ES2076608T3 - Insuflador multi-dosis para medicamentos en forma de polvo. - Google Patents
Insuflador multi-dosis para medicamentos en forma de polvo.Info
- Publication number
- ES2076608T3 ES2076608T3 ES92108490T ES92108490T ES2076608T3 ES 2076608 T3 ES2076608 T3 ES 2076608T3 ES 92108490 T ES92108490 T ES 92108490T ES 92108490 T ES92108490 T ES 92108490T ES 2076608 T3 ES2076608 T3 ES 2076608T3
- Authority
- ES
- Spain
- Prior art keywords
- receptacle
- deposit
- powder
- dose
- hole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 abstract 5
- 239000000843 powder Substances 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 210000003928 nasal cavity Anatomy 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
- B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
- B05B11/065—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material the particulate material being separated from a main storage in discrete quantities delivered one at a time
- B05B11/067—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material the particulate material being separated from a main storage in discrete quantities delivered one at a time the particulate material being separated from the main storage by a dosing device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
- B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/10—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation
- G01F11/12—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements
- G01F11/20—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements wherein the measuring chamber rotates or oscillates
- G01F11/24—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements wherein the measuring chamber rotates or oscillates for fluent solid material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/075—Bulb type
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Fluid Mechanics (AREA)
- General Physics & Mathematics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- External Artificial Organs (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Abstract
SE PRESENTA UN INSUFLADOR MULTIDOSIS PARA LA ADMINISTRACION NASAL DE MEDICAMENTOS EN FORMA DE POLVO FINO O MICRONIZADO QUE COMPRENDE UN DEPOSITO (34), UNA UNIDAD (60, 64) PARA EXTRAER Y MEDIR EL MEDICAMENTO CONTENIDO EN EL DEPOSITO, Y UNA UNIDAD INSUFLADORA (42, 46) QUE COMPRENDE UNA BOMBA (42) QUE FUNCIONA MANUALMENTE PARA GENERAR UNA CORRIENTE DE AIRE EN EL INTERIOR DEL CANAL (26) PARA TRANSPORTAR UNA DOSIS INDIVIDUAL DE MEDICAMENTO AL INTERIOR DE LA CAVIDAD NASAL DEL PACIENTE. LA UNIDAD DE EXTRACCION Y MEDIDA COMPRENDE UN DISPOSITIVO TRANSPORTADOR (60) PROVISTO CON AL MENOS UN RECEPTACULO (64) PARA EXTRAER UNA DOSIS DEL MEDICAMENTO DEL DEPOSITO (34) Y TRANSPORTARLO HASTA LA POSICION DE INSUFLADO. EL RECEPTACULO (64) TIENE UN ORIFICIO COAXIAL EN SU BASE (66) A TRAVES DEL CUAL PASA LA CORRIENTE DE AIRE GENERADA POR LA BOMBA CUANDO EL RECEPTACULO SE ENCUENTRA EN LA POSICION DE INSUFLADO. EL ORIFICIO (66) TIENE UN TAMAÑO SUBSTANCIALMENTE MAS PEQUEÑO QUE LA BOCA DEL RECEPTACULO Y ESTO ES ASIPARA EVITAR QUE EL MEDICAMENTO EN POLVO CAIGA A TRAVES DEL ORIFICIO, EN VIRTUD DE UN EFECTO DE ARQUEAMIENTO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI911643A IT1248059B (it) | 1991-06-14 | 1991-06-14 | Insufflatore multidose per farmaci in polvere |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2076608T3 true ES2076608T3 (es) | 1995-11-01 |
Family
ID=11360122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92108490T Expired - Lifetime ES2076608T3 (es) | 1991-06-14 | 1992-05-20 | Insuflador multi-dosis para medicamentos en forma de polvo. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5250287A (es) |
| EP (1) | EP0518087B1 (es) |
| JP (1) | JPH05200115A (es) |
| AT (1) | ATE125161T1 (es) |
| CA (1) | CA2070297C (es) |
| DE (1) | DE69203541T2 (es) |
| DK (1) | DK0518087T3 (es) |
| ES (1) | ES2076608T3 (es) |
| GR (1) | GR3017598T3 (es) |
| IT (1) | IT1248059B (es) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2112674C (en) * | 1991-07-02 | 2005-10-04 | John S. Patton | Method and device for delivering aerosolized medicaments |
