ES2075672T3 - Amidinocompuestos, su fabricacion y uso como medicamento. - Google Patents
Amidinocompuestos, su fabricacion y uso como medicamento.Info
- Publication number
- ES2075672T3 ES2075672T3 ES92810423T ES92810423T ES2075672T3 ES 2075672 T3 ES2075672 T3 ES 2075672T3 ES 92810423 T ES92810423 T ES 92810423T ES 92810423 T ES92810423 T ES 92810423T ES 2075672 T3 ES2075672 T3 ES 2075672T3
- Authority
- ES
- Spain
- Prior art keywords
- radical
- aliphatic
- hydrocarbon radical
- esterified
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 AMIDINO COMPOUNDS Chemical class 0.000 title abstract 10
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 229930195733 hydrocarbon Natural products 0.000 abstract 3
- 150000003254 radicals Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- 241000282693 Cercopithecidae Species 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 241000243320 Hydrozoa Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N carbonic acid monoamide Natural products NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA Y A LAS SALES DE LOS MISMOS FARMACEUTICAMENTE ACEPTABLES, EN DONDE: R1 ES AMINO QUE ESTA MONO O DISUBSTITUIDO POR UN SUSTITUYENTE SELECCIONADO ENTRE UN RADICAL DE HIDROCARBONO ALIFATICO, UN RADICAL DE HIDROCARBONO ARALIFATICO, UN RADICAL AROMATICO, Y UN RADICAL DE HIDROCARBONO CICLOALIFATICO O ES AMINO QUE ESTA SUSTITUIDO POR UN RADICAL DE HIDROCARBONO ALIFATICO DIVALENTE; R2 ES HIDROGENO, HALOGENO, TRIFLUOROMETIL, UN RADICAL DE HIDROCARBONO ALIFATICO, O ES HIDROXIDO QUE ESTA ESTERIFICADO POR UN ALCOHOL ALIFATICO, ARALIFATICO O AROMATICO O QUE ESTA ESTERIFICADO POR UN ACIDO CARBOXILICO ALIFATICO O ARALIFATICO; R3 ES HIDROGENO O UN RADICAL ACIL QUE SE DERIVA DE UN ACIDO CARBONICO ORGANICO, DE UN ACIDO CARBOXILICO ORGANICO, DE UN ACIDO SULFONICO O DE UN ACIDO CARBAMICO; X1 Y X3, INDEPENDIENTEMENTE UNA DE LA OTRA, SON OXIGENO (-O-) O AZUFRE (-S-); Y X2 ES UN RADICAL DE HIDROCARBONO ALIFATICO DIVALENTE QUE PUEDE ESTAR INTERRUMPIDO POR UN RADICAL AROMATICO; EN DONDE LOS ANILLOS DE FENIL DE LA FORMULA (I) PUEDEN ESTAR ADEMAS SUSTITUIDOS, INDEPENDIENTEMENTE UNOS DE LOS OTROS, POR UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE HALOGENO, TRIFLUOROMETIL, UN RADICAL DE HIDROCARBONO ALIFATICO, HIDROXIDO O HIDROXIDO QUE ESTE ESTERIFICADO POR UN ALCOHOL ALIFATICO O QUE ESTE ESTERIFICADO POR UN ACIDO CARBOXILICO ALIFATICO O ARALIFATICO; EN DONDE EL ARIL DE LAS DEFINICIONES ANTERIORES PUEDE ESTAR ADEMAS SUSTITUIDOS, INDEPENDIENTEMENTE UNOS DE LOS OTROS, POR UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE HALOGENO, TRIFLUOROMETIL, UN RADICAL DE HIDROCARBONO ALIFATICO, HIDROXIDO, E HIDROXIDO QUE ESTE ESTERIFICADO POR UN ALCOHOL ALIFATICO O QUE ESTE ESTERIFICADO POR UN ACIDO CARBOXILICO ALIFATICO O ARALIFATICO; EN DONDE EL RADICAL DE HIDROCARBONO CICLOALIFATICO PUEDE ESTAR SUSTITUIDO POR UN RADICAL ALIFATICO. LOS COMPUESTOS SON UTILES COMO ANTAGONISTAS RECEPTORES SELECTIVOS DEL LTB-4 PARA EL TRATAMIENTO DE CONDICIONES O SINDROMES EN MAMIFEROS QUE SEANSENSIBLES AL ANTAGONISMO LTB-4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71410891A | 1991-06-11 | 1991-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2075672T3 true ES2075672T3 (es) | 1995-10-01 |
Family
