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ES2094141T3 - 1H-IMIDAZO (4,5-C) QUINOLIN-4-AMINAS AS ANTIVIRALS. - Google Patents

1H-IMIDAZO (4,5-C) QUINOLIN-4-AMINAS AS ANTIVIRALS.

Info

Publication number
ES2094141T3
ES2094141T3 ES90301766T ES90301766T ES2094141T3 ES 2094141 T3 ES2094141 T3 ES 2094141T3 ES 90301766 T ES90301766 T ES 90301766T ES 90301766 T ES90301766 T ES 90301766T ES 2094141 T3 ES2094141 T3 ES 2094141T3
Authority
ES
Spain
Prior art keywords
aminas
antivirals
quinolin
imidazo
antiviral agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90301766T
Other languages
Spanish (es)
Inventor
John F Gerster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Application granted granted Critical
Publication of ES2094141T3 publication Critical patent/ES2094141T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)

Abstract

LOS COMPUESTOS FUNCIONAN COMO AGENTES ANTIVIRALES Y SON INTERMEDIARIOS SINTETICOS POTENCIALES EN LA PREPARACION DE AGENTES ANTIVIRALES CONOCIDOS Y AGENTES ANTIVIRALES CONOCIDOS ETIQUETADOS. TAMBIEN SE DESCRIBE EL PROCESO PARA LA PREPARACION DE LOS COMPUESTOS, METODOS PARA SU USO ANTIVIRAL Y METODOS PARA REDUCIR LA BIOSINTESIS DE LA INTERFERONA.THE COMPOUNDS OPERATE AS ANTIVIRAL AGENTS AND ARE POTENTIAL SYNTHETIC INTERMEDIARIES IN THE PREPARATION OF KNOWN ANTIVIRAL AGENTS AND KNOWN ANTIVIRAL AGENTS LABELED. THE PROCESS FOR THE PREPARATION OF THE COMPOUNDS, METHODS FOR ANTIVIRAL USE AND METHODS FOR REDUCING INTERFERONE BIOSYNTHESIS ARE ALSO DESCRIBED.

ES90301766T 1989-02-27 1990-02-19 1H-IMIDAZO (4,5-C) QUINOLIN-4-AMINAS AS ANTIVIRALS. Expired - Lifetime ES2094141T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31603589A 1989-02-27 1989-02-27

Publications (1)

Publication Number Publication Date
ES2094141T3 true ES2094141T3 (en) 1997-01-16

Family

ID=23227183

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90301766T Expired - Lifetime ES2094141T3 (en) 1989-02-27 1990-02-19 1H-IMIDAZO (4,5-C) QUINOLIN-4-AMINAS AS ANTIVIRALS.

Country Status (9)

