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ES2010445A6 - Perfluorochemical emulsion with stabilized vesicles. - Google Patents

Perfluorochemical emulsion with stabilized vesicles.

Info

Publication number
ES2010445A6
ES2010445A6 ES8900889A ES8900889A ES2010445A6 ES 2010445 A6 ES2010445 A6 ES 2010445A6 ES 8900889 A ES8900889 A ES 8900889A ES 8900889 A ES8900889 A ES 8900889A ES 2010445 A6 ES2010445 A6 ES 2010445A6
Authority
ES
Spain
Prior art keywords
perfluorochemical
stabilized vesicles
vesicles
perfluorochemical emulsion
emulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8900889A
Other languages
Spanish (es)
Inventor
Charles Michael Heldebrant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alpha Therapeutic Corp
Original Assignee
Alpha Therapeutic Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha Therapeutic Corp filed Critical Alpha Therapeutic Corp
Publication of ES2010445A6 publication Critical patent/ES2010445A6/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

A stable perfluorochemical emulsion is provided which comprises perfluorochemical particles in stabilized vesicles. The vesicles comprise a biocompatible polymer formed by coating the perfluorochemical particles with one or more phospholipid monomer(s) and polymerizing the monomer(s).
ES8900889A 1988-03-11 1989-03-10 Perfluorochemical emulsion with stabilized vesicles. Expired ES2010445A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16669088A 1988-03-11 1988-03-11

Publications (1)

Publication Number Publication Date
ES2010445A6 true ES2010445A6 (en) 1989-11-01

Family

ID=22604316

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8900889A Expired ES2010445A6 (en) 1988-03-11 1989-03-10 Perfluorochemical emulsion with stabilized vesicles.

Country Status (4)

Country Link
EP (1) EP0417104A4 (en)
JP (1) JPH02258050A (en)
ES (1) ES2010445A6 (en)
WO (1) WO1989008459A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219538A (en) * 1987-03-13 1993-06-15 Micro-Pak, Inc. Gas and oxygen carrying lipid vesicles
US5196199A (en) * 1990-12-14 1993-03-23 Fuisz Technologies Ltd. Hydrophilic form of perfluoro compounds and method of manufacture
DE4221269C1 (en) * 1992-06-26 1993-12-09 Lancaster Group Ag Preparation for topical use
DE4221256C2 (en) * 1992-06-26 1997-07-10 Lancaster Group Ag Galenic composition for topical use
DE4221268C2 (en) * 1992-06-26 1997-06-12 Lancaster Group Ag Use of a dermatological to support the oxygen transport in the skin
US5641509A (en) * 1992-06-26 1997-06-24 Lancaster Group Ag Preparation for topical use
DE4221255C2 (en) * 1992-06-26 1994-09-15 Lancaster Group Ag Cosmetolipid-containing cosmetic

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5331209B2 (en) * 1973-10-05 1978-09-01
JPS55100312A (en) * 1979-01-25 1980-07-31 Toshiro Wada Contrast medium for blood vessel
US4252827A (en) * 1979-05-23 1981-02-24 The Green Cross Corporation Oxygen-transferable fluorocarbon emulsion
US4569784A (en) * 1980-11-17 1986-02-11 Adamantech, Inc. Preparation of a gel having gas transporting capability
US4443480A (en) * 1982-04-12 1984-04-17 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4423077A (en) * 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
US4497829A (en) * 1982-07-27 1985-02-05 The University Of Pennsylvania Process for preparing perfluorochemical emulsion artificial blood
GB8407557D0 (en) * 1984-03-23 1984-05-02 Hayward J A Polymeric lipsomes
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4814446A (en) * 1985-09-17 1989-03-21 Biomed-Technology, Inc. Fluorinated triethylenediamine as an oxygen transport agent

Also Published As

Publication number Publication date
EP0417104A4 (en) 1991-10-30
EP0417104A1 (en) 1991-03-20
JPH02258050A (en) 1990-10-18
WO1989008459A1 (en) 1989-09-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980401