[go: up one dir, main page]

ES2077998T3 - Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion terapeutica. - Google Patents

Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion terapeutica.

Info

Publication number
ES2077998T3
ES2077998T3 ES92401773T ES92401773T ES2077998T3 ES 2077998 T3 ES2077998 T3 ES 2077998T3 ES 92401773 T ES92401773 T ES 92401773T ES 92401773 T ES92401773 T ES 92401773T ES 2077998 T3 ES2077998 T3 ES 2077998T3
Authority
ES
Spain
Prior art keywords
ethyl
aminopyrimidine
carboxamide
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92401773T
Other languages
English (en)
Inventor
Pascal George
Philippe Manoury
Benoit Marabout
Jacques Froissant
Jean-Pierre Merly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Application granted granted Critical
Publication of ES2077998T3 publication Critical patent/ES2077998T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

COMPUESTO QUE RESPONDE A LA FORMULA GENERAL (I) EN LA QUE N = 2 O 3, X = H, CL O OCH3, R = H O CH3, R1 = H O CH3, R2 = ALKILO, HIDROXIALKILO, (HIDROXI) (METOXI)ALKILO, DIMETOXIALKILO, 2-(AMINOSULFONIL)ETILO, 2-(METILSULFONIL)ETILO, 2-(METILSULFONILAMINO)ETILO, AMINOCARBONILMETILO EVENTUALMENTE SUSTITUIDO POR NITROGENO, FENILETILO EVENTUALMENTE SUSTITUIDO, PIRIMIDINILAMINOALKILO O ARILCARBONILAMINOALKILO, O BIEN R1 Y R2 FORMAN, CON EL NITROGENO QUE LOS LLEVA, UN CICLO DE PIPERIDINA, MORFOLINA, TIOMORFOLINA O PIPERAZINA EVENTUALMENTE SUTITUIDO POR NITROGENO. APLICACION EN TERAPIA.
ES92401773T 1991-06-27 1992-06-24 Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion terapeutica. Expired - Lifetime ES2077998T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9107939A FR2678272B1 (fr) 1991-06-27 1991-06-27 Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
ES2077998T3 true ES2077998T3 (es) 1995-12-01

Family

ID=9414359

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92401773T Expired - Lifetime ES2077998T3 (es) 1991-06-27 1992-06-24 Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion terapeutica.

Country Status (23)

Country Link
US (1) US5244894A (es)
EP (1) EP0520883B1 (es)
JP (1) JP3159526B2 (es)
KR (1) KR930000508A (es)
CN (1) CN1067885A (es)
AT (1) ATE124935T1 (es)
AU (1) AU644295B2 (es)
CA (1) CA2072433A1 (es)
CZ (1) CZ9202003A3 (es)
DE (1) DE69203402T2 (es)
DK (1) DK0520883T3 (es)
ES (1) ES2077998T3 (es)
FI (1) FI922982L (es)
FR (1) FR2678272B1 (es)
GR (1) GR3017249T3 (es)
HU (1) HUT61749A (es)
IE (1) IE922094A1 (es)
IL (1) IL102332A0 (es)
MX (1) MX9203333A (es)
NO (1) NO922525L (es)
NZ (1) NZ243340A (es)
PL (1) PL295045A1 (es)
ZA (1) ZA924785B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT70029A (en) * 1991-08-14 1995-09-28 Procter & Gamble Pharma Novel cyclic urea derivatives and antiarrhythmic and antifibrillatory compositions containing them
DE69300162T2 (de) * 1992-07-03 1995-11-02 Synthelabo, Le Plessis Robinson 2-Amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]amino]alkyl]-pyrimidin-4-carbonsäureamidderivate, ihre Herstellung und ihre Anwendung in der Therapeutica.
FR2703355B1 (fr) * 1993-03-29 1995-05-05 Synthelabo Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
US5688795A (en) * 1994-11-08 1997-11-18 Syntex (U.S.A.) Inc. 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
FR2744722B1 (fr) * 1996-02-14 1998-03-13 Synthelabo Devires de 2-((3-(piperazin-1-yl)propyl)amino)pyrimidine-4- carboxamide et leur application en therapeutique
WO1999057131A1 (en) 1998-05-06 1999-11-11 Duke University Method of treating bladder and lower urinary tract syndromes
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
KR20070024639A (ko) * 2004-06-24 2007-03-02 인사이트 산 디에고 인코포레이티드 아미도 화합물 및 약제로서의 이의 용도
JP2008504279A (ja) * 2004-06-24 2008-02-14 インサイト・コーポレイション アミド化合物およびその医薬としての使用
EP1768954A4 (en) * 2004-06-24 2008-05-28 Incyte Corp 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS
BRPI0512535A (pt) 2004-06-24 2008-03-25 Incyte Corp compostos de piperidinas n-substituìdas, suas composições e métodos de modulações
CN101080226A (zh) * 2004-08-10 2007-11-28 因塞特公司 酰氨基化合物及它们作为药物的用途
EP2847193B1 (en) * 2012-05-09 2019-08-07 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2143730A1 (de) * 1971-09-01 1973-03-08 Byk Gulden Lomberg Chem Fab Substituierte pyridine, verfahren zu deren herstellung und sie enthaltende arzneimittel
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678271B1 (fr) * 1991-06-27 1995-01-13 Synthelabo Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
US5244894A (en) 1993-09-14
AU1858892A (en) 1993-01-07
HU9202143D0 (en) 1992-10-28
PL295045A1 (en) 1993-03-08
DE69203402T2 (de) 1996-03-07
GR3017249T3 (en) 1995-11-30
NO922525L (no) 1992-12-28
IL102332A0 (en) 1993-01-14
CN1067885A (zh) 1993-01-13
EP0520883A1 (fr) 1992-12-30
FI922982A7 (fi) 1992-12-28
NZ243340A (en) 1994-02-25
JP3159526B2 (ja) 2001-04-23
ZA924785B (en) 1993-03-31
FI922982A0 (fi) 1992-06-26
NO922525D0 (no) 1992-06-26
FI922982L (fi) 1992-12-28
CZ9202003A3 (en) 1993-01-13
AU644295B2 (en) 1993-12-02
CA2072433A1 (en) 1992-12-28
IE922094A1 (en) 1992-12-30
MX9203333A (es) 1993-02-01
EP0520883B1 (fr) 1995-07-12
FR2678272B1 (fr) 1994-01-14
JPH05186435A (ja) 1993-07-27
ATE124935T1 (de) 1995-07-15
HUT61749A (en) 1993-03-01
KR930000508A (ko) 1993-01-15
DE69203402D1 (de) 1995-08-17
FR2678272A1 (fr) 1992-12-31
DK0520883T3 (da) 1995-12-11

