ES2146665T3 - Nuevos compuestos 14-aminoesteroides que contienen oligosacaridos y nuevo procedimiento en quimica de aminoesteroides diastereoselectivo. - Google Patents
Nuevos compuestos 14-aminoesteroides que contienen oligosacaridos y nuevo procedimiento en quimica de aminoesteroides diastereoselectivo.Info
- Publication number
- ES2146665T3 ES2146665T3 ES94929315T ES94929315T ES2146665T3 ES 2146665 T3 ES2146665 T3 ES 2146665T3 ES 94929315 T ES94929315 T ES 94929315T ES 94929315 T ES94929315 T ES 94929315T ES 2146665 T3 ES2146665 T3 ES 2146665T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- lower alkyl
- acetoxy
- carbon lower
- benzoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
- C07J19/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- External Artificial Organs (AREA)
- Centrifugal Separators (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPOSICIONES 14AMINOESTEROIDES QUE CONTIENEN OLIGOSACARIDOS Y A ESTERES O SALES ACIDAS DE LAS MISMAS DE LA FORMULA GENERAL (I), EN LA QUE A) R1 ES (I) COOR5, DONDE R5 ES HIDROGENO, UN ALQUILO BAJO 1-6 CARBONO; UN ALQUILO BAJO 1-6 CARBONO SUSTITUIDO POR UN GRUPO AMINO; UN ARILALQUILO O HETEROARILALQUILO O UN ANILLO CARBOCICLICO, O (II) CHR6-OH, DONDE R6 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO BAJO 1-6 CARBONO, O (III) COR'''''' DONDE R'''''' ES HIDROGENO; ALQUILO BAJO CARBONO 1-6; UN ALQUILO BAJO CARBONO 1-6 AMINO SUSTITUIDO; AMINO O DIALQUILAMINO; Y R2 ES NR7R8, DONDE R7 Y R8, QUE PUEDEN SE IGUALES O DIFERENTES, SON ATOMOS DE HIDROGENO O UN ALQUILO BAJO CARBONO 1-6; Y C) R3 ES (I) UN RESIDUO DE AZUCAR OLIGOSACARIDO QUE TIENE UNA ESTRUCTURA (II), DONDE R10 ES HIDROGENO; METILO; HIDROXI; CARBOXI; ACETOXI, ARILALQUILOXI, HETEROARILALQUILOXI, BENZOXI O HIDROXI; R11 ES OXIGENO; DONDE ADEMAS R11 ES UN SUSTITUYENTE EN EL RESIDUO DE AZUCAR MONOSACARIDO TERMINAL; R11 ES OH; METILO; ACETOXI; ARILALQUILOXI, HETEROARILALQUILOXI, Y R12 ES UN HIDROGENO; METILO; METILHIDROXIMETILO; O ACETOXIMETILO; O (II) UN RESIDUO DE AZUCAR OLIGOSACARIDO QUE TIENE UNA ESTRUCTURA (III), DONDE R14 Y R15}, QUE PUEDEN SER IGUALES O DIFERENTES SON HIDROGENO, ALQUILO BAJO 1-6 CARBONO; HETEROARILALQUILO; ARILALQUILO, HETEROARILO O ARILO; R17 PUEDE SER HIDROGENO; HIDROXI, ACETOXI, BENZOXI, R18 Y R19 SON HIDROXI, ACETOXI Y BENZOXI; O (III) UN RESIDUO OLIGOSACARIDO QUE TIENE UNA ESTRUCTURA (IV), DONDE R14 Y R15}, QUE PUEDEN SER IGUALES O DIFERENTES, SON HIDROGENO; ALQUILO BAJO 1-6 CARBONO; ARIALQUILO, HETERORARILO O ARILO; R14A ES OXIGENO; DONDE ADEMAS R14A ES UN SUSTITUYENTE EN EL RESIDUO DE AZUCAR MONOSACARIDO TERMINAL; R14A DEBE SER HIDROXI; METILO, ACETOXI; ARIALQUILOXI O HETEROARILALQUILOXI; Y D) R4 ES Y E) Z ES (I) OH, O (II) H O (III) OR13}, DONDE R13 ES UN RESTADO DE AZUCAR MONOSACARIDO; ACETOXI; BENZOXI; ARIALQUIL O HETEROARILALQUIL; Y E) Z ES (I)-CH-, DONDE A Y B SON ENLACES SIMPLES, O (II) OR13}, DONDE R13 ES UN RESIDUO DE AZUCAR MONOSACARIDO; ACETOXI, BENZOXI, ARIALQUILO O HETEROARILALQUILO; Y E) Z ES (I)-CH-, DONDE A Y B SON ENLACES SIMPLES, O (II)=C, DONDE TANTO A COMO B ES UN ENLACE DOBLE. LA PRESENTE INVENCION TAMBIEN SE REFIERE AL PROCESO PARA INTRODUCIR UN GRUPO AMINO EN LA POSICION 14 DE UN NUCLEO ESTEROIDE DONDE DICHO GRUPO AMINO ES INTRODUCIDO DIASTEREOSELECTIVAMENTE EN LA POSICION 14 DEL NUCLEO ESTEROIDE A TRAVES DE UNA ADICION DE YODOISOCIANATO QUE COMPRENDE LAS FASES DE: A) AÑADIR EL YODOISOCIANATO A LA ENLACE DOBLE DE LA POSICION 14-15 DEL NUCLEO ESTEROIDE Y B) DESHALOGENACION; Y C) CONVERSION DEL ISOCIANATO A LA MITAD AMINA DE LA POSICION 14 DEL NUCLEO ESTEROIDE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12645993A | 1993-09-24 | 1993-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2146665T3 true ES2146665T3 (es) | 2000-08-16 |
