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ES2003197A6 - Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica - Google Patents

Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica

Info

Publication number
ES2003197A6
ES2003197A6 ES8700020A ES8700020A ES2003197A6 ES 2003197 A6 ES2003197 A6 ES 2003197A6 ES 8700020 A ES8700020 A ES 8700020A ES 8700020 A ES8700020 A ES 8700020A ES 2003197 A6 ES2003197 A6 ES 2003197A6
Authority
ES
Spain
Prior art keywords
heparin
ammonium hydroxide
depolymerization
molecular weight
low molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8700020A
Other languages
English (en)
Inventor
Belmonte Lorenzo Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Farmaceuticos Rovi SA
Original Assignee
Laboratorios Farmaceuticos Rovi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Farmaceuticos Rovi SA filed Critical Laboratorios Farmaceuticos Rovi SA
Priority to ES8700020A priority Critical patent/ES2003197A6/es
Priority to AT87500051T priority patent/ATE106901T1/de
Priority to DE3750036T priority patent/DE3750036T2/de
Priority to EP87500051A priority patent/EP0293539B1/fr
Publication of ES2003197A6 publication Critical patent/ES2003197A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE DESPOLIMERIZACION DE LA HEPARINA PARA LA OBTENCION DE UNA HEPARINA DE BAJO PESO MOLECULAR DOTADA DE ACTIVIDAD ANTITROMBOTICA, EN EL QUE SE PARTE DE UNA SAL DE AMONIO CUATERNARIO DE HEPARINA QUE SE TRATA CON UN HIDROXIDO DE AMONIO CUATERNARIO, EN UN DISOLVENTE HIDROXILADO, EFECTUANDO LA REACCION A TEMPERATURA ENTRE 10J Y 60JC, HASTA OBTENER UNA HEPARINA DE PESO MOLECULAR MEDIO COMPRENDIDO ENTRE
ES8700020A 1987-01-05 1987-01-05 Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica Expired ES2003197A6 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES8700020A ES2003197A6 (es) 1987-01-05 1987-01-05 Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica
AT87500051T ATE106901T1 (de) 1987-01-05 1987-07-22 Verfahren zur depolymerisierung von heparin zum erhalten eines heparins mit niedrigem molekulargewicht und einer antithrombotischen aktivität.
DE3750036T DE3750036T2 (de) 1987-01-05 1987-07-22 Verfahren zur Depolymerisierung von Heparin zum Erhalten eines Heparins mit niedrigem Molekulargewicht und einer antithrombotischen Aktivität.
EP87500051A EP0293539B1 (fr) 1987-01-05 1987-07-22 Procédé pour la dépolymérisation de l'héparine pour l'obtention d'une héparine de bas poids moléculaire dotée d'une activité antithrombotique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8700020A ES2003197A6 (es) 1987-01-05 1987-01-05 Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica

Publications (1)

Publication Number Publication Date
ES2003197A6 true ES2003197A6 (es) 1988-10-16

Family

ID=8249032

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8700020A Expired ES2003197A6 (es) 1987-01-05 1987-01-05 Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica

Country Status (4)

Country Link
EP (1) EP0293539B1 (es)
AT (1) ATE106901T1 (es)
DE (1) DE3750036T2 (es)
ES (1) ES2003197A6 (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2161615A1 (es) * 1999-07-23 2001-12-01 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
CN103012621A (zh) * 2011-09-26 2013-04-03 徐美英 一种高纯度肝素苄酯盐及其制法和应用
WO2014020227A1 (es) 2012-08-02 2014-02-06 Laboratorios Farmaceuticos Rovi, S.A. Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular
WO2021219902A1 (es) * 2020-04-27 2021-11-04 Laboratorios Farmacéuticos Rovi, S.A. Procedimiento para la obtención de heparinas de bajo peso molecular y heparinas de bajo peso molecular obtenidas por el mismo

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
WO2003078960A2 (en) 2002-03-11 2003-09-25 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN103012620B (zh) * 2011-09-26 2017-09-19 徐美英 一种高纯度肝素苄酯盐及其制法和应用
WO2018032502A1 (zh) * 2016-08-19 2018-02-22 苏州融析生物科技有限公司 羊来源的低分子肝素及其制备方法与应用
CN107759712B (zh) * 2016-08-19 2020-03-24 苏州融析生物科技有限公司 羊来源的低分子肝素及其制备方法与应用
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
CN110092848A (zh) * 2019-05-14 2019-08-06 山东辰龙药业有限公司 一种贝米肝素钠的制备方法
CA3144968A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2161615A1 (es) * 1999-07-23 2001-12-01 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
CN103012621A (zh) * 2011-09-26 2013-04-03 徐美英 一种高纯度肝素苄酯盐及其制法和应用
CN103012621B (zh) * 2011-09-26 2017-09-19 徐美英 一种高纯度肝素苄酯盐及其制法和应用
WO2014020227A1 (es) 2012-08-02 2014-02-06 Laboratorios Farmaceuticos Rovi, S.A. Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular
ES2445494A1 (es) * 2012-08-02 2014-03-03 Laboratorios Farmacéuticos Rovi, S.A. Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular
CN104507972A (zh) * 2012-08-02 2015-04-08 罗维药品实验室有限公司 低分子量和极低分子量肝素获取工艺
CN108102007A (zh) * 2012-08-02 2018-06-01 罗维药品实验室有限公司 低分子量和极低分子量肝素获取工艺
WO2021219902A1 (es) * 2020-04-27 2021-11-04 Laboratorios Farmacéuticos Rovi, S.A. Procedimiento para la obtención de heparinas de bajo peso molecular y heparinas de bajo peso molecular obtenidas por el mismo
WO2021219907A1 (es) * 2020-04-27 2021-11-04 Laboratorios Farmacéuticos Rovi, S.A. Procedimiento para la obtención de heparinas de bajo peso molecular y heparinas de bajo peso molecular obtenidas por el mismo
CN114072430A (zh) * 2020-04-27 2022-02-18 罗威制药股份有限公司 低分子量肝素获取程序以及由此获得的低分子量肝素

Also Published As

Publication number Publication date
EP0293539A3 (en) 1989-04-12
EP0293539B1 (fr) 1994-06-08
DE3750036T2 (de) 1995-01-26
ATE106901T1 (de) 1994-06-15
DE3750036D1 (de) 1994-07-14
EP0293539A2 (fr) 1988-12-07

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2007-01-05

SPCD Supplementary protection certificate rejected

Free format text: HIBOR MOTIVOS: SUBSISTEN DEFECTOR QUE NO HAN SIDO DEBIDAMENTE SUBSANADOS EN EL PLAZO PREVISTO AL EFECTO SEGUN LO ESTABLECIDO EN EL ARTICULO 10.4 DEL REGLAMENTO (CEE) NO1768/92.

Spc suppl protection certif: C9900016

Filing date: 19990409

Effective date: 20001027

FD1A Patent lapsed

Effective date: 20070108