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ES2159523T3 - Procedimientos de encapsulado y composiciones de encapsulado reticuladas biocompatibles. - Google Patents

Procedimientos de encapsulado y composiciones de encapsulado reticuladas biocompatibles.

Info

Publication number
ES2159523T3
ES2159523T3 ES93912103T ES93912103T ES2159523T3 ES 2159523 T3 ES2159523 T3 ES 2159523T3 ES 93912103 T ES93912103 T ES 93912103T ES 93912103 T ES93912103 T ES 93912103T ES 2159523 T3 ES2159523 T3 ES 2159523T3
Authority
ES
Spain
Prior art keywords
biocompatible
recycled
crosslinked
component
composition compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93912103T
Other languages
English (en)
Inventor
Neil P Desai
Patrick Soon-Shiong
Paul A Sandford
Roswitha Heintz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AmCyte Inc
Original Assignee
AmCyte Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AmCyte Inc filed Critical AmCyte Inc
Application granted granted Critical
Publication of ES2159523T3 publication Critical patent/ES2159523T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Macromonomer-Based Addition Polymer (AREA)

Abstract

COMPOSICIONES ENTRELAZADAS BIOCOMPATIBLES QUE COMPRENDEN UN COMPONENTE ENTRELAZADO IONICAMENTE Y UN COMPONENTE COVALENTEMENTE ENTRELAZADO PARA ENCAPSULAR PRODUCTOS BIOLOGICOS SE DESCRIBEN. DE ACUERDO CON LA PRESENTE INVENCION, TAMBIEN SE DESCUBREN MEZCLAS ENTRELAZABLES BIOCOMPATIBLES QUE COMPRENDEN UN COMPONENTE ENTRELAZADO IONICAMENTE Y UN COMPONENTE ENTRELAZADO COVALENTEMENTE. METODOS PARA ENCAPSULAR PRODUCTOS BIOLOGICOS CON LAS COMPOSICIONES ENTRELAZADAS Y ENTRELAZADAS BIOCOMPATIBLES SE PROPORCIONAN. TAMBIEN, MACROCAPSULAS RECUPERABLES PARA ENCAPSULAR MICROCAPSULAS O PRODUCTOS BIOLOGICOS SE DESCRIBEN.
ES93912103T 1992-04-08 1993-04-01 Procedimientos de encapsulado y composiciones de encapsulado reticuladas biocompatibles. Expired - Lifetime ES2159523T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/866,038 US5334640A (en) 1992-04-08 1992-04-08 Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods

Publications (1)

Publication Number Publication Date
ES2159523T3 true ES2159523T3 (es) 2001-10-16

Family

ID=25346803

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93912103T Expired - Lifetime ES2159523T3 (es) 1992-04-08 1993-04-01 Procedimientos de encapsulado y composiciones de encapsulado reticuladas biocompatibles.

Country Status (13)

Country Link
US (2) US5334640A (es)
EP (1) EP0635040B1 (es)
JP (1) JPH07508048A (es)
AT (1) ATE202132T1 (es)
AU (1) AU661250B2 (es)
BR (1) BR9306219A (es)
CA (1) CA2132977C (es)
DE (1) DE69330344T2 (es)
DK (1) DK0635040T3 (es)
ES (1) ES2159523T3 (es)
GR (1) GR3036210T3 (es)
PT (1) PT635040E (es)
WO (1) WO1993021266A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7931916B2 (en) 2008-12-23 2011-04-26 Grifols, S.A. Composition of biocompatible microparticles of alginic acid for the controlled release of active ingredients by intravenous administration

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EP0635040B1 (en) 2001-06-13
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