Family
ID=22424936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94929315T Expired - Lifetime ES2146665T3 (es) | 1993-09-24 | 1994-09-23 | Nuevos compuestos 14-aminoesteroides que contienen oligosacaridos y nuevo procedimiento en quimica de aminoesteroides diastereoselectivo. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5710259A (es) |
| EP (2) | EP0863149A1 (es) |
| JP (1) | JPH09502982A (es) |
| KR (1) | KR960704914A (es) |
| CN (1) | CN1135758A (es) |
| AT (1) | ATE193538T1 (es) |
| AU (1) | AU692187B2 (es) |
| BR (1) | BR9407612A (es) |
| CA (1) | CA2182530A1 (es) |
| CZ (1) | CZ86696A3 (es) |
| DE (1) | DE69424794D1 (es) |
| DK (1) | DK0721459T3 (es) |
| ES (1) | ES2146665T3 (es) |
| GR (1) | GR3034028T3 (es) |
| HU (1) | HUT74623A (es) |
| NO (1) | NO961170L (es) |
| PL (1) | PL313620A1 (es) |
| RU (1) | RU2153503C2 (es) |
| WO (1) | WO1995008557A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922703A (en) * | 1993-09-24 | 1999-07-13 | The Procter & Gamble Company | Urethane-containing aminosteroid compounds |
| CA2563008C (en) * | 2004-04-15 | 2010-01-05 | Chr. Hansen A/S | Method for reducing the content of pathogenic organisms present in food materials |
| CA2954662C (en) | 2014-07-09 | 2024-03-19 | Midori Usa, Inc. | Oligosaccharide compositions and methods for producing thereof |
| EP4209130A1 (en) | 2015-01-26 | 2023-07-12 | DSM Nutritional Products, LLC | Oligosaccharide compositions for use animal feed and methods of producing thereof |
| RU2017130166A (ru) * | 2015-01-26 | 2019-02-28 | Кадена Байо, Инк. | Олигосахаридные композиции для применения в качестве пищевых ингредиентов и способы их получения |
| SI3285777T1 (sl) | 2015-04-23 | 2022-02-28 | Kaleido Biosciences, Inc. | Glikanski terapevtiki in postopki zdravljenja |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3567712A (en) * | 1966-10-31 | 1971-03-02 | Lepetit Spa | 10beta-amino-estranes and method for the preparation thereof |
| FR2464270A1 (fr) * | 1979-08-31 | 1981-03-06 | Nativelle Sa Ets | Nouveaux derives d'amino-14 steroides, et procede pour leur preparation |
| ES8404693A1 (es) * | 1982-08-12 | 1984-05-01 | Nativelle Sa Ets | Procedimiento de preparacion de nuevos amino-14 esteroides. |
| NZ205293A (en) * | 1982-08-20 | 1986-12-05 | Nativelle Sa Ets | 14-aminosteroids and pharmaceutical compositions |
| ES524796A0 (es) * | 1982-08-20 | 1984-05-01 | Nativelle Sa Ets | Procedimiento de preparacion de nuevos derivos de amino-14 esteroides |
| DD256134A1 (de) * | 1985-06-06 | 1988-04-27 | Akad Wissenschaften Ddr | Verfahren zur herstellung von derivaten von cardenoliden und cardenolidanalogen verbindungen |
| US5175281A (en) * | 1985-09-12 | 1992-12-29 | The Upjohn Company | Pharmaceutically active pyrimidinylpiperazinylsterioids |
| GB8600490D0 (en) * | 1986-01-09 | 1986-02-12 | Erba Farmitalia | Aminoglycoside norcholanic acid lactams |
| FR2621316B1 (fr) * | 1987-10-02 | 1991-06-21 | Nativelle Sa Ets | Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant |
