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ES2150613T3 - Compuestos benzo-condensados de acepinona y piperidinona, utiles como inhibidores de ace y nep. - Google Patents

Compuestos benzo-condensados de acepinona y piperidinona, utiles como inhibidores de ace y nep.

Info

Publication number
ES2150613T3
ES2150613T3 ES96107787T ES96107787T ES2150613T3 ES 2150613 T3 ES2150613 T3 ES 2150613T3 ES 96107787 T ES96107787 T ES 96107787T ES 96107787 T ES96107787 T ES 96107787T ES 2150613 T3 ES2150613 T3 ES 2150613T3
Authority
ES
Spain
Prior art keywords
ace
acepinone
piperidinone
benzo
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96107787T
Other languages
English (en)
Inventor
Jeffrey A Robl
Chong-Qing Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2150613T3 publication Critical patent/ES2150613T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPUESTOS QUE TIENEN LA SIGUIENTE FORMULA I, Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, INCLUYENDO INHIBIDORES DOBLES DE ACE Y NEP E INHIBIDORES ACE SELECTIVOS: EN DONDE: Y{SUP,1} E Y{SUP,2} SON CADA UNO INDEPENDIENTEMENTE HIDROGENO, ALQUILO, ARILO, HALOGENO, O ALCOXI; X ES O O S(O){SUB,T}; A ES: T ES 0,1,O 2; M Y N SON INDEPENDIENTEMENTE 0 O 1, Y EN DONDE R, R{SUP,5}, R{SUP,5A}, R{SUP,5B}, R{SUP,6}, R{SUP,7}, R{SUP,11}, Q Y R ESTAN DEFINIDOS AQUI.
ES96107787T 1995-05-17 1996-05-15 Compuestos benzo-condensados de acepinona y piperidinona, utiles como inhibidores de ace y nep. Expired - Lifetime ES2150613T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/443,278 US5877313A (en) 1995-05-17 1995-05-17 Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP

Publications (1)

Publication Number Publication Date
ES2150613T3 true ES2150613T3 (es) 2000-12-01

Family

ID=23760151

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96107787T Expired - Lifetime ES2150613T3 (es) 1995-05-17 1996-05-15 Compuestos benzo-condensados de acepinona y piperidinona, utiles como inhibidores de ace y nep.

Country Status (11)

Country Link
US (2) US5877313A (es)
EP (1) EP0743319B1 (es)
JP (1) JPH08325152A (es)
AT (1) ATE196149T1 (es)
AU (1) AU695929B2 (es)
CA (1) CA2176415A1 (es)
DE (1) DE69610145T2 (es)
DK (1) DK0743319T3 (es)
ES (1) ES2150613T3 (es)
GR (1) GR3034834T3 (es)
PT (1) PT743319E (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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US6245764B1 (en) 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6117896A (en) * 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
DE19750002A1 (de) * 1997-11-12 1999-05-20 Solvay Pharm Gmbh Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6340752B1 (en) 1998-01-06 2002-01-22 Bristol-Myers Squibb Co. Deprotection and recrystallization processes
WO1999041276A1 (en) * 1998-02-12 1999-08-19 Molecumetics Ltd. β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF
CN1642550A (zh) 2002-02-14 2005-07-20 美瑞德生物工程公司 β－折叠模拟物和组合物及其有关方法
US20100028439A1 (en) * 2005-05-23 2010-02-04 Elan Pharma International Limited Nanoparticulate stabilized anti-hypertensive compositions
CN103502279B (zh) 2011-04-26 2015-07-22 3M创新有限公司 具有混合光交联体系的压敏粘合剂
EP3149053A1 (en) 2014-05-29 2017-04-05 3M Innovative Properties Company Acrylic adhesive composition with controlled molecular weight
EP3227347A1 (en) 2014-12-05 2017-10-11 3M Innovative Properties Company Syrup polymer compositions and adhesives therefrom
JP6359199B2 (ja) 2015-02-18 2018-07-18 スリーエム イノベイティブ プロパティズ カンパニー 保護された光架橋剤由来のアクリル系接着剤組成物
WO2018080834A1 (en) 2016-10-27 2018-05-03 3M Innovative Properties Company Crosslinkable composition including a (meth)acrylic polymer and methods of making a crosslinked composition

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Also Published As

Publication number Publication date
DE69610145T2 (de) 2001-06-07
AU5230296A (en) 1996-11-28
AU695929B2 (en) 1998-08-27
PT743319E (pt) 2000-12-29
EP0743319B1 (en) 2000-09-06
CA2176415A1 (en) 1996-11-18
DE69610145D1 (de) 2000-10-12
GR3034834T3 (en) 2001-02-28
US5877313A (en) 1999-03-02
JPH08325152A (ja) 1996-12-10
EP0743319A1 (en) 1996-11-20
ATE196149T1 (de) 2000-09-15
DK0743319T3 (da) 2001-01-02
US6235922B1 (en) 2001-05-22

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