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ES2026059A6 - Procedimiento mejorado para la sintesis de 1-((1-(2-(trifluoreometil)-4-pirimidinil)-4-piperidinil)metil)-2-pirrolidinona. - Google Patents

Procedimiento mejorado para la sintesis de 1-((1-(2-(trifluoreometil)-4-pirimidinil)-4-piperidinil)metil)-2-pirrolidinona.

Info

Publication number
ES2026059A6
ES2026059A6 ES9002730A ES9002730A ES2026059A6 ES 2026059 A6 ES2026059 A6 ES 2026059A6 ES 9002730 A ES9002730 A ES 9002730A ES 9002730 A ES9002730 A ES 9002730A ES 2026059 A6 ES2026059 A6 ES 2026059A6
Authority
ES
Spain
Prior art keywords
bmy
scale production
adaption
synthesis
improved process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9002730A
Other languages
English (en)
Inventor
Gary D Madding
Joseph L Minielli
Ronald J Mattson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ES2026059A6 publication Critical patent/ES2026059A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Polymers (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

UN PROCEDIMIENTO MEJORADO, QUE PUEDE SER ADAPTADO A LA FABRICACION A GRAN ESCALA, PARA LA SINTESIS DEL AGENTE POTENCIADOR DE LA FUNCION CEREBRAL BMY 21502 ES DECIR, 1-[1- [2-(TRIFULOROMETIL)-4-PIRIMIDINIL] -4-PIPERIDINIL] METIL]-2-PIRROLIDINONA, QUE COMPRENDE AGREGAR UNA MEZCLA DE 2-PIRROLIDINONA Y 4-HALOMETIL-PIRIDINA A UNA SUSPENSION DE HIDRURO SODICO EN N, N-DIMETILFORMAMIDA A 15-20G APROXIMADAMENTE, HIDROGENAR CATALITICAMENTE UNA SOLUCION ACUOSA ACIDIFICADA DEL COMPUESTO OBTENIDO 1-(4-PIRIDINILMETIL)-2-PIRROLIDINONA, QUE SE BASIFICA Y SE CONVIERTE EN BMY 21502 A TRAVES DE COMPUESTOS INTERMEDIOS.
ES9002730A 1989-10-27 1990-10-26 Procedimiento mejorado para la sintesis de 1-((1-(2-(trifluoreometil)-4-pirimidinil)-4-piperidinil)metil)-2-pirrolidinona. Expired - Lifetime ES2026059A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/427,546 US4963678A (en) 1989-10-27 1989-10-27 Process for large-scale production of BMY 21502

Publications (1)

Publication Number Publication Date
ES2026059A6 true ES2026059A6 (es) 1992-04-01

Family

ID=23695332

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9002730A Expired - Lifetime ES2026059A6 (es) 1989-10-27 1990-10-26 Procedimiento mejorado para la sintesis de 1-((1-(2-(trifluoreometil)-4-pirimidinil)-4-piperidinil)metil)-2-pirrolidinona.

Country Status (12)

Country Link
US (1) US4963678A (es)
KR (1) KR910007917A (es)
CN (1) CN1032916C (es)
AT (1) AT397961B (es)
EG (1) EG19764A (es)
ES (1) ES2026059A6 (es)
FI (1) FI95467C (es)
GR (1) GR1001125B (es)
HU (1) HU206878B (es)
NO (1) NO177303C (es)
PT (1) PT95711B (es)
YU (1) YU203290A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95468C (fi) * 1989-10-27 1996-02-12 Squibb Bristol Myers Co Parannettu menetelmä käyttökelpoisten piperidiinijohdannaisten valmistamiseksi
HU206878B (en) * 1989-10-27 1993-01-28 Bristol Myers Squibb Co Process for producing 1-//1-/2-/trifluoromethyl/-4-pyrimidinyl/-4-piperidinyl/-methyl/-2-pirrolidinone
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
US5401744A (en) * 1993-10-04 1995-03-28 Bristol-Myers Squibb Company Useful hemi-hydrate form of a cerebral function enhancing agent
US5538985A (en) * 1994-01-27 1996-07-23 Mitsui Toatsu Chemicals, Inc. Pyrrolidinone derivatives
CZ20032475A3 (cs) 2001-03-15 2003-12-17 Basf Aktiengesellschaft 5-Fenylpyrimidiny, způsob jejich přípravy, meziprodukty pro jejich přípravu a jejich použití pro kontrolu škodlivých hub
US7073271B2 (en) * 2002-02-14 2006-07-11 Faro Technologies Inc. Portable coordinate measurement machine
CN106883185B (zh) * 2015-12-15 2021-07-09 重庆博腾制药科技股份有限公司 一种4-氯-2-三氟甲基嘧啶的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826843A (en) * 1985-07-08 1989-05-02 Bristol-Myers Cerebral function enhancing diazinylpiperidine derivatives
NZ216720A (en) * 1985-07-08 1990-09-26 Bristol Myers Co Diazinylpiperidine derivatives and pharmaceutical compositions
DE3703103A1 (de) * 1987-02-03 1988-08-11 Bayer Ag Mittel gegen fischparsiten
HU206878B (en) * 1989-10-27 1993-01-28 Bristol Myers Squibb Co Process for producing 1-//1-/2-/trifluoromethyl/-4-pyrimidinyl/-4-piperidinyl/-methyl/-2-pirrolidinone

Also Published As

Publication number Publication date
PT95711A (pt) 1991-09-13
NO177303B (no) 1995-05-15
CN1051175A (zh) 1991-05-08
GR1001125B (el) 1993-04-28
NO177303C (no) 1995-08-23
NO904587D0 (no) 1990-10-24
FI95467B (fi) 1995-10-31
FI905225A0 (fi) 1990-10-24
CN1032916C (zh) 1996-10-02
KR910007917A (ko) 1991-05-30
HU206878B (en) 1993-01-28
YU203290A (sh) 1993-10-20
EG19764A (en) 1996-01-31
AT397961B (de) 1994-08-25
PT95711B (pt) 1997-12-31
GR900100776A (en) 1992-03-20
HU910050D0 (en) 1991-08-28
US4963678A (en) 1990-10-16
NO904587L (no) 1991-04-29
FI95467C (fi) 1996-02-12
ATA212290A (de) 1993-12-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051027