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ES2146007T3 - Procedimiento de recuperacion, en un caldo de fermentacion, de compuestos insolubles en agua. - Google Patents

Procedimiento de recuperacion, en un caldo de fermentacion, de compuestos insolubles en agua.

Info

Publication number
ES2146007T3
ES2146007T3 ES96923254T ES96923254T ES2146007T3 ES 2146007 T3 ES2146007 T3 ES 2146007T3 ES 96923254 T ES96923254 T ES 96923254T ES 96923254 T ES96923254 T ES 96923254T ES 2146007 T3 ES2146007 T3 ES 2146007T3
Authority
ES
Spain
Prior art keywords
water
insoluble compounds
fermentation broth
recovery procedure
recovery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96923254T
Other languages
English (en)
Inventor
Alexander H T Chu
Gene P Wloch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2146007T3 publication Critical patent/ES2146007T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/149—Multistep processes comprising different kinds of membrane processes selected from ultrafiltration or microfiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NUEVO PROCEDIMIENTO DE RECUPERACION DE COMPUESTOS INSOLUBLES EN AGUA, A PARTIR DE UN CALDO DE FERMENTACION, QUE INCLUYE LAS FASES SECUENCIALES DE CONCENTRAR, SOLUBILIZAR Y DIAFILTRAR EL COMPUESTO DE INTERES, TODAS A TRAVES DE UN SISTEMA CERRADO DE RECIRCULACION, A FIN DE RECUPERAR EL COMPUESTO PARA UNA PURIFICACION ULTERIOR AGUAS ABAJO.
ES96923254T 1995-06-07 1996-06-07 Procedimiento de recuperacion, en un caldo de fermentacion, de compuestos insolubles en agua. Expired - Lifetime ES2146007T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/472,615 US5616595A (en) 1995-06-07 1995-06-07 Process for recovering water insoluble compounds from a fermentation broth

Publications (1)

Publication Number Publication Date
ES2146007T3 true ES2146007T3 (es) 2000-07-16

Family

ID=23876243

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96923254T Expired - Lifetime ES2146007T3 (es) 1995-06-07 1996-06-07 Procedimiento de recuperacion, en un caldo de fermentacion, de compuestos insolubles en agua.

Country Status (11)

Country Link
US (1) US5616595A (es)
EP (1) EP0832108B1 (es)
JP (1) JP3146010B2 (es)
AT (1) ATE192162T1 (es)
CA (1) CA2222810C (es)
DE (1) DE69607961T2 (es)
DK (1) DK0832108T3 (es)
ES (1) ES2146007T3 (es)
GR (1) GR3033795T3 (es)
PT (1) PT832108E (es)
WO (1) WO1996040758A1 (es)

Families Citing this family (45)

