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ES2063837T3 - NEW PROCEDURE FOR THE SYNTHESIS OF LEVODOPA. - Google Patents

NEW PROCEDURE FOR THE SYNTHESIS OF LEVODOPA.

Info

Publication number
ES2063837T3
ES2063837T3 ES89830316T ES89830316T ES2063837T3 ES 2063837 T3 ES2063837 T3 ES 2063837T3 ES 89830316 T ES89830316 T ES 89830316T ES 89830316 T ES89830316 T ES 89830316T ES 2063837 T3 ES2063837 T3 ES 2063837T3
Authority
ES
Spain
Prior art keywords
levodopa
synthesis
amino
new procedure
propionitrilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89830316T
Other languages
Spanish (es)
Inventor
Vincenzo Cannata
Giancarlo Tamerlani
Mauro Morotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Original Assignee
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST) filed Critical Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Application granted granted Critical
Publication of ES2063837T3 publication Critical patent/ES2063837T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NUEVOS PROCESOS PARA LA SINTESIS DE LEVODOPA, ACIDO L-(-)-2-AMINO-3-(3,4-DIHIDROXIFENIL) PROPIONICO, MEDICAMENTO UTILIZADO EN EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON. EL PROCESO CONSISTE EN RESOLVER CON ACIDO D-CANFORSULFONICO, O CON UNA DE SUS SALES EL D,L-2-AMINO-3-(3,4-DIMETOXIFENIL) PROPIONITRILO, OBTENIDO A PARTIR DE 3,4-DIMETOXIFENILACETALDEHIDO, Y EN LA SECUENCIA HIDROLISIS Y METILACION, POR MEDIO DE DISOLUCIONES CONCENTRADAS DE ACIDOS HALOIDEOS, DEL D-2-AMINO-3-(3,4-DIMETOXIFENIL PROPIONITRILO Y DE SUS SALES.NEW PROCESSES FOR THE SYNTHESIS OF LEVODOPA, ACID L - (-) - 2-AMINO-3- (3,4-DIHIDROXIFENIL) PROPIONICO, A MEDICINE USED IN THE TREATMENT OF PARKINSON'S DISEASE. THE PROCESS CONSISTS OF RESOLVING WITH D-CANPHORSULPHONIC ACID, OR WITH ONE OF ITS SALTS, D, L-2-AMINO-3- (3,4-DIMETOXIFENIL) PROPIONITRILO, OBTAINED FROM 3,4-DIMETOXIFENILACETALDEHIDO, AND IN THE HYDROLYSIS AND METHYLATION SEQUENCE, BY CONCENTRATED DISSOLUTIONS OF HALOID ACIDS, D-2-AMINO-3- (3,4-DIMETOXIFENIL PROPIONITRILO AND ITS SALTS.

ES89830316T 1988-07-12 1989-07-07 NEW PROCEDURE FOR THE SYNTHESIS OF LEVODOPA. Expired - Lifetime ES2063837T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821322A IT1226902B (en) 1988-07-12 1988-07-12 LEVODOPA SYNTHESIS PROCESS

Publications (1)

Publication Number Publication Date
ES2063837T3 true ES2063837T3 (en) 1995-01-16

Family

ID=11180092

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89830316T Expired - Lifetime ES2063837T3 (en) 1988-07-12 1989-07-07 NEW PROCEDURE FOR THE SYNTHESIS OF LEVODOPA.