| UA27961C2 (uk) * | 1992-12-18 | 2000-10-16 | Шерінг Корпорейшн | Інгалятор для порошкових ліків |
| US5634900A (en) * | 1993-05-12 | 1997-06-03 | Teijin Limited | Multi-dose powdered medicine administering device and method thereof |
| DE4319514C2 (de) * | 1993-06-14 | 2003-06-18 | Sofotec Gmbh & Co Kg | Pulverinhalator |
| FR2718968B1 (fr) * | 1994-04-20 | 1996-07-26 | Valois Sa | Insert délimitant une chambre de dosage d'un inhalateur. |
| DE4415462C1 (de) * | 1994-05-03 | 1995-08-31 | Transcoject Marketing Gmbh | Inhalator |
| GB9409851D0 (en) * | 1994-05-17 | 1994-07-06 | Cambridge Consultants | Improvements in and relating to containers of particulate material |
| DE19518810A1 (de) * | 1995-05-26 | 1996-11-28 | Bayer Ag | Nasal-Applikator |
| JP3434396B2 (ja) * | 1995-06-30 | 2003-08-04 | 株式会社日立ユニシアオートモティブ | 鼻腔用投薬器 |
| IN188288B (es) * | 1996-10-01 | 2002-08-31 | Cipla Ltd | |
| SE9700935D0 (sv) * | 1997-03-14 | 1997-03-14 | Astra Ab | Inhalation device |
| US6076520A (en) * | 1997-05-12 | 2000-06-20 | Cooper; Emily L. | Device for nasal therapeutic inhalation |
| US6345617B1 (en) | 1997-09-26 | 2002-02-12 | 1263152 Ontario Inc. | Aerosol medication delivery apparatus and system |
| US6293279B1 (en) | 1997-09-26 | 2001-09-25 | Trudell Medical International | Aerosol medication delivery apparatus and system |
| KR100629126B1 (ko) * | 1999-01-14 | 2006-09-27 | 데이진 가부시키가이샤 | 분말체의 정량 공급장치 및 방법 |
| US6116234A (en) * | 1999-02-01 | 2000-09-12 | Iep Pharmaceutical Devices Inc. | Metered dose inhaler agitator |
| ATE294608T1 (de) † | 1999-06-05 | 2005-05-15 | Innovata Biomed Ltd | Verabreichungsystem für medikamente |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US6679256B2 (en) * | 1999-12-17 | 2004-01-20 | Nektar Therapeutics | Systems and methods for extracting powders from receptacles |
| AU2001234005B2 (en) | 2000-02-28 | 2006-01-19 | Pharmakodex Limited | Improvements in or relating to the delivery of oral drugs |
| WO2001076671A2 (en) | 2000-04-11 | 2001-10-18 | Trudell Medical International | Aerosol delivery apparatus with positive expiratory pressure capacity |
| AU2003220125B2 (en) * | 2002-03-20 | 2006-06-15 | Mannkind Corporation | Inhalation apparatus |
| US20030205226A1 (en) | 2002-05-02 | 2003-11-06 | Pre Holding, Inc. | Aerosol medication inhalation system |
| JP3950738B2 (ja) * | 2002-05-14 | 2007-08-01 | 株式会社 バイオアクティス | 鼻腔用粉状薬剤施薬装置 |
| US6904908B2 (en) | 2002-05-21 | 2005-06-14 | Trudell Medical International | Visual indicator for an aerosol medication delivery apparatus and system |
| CA2694183C (en) | 2002-10-11 | 2013-06-25 | Otsuka Techno Corporation | Powder inhalator |
| US20040153027A1 (en) | 2002-10-28 | 2004-08-05 | Mantell Robert R. | Dual-capacity insufflator tube |
| US7654975B2 (en) * | 2003-04-24 | 2010-02-02 | Northgate Technologies, Inc. | Mixed-gas insufflation system |
| FI20031158L (fi) * | 2003-08-15 | 2005-02-16 | Perlos Oyj | Inhalaattori |
| CA2538456C (en) * | 2003-10-07 | 2013-01-15 | Northgate Technologies Inc. | System and method for delivering a substance to a body cavity |
| MXPA06003830A (es) * | 2003-10-09 | 2006-07-03 | Bioactis Ltd | Aparato para abastecer medicina pulverizada para la cavidad nasal. |
| EP1680173B1 (en) | 2003-10-31 | 2011-01-12 | Trudell Medical International | System for manipulating a catheter for delivering a substance to a body cavity |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| EP2314298B1 (en) | 2004-08-23 | 2015-05-27 | MannKind Corporation | Microparticles comprising diketopiperazine salts for drug delivery |
| AU2006290870B2 (en) | 2005-09-14 | 2013-02-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
| US20090253654A1 (en) * | 2005-09-22 | 2009-10-08 | Galantos Pharma Gmbh | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
| DK1986679T3 (da) | 2006-02-22 | 2017-11-20 | Mannkind Corp | Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof |
| WO2008001744A1 (en) * | 2006-06-27 | 2008-01-03 | Otsuka Pharmaceutical Co., Ltd. | Powder inhaler |
