[go: up one dir, main page]

ES2158034T3 - Derivado de benzotiepina opticamente activo, su preparacion y uso. - Google Patents

Derivado de benzotiepina opticamente activo, su preparacion y uso.

Info

Publication number
ES2158034T3
ES2158034T3 ES95120444T ES95120444T ES2158034T3 ES 2158034 T3 ES2158034 T3 ES 2158034T3 ES 95120444 T ES95120444 T ES 95120444T ES 95120444 T ES95120444 T ES 95120444T ES 2158034 T3 ES2158034 T3 ES 2158034T3
Authority
ES
Spain
Prior art keywords
optically active
benzotiepine
derived
preparation
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95120444T
Other languages
English (en)
Inventor
Takashi Sohda
Shigehisa Taketomi
Tsuneo Oda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2158034T3 publication Critical patent/ES2158034T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655363—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring
    • C07F9/655372—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/67—Phosphorus compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN DERIVADO DE LA BENZOTIEPINA, OPTICAMENTE ACTIVO REPRESENTADO POR LA FORMULA (I) EN DONDE R REPRESENTA UN GRUPO DE ALQUIL INFERIOR; R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE UN GRUPO DE ALQUILO INFERIOR, O SE PUEDEN UNIR ENTRE SI PARA FORMAR UN ANILLO, EL DERIVADO EXHIBE UNA EXCELENTE ACCION PROMOTORA DE LAS OSTEOGENESIS Y UTIL COMO DROGA PROFILACTICA PARA ENFERMEDADES DE LOS HUESOS.
ES95120444T 1994-12-28 1995-12-22 Derivado de benzotiepina opticamente activo, su preparacion y uso. Expired - Lifetime ES2158034T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP32727594 1994-12-28

Publications (1)

Publication Number Publication Date
ES2158034T3 true ES2158034T3 (es) 2001-09-01

Family

ID=18197308

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95120444T Expired - Lifetime ES2158034T3 (es) 1994-12-28 1995-12-22 Derivado de benzotiepina opticamente activo, su preparacion y uso.

Country Status (20)

Country Link
US (2) US6346521B1 (es)
EP (1) EP0719782B1 (es)
KR (1) KR960022542A (es)
CN (1) CN1058718C (es)
AR (1) AR002018A1 (es)
AT (1) ATE202782T1 (es)
AU (1) AU689004B2 (es)
BR (1) BR9506098A (es)
CA (1) CA2166152A1 (es)
DE (1) DE69521595T2 (es)
DK (1) DK0719782T3 (es)
ES (1) ES2158034T3 (es)
FI (1) FI956273A7 (es)
GR (1) GR3036757T3 (es)
HU (1) HUT74562A (es)
NO (1) NO303641B1 (es)
NZ (1) NZ280745A (es)
PT (1) PT719782E (es)
RU (1) RU2162083C2 (es)
TW (1) TW403757B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990022514A (ko) * 1995-06-05 1999-03-25 다께다 구니오 골재생 증진 약학 조성물
US5910492A (en) * 1995-06-05 1999-06-08 Takeda Chemical Industries, Ltd. Osteogenic promoting pharmaceutical composition
WO1997003989A1 (en) * 1995-07-24 1997-02-06 Takeda Chemical Industries, Ltd. Production of optically active benzothiepin salts
EP0949927B1 (en) 1996-08-26 2002-10-16 Takeda Chemical Industries, Ltd. Pharmaceutical composition containing osteogenesis-promoting substance and a polyethylene glycol
AU4571097A (en) * 1996-10-09 1998-05-05 Takeda Chemical Industries Ltd. A method for producing a microparticle
WO1999065474A2 (en) * 1998-06-15 1999-12-23 Takeda Chemical Industries, Ltd. Compositions for treating cartilage disease comprising certain sulfur-containing heterocyclic compounds
EP1103552A4 (en) 1998-08-07 2003-01-15 Takeda Chemical Industries Ltd BENZOTHIEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
AU5196099A (en) * 1998-08-12 2000-03-06 Takeda Chemical Industries Ltd. Enhancer of cell differentiation induction factor
AU5998799A (en) * 1998-09-30 2000-04-17 Takeda Chemical Industries Ltd. Bone repair materials/artificial bone compositions
AU2001240115A1 (en) * 2000-03-10 2001-09-24 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
IL159853A0 (en) * 2001-07-17 2004-06-20 Teva Pharma Dosage forms for immediate gastric release of a calcium transport stimulator coupled with delayed gastric release of a bis-phosphonate
US20050026871A1 (en) * 2002-07-17 2005-02-03 Moshe Flashner-Barak Method of increasing bioavailability of alendronate or other bis-phosphonate by predose administration of vitamin D derivative
EP1640010A1 (en) * 2003-07-01 2006-03-29 Astellas Pharma Inc. Agent inducing increase in bone mass
WO2009006226A1 (en) * 2007-06-29 2009-01-08 Kci Licensing Inc. Activation of bone and cartilage formation
EP2380878B1 (en) 2009-01-19 2013-08-14 Daiichi Sankyo Company, Limited Cyclic compound having hetero atom
KR20120006016A (ko) 2009-04-06 2012-01-17 다이이찌 산쿄 가부시키가이샤 치환 페닐기를 갖는 고리형 화합물
MX2012012145A (es) 2010-04-28 2012-11-21 Daiichi Sankyo Co Ltd Compuestos [5, 6] heterociclico.
JP6484555B2 (ja) 2013-08-29 2019-03-13 京都薬品工業株式会社 新規芳香族化合物およびその用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138535A3 (en) * 1983-10-13 1987-01-28 British Telecommunications Plc Visual display logic simulation system
US5158943A (en) * 1988-11-21 1992-10-27 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
NZ231939A (en) 1988-12-28 1991-07-26 Takeda Chemical Industries Ltd Benzothiopyran derivatives and medicaments
EP0460488B1 (en) * 1990-05-30 2001-07-11 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
JP3165866B2 (ja) * 1990-06-06 2001-05-14 武田薬品工業株式会社 含硫黄複素環化合物

