[go: up one dir, main page]

ES2089066T3 - Microesferas de lipidos solidos con una distribucion estrecha de tamaños y metodo para su fabricacion. - Google Patents

Microesferas de lipidos solidos con una distribucion estrecha de tamaños y metodo para su fabricacion.

Info

Publication number
ES2089066T3
ES2089066T3 ES91113152T ES91113152T ES2089066T3 ES 2089066 T3 ES2089066 T3 ES 2089066T3 ES 91113152 T ES91113152 T ES 91113152T ES 91113152 T ES91113152 T ES 91113152T ES 2089066 T3 ES2089066 T3 ES 2089066T3
Authority
ES
Spain
Prior art keywords
sizes
manufacture
solid lipid
narrow distribution
lipid microspheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91113152T
Other languages
English (en)
Other versions
ES2089066T5 (es
Inventor
Maria Rosa Gasco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8207022&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2089066(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of ES2089066T3 publication Critical patent/ES2089066T3/es
Application granted granted Critical
Publication of ES2089066T5 publication Critical patent/ES2089066T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

MICROESFERAS DE LIPIDOS SOLIDOS QUE TIENEN UN DIAMETRO INFERIOR A UNA MICRA Y UNA POLIDISPERSION COMPRENDIDA ENTRE 0,06 Y 0,90 OBTENIDAS AÑADIENDO A UNA SUBSTANCIA LIPIDICA FUNDIDA UNA MEZCLA FORMADA POR AGUA, UN SURFACTANTE Y POSIBLEMENTE UN COSURFACTANTE, DISPERSANDO EN AGUA LA MICROEMULSION OBTENIDA, LAVANDO CON AGUA LAS MICROESFERAS DE LA DISPERSION POR DIAFILTRACION Y LIOFILIZACION.
ES91113152T 1991-08-05 1991-08-05 Microesferas de lipidos solidos con una distribucion estrecha de tamaños y metodo para su fabricacion. Expired - Lifetime ES2089066T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91113152A EP0526666B2 (en) 1991-08-05 1991-08-05 Solid lipid microspheres having a narrow size distribution and method for producing them

Publications (2)

Publication Number Publication Date
ES2089066T3 true ES2089066T3 (es) 1996-10-01
ES2089066T5 ES2089066T5 (es) 2003-05-16

Family

ID=8207022

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91113152T Expired - Lifetime ES2089066T5 (es) 1991-08-05 1991-08-05 Microesferas de lipidos solidos con una distribucion estrecha de tamaños y metodo para su fabricacion.

Country Status (5)

