ES2029163A6 - New substd. di:phenylmethane derivs. - useful as analgesic and antiinflammatory agents with no ulcerogenic side effects - Google Patents
New substd. di:phenylmethane derivs. - useful as analgesic and antiinflammatory agents with no ulcerogenic side effectsInfo
- Publication number
- ES2029163A6 ES2029163A6 ES9001999A ES9001999A ES2029163A6 ES 2029163 A6 ES2029163 A6 ES 2029163A6 ES 9001999 A ES9001999 A ES 9001999A ES 9001999 A ES9001999 A ES 9001999A ES 2029163 A6 ES2029163 A6 ES 2029163A6
- Authority
- ES
- Spain
- Prior art keywords
- derivs
- substd
- phenylmethane
- analgesic
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 title 1
- 230000000202 analgesic effect Effects 0.000 title 1
- 239000000730 antalgic agent Substances 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000001562 ulcerogenic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 2-furanylmethyl Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- CZZYITDELCSZES-UHFFFAOYSA-N diphenylmethane Chemical compound C=1C=CC=CC=1CC1=CC=CC=C1 CZZYITDELCSZES-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- BIOCOYIPJQMGTN-UHFFFAOYSA-N methyl 2-(3-benzoylphenyl)propanoate Chemical compound COC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 BIOCOYIPJQMGTN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Substd. diphenylmethane derivs. of formula (I) and their salts are new. R1 = H, Me; X = -CO- or -CH2-; Y = -CH-A or -C=CH-CH2-A; A = -NR4R5 or 5-6 membered heterocyclic ring contg. 1-3 N atoms or an N/O pair (opt. substd. by 1-4C alkyl, benzyl, 2-furanylmethyl or 2-thienylmethyl); R2 = H, 1-4C alkyl, 1-4C alkoxy, di(1-4C)alkylamino, NO2 or halo; R3 = H, phenyl, 1-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, -(CH2CH2O)n-H, -(CHOH)m-H or I-bis (when X = CO); R4, R5 = independently 1-4C alkyl (opt. substd. with phenyl); n = 1-3; m = 2-4. An example of (I) is methyl 2-(3-benzoylphenyl) propionate.
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9001999A ES2029163A6 (en) | 1990-07-25 | 1990-07-25 | New substd. di:phenylmethane derivs. - useful as analgesic and antiinflammatory agents with no ulcerogenic side effects |
| EP19910107704 EP0458160A3 (en) | 1990-05-25 | 1991-05-13 | Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents |
| NZ238212A NZ238212A (en) | 1990-05-25 | 1991-05-21 | Substituted diphenylmethane derivatives and their use as analgesic or anti-inflammatory agents |
| AU77227/91A AU636033C (en) | 1990-05-25 | 1991-05-21 | Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents |
| JP3149826A JPH04235143A (en) | 1990-05-25 | 1991-05-24 | Substituted diphenylmethane derivative as analgesic or anti-inflammatory |
| US07/705,400 US5204365A (en) | 1990-05-25 | 1991-05-24 | Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents |
| PT97768A PT97768A (en) | 1990-05-25 | 1991-05-24 | METHOD FOR PREPARING DIPHENYLMETHANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| CA002043203A CA2043203A1 (en) | 1990-05-25 | 1991-05-24 | Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents |
| KR1019910008409A KR910019943A (en) | 1990-05-25 | 1991-05-24 | Alveolar diphenylmethane derivatives as analgesic or anti-inflammatory agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9001999A ES2029163A6 (en) | 1990-07-25 | 1990-07-25 | New substd. di:phenylmethane derivs. - useful as analgesic and antiinflammatory agents with no ulcerogenic side effects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2029163A6 true ES2029163A6 (en) | 1992-07-16 |
Family
ID=8268296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9001999A Expired - Fee Related ES2029163A6 (en) | 1990-05-25 | 1990-07-25 | New substd. di:phenylmethane derivs. - useful as analgesic and antiinflammatory agents with no ulcerogenic side effects |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2029163A6 (en) |
-
1990
- 1990-07-25 ES ES9001999A patent/ES2029163A6/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001204 |