ES2038180T3 - A PROCEDURE FOR PREPARING A COMPOUND THAT IS A DERIVATIVE OF PIRAZINE. - Google Patents
A PROCEDURE FOR PREPARING A COMPOUND THAT IS A DERIVATIVE OF PIRAZINE.Info
- Publication number
- ES2038180T3 ES2038180T3 ES198787305796T ES87305796T ES2038180T3 ES 2038180 T3 ES2038180 T3 ES 2038180T3 ES 198787305796 T ES198787305796 T ES 198787305796T ES 87305796 T ES87305796 T ES 87305796T ES 2038180 T3 ES2038180 T3 ES 2038180T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- aryl
- alkylene
- hydrogen
- pirazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
UN COMPUESTO QUE ES UN DERIVADO DE PIRAZINA DE FORMULA (I) DONDE Q ES -CO- O -CH2-, R ES HIDROXILO, ALCOXI C1-C4, UN HALOGENO, NH-ALQUILENO C1-C4 -OH, -NH-ALQUILENO C1-C4-ARILTIO, -NH-ALQUILENO C1-C4-HALOGENO, (II) O NH-ALQUILENO C1-C4-(III) DONDE (III) ES (II) O (IV)-ARILO Y (II) ES DIALQUILAMINO C1-C4, CICLOALQUILAMINO, MORFOLINO, (V)-ALQUILENO C1-C4 ARILO O (VI) EN DONDE R9 ES HIDROGENO, ALQUILO C1-C4 O ARILO, R10 ES HIDROGENO, ALQUILO C1-C4, HIDROXIALQUILO C1-C4, HIDROXIALCOXI C1-C4- ALQUILO C1-C4 O DI(ARILO)-ALQUILO C1-C4; M ES UN ENTERO DE 4 A 6, Y N ES 2 O 3; R1 ES ALQUILO O ARILALQUILO C1-C4; R2 Y R3 SON INDEPENDIENTEMENTE ALQUILO C1-C4 O JUNTOS FORMAN UN PUENTE TETRAMETILEMO, Y R4 ES HIDROGENO, ALQUILO C1-C4 O FENILO, ESTE ULTIMO OPCIONALMENTE SUSTITUIDO CON 1 A 3 HALOGENOS, UN GRUPO NITRO, UN ALQUILO C1-C4 O UN GRUPO ALCOXI C1-C4. ESTOS COMPUESTOS O LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS MISMOS SON UTILES EN EL TRATAMIENTO DE ALTERACIONES CIRCULATORIAS O METABOLICAS.A COMPOUND WHICH IS A DERIVATIVE OF FORMULA PIRAZINE (I) WHERE Q IS -CO- O -CH2-, R IS HYDROXYL, ALCOXY C1-C4, ONE HALOGEN, NH-ALKYLENE C1-C4 -OH, -NH-ALKYLENE C1 -C4-ARYLTIO, -NH-C1-C4-ALKYLENE HALOGEN, (II) OR NH-C1-C4-ALKYLENE- (III) WHERE (III) IS (II) O (IV) -ARYL AND (II) IS DIALKYLAMINE C1 -C4, CYCLLOALKYLAMINE, MORPHOLINE, (V) -CALKYLENE C1-C4 ARYL O (VI) WHERE R9 IS HYDROGEN, ALKYL C1-C4 OR ARYL, R10 IS HYDROGEN, C1-C4 ALKYL, HYDROXIALKYL C1-C4, HIDROXIALKYL C1-C4 C4- C1-C4 ALKYL OR DI (ARYL) -C1-C4 ALKYL; M IS AN INTEGER FROM 4 TO 6, AND N IS 2 O 3; R1 IS C1-C4 ALKYL OR ARYLALKYL; R2 AND R3 ARE INDEPENDENTLY ALKYL C1-C4 OR TOGETHER FORM A BRIDGE TETRAMETILEMO, AND R4 IS HYDROGEN, ALKYL C1-C4 OR PHENYL, THIS LAST OPTIONALLY SUBSTITUTED WITH 1 TO 3 HALOGENS, ONE NITRO GROUP, ONE ALKYL ONE OR ONE ALCOXI C1-C4. THESE COMPOUNDS OR THE PHARMACOLOGICALLY ACCEPTABLE SALTS OF THEM ARE USEFUL IN THE TREATMENT OF CIRCULATORY OR METABOLIC ALTERATIONS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15374286 | 1986-06-30 | ||
| JP15374386 | 1986-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2038180T3 true ES2038180T3 (en) | 1993-07-16 |
Family