Country Link
US (1) US5250236A (es)
EP (1) EP0526666B2 (es)
AT (1) ATE136774T1 (es)
DE (1) DE69118880T3 (es)
ES (1) ES2089066T5 (es)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5447728A (en) * 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5451410A (en) * 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
AU658608B2 (en) * 1991-03-25 1995-04-27 Astellas Pharma Europe B.V. Topical preparation containing a suspension of solid lipid particles
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5401516A (en) * 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
DE4244466C2 (de) * 1992-12-24 1995-02-23 Pharmatech Gmbh Verfahren zur Herstellung von Pseudolatices und Mikro- oder Nanopartikeln und deren Verwendung zur Herstellung von pharmazeutischen Präparaten
US5785976A (en) * 1993-03-05 1998-07-28 Pharmacia & Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US5885486A (en) * 1993-03-05 1999-03-23 Pharmaciaand Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
ES2070076B1 (es) * 1993-04-20 1996-04-16 Cusi Lab Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
EP0696208B1 (en) 1993-04-22 2001-08-22 Emisphere Technologies, Inc. Oral drug delivery compositions
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5858398A (en) * 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (pt) 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
GB2320248B (en) 1995-09-11 1999-04-14 Emisphere Tech Inc Method for preparing omega-aminoalkanoic acid derivatives from cycloalkanones
SI9720025A (sl) 1996-03-29 1999-08-31 Emishphere Technologies, Inc. Spojine in sestavki za prenos aktivne snovi
WO1997047288A1 (en) 1996-06-14 1997-12-18 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
AU742929B2 (en) * 1996-09-17 2002-01-17 Avanir Pharmaceuticals Viral inhibition by long-chain alcohols, alkanes, fatty acids and amides
US6440980B1 (en) * 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
IT1292142B1 (it) * 1997-06-12 1999-01-25 Maria Rosa Gasco Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale
SG113402A1 (en) * 1997-06-27 2005-08-29 American Bioscience Inc Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
EP3266450A1 (en) * 1997-06-27 2018-01-10 Abraxis BioScience, LLC Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
IT1296914B1 (it) * 1997-12-01 1999-08-03 Maria Rosa Gasco Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera
IT1298575B1 (it) * 1998-02-06 2000-01-12 Vectorpharma Int Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di
IT1303787B1 (it) * 1998-11-25 2001-02-23 Maria Rosa Gasco "nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule"
DE19856728B4 (de) * 1998-12-09 2004-04-22 Henkel Kgaa Verfahren zur Herstellung von Nanopartikeldispersionen
KR20020011985A (ko) 1999-05-07 2002-02-09 파르마솔 게엠베하 액상 및 고체상 지질 혼합물에 기초한 지질입자들 및 그의제조방법
AU4917900A (en) * 1999-05-07 2000-11-21 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
FR2795960B1 (fr) * 1999-07-05 2001-10-19 Sanofi Elf Microemulsions stables pour l'administration d'acides gras a l'homme ou a l'animal, et utilisation de ces microemulsions
US7153525B1 (en) 2000-03-22 2006-12-26 The University Of Kentucky Research Foundation Microemulsions as precursors to solid nanoparticles
GB0009773D0 (en) * 2000-04-19 2000-06-07 Univ Cardiff Particulate composition
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US20030072807A1 (en) * 2000-12-22 2003-04-17 Wong Joseph Chung-Tak Solid particulate antifungal compositions for pharmaceutical use
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US7037528B2 (en) * 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
EP1407294A4 (en) 2001-06-07 2007-05-30 Univ Kentucky Res Found NANOSCINTILLATION SYSTEMS FOR WATER-SUPPORTED LIQUID SCINTILLATION COUNTERS
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
WO2003026611A2 (en) 2001-09-26 2003-04-03 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
CA2421026C (en) * 2001-10-16 2005-02-15 Avanir Pharmaceuticals Viral inhibition by n-docosanol
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US20060233845A1 (en) 2002-02-28 2006-10-19 Gerold Lukowski Micro/nanoparticle obtained from lipid-containing marine organisms for use in pharmaceutics and cosmetics
US20060189554A1 (en) * 2002-09-24 2006-08-24 Russell Mumper Nanoparticle-Based vaccine delivery system containing adjuvant
ITMI20022323A1 (it) * 2002-10-31 2004-05-01 Maria Rosa Gasco Composizioni farmaceutiche atte al trattamento di malattie oftalmiche.
GB2398495B (en) * 2003-01-23 2007-08-22 Kent G Lau A drug delivery preparation comprising at least one anti-tumour drug and a topical carrier for the drug
DE10353780A1 (de) * 2003-11-18 2005-06-23 Beiersdorf Ag Partikel aus fester Hülle und potenziell feuchtigkeitsempfindliche oder wasserunlösliche Wirkstoffe enthaltendem flüssigem Kern, Zubereitungen diese enthaltend und Verfahren zu ihrer Herstellung
WO2005077337A2 (en) * 2004-02-05 2005-08-25 Baxter International Inc. Dispersions prepared by use of self-stabilizing agents
JP2007530497A (ja) * 2004-03-26 2007-11-01 セル セラピューティクス ヨーロッパ エス.アール.エル. 白金化合物のナノ粒子配合物
ITMI20041151A1 (it) * 2004-06-09 2004-09-09 Maria Rosa Gasco Nanoparticelle lipidiche come agenti veicolanti per acidi nucleici procedimento per la loro preparazione e loro uso
US7450133B2 (en) * 2004-08-20 2008-11-11 Toshiba Corporation System and method for color correction
US20070154403A1 (en) * 2006-01-05 2007-07-05 Thomas Skold Oral, Pulmonary and Transmucosal Delivery Composition
AR063704A1 (es) 2006-09-14 2009-02-11 Makhteshim Chem Works Ltd Nanoparticulas de pesticida obtenida obtenidas a partir de microemulsiones y nanoemulsiones
EP2061583B1 (en) * 2006-09-14 2019-04-10 Yissum Research Development Company, of The Hebrew University of Jerusalem Organic nanoparticles obtained from microemulsions by solvent evaporation
ITMI20061918A1 (it) * 2006-10-06 2008-04-07 Nanovector S R L Formulazioni adatte ad essere somministrate per via transdermica contenenti principi attivi incorporati in sln
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
EP2047838A1 (en) * 2007-10-10 2009-04-15 Cognis IP Management GmbH Microcapsules based on waxes
DE102008035442A1 (de) 2008-07-26 2010-01-28 Ernst-Moritz-Arndt-Universität Greifswald Zubereitungen aus Artemisia Annua, ihre Umwandlung in Mikro- und Nanopartikel und ihre Verwendung
ITMI20090284A1 (it) 2009-02-26 2010-08-27 Consiglio Nazionale Ricerche Uso di inibitori della serina palmitoiltrasferasi per la prevenzione e il rallentamento delle degenerazioni retiniche ereditarie e relative composizioni
EP2437725A4 (en) * 2009-06-05 2014-02-26 Sunev Pharma Solution Ltd TOPICAL MICROEMULSIONS FOR THE TREATMENT OF RHEUMATIC SUFFERINGS
CA2767392C (en) 2009-07-06 2017-03-14 Variation Biotechnologies, Inc. Methods for preparing vesicles and formulations produced therefrom
CA2803282C (en) 2009-07-06 2018-05-01 David E. Anderson Methods for preparing vesicles and formulations produced therefrom
EP2295044A1 (de) * 2009-09-15 2011-03-16 Bayer Technology Services GmbH Verkapselung unter Verwendung von wachsartigen Substanzen
ES2384060B1 (es) 2010-03-24 2013-09-23 Lipotec S.A. Cápsulas de nanopartículas lipídicas.
WO2012006367A2 (en) 2010-07-06 2012-01-12 Variation Biotechnologies, Inc. Compositions and methods for treating influenza
CN103501811B (zh) 2011-01-13 2016-03-30 变异生物技术公司 用于治疗病毒感染的组合物和方法
AU2012205315B2 (en) * 2011-01-13 2017-05-04 Variation Biotechnologies, Inc. Methods for preparing vesicles and formulations produced therefrom
US9907758B2 (en) 2012-01-09 2018-03-06 Panjab University Department Of Biotechnology (Dbt) Process for preparing solid lipid sustained release nanoparticles for delivery of vitamins
EP2802353A4 (en) 2012-01-12 2015-12-02 Variation Biotechnologies Inc COMPOSITIONS AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS
EP2806894A4 (en) 2012-01-27 2015-11-04 Variation Biotechnologies Inc METHODS AND COMPOSITIONS FOR THERAPEUTIC AGENTS
CN104602715A (zh) 2012-09-07 2015-05-06 伯拉考成像股份公司 用于MRI的包含金属两亲配合物的顺磁性固体脂质纳米颗粒(pSLN)
US20140256810A1 (en) * 2013-03-08 2014-09-11 Mcneil-Ppc, Inc. Low melting propionic acid derivative particles for use in oral dosage forms
US20140213653A1 (en) * 2012-09-18 2014-07-31 Mcneil-Ppc, Inc. Directly compressible proprionic acid derivative particles
CN103110643A (zh) * 2013-03-08 2013-05-22 海南卫康制药(潜山)有限公司 注射用头孢他啶药物组合物粉针剂
CN103110645A (zh) * 2013-03-08 2013-05-22 海南卫康制药(潜山)有限公司 头孢米诺钠药物组合物及其制备方法
CN103110644A (zh) * 2013-03-08 2013-05-22 海南卫康制药(潜山)有限公司 注射用头孢哌酮钠舒巴坦钠药物组合物粉针剂
MA40859A (fr) * 2014-10-29 2017-09-05 Johnson & Johnson Consumer Inc Particules de cadotril
CN111759823B (zh) * 2015-09-17 2022-12-30 阿赖耶识(上海)生物技术有限公司 一种高稳定的非囊泡型纳米颗粒及其在治疗微生物感染中的应用
CZ307681B6 (cs) 2016-02-29 2019-02-13 Ústav makromolekulární chemie AV ČR, v. v. i. Fotoaktivovatelná nanočástice pro fotodynamické aplikace, způsob její přípravy, farmaceutická kompozice ji obsahující a jejich použití
EP3786232A4 (en) * 2018-04-27 2021-06-09 Toppan Printing Co., Ltd. COMPOUND PARTICLES, METHOD FOR THE PREPARATION OF COMPOUND PARTICLES, DRY POWDER, COMPOSITION FOR APPLICATION ON THE SKIN AND METHOD FOR PREPARING THE COMPOSITION FOR USE ON THE SKIN
KR102044676B1 (ko) * 2019-03-27 2019-11-14 주식회사 씨트리 생체적합성 고분자 기반 아픽사반 함유 미립구의 제조방법
IT201900009258A1 (it) 2019-06-17 2020-12-17 R Bio Transfer S R L Metodo per la preparazione di nanoparticelle lipidiche
IT201900013353A1 (it) 2019-07-30 2021-01-30 Univ Della Calabria Sistema di veicolazione di olio essenziale di bergamotto basato su nanotecnologie, metodo di preparazione del sistema e suoi usi.
RU2706003C1 (ru) * 2019-09-09 2019-11-13 Акционерное общество "АВВА РУС" Микрогранулы, содержащие панкреатин
WO2023275648A1 (en) 2021-06-30 2023-01-05 Novocure Gmbh Compositions and methods for using alternating electric fields to disrupt lipid capsules
IT202100023570A1 (it) 2021-09-13 2023-03-13 Bioema S R L S Biotecnologia Energia Mat Ambiente Metodo per la preparazione di nanoparticelle lipidiche