Country Link
EP (1) EP0385630B1 (en)
JP (1) JP2941336B2 (en)
KR (1) KR0179992B1 (en)
AU (1) AU630921B2 (en)
CA (2) CA2355852A1 (en)
DE (1) DE69029212T2 (en)
DK (1) DK0385630T3 (en)
ES (1) ES2094141T3 (en)
NZ (1) NZ232602A (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
CA2091172C (en) * 1990-09-07 1997-05-20 Adriano Afonso Antiviral compounds and antihypertensive compounds
US5179107A (en) * 1990-09-07 1993-01-12 Schering Corporation Antiviral quinolinone compounds
UA32546C2 (en) * 1991-03-01 2001-02-15 Міннесота Майнінг Енд Мен'Юфекчурінг Компані 1,2-substituted 1h-imidazo[4,5-c]quinoline-4-amines, intermediary compounds for synthesis thereof, antiviral pharmaceutical composition, a method for treatment of infected mammals, a method for induction of interferon biosynthesis by mammals, a method for slowering growth of blastomas
US5179093A (en) * 1991-05-10 1993-01-12 Schering Corporation Quinoline-diones
US5268376A (en) * 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5266575A (en) * 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5395937A (en) * 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
US5622965A (en) * 1993-03-12 1997-04-22 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists
ATE195735T1 (en) * 1993-07-15 2000-09-15 Minnesota Mining & Mfg IMIDAZO (4,5-C)PYRIDINE-4-AMINE
US5352784A (en) * 1993-07-15 1994-10-04 Minnesota Mining And Manufacturing Company Fused cycloalkylimidazopyridines
US5648516A (en) * 1994-07-20 1997-07-15 Minnesota Mining And Manufacturing Company Fused cycloalkylimidazopyridines
US5644063A (en) * 1994-09-08 1997-07-01 Minnesota Mining And Manufacturing Company Imidazo[4,5-c]pyridin-4-amine intermediates
US5482936A (en) * 1995-01-12 1996-01-09 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]quinoline amines
US5741908A (en) * 1996-06-21 1998-04-21 Minnesota Mining And Manufacturing Company Process for reparing imidazoquinolinamines
US5840500A (en) * 1996-07-11 1998-11-24 Trega Biosciences, Inc. Quinoline derivatives and quinoline combinatorial libraries
EP0938315B9 (en) 1996-10-25 2008-02-20 Minnesota Mining And Manufacturing Company Immune response modifier compounds for treatment of th2 mediated and related diseases
US5939090A (en) * 1996-12-03 1999-08-17 3M Innovative Properties Company Gel formulations for topical drug delivery
UA75622C2 (en) 2000-12-08 2006-05-15 3M Innovative Properties Co Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon
GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
PT1543002E (en) 2002-07-23 2006-11-30 Teva Gyogyszergyar Zartkoeruen Preparation of 1h-imidazo 4,5-c
JP2005537287A (en) 2002-07-26 2005-12-08 テバ ジョジセルジャール レースベニュタールシャシャーグ 1H-imidazo [4,5-c] quinolin-4-amine with novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinoline-4-carboxamide intermediates Manufacturing
AU2004266658A1 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
BRPI0413998A (en) 2003-08-27 2006-11-07 3M Innovative Properties Co substituted aryloxy and arylalkylenoxy imidazoquinolines
US20050054665A1 (en) 2003-09-05 2005-03-10 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
BRPI0414856A (en) 2003-10-03 2006-11-21 3M Innovative Properties Co alkoxy-substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
WO2005048933A2 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
CA2545825A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
WO2005066170A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
AU2004312508A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
TW200612932A (en) 2004-03-24 2006-05-01 3M Innovative Properties Co Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
WO2006009826A1 (en) 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US8034938B2 (en) 2004-12-30 2011-10-11 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
US9248127B2 (en) 2005-02-04 2016-02-02 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
CA2597446A1 (en) 2005-02-11 2006-08-31 Coley Pharmaceutical Group, Inc. Substituted imidazoquinolines and imidazonaphthyridines
US7968563B2 (en) 2005-02-11 2011-06-28 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
WO2006107851A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
CA2602683A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
JP2009541236A (en) 2006-06-20 2009-11-26 トランジェーヌ、ソシエテ、アノニム Recombinant virus vaccine
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
EP3445761A1 (en) * 2016-04-19 2019-02-27 Innate Tumor Immunity, Inc. Nlrp3 modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73534A (en) 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
CA1271477A (en) * 1983-11-18 1990-07-10 John F. Gerster 1h-imidazo[4,5-c]quinolin-4-amines
CA1306260C (en) * 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines

Also Published As

Publication number Publication date
EP0385630B1 (en) 1996-11-27
AU5005490A (en) 1990-08-30
NZ232602A (en) 1992-10-28
EP0385630A3 (en) 1992-01-02
CA2010430A1 (en) 1990-08-27
KR0179992B1 (en) 1999-03-20
EP0385630A2 (en) 1990-09-05
DK0385630T3 (en) 1997-05-12
CA2355852A1 (en) 1990-08-27
JP2941336B2 (en) 1999-08-25
AU630921B2 (en) 1992-11-12
DE69029212T2 (en) 1997-05-22
DE69029212D1 (en) 1997-01-09
KR910015575A (en) 1991-09-30
JPH0327380A (en) 1991-02-05

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