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ES2160534A1 - Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo. - Google Patents

Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.

Info

Publication number
ES2160534A1
ES2160534A1 ES200000060A ES200000060A ES2160534A1 ES 2160534 A1 ES2160534 A1 ES 2160534A1 ES 200000060 A ES200000060 A ES 200000060A ES 200000060 A ES200000060 A ES 200000060A ES 2160534 A1 ES2160534 A1 ES 2160534A1
Authority
ES
Spain
Prior art keywords
dimethylaminomethyl
hydroxycyclohexyl
hydroxybenzoate
phenyl
esters derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200000060A
Other languages
English (en)
Other versions
ES2160534B1 (es
Inventor
Clotet Juan Huguet
Mancini Marisabel Mourelle
Ramon Amat Elisabet De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vita Invest SA
Original Assignee
Vita Invest SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200000060A priority Critical patent/ES2160534B1/es
Application filed by Vita Invest SA filed Critical Vita Invest SA
Priority to CZ20022189A priority patent/CZ20022189A3/cs
Priority to PL00356056A priority patent/PL356056A1/xx
Priority to AT00983358T priority patent/ATE284380T1/de
Priority to EEP200200365A priority patent/EE200200365A/xx
Priority to SK925-2002A priority patent/SK9252002A3/sk
Priority to DE60016631T priority patent/DE60016631D1/de
Priority to KR1020027008500A priority patent/KR20020063281A/ko
Priority to OA1200200201A priority patent/OA12132A/en
Priority to CA002395976A priority patent/CA2395976A1/en
Priority to APAP/P/2002/002571A priority patent/AP1234A/en
Priority to CN00817916A priority patent/CN1414946A/zh
Priority to AU20126/01A priority patent/AU775918B2/en
Priority to EP00983358A priority patent/EP1251120B1/en
Priority to YU50902A priority patent/YU50902A/sh
Priority to US10/169,177 priority patent/US6894076B2/en
Priority to NZ520263A priority patent/NZ520263A/en
Priority to EA200200614A priority patent/EA004770B1/ru
Priority to MXPA02006514A priority patent/MXPA02006514A/es
Priority to HR20020559A priority patent/HRP20020559A2/hr
Priority to PCT/ES2000/000486 priority patent/WO2001049650A1/es
Priority to IL15039200A priority patent/IL150392A0/xx
Priority to HU0204147A priority patent/HUP0204147A3/hu
Priority to BR0016882-3A priority patent/BR0016882A/pt
Priority to JP2001550190A priority patent/JP2003519208A/ja
Publication of ES2160534A1 publication Critical patent/ES2160534A1/es
Application granted granted Critical
Publication of ES2160534B1 publication Critical patent/ES2160534B1/es
Priority to MA26710A priority patent/MA26862A1/fr
Priority to IS6440A priority patent/IS6440A/is
Priority to NO20023098A priority patent/NO20023098D0/no
Priority to ZA200205193A priority patent/ZA200205193B/xx
Priority to BG106883A priority patent/BG106883A/xx
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Nuevos ésteres derivados de (RR, SS)-2-hidroxibenzoato de 3-(2- dimetilaminometil-1-hidroxiciclohexil) fenilo, análogos al Tramadol, procedimiento para su obtención y uso de dichos compuestos para la fabricación de un medicamento con propiedades analgésicas. Estos nuevos productos de fórmula general (I) presentan una actividad analgésica superior al tramadol.
ES200000060A 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo. Expired - Fee Related ES2160534B1 (es)

Priority Applications (30)

