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ES2071351T3 - Un procedimiento para la produccion de 6,12-dihidro-6-hidroxicannabidiol y el uso del mismo para la produccion de trans-delta-9-tetrahidrocannabinol. - Google Patents

Un procedimiento para la produccion de 6,12-dihidro-6-hidroxicannabidiol y el uso del mismo para la produccion de trans-delta-9-tetrahidrocannabinol.

Info

Publication number
ES2071351T3
ES2071351T3 ES92100258T ES92100258T ES2071351T3 ES 2071351 T3 ES2071351 T3 ES 2071351T3 ES 92100258 T ES92100258 T ES 92100258T ES 92100258 T ES92100258 T ES 92100258T ES 2071351 T3 ES2071351 T3 ES 2071351T3
Authority
ES
Spain
Prior art keywords
production
tetrahidrocannabinol
delta
same
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92100258T
Other languages
English (en)
Inventor
Peter Dr Stoss
Peter Merrath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MACK CHEM PHARM
Heinrich Mack Nachf GmbH and Co
Original Assignee
MACK CHEM PHARM
Heinrich Mack Nachf GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MACK CHEM PHARM, Heinrich Mack Nachf GmbH and Co filed Critical MACK CHEM PHARM
Application granted granted Critical
Publication of ES2071351T3 publication Critical patent/ES2071351T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE DESCRIBE UN METODO PARA LA PRODUCCION DE 6,12-DIHIDRO-6-HIDROXI-CANNABIDIOL QUE SE OBTIENE POR LA REACCION DE OLIVETOL Y CIS-P-MENT-2-ENO-1,8-DIOL Y LA REACCION DEL MISMO PARA PRODUCIR TRANS-DELTA-9-TETRAHIDROCANNABINOL.
ES92100258T 1991-01-09 1992-01-09 Un procedimiento para la produccion de 6,12-dihidro-6-hidroxicannabidiol y el uso del mismo para la produccion de trans-delta-9-tetrahidrocannabinol. Expired - Lifetime ES2071351T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4100441A DE4100441A1 (de) 1991-01-09 1991-01-09 Verfahren zur herstellung von 6,12-dihydro-6-hydroxy-cannabidiol und dessen verwendung zur herstellung von trans-delta-9-tetrahydrocannabinol

Publications (1)

Publication Number Publication Date
ES2071351T3 true ES2071351T3 (es) 1995-06-16

Family

ID=6422735

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92100258T Expired - Lifetime ES2071351T3 (es) 1991-01-09 1992-01-09 Un procedimiento para la produccion de 6,12-dihidro-6-hidroxicannabidiol y el uso del mismo para la produccion de trans-delta-9-tetrahidrocannabinol.

Country Status (7)

Country Link
US (1) US5227537A (es)
EP (1) EP0494665B1 (es)
JP (1) JP2637659B2 (es)
AT (1) ATE121066T1 (es)
DE (2) DE4100441A1 (es)
DK (1) DK0494665T3 (es)
ES (1) ES2071351T3 (es)

