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ES2148340T3 - Composicion de emulsion de 1-alfa,24-(oh)2-vitamina d3. - Google Patents

Composicion de emulsion de 1-alfa,24-(oh)2-vitamina d3.

Info

Publication number
ES2148340T3
ES2148340T3 ES94925612T ES94925612T ES2148340T3 ES 2148340 T3 ES2148340 T3 ES 2148340T3 ES 94925612 T ES94925612 T ES 94925612T ES 94925612 T ES94925612 T ES 94925612T ES 2148340 T3 ES2148340 T3 ES 2148340T3
Authority
ES
Spain
Prior art keywords
weight
vitamin
alpha
parts
oil component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94925612T
Other languages
English (en)
Inventor
Yuji Makino
Hideo Matugi
Yoshiki Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of ES2148340T3 publication Critical patent/ES2148340T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTA UNA CREMA DE 1 ,24-(OH)2-VITAMINA D3 QUE COMPRENDE: A) UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE 1 ,24-(OH)2-VITAMINA D3; B) UN COMPONENTE DE FASE ACEITOSA QUE COMPRENDE: I) UN COMPONENTE DE ACEITE SOLIDO QUE COMPRENDE ENTRE 5 Y 20 PARTES POR PESO DE VASELINA BLANCA Y ENTRE 5 Y 15 PARTES POR PESO DE UN ALCOHOL MAYOR, Y II) UN COMPONENTE DE ACEITE LIQUIDO QUE COMPRENDE ENTRE 3 Y 10 PARTES POR PESO DE ESCUALANO; C) UN COMPONENTE DE FASE ACUOSA; Y D) ENTRE 2,5 Y 7.5 PARTES POR PESO DE DOS O MAS SURFACTANTES, EN DONDE LA RELACION DEL COMPONENTE DE ACEITE SOLIDO CON RESPECTO AL ACEITE DEL COMPONENTE LIQUIDO SE ENCUENTRA ALREDEDOR DE 2 O SUPERIOR, EL ALCOHOL MAYOR ES UNA MEZCLA DE ALCOHOL DE ESTEARILO CON ALCOHOL DE CETILO CON UNA PROPORCION DE PESO DE ALCOHOL DE ESTEARILO CON RESPECTO A LA MEZCLA DE ENTRE 0.65 Y 0.9, AL MENOS UN 50% DEL PESO DE LOS SURFACTANTES ES AL MENOS UN SURFACTANTE QUE TENGA UN VALOR HLB DE ALREDEDOR DE 5 O MENOR, Y EL VALOR HLB DE LOS SURFACTANTES EN SU TOTALIDAD SE ENCUENTRA ENTRE 8 Y 18.
ES94925612T 1993-09-01 1994-09-01 Composicion de emulsion de 1-alfa,24-(oh)2-vitamina d3. Expired - Lifetime ES2148340T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21726193 1993-09-01

Publications (1)

Publication Number Publication Date
ES2148340T3 true ES2148340T3 (es) 2000-10-16

Family

ID=16701374

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94925612T Expired - Lifetime ES2148340T3 (es) 1993-09-01 1994-09-01 Composicion de emulsion de 1-alfa,24-(oh)2-vitamina d3.

Country Status (17)

Country Link
US (1) US5612327A (es)
EP (1) EP0667166B1 (es)
JP (1) JP3045179B2 (es)
KR (1) KR100221045B1 (es)
CN (1) CN1082818C (es)
AT (1) ATE195431T1 (es)
CA (1) CA2148109C (es)
CZ (1) CZ284261B6 (es)
DE (1) DE69425552T2 (es)
DK (1) DK0667166T3 (es)
ES (1) ES2148340T3 (es)
NO (1) NO312227B1 (es)
PL (1) PL175492B1 (es)
PT (1) PT667166E (es)
SG (1) SG52313A1 (es)
SK (1) SK279913B6 (es)
WO (1) WO1995006482A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
ATE249819T1 (de) 1995-04-21 2003-10-15 Seikisui Chemical Co Ltd Präparate zur äusserlichen anwendung zur behandlung von dermatosen
DE19639816A1 (de) * 1996-09-27 1998-04-02 Hoechst Ag Antimykotische Mittel mit hoher Wirkstofffreisetzung
US20040039030A1 (en) * 1996-09-27 2004-02-26 Hoechst Akeengesellschaft Use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis
US6566353B2 (en) * 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US20030129194A1 (en) * 1997-02-13 2003-07-10 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
CZ298971B6 (cs) * 1998-03-04 2008-03-26 Teijin Limited Lotion na bázi emulze aktivního vitamínu D3
EP2340840B1 (en) * 1998-03-27 2012-08-29 Oregon Health Sciences University Pulse dose Vitamin D drug for the treatment of hyperproliferative skin diseases
US8263580B2 (en) 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
IL153378A0 (en) * 2000-07-18 2003-07-06 Bone Care Internat Inc STABILIZED 1alpha-HYDROXY VITAMIN D
JP2005515996A (ja) * 2001-12-03 2005-06-02 ノバセア インコーポレイティッド 活性型ビタミンｄ化合物を含む薬学的組成物
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
WO2006129161A2 (en) * 2005-06-01 2006-12-07 Stiefel Research Australia Pty Ltd Vitamin formulation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1272953A (en) * 1984-10-08 1990-08-21 Yuji Makino Pharmaceutical composition for external use containing active-type vitamin d.sub.3
JPS6226223A (ja) * 1985-07-25 1987-02-04 Teijin Ltd 乾癬治療剤
JPH0774144B2 (ja) * 1986-03-12 1995-08-09 久光製薬株式会社 尿素を含有する皮膚用組成物
GB9226860D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Novel treatment

Also Published As

Publication number Publication date
KR950703998A (ko) 1995-11-17
DE69425552D1 (de) 2000-09-21
PT667166E (pt) 2001-02-28
US5612327A (en) 1997-03-18
CZ284261B6 (cs) 1998-10-14
CN1082818C (zh) 2002-04-17
KR100221045B1 (ko) 1999-09-15
ATE195431T1 (de) 2000-09-15
SK279913B6 (sk) 1999-05-07
CA2148109A1 (en) 1995-03-09
NO312227B1 (no) 2002-04-15
WO1995006482A1 (en) 1995-03-09
NO951639D0 (no) 1995-04-28
CN1114824A (zh) 1996-01-10
PL308748A1 (en) 1995-08-21
DK0667166T3 (da) 2000-10-16
CZ113295A3 (en) 1995-11-15
EP0667166A1 (en) 1995-08-16
NO951639L (no) 1995-06-30
PL175492B1 (pl) 1999-01-29
JP3045179B2 (ja) 2000-05-29
EP0667166A4 (en) 1995-11-02
DE69425552T2 (de) 2001-04-19
SG52313A1 (en) 1998-09-28
CA2148109C (en) 1999-11-23
EP0667166B1 (en) 2000-08-16
SK59295A3 (en) 1995-12-06

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