ID=24868773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92810423T Expired - Lifetime ES2075672T3 (es) | 1991-06-11 | 1992-06-02 | Amidinocompuestos, su fabricacion y uso como medicamento. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0518819B1 (es) |
| JP (1) | JP3370998B2 (es) |
| KR (1) | KR100249068B1 (es) |
| AT (1) | ATE125791T1 (es) |
| AU (1) | AU653603B2 (es) |
| CA (1) | CA2070795A1 (es) |
| CZ (1) | CZ279630B6 (es) |
| DE (1) | DE69203797T2 (es) |
| DK (1) | DK0518819T3 (es) |
| ES (1) | ES2075672T3 (es) |
| FI (1) | FI922643A7 (es) |
| GR (1) | GR3017028T3 (es) |
| HU (1) | HU220226B (es) |
| IE (1) | IE67513B1 (es) |
| IL (1) | IL102105A (es) |
| MX (1) | MX9202749A (es) |
| NO (1) | NO178259C (es) |
| NZ (1) | NZ243079A (es) |
| PH (1) | PH30829A (es) |
| TW (1) | TW201298B (es) |
| ZA (1) | ZA924220B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
| US5488160A (en) * | 1991-06-11 | 1996-01-30 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and method of treatment |
| EP0625138B1 (de) * | 1992-02-05 | 1999-06-02 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Neue amidinderivate, ihre herstellung und verwendung als arzneimittel mit ltb4-antagonistischer wirkung |
| DE4219158A1 (de) * | 1992-06-11 | 1993-12-16 | Thomae Gmbh Dr K | Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| JP2736952B2 (ja) * | 1992-09-18 | 1998-04-08 | 小野薬品工業株式会社 | アミジノフェノール誘導体およびその誘導体を有効成分として含有する薬剤 |
| DE4234295A1 (de) * | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE4309285A1 (de) * | 1993-03-23 | 1994-09-29 | Boehringer Ingelheim Kg | Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung |
| DK0724435T3 (da) * | 1993-10-21 | 2002-11-25 | Searle & Co | Amidinoderivater, der er nyttige som nitrogenoxid-synthase-inhibitorer |
| CA2134192A1 (en) * | 1993-11-12 | 1995-05-13 | Michael L. Denney | 5, 6-bicyclic glycoprotein iib/iiia antagonists |
| DE4424713A1 (de) * | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe |
| ES2132535T3 (es) | 1994-09-20 | 1999-08-16 | Ono Pharmaceutical Co | Derivados de amidinofenol como inhibidores de proteasa. |
| CA2265996A1 (en) * | 1996-09-26 | 1998-04-02 | Roger Aki Fujimoto | Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity |
| GB9928511D0 (en) * | 1999-12-03 | 2000-02-02 | Secr Defence Brit | Orally administrable pharmaceutical product and method of fabrication therefor |
| WO2005027886A2 (en) * | 2003-09-17 | 2005-03-31 | Decode Genetics Ehf. | Methods of preventing or treating recurrence of myocardial infarction |
| US7851486B2 (en) | 2002-10-17 | 2010-12-14 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment |
| US7507531B2 (en) | 2002-10-17 | 2009-03-24 | Decode Genetics Chf. | Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction |
| US8158362B2 (en) | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
| PL1877379T3 (pl) * | 2005-04-13 | 2013-06-28 | Astex Therapeutics Ltd | Pochodne hydroksybenzamidu i ich wykorzystanie, jako inhibitorów hsp90 |
| WO2017095722A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| WO2017095725A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl sulfonamides as blt1 antagonists |
| WO2017095724A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl sulfonamides as blt1 antagonists |
| EP3383389B1 (en) | 2015-11-30 | 2021-04-28 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1243322A (en) * | 1984-01-23 | 1988-10-18 | Joshua Rokach | Antagonists of slow reacting substances of anaphylaxis |