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WO2002026224A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
WO2002026728A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
DE10051427C1 (de) 2000-10-17 2002-06-13 Adam Mueller Verfahren zur Herstellung eines Tetrahydrocannabinol- und Cannabidiol-haltigen Extraktes aus Cannabis-Pflanzenmaterial sowie Cannabis-Extrakte
DE10106024B4 (de) * 2001-02-09 2004-10-14 Thc Pharm Gmbh Verfahren zur Herstellung von Dronabinol
AU2008200935B2 (en) * 2001-02-05 2010-02-04 Thc Pharm The Health Concept Gmbh Method for the Production of Dronabinol
GB0112748D0 (en) * 2001-05-25 2001-07-18 Johnson Matthey Plc Uncatalysed addition reactions
GB0112752D0 (en) * 2001-05-25 2001-07-18 Johnson Matthey Plc Synthesis of cannabinoids
US7109245B2 (en) * 2001-08-15 2006-09-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Vasoconstrictor cannabinoid analogs
WO2003080043A1 (en) * 2002-03-18 2003-10-02 Immugen Pharmaceuticals, Inc. Topical formulations of resorcinols and cannibinoids and methods of use
US7344736B2 (en) * 2002-08-14 2008-03-18 Gw Pharma Limited Extraction of pharmaceutically active components from plant materials
JP4657716B2 (ja) * 2002-08-14 2011-03-23 ジーダブリュー・ファーマ・リミテッド 植物材料からの薬学的に活性な成分の抽出の改良
CA2521920A1 (en) * 2003-04-10 2004-10-28 Mallinckrodt Inc. Olivetol-cyclodextrin complexes and regio-selective process for preparing delta 9-tetrahydrocannabinol
EP1633733B1 (en) * 2003-05-20 2011-01-26 The University of Tennessee Research Foundation Cannabinoid derivatives, methods of making, and use thereof
US20070287843A1 (en) * 2004-04-07 2007-12-13 Cabaj John E Methods and Intermediates for the Synthesis of Delta-9 Tetrahydrocannabinol
US7323576B2 (en) 2004-10-01 2008-01-29 Alphora Research Inc. Synthetic route to dronabinol
TWI436991B (zh) 2004-11-22 2014-05-11 Euro Celtique Sa 用於純化反-（-）-△９-四氫大麻酚與反-（＋）-△９-四氫大麻酚之方法
TWI366460B (en) 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
DE102005028937B4 (de) * 2005-06-22 2009-07-23 Bionorica Ag Verfahren zur Herstellung von Dronabinol
EP2578577A1 (en) * 2005-09-29 2013-04-10 Albany Molecular Research, Inc. Sulfonyl esters of tetrahydrocannabinol and derivatives thereof
US8323211B2 (en) * 2006-06-01 2012-12-04 Daniel Larkin Sexually transmitted infection sampling device
ES2995732T3 (en) 2014-07-21 2025-02-11 Pharmaceutical Productions Inc Solid dosage form composition for buccal or sublingual administration of cannabinoids
US10059683B2 (en) 2015-07-10 2018-08-28 Noramco, Inc. Process for the production of cannabidiol and delta-9-tetrahydrocannabinol
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
WO2018176055A2 (en) 2017-03-24 2018-09-27 Trait Biosciences, Inc. High level in vivo biosynthesis and isolation of water-soluble cannabinoids in plant systems
EP3730145A1 (en) 2017-07-11 2020-10-28 Trait Biosciences, Inc. Generation of water-soluble cannabinoid compounds in yeast and plant cell suspension cultures and compositions of matter
US10640482B2 (en) 2017-07-21 2020-05-05 University Of South Florida Synthesis of cannabinoids
WO2019147873A2 (en) 2018-01-24 2019-08-01 Trait Biosciences, Inc. Systems and methods for enhancing trichome formation and density in cannabis
EP3745884A1 (en) 2018-01-31 2020-12-09 Canopy Holdings, Llc Hemp powder
US20200138772A1 (en) 2018-07-09 2020-05-07 Volker Berl Stabilized formulations of cannabinoid compositions
WO2020031179A1 (en) 2018-08-06 2020-02-13 Beetlebung Pharma Ltd. Methods for synthesis of cannabinoid compounds
AU2019335372B2 (en) 2018-09-05 2024-12-12 Purisys Llc Cannabidiol compositions having modified cannabinoid profiles
US11040932B2 (en) 2018-10-10 2021-06-22 Treehouse Biotech, Inc. Synthesis of cannabigerol
WO2020099942A1 (en) * 2018-11-14 2020-05-22 Embio Limited Process and compounds for preparation of cannabinoids
WO2020230145A1 (en) 2019-05-16 2020-11-19 Technion Research & Development Foundation Limited Cannabinoids and uses thereof
CN111943813B (zh) 2019-05-17 2023-04-14 上海特化医药科技有限公司 大麻二酚类化合物的制备方法
CA3148950A1 (en) 2019-07-30 2021-02-04 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (A.R.O.), Volcani Center Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
CN113087599A (zh) * 2020-01-08 2021-07-09 成都百裕制药股份有限公司 大麻二酚衍生物及其制备方法和在医药上的应用
CN113087743B (zh) 2020-01-08 2023-04-28 成都百裕制药股份有限公司 四氢大麻酚衍生物及其制备方法和在医药上的应用
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol
US20230414639A1 (en) * 2020-11-15 2023-12-28 Technion Research And Development Foundation Limited Cannabinoids, pharmaceutical compositions comprising same and uses thereof
US11242328B1 (en) * 2021-02-25 2022-02-08 Acid Neutral Alkaline Laboratory Heterogeneous catalyst and method for preparation of aromatic tricyclic pyrans
US12029719B2 (en) 2021-04-16 2024-07-09 Allen Morgan Compounds comprising cannabinoids and other natural ingredients for alieving premenstrual, menstrual and menopausal symptoms
US11352337B1 (en) * 2021-06-02 2022-06-07 Acid Neutral Alkaline Laboratory Zeolite catalyst and method for preparation of aromatic tricyclic pyrans
EP4124336B1 (en) 2021-07-30 2023-10-25 Cannamedical Pharma GmbH Transmucosal patch comprising a cannabinoid and/or an opioid
US12103950B2 (en) 2022-01-27 2024-10-01 University Of Connecticut Transgenic plants that overexpress a R2R3-MYB transcription factor gene and methods for producing the same
WO2024160792A1 (en) 2023-01-30 2024-08-08 Cannamedical Pharma Gmbh Improved transmucosal patch comprising a cannabinoid and/or an opioid
WO2024231543A1 (en) 2023-05-10 2024-11-14 Gb Lab Cannabinoid derivatives for treating autism spectrum disorder

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HU194858B (en) * 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
US4758597A (en) * 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives

Also Published As

Publication number Publication date
EP0494665A1 (en) 1992-07-15
JPH06340650A (ja) 1994-12-13
US5227537A (en) 1993-07-13
DE4100441A1 (de) 1992-07-16
EP0494665B1 (en) 1995-04-12
DK0494665T3 (da) 1995-08-28
DE69201959D1 (de) 1995-05-18
DE69201959T2 (de) 1995-08-24
JP2637659B2 (ja) 1997-08-06
ATE121066T1 (de) 1995-04-15

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