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ES2098266T3 - Un metodo para hacer un nucleosido, su uso y metodo para hacer una composicion farmaceutica con el mismo. - Google Patents

Un metodo para hacer un nucleosido, su uso y metodo para hacer una composicion farmaceutica con el mismo.

Info

Publication number
ES2098266T3
ES2098266T3 ES90909080T ES90909080T ES2098266T3 ES 2098266 T3 ES2098266 T3 ES 2098266T3 ES 90909080 T ES90909080 T ES 90909080T ES 90909080 T ES90909080 T ES 90909080T ES 2098266 T3 ES2098266 T3 ES 2098266T3
Authority
ES
Spain
Prior art keywords
make
nucleoside
pharmaceutical composition
same
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909080T
Other languages
English (en)
Inventor
John A Montgomery
John A Secrist Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Southern Research Institute
Original Assignee
Southern Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Research Institute filed Critical Southern Research Institute
Application granted granted Critical
Publication of ES2098266T3 publication Critical patent/ES2098266T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN NUCLEOSIDOS TENIENDO LA FORMULA (I), DONDE 2 ES F , CL O BR Y R ES H O ARILO. ESTOS COMPUESTOS TIENEN ACTIVIDAD ANTICARICERIGENA.
ES90909080T 1989-05-23 1990-05-23 Un metodo para hacer un nucleosido, su uso y metodo para hacer una composicion farmaceutica con el mismo. Expired - Lifetime ES2098266T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/355,358 US5034518A (en) 1989-05-23 1989-05-23 2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine nucleosides

Publications (1)

Publication Number Publication Date
ES2098266T3 true ES2098266T3 (es) 1997-05-01

Family

ID=23397161

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909080T Expired - Lifetime ES2098266T3 (es) 1989-05-23 1990-05-23 Un metodo para hacer un nucleosido, su uso y metodo para hacer una composicion farmaceutica con el mismo.

Country Status (10)

Country Link
US (1) US5034518A (es)
EP (1) EP0473708B1 (es)
JP (1) JP3160288B2 (es)
AT (1) ATE147751T1 (es)
AU (1) AU5831590A (es)
DE (2) DE69029733T2 (es)
ES (1) ES2098266T3 (es)
HK (1) HK1007561A1 (es)
NL (1) NL300247I2 (es)
WO (1) WO1990014352A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384310A (en) * 1989-05-23 1995-01-24 Southern Research Institute 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
WO1992011276A1 (en) * 1990-12-18 1992-07-09 Sloan-Kettering Institute For Cancer Research Novel synthesis of 2'-'up' fluorinated 2''-deoxy-arabinofuranosylpurines
DE4141454A1 (de) 1991-11-25 1993-05-27 Schering Ag Neues verfahren zur herstellung von 2-fluorpurin-derivaten
JPH07507775A (ja) * 1992-05-19 1995-08-31 ザ スクリップス リサーチ インスティテュート 慢性骨髄性白血病の治療薬としての２−ハロアデニン誘導体の使用
US5817641A (en) * 1994-07-21 1998-10-06 Thomas Jefferson University Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives
IL138037A0 (en) * 1998-02-25 2001-10-31 Univ Emory 2'-fluoronucleosides
KR101005299B1 (ko) * 2000-10-18 2011-01-04 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
CA2381367A1 (en) * 2001-04-12 2002-10-12 Hironori Komatsu Method for purifying 5'-protected 2'-deoxypurine nucleosides
JP2005503358A (ja) 2001-06-22 2005-02-03 フアーマセツト・リミテツド β−２’−または３’−ハロヌクレオシド
WO2004028463A2 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of lupus using clofarabine
CA2500360A1 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of autoimmune disorders using clofarabine
AU2003287081A1 (en) * 2002-10-16 2004-05-04 Ilex Products, Inc. Clofarabine and taxane chemotherapy combination
ES2327252T3 (es) * 2004-08-23 2009-10-27 F. Hoffmann-La Roche Ag 4'-azido nucleosidos antivirales.
US8895531B2 (en) * 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
EP2084175B1 (en) * 2006-10-10 2010-12-29 Medivir AB Hcv nucleoside inhibitor
US20090274686A1 (en) * 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives
CN102311472B (zh) 2010-07-09 2014-09-03 神隆(昆山)生化科技有限公司 2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
CN103665075A (zh) * 2013-12-26 2014-03-26 南通康鑫药业有限公司 一种氯法拉滨的合成方法
EP2937420A1 (en) 2014-04-23 2015-10-28 Synbias Pharma AG Method for the synthesis of clofarabine
WO2018085307A1 (en) * 2016-11-03 2018-05-11 Wu Laurence I Prodrugs of clofarabine
US20220008450A1 (en) * 2018-10-04 2022-01-13 Daikin Industries, Ltd. Anti-hepatitis b virus agent
JP7378764B2 (ja) * 2018-10-04 2023-11-14 国立大学法人 鹿児島大学 抗ｂ型肝炎ウイルス剤
GB201816825D0 (en) 2018-10-16 2018-11-28 Phoremost Ltd Target for anti-cancer therapy
JP2020176082A (ja) * 2019-04-17 2020-10-29 ダイキン工業株式会社 核酸アナログ及び抗ｂ型肝炎ウイルス剤
US20220251134A1 (en) 2019-06-14 2022-08-11 Southern Research Institute 2,4,7-substituted-7-deaza-2'-deoxy-2'-fluoroarabinosyl nucleoside and nucleotide pro-drugs and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS542993A (en) * 1977-06-10 1979-01-10 Agency Of Ind Science & Technol Thermochemical production of hydrogen using wate as raw material
US4210745A (en) * 1978-01-04 1980-07-01 The United States Of America As Represented By The Department Of Health, Education And Welfare Procedure for the preparation of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4188378A (en) * 1978-01-04 1980-02-12 The United States Of America As Represented By The Department Of Health, Education And Welfare Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4357324A (en) * 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
NZ226672A (en) * 1987-10-30 1991-07-26 Hoffmann La Roche 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions
AU626296B2 (en) * 1988-03-16 1992-07-30 Scripps Clinic And Research Foundation Substituted adenine derivatives useful as therapeutic agents

Also Published As

Publication number Publication date
WO1990014352A1 (en) 1990-11-29
NL300247I1 (nl) 2007-02-01
DE69029733D1 (de) 1997-02-27
HK1007561A1 (en) 1999-04-16
NL300247I2 (nl) 2007-02-01
US5034518A (en) 1991-07-23
EP0473708A4 (en) 1992-04-22
JPH05502014A (ja) 1993-04-15
ATE147751T1 (de) 1997-02-15
AU5831590A (en) 1990-12-18
JP3160288B2 (ja) 2001-04-25
DE122006000060I1 (de) 2007-04-05
EP0473708A1 (en) 1992-03-11
DE122006000060I2 (de) 2010-10-21
EP0473708B1 (en) 1997-01-15
DE69029733T2 (de) 1997-07-17

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