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ES2082780T3 - Derivados de acido bisfosfonico heterociclicos. - Google Patents

Derivados de acido bisfosfonico heterociclicos.

Info

Publication number
ES2082780T3
ES2082780T3 ES89308180T ES89308180T ES2082780T3 ES 2082780 T3 ES2082780 T3 ES 2082780T3 ES 89308180 T ES89308180 T ES 89308180T ES 89308180 T ES89308180 T ES 89308180T ES 2082780 T3 ES2082780 T3 ES 2082780T3
Authority
ES
Spain
Prior art keywords
chem
hydrogen atom
hydroxyl group
bisphosphonic acid
hiserociclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89308180T
Other languages
English (en)
Inventor
Yasuo Isomura
Makoto Takeuchi
Tetsushi Abe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2082780T3 publication Critical patent/ES2082780T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

NUEVOS DERIVADOS DE ACIDO BIFOSFONICO HETEROCICLICO REPRESENTADOS POR LA FORMULA GENERAL (I), EN LA QUE HET SIGNIFICA UNO DE LOS RADICALES DE FORMULA (A) O (B), DONDE UNA LINEA DISCONTINUA EN (A) SIGNIFICA QUE DOS ATOMOS ADYACENTES ESTAN UNIDOS POR UN ENLACE SENCILLO O DOBLE, DONDE R6 Y R7 PUEDEN SER EL MISMO O DIFERENTE, CADA UNO REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO INFERIOR, UN ATOMO DE HALOGENO O UN GRUPO HIDROXILO; R1 REPRESENTA UN ATOMO DE HIDROGENO, O UN GRUPO HIDROXILO; R2, R3, R4 Y R5 PUEDEN SER EL MISMO O DIFERENTE, CADA UNO REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR; N ES 0 O 1, PREVIENDO QUE N ES 1 CUANDO EL ANILLO HET ES (A), Y R1 ES UN GRUPO HIDROXILO CUANDO EL ANILLO HET ES (B), SUS SALES FARMACEUTICAMENTE ACEPTABLES E INHIBIDORES DE RESORCION DE HUESOS QUE CONTIENEN LOS COMPUESTO COMO INGREDIENTE ACTIVO.
ES89308180T 1988-08-12 1989-08-11 Derivados de acido bisfosfonico heterociclicos. Expired - Lifetime ES2082780T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20153688 1988-08-12
JP20153588 1988-08-12

Publications (1)

Publication Number Publication Date
ES2082780T3 true ES2082780T3 (es) 1996-04-01

Family

ID=26512843

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89308180T Expired - Lifetime ES2082780T3 (es) 1988-08-12 1989-08-11 Derivados de acido bisfosfonico heterociclicos.

Country Status (14)

