ES2160190T3 - Esteres de acido sulfurico de alcoholes de azucar para la inhibicion de la migracion y proliferacion de celulas de los musculos lisos de las paredes vasculares. - Google Patents
Esteres de acido sulfurico de alcoholes de azucar para la inhibicion de la migracion y proliferacion de celulas de los musculos lisos de las paredes vasculares.Info
- Publication number
- ES2160190T3 ES2160190T3 ES96106471T ES96106471T ES2160190T3 ES 2160190 T3 ES2160190 T3 ES 2160190T3 ES 96106471 T ES96106471 T ES 96106471T ES 96106471 T ES96106471 T ES 96106471T ES 2160190 T3 ES2160190 T3 ES 2160190T3
- Authority
- ES
- Spain
- Prior art keywords
- sup
- radical
- derivative
- independently
- decreased
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 title abstract 6
- 150000005846 sugar alcohols Chemical class 0.000 title abstract 5
- 230000035755 proliferation Effects 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000005012 migration Effects 0.000 title 1
- 238000013508 migration Methods 0.000 title 1
- 210000002460 smooth muscle Anatomy 0.000 title 1
- 230000002792 vascular Effects 0.000 title 1
- -1 HYDROXYL GROUP Chemical group 0.000 abstract 7
- 230000003247 decreasing effect Effects 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000007983 Tris buffer Substances 0.000 abstract 1
- 230000001066 destructive effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
- C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
- C07C305/06—Hydrogenosulfates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
- C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
- C07C305/10—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated being further substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Abstract
LA PRESENTE INVENCION TRATA DE NUEVOS ESTERES DE ACIDO SULFURICO Y DE COMPUESTOS SIMILARES A LOS ALCOHOLES DE AZUCAR DE FORMULA GENERAL IA Y IB EN DONDE N{SUP,1} - N{SUP,9} SON 0 O 1, INDEPENDIENTEMENTE UNO DE OTRO; Y M{SUP,1} - M{SUP,9} SON 0 O 1 INDEPENDIENTEMENTE UNO DE OTRO, CON LA CONDICION DE QUE AL MENOS UNO DE M{SUP,1}, M{SUP,2} O M{SUP,3}, AL MENOS UNO DE M{SUP,4}, M{SUP,5} O M{SUP,6}, Y SI EXISTE, AL MENOS UNO DE M{SUP,7}, M{SUP,8} O M{SUP,9} SEAN 1; Y EN DONDE X{SUP,1}- V{SUP,18} SON INDEPENDIENTEMENTE UNO DE OTRO -O-, CONR{SUP,1}-, -NR{SUP,1}CO-, -NR{SUP,1}-; R{SUP,1} ES HIDROGENO O ALQUILO DE CADENA CORTA; W ES UN RADICAL DE BENCENO O UN RADICAL DE S-TRIAZINA; Y{SUP,1} - Y{SUP,9} SON SISTEMAS CICLICOS AROMATICOS INDEPENDIENTEMENTE UNO DE OTRO; A{SUP,1} - A{SUP,3} SON, INDEPENDIENTEMENTE UNO DE OTRO, UN RADICAL DISMINUIDO EN 1 GRUPO HIDROXILO DE UN ALCOHOL DE AZUCAR, O UN DERIVADO, UN RADICAL DISMINUIDO EN 1 GRUPO CARBOXILO DE UN ACIDO CARBOXILICO DE AZUCAR, O UN DERIVADO, UN RADICAL TRIS(HIDROXIMETIL)-METILO; D ES UN RADICAL DOBLE DE UN ALCOHOL DE AZUCAR DISMINUIDO EN DOS GRUPOS HIDROXILOS, O UN DERIVADO, O UN RADICAL DOBLE DE UN ACIDO DICARBOXILICO DE AZUCAR DISMINUIDO EN DOS GRUPOS CARBOXILOS, O UN DERIVADO; Q{SUP,1} - Q{SUP,3} Y Z{SUP,1} - Z{SUP,3} SON, INDEPENDIENTEMENTE