ES2065269B1 - 6- (4- (FENILBUTOXI) HEXILAMINOMETIL-4-HIDROXI-A1, A3-BENCENODIMETANOL. PROCEDURE FOR THE OBTAINING OF THE SAME AND NEW INTERMEDIATES USED IN ITS PREPARATION. - Google Patents
6- (4- (FENILBUTOXI) HEXILAMINOMETIL-4-HIDROXI-A1, A3-BENCENODIMETANOL. PROCEDURE FOR THE OBTAINING OF THE SAME AND NEW INTERMEDIATES USED IN ITS PREPARATION.Info
- Publication number
- ES2065269B1 ES2065269B1 ES9300996A ES9300996A ES2065269B1 ES 2065269 B1 ES2065269 B1 ES 2065269B1 ES 9300996 A ES9300996 A ES 9300996A ES 9300996 A ES9300996 A ES 9300996A ES 2065269 B1 ES2065269 B1 ES 2065269B1
- Authority
- ES
- Spain
- Prior art keywords
- fenilbutoxi
- procedure
- obtaining
- hexilaminometil
- bencenodimetanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000543 intermediate Substances 0.000 title 1
- XMUZQOKACOLCSS-UHFFFAOYSA-N [2-(hydroxymethyl)phenyl]methanol Chemical compound OCC1=CC=CC=C1CO XMUZQOKACOLCSS-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 108700001623 hexadecaisoleucinomycin Proteins 0.000 abstract 1
- CBCIHIVRDWLAME-UHFFFAOYSA-N hexanitrodiphenylamine Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O CBCIHIVRDWLAME-UHFFFAOYSA-N 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000004904 shortening Methods 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
EL OBJETO DE LA INVENCION ES UN NUEVO PROCEDIMIENTO PARA LA OBTENCION DE 6-4-(FENILBUTOXI)-HEXILAMINOMETIL-4-HIDROXI, BENCENO -DIMETANOL DE FORMULA (I). TAL PROCEDIMIENTO CONSISTE EN LA HIDROGENACION DEL NUEVO INTERMEDIO 5-(6-(4-(FENILBUTOXI)HEXIL)BENCILAMINOACETIL-SALICILALDEHIDO DE FORMULA (XIV), QUE ES OBTENIDO A SU VEZ A PARTIR DE LA CONDENSACION ENTRE 5-BROMOACETIL-SALICILALDEHIDO Y 6-(4-(FENILBUTOXI))HEXILBENCILAMINA. LA TRANSFORMACION DE (XIV) EN (I) SE REALIZA EN UN SOLO PASO Y SIN LA APRECIACION DE REACCIONES LATERALES, ACORTANDOSE DE FORMA SUSTANCIAL LOS PROCEDIMIENTOS SINTETICOS PUBLICADOS HASTA LA FECHA EN LA LITERATURA.THE OBJECT OF THE INVENTION IS A NEW PROCEDURE FOR OBTAINING 6-4- (FENYLBUTOXI) -HEXYLAMINOMETHYL-4-HYDROXY, BENZENE-DIMETHANOL OF FORMULA (I). SUCH PROCEDURE CONSISTS IN THE HYDROGENATION OF THE NEW INTERMEDIATE 5- (6- (4- (FENILBUTOXI) HEXIL) BENCILAMINOACETIL-SALICILALDEHIDO DE FORMULA (XIV), WHICH IS OBTAINED IN ITS TIME FROM THE CONDENSATION BETWEEN 5-BROMOACETIDE-SALT. - (4- (FENILBUTOXI)) HEXYLBENCILAMINE, THE TRANSFORMATION OF (XIV) IN (I) IS PERFORMED IN A SINGLE STEP AND WITHOUT THE APPRECIATION OF LATERAL REACTIONS, SUBSTANTIALLY SHORTENING THE SYNTHETIC PROCEDURES PUBLISHED TO THE DATE ON LIT.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9300996A ES2065269B1 (en) | 1993-05-11 | 1993-05-11 | 6- (4- (FENILBUTOXI) HEXILAMINOMETIL-4-HIDROXI-A1, A3-BENCENODIMETANOL. PROCEDURE FOR THE OBTAINING OF THE SAME AND NEW INTERMEDIATES USED IN ITS PREPARATION. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9300996A ES2065269B1 (en) | 1993-05-11 | 1993-05-11 | 6- (4- (FENILBUTOXI) HEXILAMINOMETIL-4-HIDROXI-A1, A3-BENCENODIMETANOL. PROCEDURE FOR THE OBTAINING OF THE SAME AND NEW INTERMEDIATES USED IN ITS PREPARATION. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2065269A1 ES2065269A1 (en) | 1995-02-01 |
| ES2065269B1 true ES2065269B1 (en) | 1995-10-01 |
Family
ID=8281755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9300996A Expired - Fee Related ES2065269B1 (en) | 1993-05-11 | 1993-05-11 | 6- (4- (FENILBUTOXI) HEXILAMINOMETIL-4-HIDROXI-A1, A3-BENCENODIMETANOL. PROCEDURE FOR THE OBTAINING OF THE SAME AND NEW INTERMEDIATES USED IN ITS PREPARATION. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2065269B1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012032546A2 (en) | 2010-09-08 | 2012-03-15 | Cadila Healthcare Limited | Process for the preparation of salmeterol and its intermediates |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2142771B1 (en) * | 1998-09-28 | 2001-01-01 | Vita Invest Sa | NEW DERIVATIVES OF 6- (4-PHENYL-BUTOXI) HEXYLAMINE AND PROCEDURE FOR OBTAINING SALMETEROL. |
| ES2288114B1 (en) * | 2006-04-26 | 2008-12-01 | Quimica Sintetica S.A. | NEW SYNTHESIS PROCEDURE OF (6- (4-PHENYLBUTOXY) HEXIL) N-SUBSTITUTED AMINES AND ITS USE IN THE SYNTHESIS OF SALMETEROL XINAFOATO. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZW6584A1 (en) * | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
| PT95542B (en) * | 1989-10-10 | 1999-09-30 | Glaxo Group Ltd | PROCESS FOR THE PREPARATION OF PHENETHANOLAMINE DERIVATIVES |
-
1993
- 1993-05-11 ES ES9300996A patent/ES2065269B1/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012032546A2 (en) | 2010-09-08 | 2012-03-15 | Cadila Healthcare Limited | Process for the preparation of salmeterol and its intermediates |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2065269A1 (en) | 1995-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20020401 |