Similar Documents

Publication Publication Date Title
ES2077998T3 (es) Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion terapeutica.
ES2062395T3 (es) Nuevos compuestos de bencimidazol y su uso.
ES2182535T3 (es) Derivados de benzo(b)tiepina-1,-dioxido, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su utilizacion.
MX9206847A (es) Derivados de indolpirrolcarbazol, proceso para su preparacion y medicamento que los contiene
PE46499A1 (es) Derivados de 6-fenilpiridil-2-amina
AR011913A1 (es) Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos.
DK249089D0 (da) Benzamid-forbindelser, der er nyttige som protease-inhibitorer
AR003137A1 (es) Una composicion farmaceutica para tratar la leucemia
ES2153019T3 (es) Derivados de benzo-dioxano, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
IL98454A0 (en) Derivatives of 2-aminoalkyl-5-arylalkyl-1,3-dioxanes,their preparation and their therapeutic application
ES2095848T3 (es) Nuevos derivados de fosfolipidos y su utilizacion para la preparacion de medicamentos antiviricos.
ES2119874T3 (es) Nuevos derivados de elipticina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
MX9203712A (es) Derivados de benzanilida y composiciones farmaceuticas que los contienen.
DE68906965D1 (de) Analgetische phenothiazinderivate.
ES2189736T3 (es) Derivados de la benzamida y medicamentos que los contienen.
ES2074144T3 (es) Derivados de 4-fenilmetil-1h-indol, procedimiento y compuestos intermedios de preparacion, aplicacion como medicamentos y composiciones que los contienen.
ES2059550T3 (es) Derivados de la bencimidazola, su preparacion y su aplicacion en terapeutica.
ES2065192T3 (es) Nuevos nicotinatos de diacil-glicerol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
MX9203929A (es) Derivados de 1,2,4-tiadiazino[3,4-b]benzotiazol, procedimiento para su preparacion y medicamentos que los contienen.
PT90815A (pt) Processo de preparacao de derivados da fenotiazina
DE3578168D1 (de) Aminoalkylnaphthalen-derivate mit pharmakologischer wirkung.
ES2054460T3 (es) Unos derivados de la ((1-arilpirrolidin-2-il)-metil)-piperazina, su preparacion y su aplicacion en terapeutica.
SE7901316L (sv) Derivat av dehydrocykliciminsyror

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 520883

Country of ref document: ES