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GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
BE1009856A5 (fr) * 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
DE69840586D1 (de) 1997-10-08 2009-04-02 Isotechnika Inc Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien
ID26894A (id) * 1998-04-14 2001-02-15 Dsm Nv Penyaringan membran
JP2002534370A (ja) 1998-12-30 2002-10-15 デクセル リミテッド サイクロスポリンを送達するための分散可能な濃縮物
PT1183261E (pt) * 1999-05-25 2004-11-30 Fujisawa Pharmaceutical Co Metodo para separar compostos organicos analogos
MXPA02005283A (es) 1999-11-30 2003-10-06 Biogal Gyogyszergyar Proceso para recuperar compuestos estatina de un caldo de fermentacion.
YU45202A (sh) * 1999-12-14 2005-11-28 Biogal Gyogyszergyar Rt. Novi oblici natrijum pravastatina
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
SK12012002A3 (sk) 2000-02-24 2003-02-04 Biogal Gyogyszergyar Rt. Spôsob purifikácie fermentačného bujónu
DE10022258A1 (de) * 2000-05-08 2001-11-15 Bayer Ag Reinigung von Proteineinschlusskörpern durch Querstrom-Mikrofiltration
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
FR2821347A1 (fr) * 2001-02-23 2002-08-30 Vanlaer Fluides Et Automation Systeme de traitement de solution aqueuse par membrane et fermentation
AU2002326398A1 (en) * 2001-04-18 2002-12-16 Buddy Don Gray System for recirculating tangential filter concentrate
CN100334106C (zh) * 2001-10-19 2007-08-29 伊索泰克尼卡股份有限公司 环孢菌素类似物的合成
WO2003068980A2 (en) * 2002-02-13 2003-08-21 Biogal Gyogyszergyar Rt Method for extracting a macrolide from biomatter
US7452692B2 (en) * 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
US8685428B2 (en) * 2002-12-10 2014-04-01 Advanced Cardiovascular Systems, Inc. Therapeutic composition and a method of coating implantable medical devices
JP2006524232A (ja) 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
AU2003269473A1 (en) * 2003-08-26 2005-03-10 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
EP1641447B1 (en) * 2003-11-24 2008-10-29 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method of purifying pravastatin
EP1697383B1 (en) * 2003-12-05 2014-04-23 Biocon Limited Process for the purification of tacrolimus
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
KR101238798B1 (ko) * 2004-09-30 2013-03-04 바이엘 헬스케어, 엘엘씨 생물학적 분자의 통합된 연속 제조를 위한 장치 및 방법
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
JP2007523201A (ja) * 2004-12-22 2007-08-16 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ タクロリムスを精製する方法
MX2007006119A (es) * 2005-01-05 2007-07-19 Teva Gyogyszergyar Zartkoruen Tacrolimus amorfo y preparacion de el.
CN101115706A (zh) * 2005-02-09 2008-01-30 特瓦药厂私人有限公司 制备普伐他汀钠的方法
TW200815458A (en) * 2006-03-15 2008-04-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for purifying Tacrolimus
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
KR101101663B1 (ko) 2009-01-13 2011-12-30 (주) 제노텍 반코마이신 습체의 정제방법
WO2014072984A1 (en) 2012-11-06 2014-05-15 Natco Pharma Limited Improved process for isolation and purification of rapamycin from fermentation broth
US10183108B2 (en) 2016-02-04 2019-01-22 Pall Corporation Inline diafiltration with multi-channel pump
US12186334B2 (en) 2018-07-27 2025-01-07 ARC Medical Inc. High-molecular-weight fucans for treating fibrous adhesions and other diseases and conditions
SG11202100393TA (en) 2018-07-27 2021-02-25 Arc Medical Devices Inc Highly purified fucans for the treatment of fibrous adhesions
MX2021000866A (es) 2019-03-05 2021-06-15 Arc Medical Devices Inc Sistemas y metodos para la filtracion de flujo tangencial de composiciones viscosas.
WO2020257950A1 (en) * 2019-06-28 2020-12-30 Grafoid Inc. Graphene based filters and systems comprising same
US11806667B2 (en) 2021-04-05 2023-11-07 Government Of The United States, As Represented By The Secretary Of The Army Portable membrane filtration
CN113325108B (zh) * 2021-06-04 2022-12-09 山东霆科药业有限公司 一种他克莫司软膏的样品前处理方法
US20240287274A1 (en) * 2021-08-03 2024-08-29 Pyrowave Inc. Method and system for extracting contaminants from waste polymers
CN113603731B (zh) * 2021-09-14 2024-02-06 陕西麦可罗生物科技有限公司 一种中生菌素分离方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法
CN115025611B (zh) * 2022-07-12 2024-03-29 景德镇富祥生命科技有限公司 一种有效去除子囊霉素发酵尾气异味的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
ATE127528T1 (de) * 1991-04-06 1995-09-15 Dresden Arzneimittel Verfahren zur fermentativen herstellung und isolierung von cyclosporin a sowie neue cyclosporin- bildende stämme.

Also Published As

Publication number Publication date
EP0832108A1 (en) 1998-04-01
DE69607961D1 (de) 2000-05-31
JP3146010B2 (ja) 2001-03-12
WO1996040758A1 (en) 1996-12-19
CA2222810C (en) 2002-02-12
DE69607961T2 (de) 2000-12-07
DK0832108T3 (da) 2000-09-25
JPH10511000A (ja) 1998-10-27
PT832108E (pt) 2000-08-31
ATE192162T1 (de) 2000-05-15
CA2222810A1 (en) 1996-12-19
EP0832108B1 (en) 2000-04-26
GR3033795T3 (en) 2000-10-31
US5616595A (en) 1997-04-01

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