Application Number Priority Date Filing Date Title
ES200000060A ES2160534B1 (es) 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
EA200200614A EA004770B1 (ru) 1999-12-30 2000-12-26 Новые сложные эфиры, производные (rr, ss)-3-(2-диметиламинометил -1-гидроксициклогексил)фенил 2-гидроксибензоата
AT00983358T ATE284380T1 (de) 1999-12-30 2000-12-26 Ester abgeleitet vom (rr,ss)-2-hydroxybenzoat des 3-(2-dimethylaminomethyl-1- hydroxycyclohexl)phenyl
EEP200200365A EE200200365A (et) 1999-12-30 2000-12-26 (RR,SS)-3-(2-dimetüülaminometüül-1-hüdroksütsükloheksüül)fenüül-2-hüdroksübens oaadist tulenevad estrid
SK925-2002A SK9252002A3 (en) 1999-12-30 2000-12-26 Novel esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
DE60016631T DE60016631D1 (de) 1999-12-30 2000-12-26 Ester abgeleitet vom (rr,ss)-2-hydroxybenzoat des 3-(2-dimethylaminomethyl-1-hydroxycyclohexl)phenyl
KR1020027008500A KR20020063281A (ko) 1999-12-30 2000-12-26 3-(2-디메틸아미노메틸-1-하이드록시사이클로헥실)페닐의(ｒｒ,ｓｓ)-2-하이드록시벤조에이트로부터 유래된 신규에스테르
OA1200200201A OA12132A (en) 1999-12-30 2000-12-26 Novel esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl.
CA002395976A CA2395976A1 (en) 1999-12-30 2000-12-26 Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
APAP/P/2002/002571A AP1234A (en) 1999-12-30 2000-12-26 New esters derived from (RR,SS)-3-(2-Dimethylaminomethyl-1-hydroxycyclohexyl) phenyl 2-hydroxybenzoate.
HR20020559A HRP20020559A2 (en) 1999-12-30 2000-12-26 Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
AU20126/01A AU775918B2 (en) 1999-12-30 2000-12-26 Novel esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
EP00983358A EP1251120B1 (en) 1999-12-30 2000-12-26 Esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
YU50902A YU50902A (sh) 1999-12-30 2000-12-26 Novi estri izvedeni iz (rr,ss)-3-(2-dimetilaminometil-1-hidroksicikloheksil)fenil 2-hidroksibenzoata
US10/169,177 US6894076B2 (en) 1999-12-30 2000-12-26 Esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
NZ520263A NZ520263A (en) 1999-12-30 2000-12-26 Esters derived from (RR,SS)-3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl 2-hydroxybenzoate and their use for the treatment of pain
CZ20022189A CZ20022189A3 (cs) 1999-12-30 2000-12-26 Nové estery odvozené od (RR, SS)-3-(2-dimethylaminomethyl-l-hydroxycyklohexyl)fenyl-2-hydroxybenzoátu
PL00356056A PL356056A1 (en) 1999-12-30 2000-12-26 Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
CN00817916A CN1414946A (zh) 1999-12-30 2000-12-26 衍生于(rr,ss)－3－(2－二甲基氨甲基－1－羟基环己基)苯基2－羟基苯甲酸酯的新酯
PCT/ES2000/000486 WO2001049650A1 (es) 1999-12-30 2000-12-26 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil)fenilo
IL15039200A IL150392A0 (en) 1999-12-30 2000-12-26 Novel esters derived from (rr, ss)-2-(hydroxbenzoate of 3-(2-dimethylaminomethyl-1-hydroxyclohexyl) phenyl
HU0204147A HUP0204147A3 (en) 1999-12-30 2000-12-26 Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl, process for their preparation, pharmaceutical compositions containing them and their use
BR0016882-3A BR0016882A (pt) 1999-12-30 2000-12-26 ésteres derivados de (rr,ss)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato
JP2001550190A JP2003519208A (ja) 1999-12-30 2000-12-26 （ｒｒ，ｓｓ）−３−（２−ジメチルアミノメチル−１−ヒドロキシシクロヘキシル）フェニル２−ヒドロキシベンゾエートから誘導される新規エステル
MXPA02006514A MXPA02006514A (es) 1999-12-30 2000-12-26 Nuevos esteres derivados de (rr, ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
MA26710A MA26862A1 (fr) 1999-12-30 2002-06-24 Nouveaux esters derivant de (rr,ss)-3-(2-dimethylaminomethyl-1-hydroxycyclohexyl) phennyle 2-hydroxybenzoate
IS6440A IS6440A (is) 1999-12-30 2002-06-25 Nýir esterar leiddir af (RR,SS)-3-(2-dímetýlamínómetýl-1-hýdroxýsýklóhexýl)fenýl 2-hýdroxýbensóati
NO20023098A NO20023098D0 (no) 1999-12-30 2002-06-26 Nye estere avledet fra (RR, SS)-3-(2-dimetylaminometyl-1- hydroksysykloheksyl)fenyl 2-hydroksybenzoat
ZA200205193A ZA200205193B (en) 1999-12-30 2002-06-27 Novel esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl.
BG106883A BG106883A (en) 1999-12-30 2002-06-28 Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200000060A ES2160534B1 (es) 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.

Publications (2)

Publication Number Publication Date
ES2160534A1 true ES2160534A1 (es) 2001-11-01
ES2160534B1 ES2160534B1 (es) 2002-04-16

Family

ID=8491916

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200000060A Expired - Fee Related ES2160534B1 (es) 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.

Country Status (30)

Country Link
US (1) US6894076B2 (es)
EP (1) EP1251120B1 (es)
JP (1) JP2003519208A (es)
KR (1) KR20020063281A (es)
CN (1) CN1414946A (es)
AP (1) AP1234A (es)
AT (1) ATE284380T1 (es)
AU (1) AU775918B2 (es)
BG (1) BG106883A (es)
BR (1) BR0016882A (es)
CA (1) CA2395976A1 (es)
CZ (1) CZ20022189A3 (es)
DE (1) DE60016631D1 (es)
EA (1) EA004770B1 (es)
EE (1) EE200200365A (es)
ES (1) ES2160534B1 (es)
HR (1) HRP20020559A2 (es)
HU (1) HUP0204147A3 (es)
IL (1) IL150392A0 (es)
IS (1) IS6440A (es)
MA (1) MA26862A1 (es)
MX (1) MXPA02006514A (es)
NO (1) NO20023098D0 (es)
NZ (1) NZ520263A (es)
OA (1) OA12132A (es)
PL (1) PL356056A1 (es)
SK (1) SK9252002A3 (es)
WO (1) WO2001049650A1 (es)
YU (1) YU50902A (es)
ZA (1) ZA200205193B (es)