UNO DE OTRO, UN RADICAL DOBLE DE UN ALCOHOL DE AZUCAR DISMINUIDO EN 2 GRUPOS HIDROXILOS, O UN DERIVADO, O UN RADICAL DOBLE DE UN ACIDO DICARBOXILICO DE AZUCAR DISMINUIDO EN 2 GRUPOS CARBOXILOS, O UN DERIVADO, O UN RADICAL DOBLE DE DESOXIGLUCOPIRANOSA, O UN DERIVADO, ESTANDO ESTERIFICADO CON ACIDO SULFURICO AL MENOS UN GRUPO HIDROXILO DE LOS RADICALES A{SUP,1} - A{SUP,3}, D, Q{SUP,1} - Q{SUP,3} Y Z{SUP,1} - Z{SUP,3}; Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. LOS COMPUESTOS DE ACUERDO CON LA INVENCION, COMO POR EJEMPLO ESTAN INDICADOS EN EL TRATAMIENTO DE ENFERMEDADES, QUE SE CARACTERIZAN POR UNA PROLIFERACION EXCESIVA O DESTRUCTIVA DE CELULAS DE MUSCULO LISO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH131095 | 1995-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2160190T3 true ES2160190T3 (es) | 2001-11-01 |
Family
ID=4207454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96106471T Expired - Lifetime ES2160190T3 (es) | 1995-05-05 | 1996-04-24 | Esteres de acido sulfurico de alcoholes de azucar para la inhibicion de la migracion y proliferacion de celulas de los musculos lisos de las paredes vasculares. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5830920A (es) |
| EP (1) | EP0741128B1 (es) |
| JP (1) | JP2881752B2 (es) |
| CN (1) | CN1150589A (es) |
| AR (1) | AR003945A1 (es) |
| AT (1) | ATE202339T1 (es) |
| BR (1) | BR9602148A (es) |
| CA (1) | CA2174583A1 (es) |
| DE (1) | DE59607115D1 (es) |
| DK (1) | DK0741128T3 (es) |
| ES (1) | ES2160190T3 (es) |
| GR (1) | GR3036660T3 (es) |
| MX (1) | MX9601521A (es) |
| PT (1) | PT741128E (es) |
| TR (1) | TR199600329A2 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1324996A2 (de) | 2000-01-17 | 2003-07-09 | Bayer CropScience AG | Substituierte arylketone |
| US6600069B2 (en) | 2000-09-07 | 2003-07-29 | Telik, Inc. | Benzene tricarboxylic acid derivatives as insulin receptor activators |
| US7354747B1 (en) * | 2003-05-08 | 2008-04-08 | The Regents Of The University Of California | Carbohydrate derived protein resistant biomaterial |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| CA2751125C (en) * | 2009-01-29 | 2017-06-20 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US9855276B2 (en) | 2012-10-25 | 2018-01-02 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| EP3060205A4 (en) | 2013-10-22 | 2017-06-28 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| WO2015151068A1 (en) * | 2014-04-03 | 2015-10-08 | Universita' Di Pisa | Synthetic analogues of 3-iodothyronamine (t1am) and uses thereof |
| WO2015150995A1 (en) | 2014-04-04 | 2015-10-08 | Pfizer Inc. | Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors |
| CN116889562A (zh) | 2016-08-31 | 2023-10-17 | 通用医疗公司 | 与神经退行性疾病相关的神经炎症中的巨噬细胞/小胶质细胞 |
| MX2020000577A (es) | 2017-07-20 | 2020-09-10 | Aztherapies Inc | Formulaciones en polvo de cromolina sodica e ibuprofeno. |
| CA3105392A1 (en) | 2018-07-02 | 2020-01-09 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and .alpha.-lactose |
