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ES2030023T3 - Formacion de imagenes por rmn con sales metalicas polivalentes paramagneticas de poli- (acido-alquilen-amino)-alcanos. - Google Patents

Formacion de imagenes por rmn con sales metalicas polivalentes paramagneticas de poli- (acido-alquilen-amino)-alcanos.

Info

Publication number
ES2030023T3
ES2030023T3 ES198787110801T ES87110801T ES2030023T3 ES 2030023 T3 ES2030023 T3 ES 2030023T3 ES 198787110801 T ES198787110801 T ES 198787110801T ES 87110801 T ES87110801 T ES 87110801T ES 2030023 T3 ES2030023 T3 ES 2030023T3
Authority
ES
Spain
Prior art keywords
patient
alquilen
alcanos
acido
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787110801T
Other languages
English (en)
Inventor
Karl F. Kraft
Steve C. Quay
Scott M. Rocklage
Dilip Worah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/057,709 external-priority patent/US5039512A/en
Application filed by Salutar Inc filed Critical Salutar Inc
Application granted granted Critical
Publication of ES2030023T3 publication Critical patent/ES2030023T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Signal Processing (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)
  • Soft Magnetic Materials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Thin Magnetic Films (AREA)
  • Cosmetics (AREA)

Abstract

EN UN METODO DE SIMULACION DE UN TEJIDO DEL CUERPO EN UN PACIENTE QUE COMPRENDE ADMINISTRAR AL PACIENTE UNA CANTIDAD EFECTIVA DE UN AGENTE FARMACEUTICO PARA INFLUIR EN LOS TIEMPOS DE REPOSO DE ATOMOS EN TEJIDOS DE UN CUERPO QUE ESTA SOMETIDO A DIAGNOSTICO DE NMR, POR LO CUAL EL CONTRASTE DE SIMULACION SE REALZA; DICHO AGENTE COMPRENDE UNA CANTIDAD EFECTIVA PARA AFECTAR DICHOS TIEMPOS DE REPOSO, DE UNA SAL PARAMAGNETICA, FISIOLOGICAMENTE COMPATIBLE, DE UN COMPLEJO QUELATO FISIOLOGICAMENTE COMPATIBLE DE UN ION DE UN ELEMENTO LANTANIDO DE NUMEROS ATOMICOS 57-70, O DE UN METAL DE TRANSICION DE NUMEROS ATOMICOS 21-29, 42 A 44 Y UN CONDUCTOR FARMACEUTICAMENTE ACEPTABLE Y SOMETER AL PACIENTE A UNA TOMOGRAFIA NMR, EN DONDE LA MENCIONADA SAL DE DICHO COMPLEJO DE QUELATO ES LA SAL DE CALCIO O MAGNESIO. ESTAS SALES SON NUEVAS ASI COMO ALQUENOS DE LOS COMPUESTOS DE QUELATO.
ES198787110801T 1986-08-04 1987-07-25 Formacion de imagenes por rmn con sales metalicas polivalentes paramagneticas de poli- (acido-alquilen-amino)-alcanos. Expired - Lifetime ES2030023T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89313686A 1986-08-04 1986-08-04
US90093086A 1986-08-27 1986-08-27
US07/057,709 US5039512A (en) 1986-08-04 1987-06-15 NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes

Publications (1)

Publication Number Publication Date
ES2030023T3 true ES2030023T3 (es) 1992-10-16

Family

ID=27369315

Family Applications (2)

Application Number Title Priority Date Filing Date
ES198787110801T Expired - Lifetime ES2030023T3 (es) 1986-08-04 1987-07-25 Formacion de imagenes por rmn con sales metalicas polivalentes paramagneticas de poli- (acido-alquilen-amino)-alcanos.
ES91116072T Expired - Lifetime ES2087938T3 (es) 1986-08-04 1987-07-25 Uso de complejos quelatos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES91116072T Expired - Lifetime ES2087938T3 (es) 1986-08-04 1987-07-25 Uso de complejos quelatos.

Country Status (16)