| US5144017A (en) * | 1988-07-13 | 1992-09-01 | University Of Manitoba | Compounds that bind to digitalis receptor |
| FR2642973A1 (fr) * | 1989-02-03 | 1990-08-17 | Cote Ivoire Ministere Rech Sc | Composition medicamenteuse renfermant comme principe actif un derive glucidique dioxymethyle de la strophanthidine |
| WO1991017176A2 (en) * | 1990-05-07 | 1991-11-14 | The Board Of Regents Of The University Of Washington | Novel steroid glycosides useful in the early detection of hypertension |
| JPH0429089A (ja) * | 1990-05-25 | 1992-01-31 | Toshiba Corp | 燃料集合体 |
| WO1993005790A1 (en) * | 1991-09-27 | 1993-04-01 | Procter & Gamble Pharmaceuticals, Inc. | Use of 14-aminosteroids for the manufacture of a medicament to slow the rate of progression of myocardial structural damages characteristic of congestive heart failure |
| CN1135757A (zh) * | 1993-09-24 | 1996-11-13 | 普罗克特和甘保尔公司 | 新型含脱氧和氧被取代的糖的14-氨基类固醇 |
| US5922703A (en) * | 1993-09-24 | 1999-07-13 | The Procter & Gamble Company | Urethane-containing aminosteroid compounds |
-
1994
- 1994-09-23 ES ES94929315T patent/ES2146665T3/es not_active Expired - Lifetime
- 1994-09-23 CZ CZ96866A patent/CZ86696A3/cs unknown
- 1994-09-23 AT AT94929315T patent/ATE193538T1/de not_active IP Right Cessation
- 1994-09-23 AU AU78414/94A patent/AU692187B2/en not_active Ceased
- 1994-09-23 EP EP98103012A patent/EP0863149A1/en not_active Withdrawn
- 1994-09-23 HU HU9600734A patent/HUT74623A/hu unknown
- 1994-09-23 DK DK94929315T patent/DK0721459T3/da active
- 1994-09-23 KR KR1019960701529A patent/KR960704914A/ko not_active Withdrawn
- 1994-09-23 DE DE69424794T patent/DE69424794D1/de not_active Expired - Lifetime
- 1994-09-23 CN CN94194217A patent/CN1135758A/zh active Pending
- 1994-09-23 BR BR9407612A patent/BR9407612A/pt not_active Application Discontinuation
- 1994-09-23 JP JP7509952A patent/JPH09502982A/ja active Pending
- 1994-09-23 CA CA002182530A patent/CA2182530A1/en not_active Abandoned
- 1994-09-23 PL PL94313620A patent/PL313620A1/xx unknown
- 1994-09-23 EP EP94929315A patent/EP0721459B1/en not_active Expired - Lifetime
- 1994-09-23 RU RU96108236/04A patent/RU2153503C2/ru active
- 1994-09-23 WO PCT/US1994/010778 patent/WO1995008557A1/en not_active Ceased
-
1995
- 1995-06-02 US US08/459,911 patent/US5710259A/en not_active Expired - Fee Related
-
1996
- 1996-03-22 NO NO961170A patent/NO961170L/no unknown
-
1997
- 1997-02-20 US US08/802,491 patent/US5849889A/en not_active Expired - Fee Related
-
2000
- 2000-07-26 GR GR20000401719T patent/GR3034028T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL313620A1 (en) | 1996-07-08 |
| RU2153503C2 (ru) | 2000-07-27 |
| ATE193538T1 (de) | 2000-06-15 |
| HU9600734D0 (en) | 1996-05-28 |
| HUT74623A (en) | 1997-01-28 |
| AU692187B2 (en) | 1998-06-04 |
| US5849889A (en) | 1998-12-15 |
| CA2182530A1 (en) | 1995-03-30 |
| AU7841494A (en) | 1995-04-10 |
| BR9407612A (pt) | 1997-01-14 |
| GR3034028T3 (en) | 2000-11-30 |
| EP0721459B1 (en) | 2000-05-31 |
| NO961170L (no) | 1996-05-24 |
| DK0721459T3 (da) | 2000-08-07 |
| CZ86696A3 (en) | 1996-10-16 |
| KR960704914A (ko) | 1996-10-09 |
| DE69424794D1 (de) | 2000-07-06 |
| US5710259A (en) | 1998-01-20 |
| CN1135758A (zh) | 1996-11-13 |
| EP0863149A1 (en) | 1998-09-09 |
| WO1995008557A1 (en) | 1995-03-30 |
| JPH09502982A (ja) | 1997-03-25 |
| NO961170D0 (no) | 1996-03-22 |
| EP0721459A1 (en) | 1996-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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