ES2156769B1 - Gen quimerico que permite expresar el gen o el cdna del factor de crecimiento similar a la insulina de tipo i (igf-i) en pancreas y su utilizacion para la terapia genica de la diabetes mellitus. - Google Patents

Gen quimerico que permite expresar el gen o el cdna del factor de crecimiento similar a la insulina de tipo i (igf-i) en pancreas y su utilizacion para la terapia genica de la diabetes mellitus.

Info

Publication number: ES2156769B1
Authority: ES; Spain
Prior art keywords: gene; igf; pancreas; allows; insulin
Prior art date: 1999-11-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

ES9902696A

Other languages

English (en)

Spanish (es)

Other versions

ES2156769A1 (es

Inventor

Tubert Fatima Bosch

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Universitat Autonoma de Barcelona UAB

Original Assignee

Universitat Autonoma de Barcelona UAB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-26

Filing date

1999-11-26

Publication date

2002-03-01

1999-11-26 Application filed by Universitat Autonoma de Barcelona UAB filed Critical Universitat Autonoma de Barcelona UAB

1999-11-26 Priority to ES9902696A priority Critical patent/ES2156769B1/es

2000-11-23 Priority to PCT/ES2000/000452 priority patent/WO2001038535A1/fr

2000-11-23 Priority to AU17081/01A priority patent/AU1708101A/en

2001-07-01 Publication of ES2156769A1 publication Critical patent/ES2156769A1/es

2002-03-01 Application granted granted Critical

2002-03-01 Publication of ES2156769B1 publication Critical patent/ES2156769B1/es

2019-11-26 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 7
108090000623 proteins and genes Proteins 0.000 title abstract 6
210000000496 pancreas Anatomy 0.000 title abstract 4
206010012601 diabetes mellitus Diseases 0.000 title abstract 3
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
102000004218 Insulin-Like Growth Factor I Human genes 0.000 title 1
239000003102 growth factor Substances 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
239000002299 complementary DNA Substances 0.000 abstract 2
239000013604 expression vector Substances 0.000 abstract 2
102000013275 Somatomedins Human genes 0.000 abstract 1
238000013459 approach Methods 0.000 abstract 1
230000004927 fusion Effects 0.000 abstract 1
238000001415 gene therapy Methods 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ES9902696A 1999-11-26 1999-11-26 Gen quimerico que permite expresar el gen o el cdna del factor de crecimiento similar a la insulina de tipo i (igf-i) en pancreas y su utilizacion para la terapia genica de la diabetes mellitus. Expired - Fee Related ES2156769B1 (es)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
ES9902696A ES2156769B1 (es)	1999-11-26	1999-11-26	Gen quimerico que permite expresar el gen o el cdna del factor de crecimiento similar a la insulina de tipo i (igf-i) en pancreas y su utilizacion para la terapia genica de la diabetes mellitus.
PCT/ES2000/000452 WO2001038535A1 (fr)	1999-11-26	2000-11-23	Gene chimerique permettant d'exprimer le gene ou le c-adn du facteur de croissance semblable a l'insuline de type i (igf-i) dans le pancreas et son utilisation dans la therapie genique du diabete mellitus
AU17081/01A AU1708101A (en)	1999-11-26	2000-11-23	Chimeric gene enabling expression of the gene or cdna of type i insulin-like growth factor (igf-i) in the pancreas and utilization thereof in genic therapy of diabetes mellitus

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES9902696A ES2156769B1 (es)	1999-11-26	1999-11-26	Gen quimerico que permite expresar el gen o el cdna del factor de crecimiento similar a la insulina de tipo i (igf-i) en pancreas y su utilizacion para la terapia genica de la diabetes mellitus.

Publications (2)

Publication Number	Publication Date
ES2156769A1 ES2156769A1 (es)	2001-07-01
ES2156769B1 true ES2156769B1 (es)	2002-03-01

Family

ID=8310852

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES9902696A Expired - Fee Related ES2156769B1 (es)	1999-11-26	1999-11-26	Gen quimerico que permite expresar el gen o el cdna del factor de crecimiento similar a la insulina de tipo i (igf-i) en pancreas y su utilizacion para la terapia genica de la diabetes mellitus.

Country Status (3)

Country	Link
AU (1)	AU1708101A (fr)
ES (1)	ES2156769B1 (fr)
WO (1)	WO2001038535A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2453019A4 (fr) *	2009-07-10	2013-04-17	Univ Barcelona Autonoma	Compositions de thérapie génique destinées à prévenir et/ou à traiter des maladies auto-immunes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5925564A (en) *	1991-11-06	1999-07-20	Baylor College Of Medicine	Expression vector systems and method of use
US5837875A (en) *	1995-09-25	1998-11-17	The Autonomous University Of Barcelona	Transgenic mouse containing an IGF-1 transgene
EP0943003B1 (fr) *	1996-12-02	2004-11-17	Valentis Inc.	Systeme d'expression du facteur de croissance insulinoide i (igf-i) et ses methodes d'utilisation
WO1999010013A1 (fr) *	1997-08-25	1999-03-04	The Trustees Of The University Of Pennsylvania	Utilisation du facteur de croissance de type insulinique dans un muscle

1999
- 1999-11-26 ES ES9902696A patent/ES2156769B1/es not_active Expired - Fee Related
2000
- 2000-11-23 WO PCT/ES2000/000452 patent/WO2001038535A1/fr not_active Ceased
- 2000-11-23 AU AU17081/01A patent/AU1708101A/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2001038535A1 (fr)	2001-05-31
AU1708101A (en)	2001-06-04
ES2156769A1 (es)	2001-07-01

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