ES2158438T3 - Proceso de preparacion de 13-cis acido retinoico. - Google Patents
Proceso de preparacion de 13-cis acido retinoico.Info
- Publication number
- ES2158438T3 ES2158438T3 ES97122732T ES97122732T ES2158438T3 ES 2158438 T3 ES2158438 T3 ES 2158438T3 ES 97122732 T ES97122732 T ES 97122732T ES 97122732 T ES97122732 T ES 97122732T ES 2158438 T3 ES2158438 T3 ES 2158438T3
- Authority
- ES
- Spain
- Prior art keywords
- cis
- preparation process
- retinoic acid
- cis retinoic
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 title 1
- 229960005280 isotretinoin Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
ISOMERIZACION FOTOQUIMICA DEL ACIDO 11 - CIS, 13 - CIS RETINOICO A ACIDO 13 - CIS RETINOICO CARACTERIZADA PORQUE SE REALIZA EN UNA SOLUCION ACUOSA DE UNA SAL ALCANINA DE DICHO ACIDO 11 - CIS, 13 - CIS RETINOICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI002752A IT1289528B1 (it) | 1996-12-27 | 1996-12-27 | Procedimento per la preparazione dell'acido 13,cis-retinoico |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2158438T3 true ES2158438T3 (es) | 2001-09-01 |
Family
ID=11375500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97122732T Expired - Lifetime ES2158438T3 (es) | 1996-12-27 | 1997-12-23 | Proceso de preparacion de 13-cis acido retinoico. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5892073A (es) |
| EP (1) | EP0850925B1 (es) |
| CN (1) | CN1091440C (es) |
| AT (1) | ATE200278T1 (es) |
| DE (1) | DE69704475T2 (es) |
| ES (1) | ES2158438T3 (es) |
| GR (1) | GR3036170T3 (es) |
| IT (1) | IT1289528B1 (es) |
| PT (1) | PT850925E (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1299582B1 (it) | 1998-05-19 | 2000-03-16 | Lab Mag Spa | Procedimento per la preparazione dell'acido 13-cis-retinoico |
| US7721948B1 (en) * | 1999-05-25 | 2010-05-25 | Silverbrook Research Pty Ltd | Method and system for online payments |
| AUPQ291299A0 (en) * | 1999-09-17 | 1999-10-07 | Silverbrook Research Pty Ltd | A self mapping surface and related applications |
| US20060013630A1 (en) * | 1999-06-30 | 2006-01-19 | Silverbrook Research Pty Ltd | Printing a photograph using a mobile device |
| IN190846B (es) * | 1999-07-30 | 2003-08-23 | Ranbaxy Lab Ltd | |
| CN104447459A (zh) * | 2014-11-28 | 2015-03-25 | 重庆华邦制药有限公司 | 异维a酸的新晶型及其制备方法与应用 |
| CN111454141A (zh) * | 2020-04-26 | 2020-07-28 | 上海新华联制药有限公司 | 一种异维a酸缩合物及其制备方法和应用 |
| WO2022145617A1 (ko) * | 2020-12-28 | 2022-07-07 | (주)아크에이르 | 신규 화합물 potassium all-trans retinoate 및 potassium 9-cis retinoate의 합성방법 및 이를 포함하는 심혈관 치료용 약학적 조성물 |
| KR102271364B1 (ko) * | 2020-12-28 | 2021-06-30 | (주)아크에이르 | 신규화합물 Potassium all-trans retinoate 및 Potassium 9-cis retinoate의 합성방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556518A (en) * | 1982-12-10 | 1985-12-03 | Hoffmann-La Roche Inc. | Preparation of 13-cis retinoic acid |
| DE4313089A1 (de) * | 1993-04-22 | 1994-10-27 | Basf Ag | Verfahren zur Herstellung von 13-(Z)-Retinsäure |
| IT1274494B (it) * | 1995-05-12 | 1997-07-17 | Lab Mag Spa | Procedimento fotochimico per la preparazione dell'acido 13-cis-retinoico |
-
1996
- 1996-12-27 IT IT96MI002752A patent/IT1289528B1/it active IP Right Grant
-
1997
- 1997-12-22 US US08/995,392 patent/US5892073A/en not_active Expired - Lifetime
- 1997-12-23 EP EP97122732A patent/EP0850925B1/en not_active Expired - Lifetime
- 1997-12-23 PT PT97122732T patent/PT850925E/pt unknown
- 1997-12-23 DE DE69704475T patent/DE69704475T2/de not_active Expired - Lifetime
- 1997-12-23 ES ES97122732T patent/ES2158438T3/es not_active Expired - Lifetime
- 1997-12-23 AT AT97122732T patent/ATE200278T1/de active
- 1997-12-25 CN CN97125927A patent/CN1091440C/zh not_active Expired - Lifetime
-
2001
- 2001-07-04 GR GR20010401021T patent/GR3036170T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69704475T2 (de) | 2001-10-11 |
| GR3036170T3 (en) | 2001-10-31 |
| EP0850925B1 (en) | 2001-04-04 |
| CN1091440C (zh) | 2002-09-25 |
| IT1289528B1 (it) | 1998-10-15 |
| EP0850925A1 (en) | 1998-07-01 |
| ATE200278T1 (de) | 2001-04-15 |
| US5892073A (en) | 1999-04-06 |
| PT850925E (pt) | 2001-08-30 |
| ITMI962752A1 (it) | 1998-06-27 |
| CN1186070A (zh) | 1998-07-01 |
| DE69704475D1 (de) | 2001-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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