ES2039161B1 - PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. - Google Patents
PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY.Info
- Publication number
- ES2039161B1 ES2039161B1 ES9200051A ES9200051A ES2039161B1 ES 2039161 B1 ES2039161 B1 ES 2039161B1 ES 9200051 A ES9200051 A ES 9200051A ES 9200051 A ES9200051 A ES 9200051A ES 2039161 B1 ES2039161 B1 ES 2039161B1
- Authority
- ES
- Spain
- Prior art keywords
- solvent
- procedure
- compound
- antiproliferative activity
- obtaining new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001028 anti-proliverative effect Effects 0.000 title abstract 2
- 150000007857 hydrazones Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 101150071456 CSI2 gene Proteins 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE NUEVAS HIDRAZONAS CON ACTIVIDAD ANTIPROLIFERATIVA. COMPRENDE: HACER REACCIONAR UN COMPUESTO DE FORMULA II CON UN COMPUESTO DE FORMULA III, EN UN DISOLVENTE, EN PRESENCIA OPCIONAL DE UN CATALIZADOR Y A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LA DE REFLUJO DEL DISOLVENTE, PARA OBTENER UN COMPUESTO DE FORMULA I. EN DICHAS FORMULAS X ES H, OH O OCHSI3 SC; Y ES H, OH O OCHSI3 SC, Z ES H, CHSI3 SC, CSI2 SCHSI5 SC U OTRO ALQUILO DE BAJO PESO MOLECULAR; Y R ES UN GRUPO ALQUILO LINEAL O CICLICO QUE PUEDE ESTAR SUSTITUIDO, UN GRUPO ARILO O ARILO SUSTITUIDO O UN GRUPO HETEROCICLICO. LOS COMPUESTOS DE FORMULA I TIENEN APLICACION COMO INHIBIDORES DE LA PROLIFERACION CELULAR Y, MAS CONCRETAMENTE, TIENEN APLICACION EN LA TERAPIA DEL CANCER Y EN EL TRATAMIENTO DE LA ARTERIOESCLEROSIS.PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. IT INCLUDES: REACTING A COMPOUND OF FORMULA II WITH A COMPOUND OF FORMULA III, IN A SOLVENT, IN THE OPTIONAL PRESENCE OF A CATALYST AND AT A TEMPERATURE COMPRISED BETWEEN THE ENVIRONMENT AND THE REFLUX OF THE SOLVENT, TO OBTAIN A COMPOUND OF SOLVENT I. FORMULAS X ES H, OH OR OCHSI3 SC; Y IS H, OH OR OCHSI3 SC, Z IS H, CHSI3 SC, CSI2 SCHSI5 SC OR ANOTHER LOW MOLECULAR WEIGHT ALKYL; AND R IS A LINEAR OR CYCLIC ALKYL GROUP THAT MAY BE SUBSTITUTED, A GROUP ARILO OR ARILO SUBSTITUTED OR A HETEROCICLICO GROUP. FORMULA I COMPOUNDS HAVE APPLICATION AS INHIBITORS OF CELL PROLIFERATION AND, MORE SPECIFICALLY, HAVE APPLICATION IN CANCER THERAPY AND IN THE TREATMENT OF ARTERIOSCLEROSIS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9200051A ES2039161B1 (en) | 1992-01-13 | 1992-01-13 | PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9200051A ES2039161B1 (en) | 1992-01-13 | 1992-01-13 | PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2039161A1 ES2039161A1 (en) | 1993-08-16 |
| ES2039161B1 true ES2039161B1 (en) | 1994-04-01 |
Family
ID=8275718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9200051A Expired - Fee Related ES2039161B1 (en) | 1992-01-13 | 1992-01-13 | PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2039161B1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10338673A (en) * | 1997-06-04 | 1998-12-22 | Nippon Bayeragrochem Kk | Isonicotinic acid hydrazide derivative and pest controlling agent |
| WO1999052936A2 (en) * | 1998-04-09 | 1999-10-21 | Eisai Co., Ltd. | Arginine peptide analogs useful as fibroblast growth factor antagonists |
| AU2002303694A1 (en) * | 2001-05-10 | 2002-11-18 | Sui Xiong Cai | Substituted n'-(arylcarbonyl)-benzhydrazides, n'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| KR20170141542A (en) * | 2016-06-15 | 2017-12-26 | 국립암센터 | Pharmaceutical composition of RHOA inhibitor to prevent and treat gastric cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8104205A1 (en) * | 1980-03-27 | 1981-04-01 | Barisintex Sa | Procedure for the preparation of aromatic aldehydroxy alcoholic hydrochloride (Machine-translation by Google Translate, not legally binding) |
| PT87487B (en) * | 1987-05-15 | 1992-09-30 | Schering Corp | PROCESS FOR THE PREPARATION OF NAFTALENE, BENZOXEPIN, BENZAZEPINE AND BENZOCYCLOHEPTEN DERIVATIVES |
| DE3903990A1 (en) * | 1989-02-10 | 1990-08-30 | Basf Ag | PHENYL HYDRAZONE, THEIR MANUFACTURE, AND MEDICAMENTS AND COSMETICS PRODUCED FROM THEM |
-
1992
- 1992-01-13 ES ES9200051A patent/ES2039161B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2039161A1 (en) | 1993-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20041004 |