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ES2064228B1 - Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion. - Google Patents

Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.

Info

Publication number
ES2064228B1
ES2064228B1 ES09202203A ES9202203A ES2064228B1 ES 2064228 B1 ES2064228 B1 ES 2064228B1 ES 09202203 A ES09202203 A ES 09202203A ES 9202203 A ES9202203 A ES 9202203A ES 2064228 B1 ES2064228 B1 ES 2064228B1
Authority
ES
Spain
Prior art keywords
hydrogen
contain
new
tetralones
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09202203A
Other languages
English (en)
Other versions
ES2064228A1 (es
Inventor
Carmen Almansa
Concepcion Gonzalez
M Carmen Torres
Elena Carceller
Javier Bartroli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES09202203A priority Critical patent/ES2064228B1/es
Priority to US08/049,865 priority patent/US5356915A/en
Priority to MX9302429A priority patent/MX9302429A/es
Priority to EP93107289A priority patent/EP0600147A1/en
Priority to JP5144239A priority patent/JPH07291932A/ja
Priority to CA002097045A priority patent/CA2097045A1/en
Priority to KR1019930020516A priority patent/KR940009154A/ko
Publication of ES2064228A1 publication Critical patent/ES2064228A1/es
Application granted granted Critical
Publication of ES2064228B1 publication Critical patent/ES2064228B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/22—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

NUEVAS TETRALONAS DE FORMULA GENERAL I, UTILES COMO REGULADORES DE LA CONTRACCION DE LA MUSCULATURA LISA EN LOS SISTEMAS CARDIOVASCULAR, BRONCOPULMONAR Y DIGESTIVO, EN DONDE RBS1 SC Y RBS2 SC SIGNIFICAN HIDROGENO, CIANO, NITRO, HALOGENO, HIDROXI O CSI1-4 SC ALCOXI; RBS3 SC Y RBS4 SC REPRESENTAN CSI1-4 SC ALQUILO, O BIEN RBS3 SC Y RBS4 SC JUNTOS FORMAN UNA CADENA DE CSI2-5 SC POLIMETILENO; RBS5 SC ES HIDROGENO EN CUYO CASO RBS6 SC ES HIDROGENO, HIDROXILO O CSI1-4 SC ALCOXI, O BIEN RBS5 SC ES HIDROXILO Y ENTONCES RBS6 SC ES HIDROGENO, O BIEN RBS5 SC-RBS6 SC JUNTO CON LOS CARBONOS DEL ANILLO FORMAN UN DOBLE ENLACE O UNA AGRUPACION DE TIPO EPOXIDO; RBS7 SC ES UN GRUPO 2-, 3- O 4-PIRIDILO QUE PUEDE ESTAR OPCIONALMENTE SUSTITUIDO POR UN GRUPO HIDROXILO O BIEN CUYO ATOMO DE NITROGENO PUEDE ESTAR OPCIONALMENTE EN FORMA DE N-OXIDO; Y SUS SALES LA PRESENTE INVENCION TAMBIEN DESCRIBE PROCEDIMIENTOS PARA SU OBTENCION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES09202203A 1992-10-19 1992-10-19 Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion. Expired - Fee Related ES2064228B1 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES09202203A ES2064228B1 (es) 1992-10-19 1992-10-19 Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.
US08/049,865 US5356915A (en) 1992-10-19 1993-04-20 Tetralones with pharmacological activity, compositions containing them
MX9302429A MX9302429A (es) 1992-10-19 1993-04-26 Nuevas tetralonas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
EP93107289A EP0600147A1 (en) 1992-10-19 1993-05-05 Tetralones with pharmacological activity, compositions containing them and process for their preparation
JP5144239A JPH07291932A (ja) 1992-10-19 1993-05-24 薬理活性を有する新規テトラロン類、それらを含有した組成物及びそれらの製造方法
CA002097045A CA2097045A1 (en) 1992-10-19 1993-05-26 Tetralones with pharmacological activity, compositions containing them and process for their preparation
KR1019930020516A KR940009154A (ko) 1992-10-19 1993-10-05 약리학적 활성을 갖는 테트랄론, 이를 함유하는 조성물 및 이의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09202203A ES2064228B1 (es) 1992-10-19 1992-10-19 Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.

Publications (2)

Publication Number Publication Date
ES2064228A1 ES2064228A1 (es) 1995-01-16
ES2064228B1 true ES2064228B1 (es) 1995-09-01

Family

ID=8278646

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09202203A Expired - Fee Related ES2064228B1 (es) 1992-10-19 1992-10-19 Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.

Country Status (7)

Country Link
US (1) US5356915A (es)
EP (1) EP0600147A1 (es)
JP (1) JPH07291932A (es)
KR (1) KR940009154A (es)
CA (1) CA2097045A1 (es)
ES (1) ES2064228B1 (es)
MX (1) MX9302429A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
JP4976134B2 (ja) * 2003-10-01 2012-07-18 アドラー コーポレーション スピロ環複素環誘導体及びそれらを使用する方法
US20060029530A1 (en) * 2004-08-09 2006-02-09 Gloria Gremillion Perfect tooth brush sterilize
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
JP2010503669A (ja) * 2006-09-12 2010-02-04 アドラー コーポレーション 認知機能の強化のためのｎ含有スピロ化合物の使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1493848A (en) * 1975-07-24 1977-11-30 Beecham Group Ltd Aryltetralins
GB8414987D0 (en) * 1984-06-12 1984-07-18 Beecham Group Plc Active compounds
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
DE3837809A1 (de) * 1988-11-08 1990-05-10 Merck Patent Gmbh Tetralinderivate
EP0489300A3 (en) * 1990-12-05 1993-03-17 J. Uriach & Cia. S.A. New tetralones with pharmacological activity
CA2074864A1 (en) * 1991-07-30 1993-01-31 Carmen Almansa Tetralones with pharmacological activity

Also Published As

Publication number Publication date
ES2064228A1 (es) 1995-01-16
US5356915A (en) 1994-10-18
KR940009154A (ko) 1994-05-20
CA2097045A1 (en) 1994-04-20
MX9302429A (es) 1994-04-29
JPH07291932A (ja) 1995-11-07
EP0600147A1 (en) 1994-06-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971020