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ES2087917T3 - Derivados de 1,2-dihidro-2-oxo-quinoxalinas, su preparacion y su aplicacion en terapeutica. - Google Patents

Derivados de 1,2-dihidro-2-oxo-quinoxalinas, su preparacion y su aplicacion en terapeutica.

Info

Publication number
ES2087917T3
ES2087917T3 ES90916034T ES90916034T ES2087917T3 ES 2087917 T3 ES2087917 T3 ES 2087917T3 ES 90916034 T ES90916034 T ES 90916034T ES 90916034 T ES90916034 T ES 90916034T ES 2087917 T3 ES2087917 T3 ES 2087917T3
Authority
ES
Spain
Prior art keywords
radical
group
alkyl
branched
straight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90916034T
Other languages
English (en)
Inventor
Guy Pitet
Christian Faure
Francoise Couret
Dennis Bigg
Jean-Pierre Tarayre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Application granted granted Critical
Publication of ES2087917T3 publication Critical patent/ES2087917T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NUEVOS DERIVADOS DE DIHIDRO-1, 2 OXO-2 QUINOXALINAS QUE CORRESPONDEN A LA FORMULA GENERAL (I), EN LA QUE: R REPRESENTA UN ATOMO DE HIDROGENO O DE HALOGENO, R SUB 1 REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL ALQUILO EN C SUB 1 -C SUB 4, LINEAL O RAMIFICADO, R SUB 2 REPRESENTA UN ATOMO DE HIDROGENO, UN RADICAL C(O)R SUB 4, DONDE R SUB 4 ES UN GRUPO ALQUILO EN C SUB 1 -C SUB 4 LINEAL O RAMIFICADO,UN RADICAL C(O)NHR SUB 5 DONDE R SUB 5 ES UN GRUPO ALQUILO EN C SUB 1 -C SUB 4 LINEAL O RAMIFICADO, O UN GRUPO FENILO, A REPRESENTA UNA CADENA DE ALQUILENO EN C SUB 1 -C SUB 4, R SUB 3 REPRESENTA UN ATOMO DE HIDROGENO, UN RADICAL ALQUILO EN C SUB 1 -C SUB 4, UN RADICAL CICLOALQUILO EN C SUB 3 -C SUB 6, UN GRUPO ALQUILO EN C SUB 1 -C SUB 4, UN GRUPO ALCOXIA C SUB 1 -C SUB 4, O UN GRUPO NITRO, UN RADICAL ALCENILO DE FORMULA (ALFA) DONDE R SUB 6, R SUB 7 PUEDEN SER, INDEPENDIENTEMENTE AL UNO DEL OTRO, UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO EN C SUB 1 -C SUB 4, UN GRUPO FENILO, O UN GRUPO ALCOXICARBONILO, UN RADICAL DE FORMULA -OC(O)R SUB 8, DONDE R SUB 8 REPRESENTA UN RADICAL ALQUILO EN C SUB 1 -C SUB 4, UN RADICAL DE FORMULA -OC(O)NHR SUB 8, DONDE R SUB 8 REPRESENTA UN GRUPO ALQUILO EN C SUB 1 -C SUB 4 LINEAL O RAMIFICADO O UN GRUPO FENILO, N PUEDE TOMAR LOS VALORES QUE VAN DE 2 A 4 ASI COMO LAS SALES ORGANICAS O MINERALES TERAPEUTICAMENTE ACEPTABLES DE ESTAS MOLECULAS.
ES90916034T 1989-10-23 1990-10-17 Derivados de 1,2-dihidro-2-oxo-quinoxalinas, su preparacion y su aplicacion en terapeutica. Expired - Lifetime ES2087917T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8913961A FR2653430B1 (fr) 1989-10-23 1989-10-23 Nouveaux derives de dihydro-1,2 oxo-2 quinoxalines, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
ES2087917T3 true ES2087917T3 (es) 1996-08-01

Family

ID=9386749

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90916034T Expired - Lifetime ES2087917T3 (es) 1989-10-23 1990-10-17 Derivados de 1,2-dihidro-2-oxo-quinoxalinas, su preparacion y su aplicacion en terapeutica.

Country Status (10)

Country Link
US (1) US5198441A (es)
EP (1) EP0450039B1 (es)
JP (1) JPH04502475A (es)
AT (1) ATE138915T1 (es)
DE (1) DE69027300T2 (es)
DK (1) DK0450039T3 (es)
ES (1) ES2087917T3 (es)
FR (1) FR2653430B1 (es)
GR (1) GR3020392T3 (es)
WO (1) WO1991005772A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696456B1 (fr) * 1992-10-07 1995-01-06 Pf Medicament Dérivés de dihydro-1,2 oxo amino-3 quinoxalines, leur préparation et leur application en thérapeutique.
US6690251B2 (en) * 2001-04-11 2004-02-10 Kyocera Wireless Corporation Tunable ferro-electric filter
JP5618837B2 (ja) * 2008-03-05 2014-11-05 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ インスリン分泌刺激剤としてのキノキサリノン誘導体、それらを得る方法および糖尿病を治療するためのそれらの使用
CN108699040B (zh) 2015-12-24 2021-08-10 加利福尼亚大学董事会 Cftr调节剂及其使用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA728649A (en) * 1966-02-22 Donau-Pharmazie Gesellschaft M.B.H. Dihydroquinoxalone-(2) derivatives and process of preparing same
CH624395A5 (es) * 1976-01-08 1981-07-31 Ciba Geigy Ag
US4181724A (en) * 1978-09-11 1980-01-01 The Upjohn Company Quinoxalinone compounds useful for expanding the lumina or air passages in mammals
EP0032564A1 (de) * 1979-12-28 1981-07-29 Medichemie Ag Pharmazeutische Verwendung von Caroverin und/oder Caroverinsalzen sowie Caroverinsalze mit Xanthinderivat-Säureresten und Nicotinsäurerest
JPS572277A (en) * 1980-06-07 1982-01-07 Nissan Chem Ind Ltd Quinoxalinone derivative, its preparation, and fungicide for agricultural and horticultural use
JPS62198671A (ja) * 1986-02-25 1987-09-02 Toyo Jozo Co Ltd １−置換アルキル１，２−ジヒドロ−２−ピラジノン誘導体
US5034537A (en) * 1988-09-23 1991-07-23 Smithkline Beecham Corporation Leukotriene antagonists

Also Published As

Publication number Publication date
US5198441A (en) 1993-03-30
FR2653430B1 (fr) 1991-12-20
JPH04502475A (ja) 1992-05-07
DE69027300T2 (de) 1997-01-23
DE69027300D1 (de) 1996-07-11
DK0450039T3 (da) 1996-10-07
ATE138915T1 (de) 1996-06-15
EP0450039A1 (fr) 1991-10-09
GR3020392T3 (en) 1996-09-30
FR2653430A1 (fr) 1991-04-26
WO1991005772A1 (fr) 1991-05-02
EP0450039B1 (fr) 1996-06-05

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