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ES2072118T3 - Nuevos derivados de benzoato de etanolamina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de benzoato de etanolamina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2072118T3
ES2072118T3 ES92403073T ES92403073T ES2072118T3 ES 2072118 T3 ES2072118 T3 ES 2072118T3 ES 92403073 T ES92403073 T ES 92403073T ES 92403073 T ES92403073 T ES 92403073T ES 2072118 T3 ES2072118 T3 ES 2072118T3
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
compositions containing
new derivatives
preparation procedure
ethanolamine benzoate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92403073T
Other languages
English (en)
Inventor
Michel Wierzbicki
Pierre Hugon
Jacques Duhault
Michelle Boulanger
Francoise Lacour
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2072118T3 publication Critical patent/ES2072118T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NUEVOS DERIVADOS DE BENZOATO DE ETANOLAMINA, UTILIZABLES COMO MEDICAMENTOS Y QUE RESPONDEN A LA FORMULA: EN LA QUE R ES TAL COMO SE DEFINE EN LA DESCRIPCION, BAJO FORMAS RACEMICAS Y ENANTIOMERAS. ESTOS NUEVOS DERIVADOS Y SUS SALES FISIOLOGICAMENTE TOLERABLES PUEDEN SER UTILIZADOS EN TERAPIA, PARTICULARMENTE PARA EL TRATAMIENTO DEL SINDROME X, ASOCIANDO INTOLERANCIA A LA GLUCOSA, HIPERINSULINEMIA, DISLIPEMIA E HIPERTENSION, Y PARA EL TRATAMIENTO DE LA HIPERTENSION EN LOS SUJETOS INSULINORRESISTENTES O QUE TIENEN UNA O VARIAS ANOMALIAS METABOLICAS.
ES92403073T 1991-11-22 1992-11-16 Nuevos derivados de benzoato de etanolamina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2072118T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9114357A FR2684101B1 (fr) 1991-11-22 1991-11-22 Nouveaux derives de benzoate d'ethanolamine, leur procede de preparation et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number Publication Date
ES2072118T3 true ES2072118T3 (es) 1995-07-01

Family

ID=9419177

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92403073T Expired - Lifetime ES2072118T3 (es) 1991-11-22 1992-11-16 Nuevos derivados de benzoato de etanolamina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (13)

Country Link
US (1) US5266591A (es)
EP (1) EP0543713B1 (es)
JP (1) JPH0694447B2 (es)
AT (1) ATE118759T1 (es)
AU (1) AU649896B2 (es)
CA (1) CA2083475C (es)
DE (1) DE69201480T2 (es)
DK (1) DK0543713T3 (es)
ES (1) ES2072118T3 (es)
FR (1) FR2684101B1 (es)
GR (1) GR3015794T3 (es)
NZ (1) NZ245201A (es)
ZA (1) ZA928995B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2677647B1 (fr) * 1991-06-14 1993-08-20 Adir Nouveaux derives de benzoate d'ethanolamine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
AU7947594A (en) * 1993-10-27 1995-05-22 Merck Sharp & Dohme Limited Substituted amides as tachykinin antagonists
RU2153873C2 (ru) * 1994-08-09 2000-08-10 Кортендо АБ Применение кетоконазола и родственных веществ в лекарствах, предназначенных для лечения диабета типа ii
US7659256B2 (en) * 1999-06-14 2010-02-09 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US7674776B2 (en) 1999-06-14 2010-03-09 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US7553818B2 (en) * 1999-06-14 2009-06-30 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US7056890B2 (en) * 1999-06-14 2006-06-06 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US20080255093A1 (en) * 1999-06-14 2008-10-16 Tam Peter Y Compositions and methods for treating obesity and related disorders
US20080103179A1 (en) * 2006-10-27 2008-05-01 Tam Peter Y Combination Therapy
ES2542892T3 (es) * 1999-06-14 2015-08-12 Vivus, Inc. Terapia de combinación para el tratamiento de hipertensión asociada con la obesidad
US20090304789A1 (en) 2008-06-09 2009-12-10 Thomas Najarian Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders
US8580298B2 (en) 2008-06-09 2013-11-12 Vivus, Inc. Low dose topiramate/phentermine composition and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1175516A (en) * 1966-04-15 1969-12-23 Science Union & Cie New Phenyl-Aminopropane Derivatives and Preparations Containing them
DE2629752A1 (de) * 1976-07-02 1978-01-05 Boehringer Mannheim Gmbh Neue carbonsaeurederivate und verfahren zu ihrer herstellung
US4237165A (en) * 1976-06-04 1980-12-02 Science Union Et Cie Treatment of carbohydrate metabolism disorders

Also Published As

Publication number Publication date
CA2083475C (fr) 1998-09-08
DE69201480T2 (de) 1995-10-05
CA2083475A1 (fr) 1993-05-23
AU649896B2 (en) 1994-06-02
US5266591A (en) 1993-11-30
GR3015794T3 (en) 1995-07-31
EP0543713A1 (fr) 1993-05-26
NZ245201A (en) 1995-07-26
FR2684101A1 (fr) 1993-05-28
AU2854892A (en) 1993-05-27
DE69201480D1 (de) 1995-03-30
FR2684101B1 (fr) 1993-12-31
ATE118759T1 (de) 1995-03-15
DK0543713T3 (da) 1995-07-24
EP0543713B1 (fr) 1995-02-22
JPH0694447B2 (ja) 1994-11-24
ZA928995B (en) 1993-05-25
JPH05221943A (ja) 1993-08-31

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