ES2085627T3 - Nuevos derivados de perhidroisoindol, su preparacion y las composiciones farmaceuticas que les contienen. - Google Patents
Nuevos derivados de perhidroisoindol, su preparacion y las composiciones farmaceuticas que les contienen.Info
- Publication number
- ES2085627T3 ES2085627T3 ES92911474T ES92911474T ES2085627T3 ES 2085627 T3 ES2085627 T3 ES 2085627T3 ES 92911474 T ES92911474 T ES 92911474T ES 92911474 T ES92911474 T ES 92911474T ES 2085627 T3 ES2085627 T3 ES 2085627T3
- Authority
- ES
- Spain
- Prior art keywords
- alcoil
- new derivatives
- halogen
- perhydroisoindol
- contain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
NUEVOS DERIVADOS DE PERIDROISOINDOLA DE FORMULA GENERAL (I), EN LA QUE LOS RADICALES R SON ATOMOS DE HIDROGENO, O FORMAN EN CONJUNTO UN ENLACE, LOS SIMBOLOS R'' SON RADICALES DE FENILO, PUDIENDO SER SUSTITUIDOS POR UN ATOMO DE HALOGENO O UN RADICAL DE METILO, EN POSICION 2 O 3, X ES UN ATOMO DE OXIGENO O UN RADICAL NH, R1 ES FENILO EVENTUALMENTE SUSTITUIDO, CICLOHEXADIENILO, NAFTILO O HETEROCICLILO, R2 ES H, HALOGENO, OH, ALCOILO, AMINOALCOILO, ALCOILAMINOALCOILO, DIALCOILAMINOALCOILO, ALCOILOXI, ALCOITIO, ACILOXI, CARBOXI, ALCOILOXICARBONILO EVENTUALMENTE SUSTITUIDO, BENZILOXICARBONILO, AMINO O ACILAMINO, R3 ES HALOGENO O OH Y R4 ES H O HALOGENO, SI R3 ES HALOGENO BAJO SUS FORMAS ISOMERAS O SUS MEZCLAS, EVENTUALMENTE SUS SALES CUANDO EXISTEN Y SU PREPARACION. LOS NUEVOS DERIVADOS CONFORME A LA INVENCION RESULTAN DE ESPECIAL INTERES COMO ANTAGONISTAS DE LA SUSTANCIA P.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9106035A FR2676442B1 (fr) | 1991-05-17 | 1991-05-17 | Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2085627T3 true ES2085627T3 (es) | 1996-06-01 |
Family
ID=9412907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92911474T Expired - Lifetime ES2085627T3 (es) | 1991-05-17 | 1992-05-15 | Nuevos derivados de perhidroisoindol, su preparacion y las composiciones farmaceuticas que les contienen. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5451601A (es) |
| EP (2) | EP0586490B1 (es) |
| JP (1) | JPH06507627A (es) |
| AT (1) | ATE135687T1 (es) |
| AU (1) | AU1883692A (es) |
| CA (1) | CA2109298A1 (es) |
| CZ (1) | CZ244793A3 (es) |
| DE (1) | DE69209290T2 (es) |
| DK (1) | DK0586490T3 (es) |
| ES (1) | ES2085627T3 (es) |
| FI (1) | FI935071A0 (es) |
| FR (1) | FR2676442B1 (es) |
| GR (1) | GR3019386T3 (es) |
| HU (1) | HUT67649A (es) |
| IE (1) | IE921578A1 (es) |
| IL (1) | IL101866A0 (es) |
| MX (1) | MX9202287A (es) |
| NO (1) | NO933964L (es) |
| NZ (1) | NZ242772A (es) |
| SK (1) | SK126793A3 (es) |
| TW (1) | TW200459B (es) |
| WO (1) | WO1992020653A1 (es) |
| ZA (1) | ZA923540B (es) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2689888B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| US5508424A (en) * | 1993-03-26 | 1996-04-16 | Ortho Pharmaceutical Corporation | 4-arylisoindole analgesics |
| FR2703679B1 (fr) * | 1993-04-05 | 1995-06-23 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| TW365603B (en) * | 1993-07-30 | 1999-08-01 | Rhone Poulenc Rorer Sa | Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them |
| FR2710913B1 (fr) * | 1993-10-07 | 1995-11-24 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2709752B1 (fr) * | 1993-07-30 | 1995-10-06 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2710842B1 (fr) * | 1993-10-07 | 1995-11-24 | Rhone Poulenc Rorer Sa | Nouvelle application thérapeutique de dérivés de perhydroisoindole. |
| FR2719476B1 (fr) * | 1994-05-05 | 1997-05-23 | Oreal | Utilisation d'un antagoniste de substance P dans une composition cosmétique et composition obtenue. |
