ES2161655A1 (es) 2001-12-01
ES2161655B1 true ES2161655B1 (es) 2002-06-01

Family

ID=8309058

Family Applications (3)

Application Number Title Priority Date Filing Date
ES200002074A Expired - Fee Related ES2161655B1 (es) 1999-07-01 1999-07-01 Procedimiento para determinar la capacidad invasiva y metastasica de un tumor epitelial mediante el uso de snail.
ES009901466A Expired - Fee Related ES2161612B1 (es) 1999-07-01 1999-07-01 Procedimiento para identificar un compuesto que inhiba la funcion represora de snail.
ES00938837T Expired - Lifetime ES2234619T3 (es) 1999-07-01 2000-06-27 Snail, nuevo marcador de progresion tumoral y proteina diana de nuevos compuestos antitumorales.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES009901466A Expired - Fee Related ES2161612B1 (es) 1999-07-01 1999-07-01 Procedimiento para identificar un compuesto que inhiba la funcion represora de snail.
ES00938837T Expired - Lifetime ES2234619T3 (es) 1999-07-01 2000-06-27 Snail, nuevo marcador de progresion tumoral y proteina diana de nuevos compuestos antitumorales.

Country Status (10)

Country Link
US (6) US6617121B1 (es)
EP (1) EP1109021B1 (es)
AT (1) ATE284537T1 (es)
AU (1) AU5408300A (es)
CA (1) CA2383943A1 (es)
DE (1) DE60016548T2 (es)
DK (1) DK1109021T3 (es)
ES (3) ES2161655B1 (es)
PT (1) PT1109021E (es)
WO (1) WO2001002860A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE485515T1 (de) * 2001-06-22 2010-11-15 Burkhard Jansen Verfahren zur diagnose einer person mit multipler sklerose
ES2195751B1 (es) 2001-11-27 2005-04-01 Universidad De Salamanca (Otri) Mamiferos no humanos transgenicos como modelos para patologias humanas con origen en celulas stem.
US20050089896A1 (en) 2003-02-18 2005-04-28 Roy Frans V. Method to control tumor progression and invasiveness
CA2476965A1 (en) * 2002-02-20 2003-08-28 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Method of modulating e-cadherin mediated cell adhesion
WO2004065602A1 (es) * 2003-01-17 2004-08-05 Universidad Autónoma de Madrid Procedimiento para identificar la transición epitelio-mesenquimal de células mesoteliales (temcm) e identificar compuestos moduladores de temcm, composiciones farmacéuticas y su uso en el diagnóstico y tratamiento de enfermedades que cursan con temcm
WO2004086038A2 (en) * 2003-03-28 2004-10-07 Institut Curie A method for screening compounds having the capacity to control tumor cell invasion or metastasis using constitutively active akt
US20060003956A1 (en) * 2004-03-03 2006-01-05 Casadome David O Materials and methods for the derepression of the E-cadherin promoter
ES2301268B1 (es) * 2004-10-25 2009-05-01 Centro De Investigacion Biomolecular Aplicada Salamanca, S.L. Empleo del gen slug, o de sus productos de replicacion, transcripcion o expresion, en la identificacion, diagnostico, prevencion o tratamiento de la diseminacion del cancer y/o desarrollo de metastasis.
US8093011B2 (en) * 2005-03-16 2012-01-10 Haley John D Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
US8383357B2 (en) * 2005-03-16 2013-02-26 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
JP2009502159A (ja) * 2005-07-28 2009-01-29 オンコステム ファルマ ソシエダッド リミタード ガン成長ならびにｄｎａ損傷に基づく疾患のマーカーとしてのスネイルの段階的発現
WO2007025231A2 (en) * 2005-08-26 2007-03-01 The Trustees Of The University Of Pennsylvania Methods using snail transcriptional repressor
GB0602063D0 (en) 2006-02-02 2006-03-15 Univ Manchester Cell Culture
US8377636B2 (en) * 2007-04-13 2013-02-19 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to kinase inhibitors
CA2694154A1 (en) * 2007-10-03 2009-04-09 Osi Pharmaceuticals, Inc. Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
JP2011501660A (ja) * 2007-10-03 2011-01-13 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド インスリン様成長因子−１受容体キナーゼ阻害剤に対する抗癌反応を予測する生物学的マーカー
JP2012519170A (ja) * 2009-02-26 2012-08-23 オーエスアイ・ファーマシューティカルズ，エルエルシー 生体内の腫瘍細胞のｅｍｔステータスをモニターするためのｉｎｓｉｔｕ法
US20110217309A1 (en) * 2010-03-03 2011-09-08 Buck Elizabeth A Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
JP2014519813A (ja) 2011-04-25 2014-08-21 オーエスアイ・ファーマシューティカルズ，エルエルシー 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用
CN109984062B (zh) * 2018-12-29 2021-07-27 广西桂螺农业科技有限公司 一种厚壳田螺的繁育方法
EP4457341A1 (en) * 2021-12-30 2024-11-06 Mestastop Solutions Private Limited Method for producing a spontaneous metastasis model

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547432A (en) * 1984-07-31 1985-10-15 The United States Of America As Represented By The United States Department Of Energy Method of bonding silver to glass and mirrors produced according to this method
FR2656129B1 (fr) * 1989-12-20 1992-03-13 Gen Electric Cgr Procede de reconstruction multi-echelle de l'image de la structure d'un corps.
WO1996002002A1 (en) * 1994-07-08 1996-01-25 Schalken Jack A Assay for increased invasiveness of epithelial cells
DE19503510C2 (de) * 1995-02-03 1996-12-19 Sekurit Saint Gobain Deutsch Verfahren zur Herstellung einer IR-reflektierenden Verbundglasscheibe für Kraftfahrzeuge
WO1999020168A2 (en) * 1997-10-17 1999-04-29 University Of Otago Germline mutations in the e-cadherin gene and method for detecting predisposition to cancer
AU4742400A (en) * 1999-09-29 2001-04-30 Ip2H Ag Process for production of a dielectric multi-layered reflecting coating

Also Published As

Publication number Publication date
DE60016548D1 (de) 2005-01-13
US7482159B2 (en) 2009-01-27
US7482126B2 (en) 2009-01-27
EP1109021B1 (en) 2004-12-08
US6617121B1 (en) 2003-09-09
WO2001002860A1 (es) 2001-01-11
ES2161655A1 (es) 2001-12-01
US20070077590A1 (en) 2007-04-05
DE60016548T2 (de) 2005-12-08
CA2383943A1 (en) 2001-01-11
ATE284537T1 (de) 2004-12-15
AU5408300A (en) 2001-01-22
US20070065450A1 (en) 2007-03-22
ES2234619T3 (es) 2005-07-01
US20070054307A1 (en) 2007-03-08
US20070053891A1 (en) 2007-03-08
DK1109021T3 (da) 2005-03-29
PT1109021E (pt) 2005-04-29
US20040037832A1 (en) 2004-02-26
US7794930B2 (en) 2010-09-14
ES2161612A1 (es) 2001-12-01
EP1109021A1 (en) 2001-06-20
ES2161612B1 (es) 2002-06-01

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