| JP2021535181A (ja) * | 2018-09-05 | 2021-12-16 | ザ ジェネラル ホスピタル コーポレイション | サイトカイン放出症候群を処置する方法 |
| AU2019397436A1 (en) | 2018-12-10 | 2021-07-22 | The General Hospital Corporation | Cromolyn esters and uses thereof |
| JP7388022B2 (ja) * | 2019-07-12 | 2023-11-29 | 日産化学株式会社 | 高分子架橋剤を用いたレジスト下層膜形成組成物 |
| WO2021207060A1 (en) | 2020-04-06 | 2021-10-14 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1144905A (en) * | 1965-03-25 | 1969-03-12 | Fisons Pharmaceuticals Ltd | Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof |
| DE3101376A1 (de) * | 1981-01-17 | 1982-09-02 | Bayer Ag, 5090 Leverkusen | Sisomicin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB8612940D0 (en) * | 1986-05-28 | 1986-07-02 | Dow Chemical Co | Derivative esters |
| DE3734815A1 (de) * | 1987-10-14 | 1989-04-27 | Luitpold Werk Chem Pharm | Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel |
| DE3734853A1 (de) * | 1987-10-14 | 1989-04-27 | Luitpold Werk Chem Pharm | Bis-aldonsaeureamide und verfahren zu ihrer herstellung |
| US5298616A (en) * | 1990-10-03 | 1994-03-29 | Hoffmann-La Roche Inc. | Sulfated O-polysaccharide-trehaloses |
| CA2061370A1 (en) * | 1991-03-13 | 1992-09-14 | Markus Hosang | Pharmaceutical preparations |
| TW308598B (es) * | 1994-01-14 | 1997-06-21 | Hoffmann La Roche |
-
1996
- 1996-04-19 CA CA002174583A patent/CA2174583A1/en not_active Abandoned
- 1996-04-19 TR TR96/00329A patent/TR199600329A2/xx unknown
- 1996-04-23 JP JP8100874A patent/JP2881752B2/ja not_active Expired - Lifetime
- 1996-04-23 MX MX9601521A patent/MX9601521A/es unknown
- 1996-04-24 DE DE59607115T patent/DE59607115D1/de not_active Expired - Fee Related
- 1996-04-24 EP EP96106471A patent/EP0741128B1/de not_active Expired - Lifetime
- 1996-04-24 AT AT96106471T patent/ATE202339T1/de not_active IP Right Cessation
- 1996-04-24 ES ES96106471T patent/ES2160190T3/es not_active Expired - Lifetime
- 1996-04-24 DK DK96106471T patent/DK0741128T3/da active
- 1996-04-24 PT PT96106471T patent/PT741128E/pt unknown
- 1996-04-26 US US08/639,986 patent/US5830920A/en not_active Expired - Fee Related
- 1996-04-30 CN CN96100231A patent/CN1150589A/zh active Pending
- 1996-05-02 AR ARP960102418A patent/AR003945A1/es unknown
- 1996-05-03 BR BR9602148-9A patent/BR9602148A/pt not_active IP Right Cessation
-
2001
- 2001-09-18 GR GR20010401520T patent/GR3036660T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2174583A1 (en) | 1996-11-06 |
| EP0741128B1 (de) | 2001-06-20 |
| US5830920A (en) | 1998-11-03 |
| JPH08301839A (ja) | 1996-11-19 |
| MX9601521A (es) | 1997-02-28 |
| EP0741128A2 (de) | 1996-11-06 |
| DE59607115D1 (de) | 2001-07-26 |
| ATE202339T1 (de) | 2001-07-15 |
| GR3036660T3 (en) | 2001-12-31 |
| BR9602148A (pt) | 2005-06-21 |
| EP0741128A3 (de) | 1997-03-26 |
| PT741128E (pt) | 2001-11-30 |
| CN1150589A (zh) | 1997-05-28 |
| TR199600329A2 (tr) | 1997-03-21 |
| JP2881752B2 (ja) | 1999-04-12 |
| AR003945A1 (es) | 1998-09-30 |
| DK0741128T3 (da) | 2001-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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