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ES2031457T3 - DERIVATIVES OF 5-AMINIALKYL-BETA-CARBOLINE, TO ITS PREPARATION AND TO ITS USE AS MEDICINES. - Google Patents

DERIVATIVES OF 5-AMINIALKYL-BETA-CARBOLINE, TO ITS PREPARATION AND TO ITS USE AS MEDICINES.

Info

Publication number
ES2031457T3
ES2031457T3 ES198686730212T ES86730212T ES2031457T3 ES 2031457 T3 ES2031457 T3 ES 2031457T3 ES 198686730212 T ES198686730212 T ES 198686730212T ES 86730212 T ES86730212 T ES 86730212T ES 2031457 T3 ES2031457 T3 ES 2031457T3
Authority
ES
Spain
Prior art keywords
hydrogen
acil
lower alkyl
aminialkyl
carboline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686730212T
Other languages
Spanish (es)
Inventor
Helmut Dr. Biere
Andreas Dr. Huth
Dieter Dr. Rahtz
Ralph Dr. Schmiechen
Dieter Dr. Seidelmann
David Norman Dr. Stephens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2031457T3 publication Critical patent/ES2031457T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Fats And Perfumes (AREA)
  • Braking Arrangements (AREA)

Abstract

COMPUESTOS DE FORMULA GENERAL (I) EN LA QUE N=0 O 1, R1 SIGNIFICA HIDROGENO, O ALQUILO INFERIOR, R2 Y R3 REPRESENTAN CADA UNO HIDROGENO, ALQUILO, ACILO O ARILO, OPCIONALMENTE SUSTITUIDOS, O BIEN, FORMAN JUNTO CON EL ATOMO DE NITROGENO UN HETEROCICLO DE 5-6 ATOMOS, R4 REPRESENTA HIDROGENO, ALQUILO INFERIOR O ALCOXILO INFERIOR, Y X ES UN RADICAL OXADIAZOLILO DE FORMULA (II) O (III) EN LA QUE R5 REPRESENTA HIDROGENO, ALQUILO INFERIOR O CICLOALQUILO INFERIOR, O BIEN, UN GRUPO COOR6 EN EL QUE R6 ES HIDROGENO O ALQUILO INFERIOR, O BIEN, UN GRUPO CO-NR7R8 EN EL QUE R7 Y R8 REPRESENTAN CADA UNO HIDROGENO O ALQUILO, ACILO O ARILO INFERIORES, OPCIONALMENTE SUSTITUIDOS, PUDIENDO FORMAR R7 Y R8 JUNTO CON EL ATOMO DE NITROGENO UN HETEROCICLO DE 5-6 ATOMOS. ESTOS COMPUESTOS CONSTITUYEN VALIOSOS FARMACOS.COMPOUNDS OF GENERAL FORMULA (I) IN WHICH N = 0 OR 1, R1 MEANS HYDROGEN, OR LOWER ALKYL, R2 AND R3 REPRESENT EACH HYDROGEN, RENT, ACIL OR ARYL, OPTIONALLY SUBSTITUTED TOGETHER WITH IT NITROGEN A HETEROCICLE OF 5-6 ATOMS, R4 REPRESENTS HYDROGEN, LOWER ALKYL OR LOWER ALCOXYL, AND X IS A RADICAL OXADIAZOLYL OF FORMULA (II) OR (III), LOWER ALKYL, OTHER LOWER ACIL. GROUP COOR6 IN WHICH R6 IS HYDROGEN OR LOWER RENT, OR A GROUP CO-NR7R8 IN WHICH R7 AND R8 REPRESENT EACH LOWER HYDROGEN OR ACIL, ACID OR SUBSTITUTE, POSTALLY FORGIVING RIB7 OF NITROGEN A HETERO CYCLE OF 5-6 ATOMS. THESE COMPOUNDS CONSTITUTE VALUABLE PHARMACS.

