[go: up one dir, main page]

ES2087568T3 - Esteres aromaticos de fenilendialcanoatos como inhibidores de neutrofilo elastasa humana. - Google Patents

Esteres aromaticos de fenilendialcanoatos como inhibidores de neutrofilo elastasa humana.

Info

Publication number
ES2087568T3
ES2087568T3 ES92925470T ES92925470T ES2087568T3 ES 2087568 T3 ES2087568 T3 ES 2087568T3 ES 92925470 T ES92925470 T ES 92925470T ES 92925470 T ES92925470 T ES 92925470T ES 2087568 T3 ES2087568 T3 ES 2087568T3
Authority
ES
Spain
Prior art keywords
phenylendialcanoates
neutrophil elastase
human neutrophil
aromatic esters
elastase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92925470T
Other languages
English (en)
Inventor
Jozef Oleksyszyn
Gary P Kirschenheuter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cortech Inc
Original Assignee
Cortech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortech Inc filed Critical Cortech Inc
Application granted granted Critical
Publication of ES2087568T3 publication Critical patent/ES2087568T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

COMPONENTES DE LAS FORMULAS (I,II O III) EN DONDE: R1, R2, R Y R4 QUE DEBEN SER EL MISMO O DIFERENTE, SON SELECCIONADOS DEL GRUPO QUE CONSTA DE HIDROGENO, ALQUIL DE 1 A 6 CARBONOS, CICLOALQUIL DE 3 A 6 CARBONOS, ALQUENIL DE 2-6 CARBONOS, O JUNTOS REPRESENTAN GRUPOS METILENO -(CH2)N NTERO DE 1 A 6, PROVISTO QUE R1 Y R2 O R3 Y R4 NO SEAN AMBOS HIDROGENO.
ES92925470T 1991-12-19 1992-12-01 Esteres aromaticos de fenilendialcanoatos como inhibidores de neutrofilo elastasa humana. Expired - Lifetime ES2087568T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/809,378 US5216022A (en) 1991-12-19 1991-12-19 Aromatic esters of phenylenedialkanoates as inhibitors of human neutrophil elastase

Publications (1)

Publication Number Publication Date
ES2087568T3 true ES2087568T3 (es) 1996-07-16

Family

ID=25201206

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92925470T Expired - Lifetime ES2087568T3 (es) 1991-12-19 1992-12-01 Esteres aromaticos de fenilendialcanoatos como inhibidores de neutrofilo elastasa humana.

Country Status (20)

Country Link
US (1) US5216022A (es)
EP (1) EP0618899B1 (es)
JP (1) JP3127436B2 (es)
KR (1) KR100250099B1 (es)
AT (1) ATE135344T1 (es)
AU (1) AU662379B2 (es)
CA (1) CA2126195C (es)
DE (1) DE69209092T2 (es)
DK (1) DK0618899T3 (es)
ES (1) ES2087568T3 (es)
FI (1) FI942928L (es)
GR (1) GR3019438T3 (es)
HU (1) HUT71518A (es)
IL (1) IL104122A (es)
MX (1) MX9207428A (es)
NO (1) NO302518B1 (es)
NZ (1) NZ246115A (es)
TW (1) TW211562B (es)
WO (1) WO1993011760A1 (es)
ZA (1) ZA929697B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100266467B1 (ko) * 1995-09-27 2000-10-02 우에노 도시오 설폰아미드 유도체
EP0994104A4 (en) * 1996-06-27 2001-09-12 Ono Pharmaceutical Co ARYL SULFIDE, SULFOXIDE AND SULPHONE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM AS AN ACTIVE INGREDIENT
US6300514B1 (en) 1997-06-25 2001-10-09 Ono Pharmaceutical Co., Ltd. Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient
WO2000051623A2 (en) 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
AU3864000A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
US7704958B1 (en) 1999-03-05 2010-04-27 Bio Holding, Inc. Methods and compositions for inhibiting apoptosis using serine protease inhibitors
IL148924A (en) * 2002-03-26 2015-06-30 Mor Research Applic Ltd Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
US7850970B2 (en) 2003-08-26 2010-12-14 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
US9938353B2 (en) 2011-06-24 2018-04-10 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
US10478508B2 (en) 2012-01-10 2019-11-19 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
WO2021053058A1 (en) 2019-09-17 2021-03-25 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
DK4106757T3 (da) 2020-04-16 2023-10-23 Mereo Biopharma 4 Ltd Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683241A (en) * 1984-05-21 1987-07-28 G. D. Searle & Co. Phenolic ester derivatives as elastase inhibitors
US5214191A (en) * 1990-05-22 1993-05-25 Cortech, Inc. Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase

