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ES2096066T3 - Procedimiento de desdoblamiento de hidantoinas quirales. - Google Patents

Procedimiento de desdoblamiento de hidantoinas quirales.

Info

Publication number
ES2096066T3
ES2096066T3 ES92900281T ES92900281T ES2096066T3 ES 2096066 T3 ES2096066 T3 ES 2096066T3 ES 92900281 T ES92900281 T ES 92900281T ES 92900281 T ES92900281 T ES 92900281T ES 2096066 T3 ES2096066 T3 ES 2096066T3
Authority
ES
Spain
Prior art keywords
pct
hydantoin
lower alkyl
radical
enantiomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92900281T
Other languages
English (en)
Inventor
Dominique Depernet
Roger Bouaziz
Gerard Coquerel
Marie-Noelle Petit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jouveinal SA
Original Assignee
Jouveinal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jouveinal SA filed Critical Jouveinal SA
Application granted granted Critical
Publication of ES2096066T3 publication Critical patent/ES2096066T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCESO DE DESDOBLAMIENTO DE HIDANTOINAS QUIRALES DE FORMULA GENERAL (I) EN LA QUE: R1 REPRESENTA UN RADICAL ALQUILO INFERIOR QUE COMPRENDE DE 1 A 5 ATOMOS DE CARBONO EN CADENA LINEAL O RAMIFICADA, R2 REPRESENTA UN RADICAL FENILO EVENTUALMENTE MONO, DI O TRISUSTITUIDO POR RADICALES ALQUILO O ALCOXI INFERIORES O ATOMOS DE HALOGENO, IDENTICOS O DIFERENTES, O UN RADICAL HETEROARILO QUE CONTIENE UN CICLO DE 5 A 7 ESLABONES EN EL QUE EL UNICO HETEROATOMO ES EL NITROGENO, EL OXIGENO O EL AZUFRE, O TAMBIEN UN RADICAL ARALQUILO CUYA PARTE ALQUILO COMPRENDE UNO O DOS ATOMOS DE CARBONO Y EL CICLO ARILO ES UN GRUPO FENILO EVENTUALMENTE MONO, DI O TRISUSTITUIDO POR RADICALES QUE SON ALQUILO O ALCOXI INFERIORES O ATOMOS DE HALOGENO, IDENTICOS O DIFERENTES. SE DISUELVE LA HIDANTOINA (I) A DESDOBLAR EN UN ALCOHOL O UNA SOLUCION ALCALINA, SE AÑADE A LA SOLUCION OBTENIDA UN ENANTIOMERO DE LA ALFA-METILBENZILAMINA EN PROPORCION DEFINIDA, Y DESPUES SE AISLA LA SAL DIASTEREOISOMERA OBTENIDA Y SE LA TRATA POR UNA SOLUCION ACIDA PARA CRISTALIZAR EL ENANTIOMERO DE LA HIDANTOINA (I).
ES92900281T 1990-11-16 1991-11-15 Procedimiento de desdoblamiento de hidantoinas quirales. Expired - Lifetime ES2096066T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9014487A FR2669333B1 (fr) 1990-11-16 1990-11-16 Procede de separation des enantiomeres des 5-aryl-5-alkylhydantouines.

Publications (1)

Publication Number Publication Date
ES2096066T3 true ES2096066T3 (es) 1997-03-01

Family

ID=9402406

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92900281T Expired - Lifetime ES2096066T3 (es) 1990-11-16 1991-11-15 Procedimiento de desdoblamiento de hidantoinas quirales.

Country Status (10)

Country Link
US (1) US5326878A (es)
EP (1) EP0510168B1 (es)
JP (1) JP3125101B2 (es)
AT (1) ATE147379T1 (es)
AU (1) AU9035491A (es)
CA (1) CA2073762A1 (es)
DE (1) DE69124088T2 (es)
ES (1) ES2096066T3 (es)
FR (1) FR2669333B1 (es)
WO (1) WO1992008702A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2788271B1 (fr) * 1999-01-07 2001-02-09 Rhone Poulenc Agrochimie Nouveau procede de preparation d'aminoacides chiraux
WO2005090316A1 (en) * 2004-03-12 2005-09-29 Wyeth HYDANTOINS HAVING RNase MODULATORY ACTIVITY
FR2927076B1 (fr) 2008-01-31 2010-03-26 Oroxcell Derives de 2-amino-2-phenyl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent
CN101255136B (zh) * 2008-03-11 2011-08-17 武汉大学 5-环丙烷螺环乙内酰脲衍生物及其制备方法和应用
FR2948660B1 (fr) 2009-07-30 2011-08-19 Oroxcell Derives de 2-amino-2-phenyl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent
JPWO2015037243A1 (ja) * 2013-09-12 2017-03-02 興和株式会社 光学活性ヒダントイン化合物の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634713A (en) * 1982-05-28 1987-01-06 Ciba-Geigy Corporation Antihypertensive 3-(ureidocyclohexyleneamino)propane-1,2-diol derivatives

Also Published As

Publication number Publication date
ATE147379T1 (de) 1997-01-15
AU9035491A (en) 1992-06-11
FR2669333B1 (fr) 1993-03-19
WO1992008702A1 (fr) 1992-05-29
JPH05503718A (ja) 1993-06-17
DE69124088T2 (de) 1997-07-10
EP0510168B1 (fr) 1997-01-08
CA2073762A1 (fr) 1992-05-17
FR2669333A1 (fr) 1992-05-22
DE69124088D1 (de) 1997-02-20
US5326878A (en) 1994-07-05
JP3125101B2 (ja) 2001-01-15
EP0510168A1 (fr) 1992-10-28

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