Country Link
EP (2) EP0463644B1 (es)
JP (1) JP2667666B2 (es)
AT (1) ATE138809T1 (es)
AU (1) AU608759B2 (es)
CA (1) CA1321346C (es)
DE (2) DE3777727D1 (es)
DK (1) DK167797B1 (es)
ES (2) ES2030023T3 (es)
FI (1) FI88677C (es)
GR (1) GR3004576T3 (es)
HK (1) HK96597A (es)
IE (1) IE64108B1 (es)
IL (2) IL83377A0 (es)
NO (1) NO173767C (es)
NZ (1) NZ221288A (es)
SG (1) SG78250A1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
DE3854717T3 (de) * 1987-06-30 1999-04-15 Mallinckrodt, Inc. (N.D.Ges.Des Staates Delaware), St. Louis, Mo. Verfahren zur erhöhung der sicherheit von metall-ligandchelaten als röntgenstrahlen-kontrastmittel.
GB8813144D0 (en) * 1988-06-03 1988-07-06 Nycomed As Compositions
GB8900719D0 (en) * 1989-01-13 1989-03-08 Nycomed As Compounds
GB8900732D0 (en) * 1989-01-13 1989-03-08 Nycomed As Agents
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
US5516503A (en) * 1989-11-16 1996-05-14 Guerbet S.A. Diagnostic composition comprising a binuclear complex, its method of preparation and its use in magnetic resonance imaging
FR2654344B1 (fr) * 1989-11-16 1994-09-23 Cis Bio Int Complexe paramagnetique de gadolinium, son procede de preparation et son utilisation pour le diagnostic par irm.
US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
DE69028001T2 (de) * 1989-11-27 1996-12-19 Concat Ltd Qualitätssteigerung von mr-bildern von knochen und ähnlichem gewebe mittels paramagnetischer kationenkomplexe und polyphosphonatliganden
DE4011684A1 (de) 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5843399A (en) * 1990-04-06 1998-12-01 Schering Aktiengesellschaft DTPA monoamides for MRI
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
IT1252145B (it) * 1991-11-29 1995-06-05 Bracco Ind Chimica Spa Metodo e formulazioni adatte a migliorare lo studio degli organi cavi nell'uomo
DE4302287A1 (de) * 1993-01-25 1994-07-28 Schering Ag Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
US5409689A (en) * 1993-08-13 1995-04-25 Concat, Ltd. MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
US5476644A (en) * 1994-04-13 1995-12-19 Sterling Winthrop Inc. Cyclic triamine chelating agents
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
TW319763B (es) 1995-02-01 1997-11-11 Epix Medical Inc
CN1203899C (zh) 1995-06-26 2005-06-01 螯合剂有限公司 对第一过渡系元素具有螯合亲和力和选择性的化合物及它们在医学冶疗中的用途
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US5980863A (en) * 1998-11-02 1999-11-09 Eagle Vision Pharmaceutical Corporation Manganese compositions and methods for MRI
JP2003501488A (ja) 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
AU2002249935A1 (en) 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
JP2007062462A (ja) * 2005-08-30 2007-03-15 Nifco Inc 多用途収容装置
US8378134B2 (en) 2009-09-30 2013-02-19 General Electric Company Hydroxylated contrast enhancement agents
NO331773B1 (no) 2009-12-18 2012-03-26 Ge Healthcare As Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
KR102231121B1 (ko) 2013-04-26 2021-03-23 게르브 조영제 제형 및 이와 관련된 제조 방법
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
WO2018115314A1 (en) 2016-12-21 2018-06-28 Ge Healthcare As Tetraazabicyclo-macrocycle based manganese chelate compounds suitable as mri imaging agents
EP3728168B1 (en) 2017-12-20 2022-03-30 General Electric Company Anionic chelate compounds
GB201919073D0 (en) 2019-12-20 2020-02-05 Ge Healthcare As Novel manufacturing process

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3818061A (en) * 1971-11-09 1974-06-18 Merck Sharp & Dohme Transparent nmr shift reagents
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
FR2550449B1 (fr) * 1983-08-12 1986-01-31 Commissariat Energie Atomique Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire
CA1242643A (en) * 1983-08-12 1988-10-04 Eric T. Fossel Nmr imaging utilizing chemical shift reagents
US4749560A (en) * 1984-08-13 1988-06-07 Research Corporation Metal organo phosphorous compounds for NMR analysis
US4687659A (en) * 1984-11-13 1987-08-18 Salutar, Inc. Diamide-DTPA-paramagnetic contrast agents for MR imaging
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
GB8518300D0 (en) * 1985-07-19 1985-08-29 Amersham Int Plc Contrast agent
DE3854717T3 (de) * 1987-06-30 1999-04-15 Mallinckrodt, Inc. (N.D.Ges.Des Staates Delaware), St. Louis, Mo. Verfahren zur erhöhung der sicherheit von metall-ligandchelaten als röntgenstrahlen-kontrastmittel.

Also Published As

Publication number Publication date
ATE138809T1 (de) 1996-06-15
GR3004576T3 (es) 1993-04-28
CA1321346C (en) 1993-08-17
IL101210A (en) 1996-10-31
DE3751829D1 (de) 1996-07-11
EP0258616B1 (en) 1992-03-25
DE3751829T2 (de) 1996-10-31
AU608759B2 (en) 1991-04-18
AU7573587A (en) 1988-02-11
EP0463644A2 (en) 1992-01-02
DK167797B1 (da) 1993-12-20
FI88677B (fi) 1993-03-15
FI88677C (fi) 1993-06-28
IE64108B1 (en) 1995-07-12
NZ221288A (en) 1990-10-26
NO173767B (no) 1993-10-25
EP0463644B1 (en) 1996-06-05
DK401087A (da) 1988-02-05
HK96597A (en) 1997-08-08
NO873237D0 (no) 1987-08-03
IE872076L (en) 1988-02-04
NO173767C (no) 1994-02-02
SG78250A1 (en) 2001-02-20
EP0258616A1 (en) 1988-03-09
DK401087D0 (da) 1987-07-31
ES2087938T3 (es) 1996-08-01
FI873382L (fi) 1988-02-05
FI873382A0 (fi) 1987-08-04
JP2667666B2 (ja) 1997-10-27
EP0463644A3 (en) 1992-11-19
JPS63119446A (ja) 1988-05-24
NO873237L (no) 1988-02-05
DE3777727D1 (de) 1992-04-30
IL83377A0 (en) 1987-12-31

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