[go: up one dir, main page]

ES2036137A1 - Procedimiento para la preparacion de la nueva 1-(3-clorofenil)-4-hidroximetil-7,8-dimetoxi-5h-2,3-benzodiacepina y de sus sales de adicion acida. - Google Patents

Procedimiento para la preparacion de la nueva 1-(3-clorofenil)-4-hidroximetil-7,8-dimetoxi-5h-2,3-benzodiacepina y de sus sales de adicion acida.

Info

Publication number
ES2036137A1
ES2036137A1 ES919102303A ES9102303A ES2036137A1 ES 2036137 A1 ES2036137 A1 ES 2036137A1 ES 919102303 A ES919102303 A ES 919102303A ES 9102303 A ES9102303 A ES 9102303A ES 2036137 A1 ES2036137 A1 ES 2036137A1
Authority
ES
Spain
Prior art keywords
compounds
benzodiazepin
derivative
antiaggressive
benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES919102303A
Other languages
English (en)
Other versions
ES2036137B1 (es
Inventor
Ferenc Andrasi
Peter Botka
Katalin Goldschmidt
Tamas Hamori
Gyula Horvath
Jeno Korosti
Imre Moravcsik
Marta Rusz
Eva Tomori
Gabor Zolyomi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES2036137A1 publication Critical patent/ES2036137A1/es
Application granted granted Critical
Publication of ES2036137B1 publication Critical patent/ES2036137B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE LA NUEVA 1-(3-CLOROFENIL)-4-HIDROXIMETIL-7,8-DIMETOXI-5H-2,3-BENZODIACEPINA Y DE SUS SALES DE ADICION ACIDA. EL INVENTO SE REFIERE A LA NUEVA 1-(3-CLOROFENIL)-4-HIDROXIMETIL-7,8-DIMETOXI-5H-2,3-BENZODIACEPENINA DE FORMULA (I) Y DE SUS SALES DE ADICION ACIDA. LOS COMPUESTOS SEGUN EL INVENTO POSEEN VALIOSOS EFECTOS ANSIOLITICOS, ANTIAGRESIVOS Y ANTIDEPRESIVOS Y, AL MISMO TIEMPO, TIENEN VALORES DE TOXICIDAD AGUDA FAVORABLES, DE TAL FORMA QUE PUEDEN SER UTILIZADOS VENTAJOSAMENTE DE FORMA TERAPEUTICA.
ES9102303A 1990-10-17 1991-10-17 Procedimiento para la preparacion de la nueva 1-(3-clorofenil)-4-hidroximetil-7,8-dimetoxi-5h-2,3-benzodiacepina y de sus sales de adicion acida. Expired - Lifetime ES2036137B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU906469A HU207055B (en) 1990-10-17 1990-10-17 Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
ES2036137A1 true ES2036137A1 (es) 1993-05-01
ES2036137B1 ES2036137B1 (es) 1994-03-01

Family

ID=10971685

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9102303A Expired - Lifetime ES2036137B1 (es) 1990-10-17 1991-10-17 Procedimiento para la preparacion de la nueva 1-(3-clorofenil)-4-hidroximetil-7,8-dimetoxi-5h-2,3-benzodiacepina y de sus sales de adicion acida.

Country Status (28)

Country Link
US (1) US5204343A (es)
JP (1) JPH04282374A (es)
KR (1) KR920008011A (es)
CN (1) CN1033582C (es)
AT (1) AT399506B (es)
AU (1) AU648111B2 (es)
BE (1) BE1004995A3 (es)
BG (1) BG95336A (es)
CA (1) CA2053622A1 (es)
CH (1) CH682400A5 (es)
CZ (1) CZ282249B6 (es)
DE (1) DE4134402A1 (es)
DK (1) DK174891A (es)
ES (1) ES2036137B1 (es)
FI (1) FI914918A7 (es)
FR (1) FR2668148B1 (es)
GB (1) GB2248838B (es)
GR (1) GR1001068B (es)
HU (1) HU207055B (es)
IL (1) IL99637A (es)
IT (1) IT1256279B (es)
NL (1) NL9101741A (es)
NO (1) NO914056L (es)
PL (1) PL167108B1 (es)
RU (1) RU2058982C1 (es)
SE (1) SE506380C2 (es)
YU (1) YU47859B (es)
ZA (1) ZA918273B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK283859B6 (sk) * 1995-02-09 2004-03-02 Egis Gy�Gyszergy�R Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
HUP9701284A3 (en) * 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
US6649607B2 (en) 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
JP2006514084A (ja) * 2002-12-03 2006-04-27 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３−ヒドロキシ−４−メトキシフェニル）−４−メチル−５−エチル−７，８−ジメトキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
AU2003293405A1 (en) * 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2257274A1 (en) * 1974-01-16 1975-08-08 Synthelabo Substd. 1,2-diazepin-7-one analgesic and psychotropic agents - prepd by cyclizing a delta keto acid and a substd hydrazine
ES485163A1 (es) * 1978-10-19 1980-06-16 Egyt Gyogyszervegyeszeti Gyar Procedimiento de preparacion de un nuevo derivado 5h-2,3- benzodiazepinos o de una sal de adicion acida