| US4808604A (en) * | 1985-10-03 | 1989-02-28 | Ciba-Geigy Corporation | N-(substituted phenyl) tetrazol-5-yl carboxamides and anti-allergic use thereof |
| AU626033B2 (en) * | 1988-10-25 | 1992-07-23 | Government Of The United States Of America, As Represented By The Secretary Of The Army, The | Methods for the treatment and prophylaxis of pneumocystis carinii pneumonia and other diseases and compounds and formulations for use in said methods |
| EP0518818A3 (en) * | 1991-06-11 | 1993-04-28 | Ciba-Geigy Ag | Arylethers, their manufacture and use as medicament |
-
1992
- 1992-06-02 DK DK92810423.1T patent/DK0518819T3/da active
- 1992-06-02 AT AT92810423T patent/ATE125791T1/de not_active IP Right Cessation
- 1992-06-02 EP EP92810423A patent/EP0518819B1/en not_active Expired - Lifetime
- 1992-06-02 DE DE69203797T patent/DE69203797T2/de not_active Expired - Fee Related
- 1992-06-02 ES ES92810423T patent/ES2075672T3/es not_active Expired - Lifetime
- 1992-06-04 IL IL10210592A patent/IL102105A/en not_active IP Right Cessation
- 1992-06-05 AU AU18073/92A patent/AU653603B2/en not_active Ceased
- 1992-06-05 PH PH44466A patent/PH30829A/en unknown
- 1992-06-08 FI FI922643A patent/FI922643A7/fi unknown
- 1992-06-08 JP JP14733392A patent/JP3370998B2/ja not_active Expired - Fee Related
- 1992-06-09 MX MX9202749A patent/MX9202749A/es unknown
- 1992-06-09 NZ NZ243079A patent/NZ243079A/en not_active IP Right Cessation
- 1992-06-09 CA CA002070795A patent/CA2070795A1/en not_active Abandoned
- 1992-06-09 KR KR1019920009920A patent/KR100249068B1/ko not_active Expired - Fee Related
- 1992-06-10 NO NO922274A patent/NO178259C/no unknown
- 1992-06-10 ZA ZA924220A patent/ZA924220B/xx unknown
- 1992-06-10 HU HU9201938A patent/HU220226B/hu not_active IP Right Cessation
- 1992-06-11 TW TW081104576A patent/TW201298B/zh active
- 1992-06-11 CZ CS921780A patent/CZ279630B6/cs not_active IP Right Cessation
- 1992-07-01 IE IE921878A patent/IE67513B1/en not_active IP Right Cessation
-
1995
- 1995-08-03 GR GR950401946T patent/GR3017028T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO178259C (no) | 1996-02-21 |
| JP3370998B2 (ja) | 2003-01-27 |
| PH30829A (en) | 1997-10-17 |
| EP0518819A3 (en) | 1993-04-21 |
| HU220226B (hu) | 2001-11-28 |
| NO922274L (no) | 1992-12-14 |
| DK0518819T3 (da) | 1995-09-25 |
| EP0518819B1 (en) | 1995-08-02 |
| KR930000470A (ko) | 1993-01-15 |
| KR100249068B1 (ko) | 2000-03-15 |
| DE69203797D1 (de) | 1995-09-07 |
| TW201298B (es) | 1993-03-01 |
| MX9202749A (es) | 1992-12-01 |
| CZ279630B6 (cs) | 1995-05-17 |
| NO922274D0 (no) | 1992-06-10 |
| IL102105A (en) | 1996-10-31 |
| ATE125791T1 (de) | 1995-08-15 |
| AU1807392A (en) | 1992-12-17 |
| EP0518819A2 (en) | 1992-12-16 |
| NZ243079A (en) | 1994-11-25 |
| FI922643A7 (fi) | 1992-12-12 |
| GR3017028T3 (en) | 1995-11-30 |
| AU653603B2 (en) | 1994-10-06 |
| HUT62264A (en) | 1993-04-28 |
| CA2070795A1 (en) | 1992-12-12 |
| DE69203797T2 (de) | 1996-02-08 |
| IE921878A1 (en) | 1992-12-16 |
| HU9201938D0 (en) | 1992-08-28 |
| FI922643A0 (fi) | 1992-06-08 |
| ZA924220B (en) | 1993-02-24 |
| IL102105A0 (en) | 1993-01-14 |
| IE67513B1 (en) | 1996-04-03 |
| CZ178092A3 (en) | 1993-01-13 |
| NO178259B (no) | 1995-11-13 |
| JPH05239009A (ja) | 1993-09-17 |
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