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ES2001586A6 - Un procedimiento para producir un complejo de diamina platino (ii) - Google Patents

Un procedimiento para producir un complejo de diamina platino (ii)

Info

Publication number
ES2001586A6
ES2001586A6 ES8601351A ES8601351A ES2001586A6 ES 2001586 A6 ES2001586 A6 ES 2001586A6 ES 8601351 A ES8601351 A ES 8601351A ES 8601351 A ES8601351 A ES 8601351A ES 2001586 A6 ES2001586 A6 ES 2001586A6
Authority
ES
Spain
Prior art keywords
platinum complexes
image
novel platinum
lower alkyl
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601351A
Other languages
English (en)
Inventor
Hiroyoshi Nowatari
Hiroshi Hayami
Yasuo Kuroda
Sumio Yoda
Katsutoshi Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61152635A external-priority patent/JPS6345290A/ja
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Publication of ES2001586A6 publication Critical patent/ES2001586A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)

Abstract

EL PROCEDIMIENTO DESCRITO PRODUCE COMPUESTOS DE FORMULA DONDE R1, R2, R3 Y R4 SON, CADA UNA, HIDROGENO O ALQUILO INFERIOR; Y LAS DOS X SON, CADA UNA, HALOGENO O FORMAN CONJUNTAMENTE UN GRUPO REPRESENTADO POR (DONDE R5 Y R6 SON, CADA UNA, HIDROGENO O ALQUILO INFERIOR) O UN GRUPO REPRESENTADO POR (DONDE M ES 1 O 2), HACIENDO REACCIONAR UNA DIAMINA CON TETRAHALOGENOPLATINATO, PARA OBTENER UN COMPLEJO DE DIHALOGENODIAMINA PLATINO, Y, CUANDO SEA NECESARIO, HACIENDO REACCIONAR ESTE CON IONES PLATA EN PRESENCIA DE AGUA Y HACER REACCIONAR EL COMPLEJO DIAQUA RESULTANTE CON UN ACIDO DICARBOXILICO O SUS SALES. LOS COMPUESTOS OBTENIDOS TIENEN BAJA TOXICIDAD Y PUEDEN UTILIZARSE COMO AGENTES ANTITUMORALES.
ES8601351A 1985-08-27 1986-08-26 Un procedimiento para producir un complejo de diamina platino (ii) Expired ES2001586A6 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP18771085 1985-08-27
JP2680086 1986-02-12
JP2679986 1986-02-12
JP9462686 1986-04-25
JP61152635A JPS6345290A (ja) 1985-08-27 1986-07-01 新規白金錯体

Publications (1)

Publication Number Publication Date
ES2001586A6 true ES2001586A6 (es) 1988-06-01

Family

ID=27520873

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601351A Expired ES2001586A6 (es) 1985-08-27 1986-08-26 Un procedimiento para producir un complejo de diamina platino (ii)

Country Status (10)

Country Link
US (4) US4737589A (es)
EP (1) EP0219936B1 (es)
AU (1) AU595827B2 (es)
CA (1) CA1258865A (es)
DE (1) DE3667468D1 (es)
DK (1) DK405986A (es)
ES (1) ES2001586A6 (es)
HU (1) HU198302B (es)
IE (1) IE59225B1 (es)
IL (1) IL79819A0 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737589A (en) * 1985-08-27 1988-04-12 Nippon Kayaku Kabushiki Kaisha Platinum Complexes
JPH0665648B2 (ja) * 1985-09-25 1994-08-24 塩野義製薬株式会社 白金系抗癌物質の安定な凍結真空乾燥製剤
US5256653A (en) * 1987-02-19 1993-10-26 Henkel Kommanditgesellschaft Auf Aktien Pharmaceutical preparations containing platinum complexes/phosphonic acid liquid and processes for their use
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
US4996337A (en) * 1987-06-23 1991-02-26 American Cyanamid Company Synthesis of cisplatin analogs
US4870070A (en) * 1987-08-10 1989-09-26 American Cyanamid Company Water soluble platinum complexes of novel malonate derivatives
US4904809A (en) * 1987-09-25 1990-02-27 Ss Pharmaceutical Co., Ltd. Platinum complex
JPH01146826A (ja) * 1987-12-03 1989-06-08 Nippon Kayaku Co Ltd 白金化合物の凍結乾燥製剤
IT1216687B (it) * 1988-04-01 1990-03-08 Boehringer Biochemia Srl Complessi di platino (ii), loro preparazione e impiego come antitumorali.
NL8802150A (nl) * 1988-08-31 1990-03-16 Tno Platina-(ii)-diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat deze verbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
WO1990012018A1 (fr) * 1989-04-04 1990-10-18 Daikin Industries, Ltd. Nouveaux composes de platine au fluorcarbone
US5049686A (en) * 1989-09-13 1991-09-17 Warner-Lambert Company Novel large-ring diamine platinum(II) and platinum(IV) chelates
US5196555A (en) * 1989-10-17 1993-03-23 Bristol-Myers Squibb Company Water and solvent soluble axial hydroxy and mono- and di- carboxylic acid derivatives having high tumor activity
EP0464210A4 (en) * 1989-12-15 1992-11-25 Tsumura & Co. Novel platinum complex and antitumor drug containing the same as active ingredient
NZ237443A (en) * 1990-04-10 1993-11-25 Asta Medica Ag Phenalkylethylenediamine and aminomethyltetra hydroisoquinoline derivatives, platinum (ii) and (iv) complexes, methods of preparation and pharmaceutical compositions
US5238955A (en) * 1990-04-10 1993-08-24 Asta Pharma Ag Ethylene-substituted phenylalkylethylenediamine-platinum (II or IV) derivatives and phenylalkylethylenediamines
JPH06287021A (ja) * 1992-04-22 1994-10-11 Tanaka Kikinzoku Kogyo Kk 光学活性な白金錯化合物の光学的分割方法
US5948083A (en) * 1997-09-30 1999-09-07 S3 Incorporated System and method for self-adjusting data strobe
US6689928B2 (en) 2000-04-04 2004-02-10 Exxonmobil Research And Engineering Company Transition metal complexes and oligomers therefrom
US8080026B2 (en) 2003-01-21 2011-12-20 Angioscore, Inc. Apparatus and methods for treating hardened vascular lesions
US7686824B2 (en) 2003-01-21 2010-03-30 Angioscore, Inc. Apparatus and methods for treating hardened vascular lesions
US10076641B2 (en) 2005-05-11 2018-09-18 The Spectranetics Corporation Methods and systems for delivering substances into luminal walls
CN101578098B (zh) * 2006-06-28 2015-12-16 株式会社Ihi 药物、药物引导装置、磁性检测装置和药物设计方法
CN103130836A (zh) * 2013-03-01 2013-06-05 昆明贵研药业有限公司 具有抗肿瘤活性的铂（ii）配合物及其制备方法
US9724121B2 (en) 2014-02-02 2017-08-08 TriReme Medical, LLC Apparatus and methods for recannalization, valve repair and replacement