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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
US8383152B2 (en) 2008-01-25 2013-02-26 Gruenenthal Gmbh Pharmaceutical dosage form
TWI524904B (zh) 2008-05-09 2016-03-11 歌林達股份有限公司 製備醫藥用固體劑型，尤指錠劑之方法，及製備固體劑型，尤指錠劑之前驅物之方法
US8058469B2 (en) * 2008-11-03 2011-11-15 Sabic Innovative Plastics Ip B.V. Method for making carbamates, ureas and isocyanates
JP5667183B2 (ja) 2009-07-22 2015-02-12 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 加熱溶融押出成型した制御放出性投与剤型
NZ596668A (en) 2009-07-22 2013-09-27 Gruenenthal Chemie Oxidation-stabilized tamper-resistant dosage form
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MX2013002293A (es) 2010-09-02 2013-05-09 Gruenenthal Gmbh Forma de dosificacion resistente a alteracion que comprende un polimero anionico.
ES2486791T3 (es) 2010-09-02 2014-08-19 Grünenthal GmbH Forma de dosificación resistente a la manipulación que comprende una sal inorgánica
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
EA201400172A1 (ru) 2011-07-29 2014-06-30 Грюненталь Гмбх Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
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WO2013127831A1 (en) 2012-02-28 2013-09-06 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
ES2692944T3 (es) 2012-04-18 2018-12-05 Grünenthal GmbH Forma de dosificación farmacéutica resistente a la manipulación y resistente a la descarga rápida de la dosis
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
BR112015026549A2 (pt) 2013-05-29 2017-07-25 Gruenenthal Gmbh forma de dosagem à prova de violação contendo uma ou mais partículas
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
AU2014289187B2 (en) 2013-07-12 2019-07-11 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
AU2014356581C1 (en) 2013-11-26 2020-05-28 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
MX2016014738A (es) 2014-05-12 2017-03-06 Gruenenthal Gmbh Formulacion en capsula de liberacion inmediata resistente a alteraciones que comprende tapentadol.
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
CA2998259A1 (en) 2015-09-10 2017-03-16 Grunenthal Gmbh Protecting oral overdose with abuse deterrent immediate release formulations
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US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US5733936A (en) * 1995-07-11 1998-03-31 Gruenenthal Gmbh 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients
WO2000027799A1 (es) * 1998-11-06 2000-05-18 Vita-Invest, S.A. Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos

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GB997399A (en) * 1963-04-02 1965-07-07 Gruenenthal Chemie Phenol ethers that contain basic groups
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US5733936A (en) * 1995-07-11 1998-03-31 Gruenenthal Gmbh 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients
WO2000027799A1 (es) * 1998-11-06 2000-05-18 Vita-Invest, S.A. Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos

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Title
Chemical Abstract, Vol. 88, No 21, 22.05.1978 (Columbus, OH, USA), resumen 14597ot, FLICK, K. et al. "Studies on chemical structure and analgetic activity of phenyl substituted aminomethylcyclohexanols". *

Also Published As

Publication number Publication date
ES2160534B1 (es) 2002-04-16
JP2003519208A (ja) 2003-06-17
EP1251120A1 (en) 2002-10-23
US20030100598A1 (en) 2003-05-29
EA200200614A1 (ru) 2002-12-26
OA12132A (en) 2006-05-05
BR0016882A (pt) 2002-11-05
AU775918B2 (en) 2004-08-19
KR20020063281A (ko) 2002-08-01
EP1251120B1 (en) 2004-12-08
HUP0204147A2 (hu) 2003-04-28
HUP0204147A3 (en) 2003-10-28
IL150392A0 (en) 2002-12-01
YU50902A (sh) 2006-01-16
ATE284380T1 (de) 2004-12-15
MA26862A1 (fr) 2004-12-20
SK9252002A3 (en) 2003-04-01
MXPA02006514A (es) 2004-07-30
WO2001049650A1 (es) 2001-07-12
ZA200205193B (en) 2003-06-27
BG106883A (en) 2003-05-30
AU2012601A (en) 2001-07-16
IS6440A (is) 2002-06-25
PL356056A1 (en) 2004-06-14
CN1414946A (zh) 2003-04-30
DE60016631D1 (de) 2005-01-13
NO20023098L (no) 2002-06-26
CZ20022189A3 (cs) 2003-03-12
AP2002002571A0 (en) 2002-09-30
NO20023098D0 (no) 2002-06-26
NZ520263A (en) 2004-07-30
HRP20020559A2 (en) 2004-02-29
US6894076B2 (en) 2005-05-17
EE200200365A (et) 2003-10-15
AP1234A (en) 2003-12-28
CA2395976A1 (en) 2001-07-12
EA004770B1 (ru) 2004-08-26

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