Country Link
US (2) US4990503A (es)
EP (1) EP0354806B1 (es)
KR (1) KR0156239B1 (es)
CN (1) CN1027167C (es)
AT (1) ATE129714T1 (es)
AU (1) AU624405B2 (es)
CA (1) CA1332058C (es)
DE (1) DE68924681T2 (es)
DK (1) DK170257B1 (es)
ES (1) ES2082780T3 (es)
GR (1) GR3018086T3 (es)
HU (2) HU205766B (es)
IE (1) IE71185B1 (es)
PH (1) PH26376A (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521622B1 (en) * 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
TW222637B (es) * 1991-12-12 1994-04-21 Hoechst Ag
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
JPH05345791A (ja) * 1992-03-18 1993-12-27 Hoechst Japan Ltd 環状アミノメチレンビスホスホン酸誘導体
AU4356693A (en) * 1992-06-23 1994-01-24 Yamanouchi Pharmaceutical Co., Ltd. Novel crystal of monohydrate of heterocyclic bis(phosphonic acid) derivative
WO1994009017A1 (en) * 1992-10-09 1994-04-28 The Upjohn Company Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories
DE59309360D1 (de) * 1992-12-02 1999-03-18 Hoechst Ag Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
JPH06298779A (ja) * 1993-04-15 1994-10-25 Hoechst Japan Ltd ヘテロ環イミノビスメチレンビスホスホン酸誘導体
US5728650A (en) * 1993-10-07 1998-03-17 Zeneca Limited Herbicidal aza bisphosphonic acids and compositions containing the same
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
AU6691798A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
AU6452098A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
US7008645B2 (en) * 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
KR100609256B1 (ko) * 1998-12-25 2006-08-04 아스텔라스세이야쿠 가부시키가이샤 다발성 골수종의 골 병변 치료용 의약 조성물
US20030036537A1 (en) * 2001-07-16 2003-02-20 Marc Lecouvey Bisphosphonate derivatives, their preparations and uses
PL212072B1 (pl) 2002-12-20 2012-08-31 Hoffmann La Roche Tabletka zawierająca jako substancję czynną do 250 mg kwasu ibandronowego oraz sposób jej wytwarzania
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US10517883B2 (en) * 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
US20060051407A1 (en) * 2003-06-27 2006-03-09 Yoram Richter Method of treating ischemia-reperfusion injury
CA2554749A1 (en) * 2004-01-30 2005-08-11 Astellas Pharma Inc. P2x receptor inhibitor
CN101531681B (zh) * 2008-03-10 2013-06-05 北京德众万全医药科技有限公司 一种高纯度的米诺膦酸及其制备方法
ES2436305T3 (es) * 2008-09-22 2013-12-30 Isis Innovation Ltd Bisfosfonatos de imidazo[1,2-a]piridinilo
WO2010033980A2 (en) * 2008-09-22 2010-03-25 Isis Innovation Ltd. 4-azaindole bisphosphonates
MX2012004769A (es) 2009-10-26 2012-08-08 Warner Chilcott Co Llc Compuestos de bisfosfonato para tratar transtornos del metabolismo oseo.
CN101973993A (zh) * 2010-11-05 2011-02-16 天津药物研究院 一种制备2-[咪唑并(1,2-a)吡啶-3-基]乙酸的方法
CN102153585B (zh) * 2011-02-24 2013-04-17 北京欧克兰医药技术开发中心 一种米诺膦酸中间体的合成方法及米诺膦酸的合成
CN102268042B (zh) * 2011-06-01 2014-06-25 广东宏远集团药业有限公司 一种米诺膦酸晶型ii及其制备方法
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
CN107033187A (zh) * 2017-04-28 2017-08-11 江苏笃诚医药科技股份有限公司 一种米诺膦酸的制备方法
KR20220115062A (ko) 2021-02-09 2022-08-17 (주)오스티오뉴로젠 크로몬 구조의 화합물을 포함하는 골다공증의 예방 및 치료용 약학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
EP0272208B1 (de) * 1986-11-21 1991-06-12 Ciba-Geigy Ag Aromatisch substituierte Azacyclo-alkylalkandiphosphonsäuren
DE3640938A1 (de) * 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
EP0317505A1 (de) * 1987-11-13 1989-05-24 Ciba-Geigy Ag Neue Azacycloalkylalkandiphosphonsäuren

Also Published As

Publication number Publication date
KR0156239B1 (ko) 1998-12-01
HU211949A9 (en) 1996-01-29
HUT51637A (en) 1990-05-28
AU624405B2 (en) 1992-06-11
GR3018086T3 (en) 1996-02-29
DK394789A (da) 1990-02-13
IE892601L (en) 1990-02-12
US4990503A (en) 1991-02-05
EP0354806B1 (en) 1995-11-02
KR900003186A (ko) 1990-03-26
HU205766B (en) 1992-06-29
DK394789D0 (da) 1989-08-11
CN1040590A (zh) 1990-03-21
DE68924681T2 (de) 1996-04-04
AU3941989A (en) 1990-02-15
CA1332058C (en) 1994-09-20
DK170257B1 (da) 1995-07-17
ATE129714T1 (de) 1995-11-15
DE68924681D1 (de) 1995-12-07
EP0354806A2 (en) 1990-02-14
CN1027167C (zh) 1994-12-28
IE71185B1 (en) 1997-01-29
EP0354806A3 (en) 1991-05-02
PH26376A (en) 1992-06-01
US5039669A (en) 1991-08-13

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