ES198686730212T 1985-12-20 1986-12-19 DERIVATIVES OF 5-AMINIALKYL-BETA-CARBOLINE, TO ITS PREPARATION AND TO ITS USE AS MEDICINES. Expired - Lifetime ES2031457T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853545776 DE3545776A1 (en) 1985-12-20 1985-12-20 5-AMINOALKYL-SS-CARBOLINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
ES2031457T3 true ES2031457T3 (en) 1992-12-16

Family

ID=6289387

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686730212T Expired - Lifetime ES2031457T3 (en) 1985-12-20 1986-12-19 DERIVATIVES OF 5-AMINIALKYL-BETA-CARBOLINE, TO ITS PREPARATION AND TO ITS USE AS MEDICINES.

Country Status (17)

Country Link
US (2) US4731365A (en)
EP (1) EP0232675B1 (en)
JP (1) JPH0780878B2 (en)
AT (1) ATE58536T1 (en)
AU (1) AU597923B2 (en)
CA (1) CA1277319C (en)
DD (1) DD252829A5 (en)
DE (2) DE3545776A1 (en)
DK (1) DK165878C (en)
ES (1) ES2031457T3 (en)
FI (1) FI82245C (en)
GR (1) GR3001468T3 (en)
HU (1) HU195656B (en)
IE (1) IE59757B1 (en)
IL (1) IL81003A (en)
NO (1) NO165106C (en)
PT (1) PT83975B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3609699A1 (en) * 1986-03-20 1987-09-24 Schering Ag 5- OR 6-SUBSTITUTED (BETA) CARBOLIN-3-CARBONIC ACID ESTERS
DE4130933A1 (en) * 1991-09-13 1993-03-18 Schering Ag NEW (BETA) CARBOLINE DERIVATIVES, THEIR PRODUCTION AND USE IN MEDICINAL PRODUCTS
DE4212529A1 (en) * 1992-04-10 1993-10-14 Schering Ag Use of µ-carbolines as non-competitive glutamate antagonists
DE4330175A1 (en) * 1993-08-31 1995-03-02 Schering Ag Alkoxy substituted beta carbolines
EP4144707A1 (en) 2021-09-07 2023-03-08 Biolac GmbH & Co. KG Mixture for the preparation of a shaped body with improved binder

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3322895A1 (en) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen NEW SS CARBOLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT (S)
DE3322894A1 (en) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen NEW (BETA) CARBOLINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS (H)
DE3335323A1 (en) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen SUBSTITUTED SS-CARBOLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DK240084D0 (en) * 1984-05-15 1984-05-15 Ferrosan As NEW BETA-CARBOLINE-3-OXADIAZOLYL DERIVATIVES
DE3504045A1 (en) * 1985-02-04 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen METHOD FOR PRODUCING SS CARBOLINES BY DEHYDRATION

Also Published As

Publication number Publication date
FI865234A0 (en) 1986-12-19
DE3675758D1 (en) 1991-01-03
PT83975A (en) 1987-01-01
CA1277319C (en) 1990-12-04
FI82245C (en) 1991-02-11
PT83975B (en) 1989-05-12
NO865180D0 (en) 1986-12-19
NO165106B (en) 1990-09-17
AU597923B2 (en) 1990-06-14
IE863329L (en) 1987-06-20
NO865180L (en) 1987-06-22
IL81003A0 (en) 1987-03-31
EP0232675B1 (en) 1990-11-22
AU6679786A (en) 1987-06-25
DK610586D0 (en) 1986-12-17
ATE58536T1 (en) 1990-12-15
DK165878C (en) 1993-06-21
HU195656B (en) 1988-06-28
JPH0780878B2 (en) 1995-08-30
JPS62195378A (en) 1987-08-28
DD252829A5 (en) 1987-12-30
FI865234A7 (en) 1987-06-21
HUT43068A (en) 1987-09-28
DK610586A (en) 1987-06-21
GR3001468T3 (en) 1992-10-08
NO165106C (en) 1990-12-27
DK165878B (en) 1993-02-01
US4731365A (en) 1988-03-15
IE59757B1 (en) 1994-03-23
DE3545776A1 (en) 1987-06-25
IL81003A (en) 1990-04-29
EP0232675A1 (en) 1987-08-19
FI82245B (en) 1990-10-31
US4757070A (en) 1988-07-12

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