Also Published As

Publication number Publication date
HU9401842D0 (en) 1994-09-28
TW211562B (es) 1993-08-21
EP0618899B1 (en) 1996-03-13
GR3019438T3 (en) 1996-06-30
FI942928A0 (fi) 1994-06-17
HUT71518A (en) 1995-12-28
FI942928A7 (fi) 1994-06-20
FI942928L (fi) 1994-06-20
NO302518B1 (no) 1998-03-16
DE69209092D1 (de) 1996-04-18
ZA929697B (en) 1993-06-22
JP3127436B2 (ja) 2001-01-22
IL104122A (en) 1998-03-10
AU3151093A (en) 1993-07-19
WO1993011760A1 (en) 1993-06-24
NO942308D0 (no) 1994-06-17
EP0618899A4 (en) 1994-11-02
CA2126195C (en) 2004-11-09
AU662379B2 (en) 1995-08-31
JPH07502505A (ja) 1995-03-16
IL104122A0 (en) 1993-05-13
DK0618899T3 (da) 1996-04-01
KR100250099B1 (ko) 2000-04-01
NZ246115A (en) 1996-02-27
DE69209092T2 (de) 1996-07-25
ATE135344T1 (de) 1996-03-15
CA2126195A1 (en) 1993-06-24
MX9207428A (es) 1993-06-01
EP0618899A1 (en) 1994-10-12
US5216022A (en) 1993-06-01
NO942308L (no) 1994-06-17

Similar Documents

Publication Publication Date Title
ES2087568T3 (es) Esteres aromaticos de fenilendialcanoatos como inhibidores de neutrofilo elastasa humana.
MX9308042A (es) Pirazoles y pirazolopirimidinas.
ES2118283T3 (es) Derivados de acidos benzofuranil- y -tiofenil-alcanocarboxilicos.
ES2162942T3 (es) Nuevos derivados de acidos carboxilicos, su obtencion y empleo.
ES2059207T3 (es) Procedimiento para la preparacion de derivados del taxano, nuevos derivados obtenidos y composiciones farmaceuticas que les contienen.
MX9203018A (es) Fluoroalcoxibencilamino-derivados de heterociclos nitrogenados.
ES2112913T3 (es) N-fenilpirazoles utiles como insecticidas y acaricidas.
ES2079360T3 (es) Fluoropolieteres funcionalizados.
MX9304698A (es) Heterociclos que contienen nitrogeno substituido.
ATE311184T1 (de) 1-benzyl-3-(substituiertes-hetaryl)-kondensiert n pyrazol-derivaten zur behandlung von erkrankungen des herz-kreislaufsystems und des zentralnervensystems
ES2127946T3 (es) Antagonistas de neurocinina diazabiciclica.
ES2119912T3 (es) Nuevos aminometilenpeptidos como inmunosupresores.
ES2130269T3 (es) Oximas sustituidas con piridina, pirrolidina y azepina utiles como agentes contra la aterosclerosis y antihipercolesterolemicos.
UY24006A1 (es) Derivado del 2-(2-amino -1,6-dihidro-6-oxo-purin-9-il)metoxil-1,3-propanodiol.
ES2062374T3 (es) Heteroarilpiperazinas, agentes antipsicoticos.
ES2142379T3 (es) Fosfitos ciclicos como estabilizadores de polimeros.
ES2134777T3 (es) Nuevos compuestos de sulfonilo.
ES2054944T3 (es) Bis-(tri-t-alquilfenoxi) difosfaespiroundecanos.
ES2062758T3 (es) Nuevos analogos de vitamina d.
ES2104821T3 (es) Cetoacidos que contienen quinoleina como antagonistas de leucotrienos.
ES2100689T3 (es) Asociacion sinergizante que tiene un efecto antagonista de los receptores nk1 y nk2.
MX9307475A (es) Monofilamentos antimicrobianos para cepillos de dientes.
ES2148816T3 (es) Analogo de vitamina d.
ES2179070T3 (es) Derivados del taxano c9 y composiciones farmaceuticas que las contienen.
ES2127263T3 (es) Nuevos trien-derivados cromenicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 0618899

Country of ref document: ES