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL282895A (es) * 1961-09-05
US3856699A (en) * 1969-08-08 1974-12-24 Fuji Photo Film Co Ltd Process for producing capsules having walls of a waxy material
JPS4945224B1 (es) * 1970-12-14 1974-12-03
GB1413186A (en) * 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
DE3305935C2 (de) * 1983-02-21 1985-05-30 Medice Chem.-Pharm. Fabrik Pütter GmbH & Co KG, 5860 Iserlohn Kaliumneutrales Saluretikum mit antihypertensiver Wirkung
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
JPS61249918A (ja) * 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
JPS61263914A (ja) * 1985-05-17 1986-11-21 Yutaka Mizushima リピツドマイクロスフエア−
US4776991A (en) * 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
JPS63151353A (ja) * 1986-12-15 1988-06-23 Oogawara Kakoki Kk ワツクスコ−テイングマイクロカプセルの製造方法
US4919841A (en) * 1988-06-06 1990-04-24 Lever Brothers Company Wax encapsulated actives and emulsion process for their production
JP2847783B2 (ja) * 1988-08-11 1999-01-20 日清製粉株式会社 抗癌活性増強剤
US5039527A (en) * 1989-02-24 1991-08-13 Medicontrol Corporation Hexamethylmelamine containing parenteral emulsions
ATE219356T1 (de) 1990-11-06 2002-07-15 Nippon Shinyaku Co Ltd Lyophilisierte zubereitung sowie deren herstellung
AU658608B2 (en) 1991-03-25 1995-04-27 Astellas Pharma Europe B.V. Topical preparation containing a suspension of solid lipid particles