| WO2008015566A2 (en) | 2006-08-04 | 2008-02-07 | Northgate, Technologies, Inc. | In-dwelling port for access into a body |
| CN103252007B (zh) | 2008-06-13 | 2016-06-22 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| JP5479465B2 (ja) | 2008-06-20 | 2014-04-23 | マンカインド コーポレイション | 吸入努力をリアルタイムにプロファイルする対話式機器および方法 |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US9205240B2 (en) * | 2008-12-15 | 2015-12-08 | Profibrix B.V. | Powder delivery device |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| EP2676695A3 (en) | 2009-03-11 | 2017-03-01 | MannKind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| KR101875969B1 (ko) | 2009-06-12 | 2018-07-06 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
| CN105667994B (zh) | 2011-04-01 | 2018-04-06 | 曼金德公司 | 用于药物药盒的泡罩包装 |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| WO2013063160A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
| SG11201500218VA (en) | 2012-07-12 | 2015-03-30 | Mannkind Corp | Dry powder drug delivery systems and methods |
| ES2880399T3 (es) | 2012-07-27 | 2021-11-24 | Neurodyn Life Sciences Inc | Biodisponibilidad cerebral mejorada de galantamina mediante formulaciones seleccionadas y administración transmucosa de profármacos lipofílicos |
| CN108245522A (zh) * | 2012-07-27 | 2018-07-06 | 神经动力生命科学公司 | Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用 |
| EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
| EP2970149B1 (en) | 2013-03-15 | 2019-08-21 | MannKind Corporation | Microcrystalline diketopiperazine compositions and methods |
| CN105451716A (zh) | 2013-07-18 | 2016-03-30 | 曼金德公司 | 热稳定性干粉药物组合物和方法 |
| WO2015021064A1 (en) | 2013-08-05 | 2015-02-12 | Mannkind Corporation | Insufflation apparatus and methods |
| US9572595B1 (en) | 2014-03-05 | 2017-02-21 | Northgate Technologies Inc. | In-dwelling port for access into a body |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2587215A (en) * | 1949-04-27 | 1952-02-26 | Frank P Priestly | Inhalator |
| US2992645A (en) * | 1958-05-06 | 1961-07-18 | Benger Lab Ltd | Disperser for powders |
| US3897779A (en) * | 1973-06-27 | 1975-08-05 | American Cyanamid Co | Triamcinolone acetonide inhalation therapy |
| IT7920688U1 (it) * | 1979-02-05 | 1980-08-05 | Chiesi Paolo | Inalatore per sostanze medicamentose pulverulente, con combinata funzione di dosatore |
| IT1222509B (it) * | 1987-08-17 | 1990-09-05 | Miat Spa | Insufflatore per la somministrazione di farmaci sotto forma di polvere predosata in opercoli |
| SE466684B (sv) * | 1989-03-07 | 1992-03-23 | Draco Ab | Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator |
| IT1237118B (it) * | 1989-10-27 | 1993-05-18 | Miat Spa | Inalatore multidose per farmaci in polvere. |
-
1991
- 1991-06-14 IT ITMI911643A patent/IT1248059B/it active IP Right Grant
-
1992
- 1992-05-11 US US07/881,433 patent/US5250287A/en not_active Expired - Lifetime
- 1992-05-20 ES ES92108490T patent/ES2076608T3/es not_active Expired - Lifetime
- 1992-05-20 DK DK92108490.1T patent/DK0518087T3/da active
- 1992-05-20 AT AT92108490T patent/ATE125161T1/de not_active IP Right Cessation
- 1992-05-20 DE DE69203541T patent/DE69203541T2/de not_active Expired - Fee Related
- 1992-05-20 EP EP92108490A patent/EP0518087B1/en not_active Expired - Lifetime
- 1992-06-03 CA CA002070297A patent/CA2070297C/en not_active Expired - Fee Related
- 1992-06-12 JP JP4179291A patent/JPH05200115A/ja active Pending
-
1995
- 1995-10-02 GR GR950402711T patent/GR3017598T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT1248059B (it) | 1995-01-05 |
| DE69203541T2 (de) | 1996-01-11 |
| EP0518087B1 (en) | 1995-07-19 |
| US5250287A (en) | 1993-10-05 |
| ITMI911643A1 (it) | 1992-12-14 |
| ATE125161T1 (de) | 1995-08-15 |
| ITMI911643A0 (it) | 1991-06-14 |
| CA2070297A1 (en) | 1992-12-15 |
| CA2070297C (en) | 1999-01-26 |
| JPH05200115A (ja) | 1993-08-10 |
| DK0518087T3 (da) | 1995-11-27 |
| GR3017598T3 (en) | 1996-01-31 |
| DE69203541D1 (de) | 1995-08-24 |
| EP0518087A1 (en) | 1992-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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