| US6203803B1 (en) | 1994-12-14 | 2001-03-20 | Societe L'oreal S.A. | Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained |
| FR2719474B1 (fr) * | 1994-05-05 | 1996-05-31 | Oreal | Utilisation d'un antagoniste de substance P dans une composition cosmétique et composition obtenue. |
| FR2727411B1 (fr) * | 1994-11-30 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2728169A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales |
| FR2728165A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene |
| FR2728166A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Composition topique contenant un antagoniste de substance p |
| FR2741262B1 (fr) | 1995-11-20 | 1999-03-05 | Oreal | Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene |
| ATE387429T1 (de) | 1999-11-03 | 2008-03-15 | Amr Technology Inc | Arly- und heteroaryl-substituierte tetrahydroisoquinoline und ihre verwendung als hemmer der wiederaufnahme von norepinephrin, dopamin und serotonin |
| US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
| CN100430401C (zh) | 2000-07-11 | 2008-11-05 | Amr科技公司 | 新的4-苯基取代的四氢异喹啉类化合物及其治疗用途 |
| CN101119969B (zh) | 2004-07-15 | 2014-04-09 | 阿尔巴尼分子研究公司 | 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用 |
| WO2006123182A2 (en) | 2005-05-17 | 2006-11-23 | Merck Sharp & Dohme Limited | Cyclohexyl sulphones for treatment of cancer |
| EA019115B1 (ru) | 2005-07-15 | 2014-01-30 | Олбани Молекьюлар Рисерч, Инк. | Арил- и гетероарилзамещенные тетрагидробензазепины и их применение для блокировки обратного захвата норэпинефрина, допамина и серотонина |
| GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| GEP20115337B (en) | 2007-01-10 | 2011-11-25 | St Di Ricerche Di Biologia Molecolare P Angeletti Spa | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
| WO2008090114A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
| AU2008269154B2 (en) | 2007-06-27 | 2014-06-12 | Merck Sharp & Dohme Llc | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| AR071997A1 (es) | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| MX2011011900A (es) | 2009-05-12 | 2012-01-20 | Squibb Bristol Myers Co | Formas cristalinas de (s)-7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4 -(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y usos de las misma. |
| WO2010132437A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| CN102595902B (zh) | 2009-05-12 | 2015-04-29 | 阿尔巴尼分子研究公司 | 7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途 |
| MY174452A (en) | 2009-10-14 | 2020-04-19 | Schering Corp | Substituted piperidines that increase p53 activity and the uses thereof |
| US8518907B2 (en) | 2010-08-02 | 2013-08-27 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
| EP3587574B1 (en) | 2010-08-17 | 2022-03-16 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina) |
| US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
| US8946216B2 (en) | 2010-09-01 | 2015-02-03 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
| US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
| US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
| EP2654748B1 (en) | 2010-12-21 | 2016-07-27 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
| CA2833009A1 (en) | 2011-04-21 | 2012-10-26 | Merck Sharp & Dohme Corp. | Insulin-like growth factor-1 receptor inhibitors |
| US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
| EP3919620A1 (en) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
| JP6280554B2 (ja) | 2012-09-28 | 2018-02-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｅｒｋ阻害剤である新規化合物 |
| DK2925888T3 (en) | 2012-11-28 | 2017-12-18 | Merck Sharp & Dohme | COMPOSITIONS AND METHODS OF CANCER TREATMENT |