ID=26482275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198787305796T Expired - Lifetime ES2038180T3 (en) | 1986-06-30 | 1987-06-30 | A PROCEDURE FOR PREPARING A COMPOUND THAT IS A DERIVATIVE OF PIRAZINE. |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US4894453A (en) |
| EP (1) | EP0252670B1 (en) |
| DE (1) | DE3776011D1 (en) |
| ES (1) | ES2038180T3 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2599665B2 (en) * | 1991-05-01 | 1997-04-09 | 大塚製薬株式会社 | Pyrazine derivatives |
| GB2266716A (en) * | 1992-05-05 | 1993-11-10 | Merck & Co Inc | Inhibitors of HIV reverse transcriptase |
| EP0668276A1 (en) * | 1992-11-09 | 1995-08-23 | Asahi Kasei Kogyo Kabushiki Kaisha | 2-alkoxy-5,6,7,8-tetrahydroquinoxaline derivative, process for producing the same, and use thereof |
| US5605908A (en) * | 1994-10-24 | 1997-02-25 | Eli Lilly And Company | Heterocyclic compounds and their use |
| US5998404A (en) * | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
| CN103951623A (en) * | 2014-04-15 | 2014-07-30 | 西北农林科技大学 | Pyrazine compound, preparation method thereof and medicinal composition containing same |
| ES2760625T3 (en) | 2015-07-29 | 2020-05-14 | Esteve Pharmaceuticals Sa | Derivatives of N- (2- (3- (benzyl (methyl) amino) pyrrolidin-1-yl) ethyl) -N-phenyl) propionamide and related compounds as dual ligands of sigma 1 and mu opioid receptors and for the treatment of pain |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1473815A (en) * | 1962-11-16 | 1967-03-24 | Nl Combinatie Chem Ind | Process for preparing tertiary amines and novel compounds thus obtained |
| BE756127A (en) * | 1969-09-12 | 1971-03-15 | Hoechst Ag | HETEROCYCLIC ETHERS AND THEIR PREPARATION |
| CH607585A5 (en) * | 1976-10-05 | 1978-09-15 | Ciba Geigy Ag | Process for the preparation of 2-[3'-(2-(3,4-dimethoxy-phenyl)ethylamino)-2'-hydroxypropoxy]-3-cyanop yridine |
| DE3242195A1 (en) * | 1982-11-15 | 1984-05-17 | Basf Ag, 6700 Ludwigshafen | NEW 2-AMINOPYRAZINE AND METHOD FOR PRODUCING 2-AMINOPYRAZINE AND PYRAZINE |
| JPS59219269A (en) * | 1983-05-30 | 1984-12-10 | Terumo Corp | Pyrazine derivative and blood platelet coagulation inhibiting agent containing the same |
| JPH06299383A (en) * | 1993-04-13 | 1994-10-25 | Suzuki Shiyoukan:Kk | Vacuum treatment apparatus |
-
1987
- 1987-06-30 ES ES198787305796T patent/ES2038180T3/en not_active Expired - Lifetime
- 1987-06-30 EP EP87305796A patent/EP0252670B1/en not_active Expired
- 1987-06-30 US US07/068,228 patent/US4894453A/en not_active Expired - Fee Related
- 1987-06-30 DE DE8787305796T patent/DE3776011D1/en not_active Expired - Lifetime
-
1989
- 1989-07-19 US US07/381,958 patent/US5001237A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0252670A2 (en) | 1988-01-13 |
| EP0252670B1 (en) | 1992-01-15 |
| US4894453A (en) | 1990-01-16 |
| DE3776011D1 (en) | 1992-02-27 |
| US5001237A (en) | 1991-03-19 |
| EP0252670A3 (en) | 1989-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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