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2257274A1 (en) * 1974-01-16 1975-08-08 Synthelabo Substd. 1,2-diazepin-7-one analgesic and psychotropic agents - prepd by cyclizing a delta keto acid and a substd hydrazine
ES485163A1 (es) * 1978-10-19 1980-06-16 Egyt Gyogyszervegyeszeti Gyar Procedimiento de preparacion de un nuevo derivado 5h-2,3- benzodiazepinos o de una sal de adicion acida

Also Published As

Publication number Publication date
IL99637A (en) 1996-06-18
FR2668148B1 (fr) 1993-07-30
DE4134402A1 (de) 1992-05-14
HUT59381A (en) 1992-05-28
ITMI912745A0 (it) 1991-10-17
KR920008011A (ko) 1992-05-27
SE9103022L (sv) 1992-04-18
RU2058982C1 (ru) 1996-04-27
AT399506B (de) 1995-05-26
IL99637A0 (en) 1992-08-18
FR2668148A1 (fr) 1992-04-24
ITMI912745A1 (it) 1993-04-17
NO914056D0 (no) 1991-10-16
NL9101741A (nl) 1992-05-18
CN1033582C (zh) 1996-12-18
GB9122090D0 (en) 1991-11-27
HU906469D0 (en) 1991-04-29
ES2036137B1 (es) 1994-03-01
US5204343A (en) 1993-04-20
GR1001068B (el) 1993-04-28
SE506380C2 (sv) 1997-12-08
YU166991A (sh) 1994-06-10
YU47859B (sh) 1996-02-19
GR910100426A (en) 1992-09-25
PL167108B1 (pl) 1995-07-31
GB2248838A (en) 1992-04-22
PL292091A1 (en) 1992-06-26
BG95336A (bg) 1993-12-24
BE1004995A3 (fr) 1993-03-16
CS314191A3 (en) 1992-05-13
ATA207191A (de) 1994-10-15
CA2053622A1 (en) 1992-04-18
IT1256279B (it) 1995-11-29
DK174891D0 (da) 1991-10-16
CZ282249B6 (cs) 1997-06-11
AU8592291A (en) 1992-04-30
ZA918273B (en) 1994-10-04
CH682400A5 (de) 1993-09-15
HU207055B (en) 1993-03-01
FI914918A7 (fi) 1992-04-18
GB2248838B (en) 1994-04-06
SE9103022D0 (sv) 1991-10-17
AU648111B2 (en) 1994-04-14
DK174891A (da) 1992-04-18
JPH04282374A (ja) 1992-10-07
NO914056L (no) 1992-04-21
FI914918A0 (fi) 1991-10-17
CN1060838A (zh) 1992-05-06

Similar Documents

Publication Publication Date Title
ATE246190T1 (de) Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten
IL99759A (en) Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them
BG103195A (en) Substituted indazole derivatives and their application as inhibitors of phosphodiesterase (pde) type iv and of the production of a tumournecrotic factor (tnf)
PL295030A1 (en) Method of obtaining substituted derivatives of 2-cyclohexan-1-yl amine
HUT70499A (en) Fluoroalkoxybenzaldehyde derivatives and process for producing them
AU1120599A (en) New heterocyclic compounds and their use in medicine, process for their reparation and pharmaceutical compositions containing them
ES8801204A1 (es) Un procedimiento para la preparacion de derivados de indol
DE3366141D1 (en) 1-phenylisoquinoline derivatives, process for their preparation, pharmaceutical compositions containing these compounds and their use
IL112622A (en) Iminoalkylamino or aminoalkylideneamino camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them
ES2036137A1 (es) Procedimiento para la preparacion de la nueva 1-(3-clorofenil)-4-hidroximetil-7,8-dimetoxi-5h-2,3-benzodiacepina y de sus sales de adicion acida.
DE69515038D1 (de) Verwendung von raloxifen und dessen analogen zur herstellung eines medikaments zur behandlung viraler erkrankungen
IL107287A (en) Heterocyclic derivatives process for their preparation and pharmaceutical compositions containing some of them
EP0398720A3 (en) Piperazine derivatives
HU9303000D0 (en) Aryl-morpholine-derivatives and pharmaceutical compositions containing it and process for production thereof
TW252979B (es)
HU9602402D0 (en) Novel amino acid derivatives, method of producing them and pharmaceutically compositions containing these compounds
EP0186023A3 (en) Biliary acid derivatives, process for their preparation and pharmaceutical compositions containing them
HRP950437B1 (en) N-substituted azabicycloheptane derivatives, their production and use
ES8107211A1 (es) Un procedimiento para la preparacion de nuevos derivados de benzoxocina.
YU140491A (sh) 6-supstituisani-tetrahidrobenz(c,d) indoli
ES8601099A1 (es) Procedimiento para la preparacion de nuevos derivados de n-(metoxifenacil)-amina
MX9704704A (es) Amidas de acido 4-amino-2-ureido-pirimidin-5-carboxilico, procedimientos para su obtencion, medicamentos que contienen estos compuestos, y su utilizacion.
ES8504181A1 (es) Procedimiento para preparar nuevos derivados de piperidina
HU9203928D0 (en) 6-sulfonyl-substituted 3-hydroxi-chromane derivatives and pharmaceutical preparatives containing them
ZA888663B (en) Substituted derivatives of 20,21-dinoreburanamenine,their preparation process and the new intermediates thus obtained,their use as medicaments and the pharmaceutical compositions containing them