Also Published As

Publication number Publication date
DE69118880T2 (de) 1996-11-07
DE69118880T3 (de) 2003-05-08
EP0526666B1 (en) 1996-04-17
US5250236A (en) 1993-10-05
EP0526666A1 (en) 1993-02-10
DE69118880D1 (de) 1996-05-23
ATE136774T1 (de) 1996-05-15
EP0526666B2 (en) 2002-12-11
ES2089066T5 (es) 2003-05-16

Similar Documents

Publication Publication Date Title
ES2089066T3 (es) Microesferas de lipidos solidos con una distribucion estrecha de tamaños y metodo para su fabricacion.
ES2102531T3 (es) Procedimiento para la preparacion de una dispersion acuosa.
MX160913A (es) Metodo mejorado para preparar una composicion floculante y producto resultante
BR9712397A (pt) Microemulsão e processo
ES2136274T3 (es) Mezcla de tensioactivos con propiedades tensioactivas mejoradas.
DE59709251D1 (de) Tensidhaltige Reinigungsmittel in Form einer Mikroemulsion
HUP9802095A2 (hu) Ultrahang kontrasztjának fokozására alkalmazható, foszfolipidet tartalmazó, stabilizált gázemulzió
EP0428913A3 (en) Coupled quantum well strained superlattice structure and optically bistable semiconductor laser incorporating the same
EP0395910A3 (de) Spiegel zur Veränderung der geometrischen Gestalt eines Lichtbündels
ES2089839T3 (es) Mezclas de agentes encolantes para papel.
EG20192A (en) Mild personal cleansing bar composition with balanced surfactants fatty acids and parafin wax
BR9501068A (pt) Composição corante,processo para sua preparação e uso
NO953919D0 (no) Sekundære (2,3) alkylsulfat-overflateaktive midler i blandede overflateaktive partikler
TR199901716T2 (en) So�utucu ya�lama em�lsiyonu.
ES464516A1 (es) Procedimiento para la preparacion de preparados de sustan- cias solidas, facilmente distribuibles en medios hidrofilos e hidrofobos.
DE69030540D1 (de) Hilfsstoffzusammensetzungen in fester Form, dispergierbar in wässerigen Medien, und Verfahren zu ihrer Herstellung
DE69414779D1 (de) Reinigungsmittel in Form einer stabilen Mikroemulsion
DK0381220T3 (da) Vanddispergerbart gemfibrozilpræparat
ATE96015T1 (de) Haarfaerbe- und haartoenungsmittel.
IL105947A (en) Preparation of melanin in fluorocarbons for topical use and its production
DE59009425D1 (de) Schwachschäumende und kältestabile flüssige Tensidzusammensetzungen aus Wasser und nichtionischen, anionischen und kationischen Tensiden und deren Verwendung.
BR8600888A (pt) Dispersao de silica redispersivel e processo para sua preparacao
NO985212D0 (no) Pulver vesikulµrt produkt
AR008542A1 (es) Metodo para provocar la caida de insectos rastreros.
IT8920508A0 (it) Accoppiatore direzionale a 3 db, 90 gradi, un'ottava, realizzato in microstriscia e slotline.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 526666

Country of ref document: ES

FG2A Definitive protection

Ref document number: 526666

Country of ref document: ES