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7903361L (sv) * 1978-04-20 1979-10-21 Johnson Matthey Co Ltd Kompositioner innehallande platina
NL7807334A (nl) * 1978-07-06 1980-01-08 Tno Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel.
JPS6034958B2 (ja) * 1978-09-02 1985-08-12 喜徳 喜谷 新規白金錯体
NL8204067A (nl) * 1982-10-21 1984-05-16 Tno Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
NL181434C (nl) * 1980-01-03 1987-08-17 Tno Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing.
JPS56103192A (en) * 1980-01-18 1981-08-18 Yoshinori Kitani Novel platinum complex
AU538863B2 (en) * 1980-05-27 1984-08-30 Bristol-Myers Company Platinum complex salts have anti-tumor property
JPS5715641A (en) * 1980-07-01 1982-01-27 Ntn Toyo Bearing Co Ltd Cutting and hardening of steel machine parts
JPS5716895A (en) * 1980-07-05 1982-01-28 Otsuka Chem Co Ltd Platinum 2 complex and antitumor agent containing the same as active principle
NL8101026A (nl) * 1981-03-03 1982-10-01 Tno Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel.
JPS57156416A (en) * 1981-03-24 1982-09-27 Otsuka Chem Co Ltd Platinum (2) complex and antitumor agent comprising it as active ingredient
US4500465A (en) * 1982-06-28 1985-02-19 Engelhard Corporation Solubilized platinum (II) complexes
US4598091A (en) * 1983-02-18 1986-07-01 Degussa Aktiengesellschaft (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds
JPS6087295A (ja) * 1983-10-19 1985-05-16 Nippon Kayaku Co Ltd 新規白金錯体
US4562275A (en) * 1984-03-23 1985-12-31 Bristol-Myers Co. Antitumor platinum complexes
US4665210A (en) * 1984-12-17 1987-05-12 American Cyanamid Company Platinum complexes of aliphatic tricarboxylic acids
US4737589A (en) * 1985-08-27 1988-04-12 Nippon Kayaku Kabushiki Kaisha Platinum Complexes
US4760157A (en) * 1986-01-31 1988-07-26 American Cyanamid Company (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
US4937358A (en) * 1987-06-23 1990-06-26 American Cyanamid Company Synthesis of cisplatin analogs

Also Published As

Publication number Publication date
US4921984A (en) 1990-05-01
EP0219936A1 (en) 1987-04-29
CA1258865A (en) 1989-08-29
DK405986A (da) 1987-02-28
AU6180186A (en) 1987-03-05
DE3667468D1 (de) 1990-01-18
IE862281L (en) 1987-02-27
HU198302B (en) 1989-09-28
IE59225B1 (en) 1994-01-26
US4737589A (en) 1988-04-12
HUT44266A (en) 1988-02-29
IL79819A0 (en) 1986-11-30
US5068376A (en) 1991-11-26
EP0219936B1 (en) 1989-12-13
AU595827B2 (en) 1990-04-12
US4864043A (en) 1989-09-05
DK405986D0 (da) 1986-08-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980401