| AR094116A1 (es) | 2012-12-20 | 2015-07-08 | Merck Sharp & Dohme | Imidazopiridinas sustituidas como inhibidores de hdm2 |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3525785B1 (en) | 2016-10-12 | 2025-08-27 | Merck Sharp & Dohme LLC | Kdm5 inhibitors |
| US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
| EP3706747B1 (en) | 2017-11-08 | 2025-09-03 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| EP3833355A4 (en) | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme Corp. | PRMT5 INHIBITORS |
| US11993602B2 (en) | 2018-08-07 | 2024-05-28 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
| FR2654725B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2654726B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone et leur preparation. |
| FR2676443B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole et leur preparation. |
-
1991
- 1991-05-17 FR FR9106035A patent/FR2676442B1/fr not_active Expired - Fee Related
-
1992
- 1992-05-14 IL IL101866A patent/IL101866A0/xx unknown
- 1992-05-15 EP EP92911474A patent/EP0586490B1/fr not_active Expired - Lifetime
- 1992-05-15 MX MX9202287A patent/MX9202287A/es unknown
- 1992-05-15 JP JP4510462A patent/JPH06507627A/ja active Pending
- 1992-05-15 AU AU18836/92A patent/AU1883692A/en not_active Abandoned
- 1992-05-15 NZ NZ242772A patent/NZ242772A/en unknown
- 1992-05-15 DE DE69209290T patent/DE69209290T2/de not_active Expired - Fee Related
- 1992-05-15 ZA ZA923540A patent/ZA923540B/xx unknown
- 1992-05-15 FI FI935071A patent/FI935071A0/fi unknown
- 1992-05-15 EP EP92401329A patent/EP0514273A1/fr active Pending
- 1992-05-15 CZ CS932447A patent/CZ244793A3/cs unknown
- 1992-05-15 SK SK1267-93A patent/SK126793A3/sk unknown
- 1992-05-15 DK DK92911474.2T patent/DK0586490T3/da active
- 1992-05-15 AT AT92911474T patent/ATE135687T1/de active
- 1992-05-15 TW TW081103795A patent/TW200459B/zh active
- 1992-05-15 CA CA002109298A patent/CA2109298A1/fr not_active Abandoned
- 1992-05-15 HU HU9303249A patent/HUT67649A/hu unknown
- 1992-05-15 WO PCT/FR1992/000429 patent/WO1992020653A1/fr not_active Ceased
- 1992-05-15 US US08/146,143 patent/US5451601A/en not_active Expired - Fee Related
- 1992-05-15 ES ES92911474T patent/ES2085627T3/es not_active Expired - Lifetime
- 1992-07-01 IE IE157892A patent/IE921578A1/en not_active Application Discontinuation
-
1993
- 1993-11-02 NO NO933964A patent/NO933964L/no unknown
-
1996
- 1996-03-21 GR GR950403441T patent/GR3019386T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0514273A1 (fr) | 1992-11-19 |
| FI935071A7 (fi) | 1993-11-16 |
| FI935071L (fi) | 1993-11-16 |
| AU1883692A (en) | 1992-12-30 |
| ZA923540B (en) | 1993-01-27 |
| JPH06507627A (ja) | 1994-09-01 |
| FI935071A0 (fi) | 1993-11-16 |
| IE921578A1 (en) | 1992-11-18 |
| CA2109298A1 (fr) | 1992-11-18 |
| NO933964D0 (no) | 1993-11-02 |
| DK0586490T3 (da) | 1996-04-15 |
| DE69209290D1 (de) | 1996-04-25 |
| HUT67649A (en) | 1995-04-28 |
| NZ242772A (en) | 1994-04-27 |
| EP0586490A1 (fr) | 1994-03-16 |
| EP0586490B1 (fr) | 1996-03-20 |
| WO1992020653A1 (fr) | 1992-11-26 |
| GR3019386T3 (en) | 1996-06-30 |
| NO933964L (no) | 1993-11-02 |
| ATE135687T1 (de) | 1996-04-15 |
| TW200459B (es) | 1993-02-21 |
| DE69209290T2 (de) | 1996-10-31 |
| HU9303249D0 (en) | 1994-03-28 |
| CZ244793A3 (en) | 1994-03-16 |
| FR2676442A1 (fr) | 1992-11-20 |
| US5451601A (en) | 1995-09-19 |
| FR2676442B1 (fr) | 1993-08-06 |
| MX9202287A (es) | 1993-02-01 |
| SK126793A3 (en) | 1994-11-09 |
| IL101866A0 (en) | 1992-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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