Also Published As

Publication number Publication date
NZ280745A (en) 1997-09-22
DE69521595D1 (de) 2001-08-09
EP0719782B1 (en) 2001-07-04
CN1131669A (zh) 1996-09-25
KR960022542A (ko) 1996-07-18
GR3036757T3 (en) 2001-12-31
FI956273L (fi) 1996-06-29
TW403757B (en) 2000-09-01
CA2166152A1 (en) 1996-06-29
RU2162083C2 (ru) 2001-01-20
NO955305L (no) 1996-07-01
HU9503802D0 (en) 1996-02-28
NO303641B1 (no) 1998-08-10
NO955305D0 (no) 1995-12-27
AR002018A1 (es) 1998-01-07
CN1058718C (zh) 2000-11-22
DK0719782T3 (da) 2001-09-24
FI956273A0 (fi) 1995-12-27
HUT74562A (en) 1997-01-28
US6632807B1 (en) 2003-10-14
FI956273A7 (fi) 1996-06-29
DE69521595T2 (de) 2002-05-23
AU4069395A (en) 1996-07-04
ATE202782T1 (de) 2001-07-15
US6346521B1 (en) 2002-02-12
AU689004B2 (en) 1998-03-19
EP0719782A1 (en) 1996-07-03
BR9506098A (pt) 1997-12-23
PT719782E (pt) 2001-10-31

Similar Documents

Publication Publication Date Title
ES2158034T3 (es) Derivado de benzotiepina opticamente activo, su preparacion y uso.
ES2184070T3 (es) Derivados de oximas sustituidas utiles como antagonistas de la neuroquinina.
EA200702346A1 (ru) КРИСТАЛЛИЧЕСКАЯ ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГИДРОФУРАН-3-ИЛОКСИ)БЕНЗИЛ]БЕНЗОЛА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ЕЁ ПРИМЕНЕНИЕ ДЛЯ ПРИГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ
BR0112756A (pt) Composto, composição farmacêutica, métodos para o tratamento de doenças mediadas por prostaglandina, de congestão nasal, asma alérgica, e rinite alérgica, e, uso de um composto
ES2192301T3 (es) Derivados de resorcinol.
HN2001000027A (es) Derivados de purina
ES2159491B1 (es) Base cristalina de citalopram
DK0813525T3 (da) Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
HN1999000124A (es) Derivados de pirazol substituido.
PA8577001A1 (es) Benzoilureas heterociclicamente sustituidas, procedimiento para su preparacion y su uso como farmacos
ES2112650T3 (es) Sales de un derivado de indol antimigraña.
AR008861A1 (es) COMPUESTOS DE LACTAMA E IMIDA HETEROCICLICOS DE ARALQUILO Y ARALQUILEDENO, COMPUESTOS INTERMEDIARIOS PARA SU SíNTESIS, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN.
GT199900055A (es) Nuevas dihidropirimidinas2 heterocìclicamente sustituidas.
HN2004000538A (es) "PIRIDO[ 2,3-d ] PIRIMIDINA-2,4-DIAMINAS COMO-INHIBIDORES DE PDE 2"
CY1105301T1 (el) Αρυλοσυμπυκνωμενες αζαπολυκυκλικες ενωσεις
EA200300937A1 (ru) Оральная фармацевтическая композиция цефподоксима проксетила
DK0929547T3 (da) Benzamidinderivater substitueret af cykliske aminosyrederivater eller cykliske hydroxysyrederivater og deres anvendelse som antikoagulantia
ES2055159T3 (es) Composiciones que inducen la union entre partes de tejido mineralizado vivo.
BR0015836A (pt) Cristal de 4-carboxiamino-2-etil-1,2,3,4-tetra-hidroquinolina como inibidor de cetp
UY27338A1 (es) Nuevos derivados de ácido sulfónico
SE9901077D0 (sv) Novel use
EA200600605A1 (ru) Перегруппированные пентанолы, способ их получения и их применение в качестве противовоспалительных средств
ECSP044973A (es) Nuevas formas polimorficas cristalinas de clorhidrato de lercanidipina y proceso para su preparacion
HN2000000045A (es) Nuevas combinaciones farmaceuticas para inhibidores de la nos.
PA8492701A1 (es) Derivados de resorcinol.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 719782

Country of ref document: ES