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ES2098032T3 - Procedimiento de preparacion de inhibidores de ribonucleotido-reductasa. - Google Patents

Procedimiento de preparacion de inhibidores de ribonucleotido-reductasa.

Info

Publication number
ES2098032T3
ES2098032T3 ES93909461T ES93909461T ES2098032T3 ES 2098032 T3 ES2098032 T3 ES 2098032T3 ES 93909461 T ES93909461 T ES 93909461T ES 93909461 T ES93909461 T ES 93909461T ES 2098032 T3 ES2098032 T3 ES 2098032T3
Authority
ES
Spain
Prior art keywords
ribonucleotide
reductase inhibitors
preparation procedure
reductase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93909461T
Other languages
English (en)
Inventor
James R Mccarthy
Donald P Matthews
Jeffrey S Sabol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2098032T3 publication Critical patent/ES2098032T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN NUEVO PROCESO DE DERIVADOS DE VINILFLUORURO 2-EXOCICLICOS DE ANALOGOS DE LA CITIDINA (I) A UTILIZAR COMO INHIBIDORES DE LA REDUCTASA DE RIBONUCLEOTIDOS, EN DONDE V ES OXI O METILENO E Y ES HIDROGENO, ALKILO C1-C4 O ALCOXI C1-C4.
ES93909461T 1992-05-12 1993-04-01 Procedimiento de preparacion de inhibidores de ribonucleotido-reductasa. Expired - Lifetime ES2098032T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88197892A 1992-05-12 1992-05-12
US3101293A 1993-03-26 1993-03-26

Publications (1)

Publication Number Publication Date
ES2098032T3 true ES2098032T3 (es) 1997-04-16

Family

ID=26706717

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93909461T Expired - Lifetime ES2098032T3 (es) 1992-05-12 1993-04-01 Procedimiento de preparacion de inhibidores de ribonucleotido-reductasa.

Country Status (15)

Country Link
EP (1) EP0640092B1 (es)
JP (1) JP3265548B2 (es)
KR (1) KR100255258B1 (es)
AT (1) ATE146183T1 (es)
AU (1) AU662630B2 (es)
CA (1) CA2133961C (es)
DE (1) DE69306570T2 (es)
DK (1) DK0640092T3 (es)
ES (1) ES2098032T3 (es)
FI (1) FI106127B (es)
GR (1) GR3022400T3 (es)
HU (1) HU217963B (es)
NO (1) NO302524B1 (es)
NZ (1) NZ251886A (es)
WO (1) WO1993023414A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU217849B (hu) * 1994-01-07 2000-04-28 Merrell Pharmaceuticals Inc. (E)-2'-dezoxi-2'-(fluor-metilén)-citidin monohidrát
WO1996001638A1 (en) * 1994-07-11 1996-01-25 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
WO2003068162A2 (en) * 2002-02-14 2003-08-21 Pharmasset Ltd. Modified fluorinated nucleoside analogues
MX356509B (es) 2011-12-22 2018-05-30 Alios Biopharma Inc Nucleósidos sustituidos, nucleótidos y análogos de los mismos.
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
ZA898567B (en) * 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives
JP2559917B2 (ja) 1990-06-15 1996-12-04 三共株式会社 ピリミジンヌクレオシド誘導体

Also Published As

Publication number Publication date
HUT68903A (en) 1995-08-28
NO944309D0 (no) 1994-11-11
NZ251886A (en) 1996-02-27
DK0640092T3 (da) 1996-12-30
JPH07507774A (ja) 1995-08-31
NO944309L (no) 1994-11-11
CA2133961A1 (en) 1993-11-25
FI106127B (fi) 2000-11-30
EP0640092A1 (en) 1995-03-01
KR100255258B1 (ko) 2000-05-01
FI945290A0 (fi) 1994-11-10
AU4024793A (en) 1993-12-13
EP0640092B1 (en) 1996-12-11
CA2133961C (en) 1998-03-31
JP3265548B2 (ja) 2002-03-11
FI945290L (fi) 1994-11-10
DE69306570T2 (de) 1997-04-10
AU662630B2 (en) 1995-09-07
NO302524B1 (no) 1998-03-16
DE69306570D1 (de) 1997-01-23
WO1993023414A1 (en) 1993-11-25
HU217963B (hu) 2000-05-28
KR950701641A (ko) 1995-04-28
ATE146183T1 (de) 1996-12-15
HU9403252D0 (en) 1995-02-28
GR3022400T3 (en) 1997-04-30

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