Country Status (23)

Country Link
US (1) US4962223A (en)
EP (1) EP0357565B1 (en)
JP (1) JP2507069B2 (en)
KR (1) KR960004185B1 (en)
AR (1) AR248267A1 (en)
AT (1) ATE111439T1 (en)
AU (1) AU615083B2 (en)
CA (1) CA1338672C (en)
DD (1) DD284674A5 (en)
DE (1) DE68918207T2 (en)
DK (1) DK172106B1 (en)
ES (1) ES2063837T3 (en)
FI (1) FI101534B1 (en)
HU (1) HU203318B (en)
IE (1) IE65956B1 (en)
IL (1) IL90844A0 (en)
IT (1) IT1226902B (en)
NO (1) NO174293C (en)
NZ (1) NZ229910A (en)
PL (1) PL160103B1 (en)
PT (1) PT91144B (en)
YU (1) YU47907B (en)
ZA (1) ZA895255B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459145A (en) * 1988-01-19 1995-10-17 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
IT1226903B (en) * 1988-07-12 1991-02-21 Mini Ricerca Scient Tecnolog PROCESS FOR THE SYNTHESIS OF OPTICALLY ACTIVE AMINO ACIDS
US5395935A (en) * 1992-05-08 1995-03-07 Pfizer Inc. Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents
DE19502967A1 (en) * 1995-01-31 1996-08-01 Basf Ag Process for the resolution of 2-aryl-2-omega-alkylaminoalkanenitriles
JP3634207B2 (en) * 1999-09-14 2005-03-30 独立行政法人科学技術振興機構 Process for producing optically active α-amino nitrile and α-amino acids
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
CA2501345A1 (en) * 2002-10-11 2004-04-22 Depomed Development, Ltd. Gastro-retentive levodopa delivery form
DE10261807A1 (en) * 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterated catecholamine derivatives and medicinal products containing these compounds
WO2004069146A2 (en) * 2003-02-07 2004-08-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem L-dopa amide derivatives and uses thereof
BRPI0708071A8 (en) 2006-02-17 2017-12-26 Birds Pharma Gmbh Berolina Innovative Res & Development Services DEUTERATED CATECHOLAMINE DERIVATIVES AND DRUGS INCLUDING SAID COMPOUNDS
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
PT3116475T (en) 2014-03-13 2020-12-15 Neuroderm Ltd Dopa decarboxylase inhibitor compositions
MX2021003730A (en) 2018-09-28 2021-06-18 Univ Griffith Agents and methods for modulating pathogen activity.
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US12161612B2 (en) 2023-04-14 2024-12-10 Neuroderm, Ltd. Methods and compositions for reducing symptoms of Parkinson's disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA504449A (en) * 1954-07-20 C. Britton Edgar Alpha-amino-beta-alkoxy-butyronitriles and method of making same
NL299155A (en) * 1962-10-11
US3845076A (en) * 1971-04-20 1974-10-29 Sagami Chem Res Method of preparing aldehydes
JPS4920305A (en) * 1972-06-21 1974-02-22
HU165026B (en) * 1972-08-11 1974-06-28
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
YU93877A (en) * 1977-04-08 1982-06-30 Krka Process for the resolution of racemic alpha-aminonitrils
IL59048A (en) * 1979-12-27 1984-01-31 Plantex Ltd Process for the preparation of alpha-amino-3-phenyl-propionitriles and novel benzylidene amino acetonitriles as intermediates therefor
DE3002543A1 (en) * 1980-01-25 1981-07-30 Basf Ag, 6700 Ludwigshafen 4-TERT.-BUTOXYPHENYLGLYCINNITRILE AND METHOD FOR PRODUCING D - (-) - AND L - (+) - 4-HYDROXYPHENYLGLYCIN
JPS56115749A (en) * 1980-02-18 1981-09-11 Sagami Chem Res Center Dopa derivative
JPS61275253A (en) * 1985-05-30 1986-12-05 Nippon Kayaku Co Ltd Production of 3-(3,4-dihydroxyphenyl)-2-methylalanine
FR2614626B1 (en) * 1987-04-30 1989-07-21 Ranoux Claude CONTAINER FOR FERTILIZATION OF OVOCYTES AND REPLACEMENT OF EMBRYOS IN HUMANS AND ANIMALS

Also Published As

Publication number Publication date
DK342489A (en) 1990-01-13
YU139989A (en) 1990-12-31
EP0357565A2 (en) 1990-03-07
EP0357565A3 (en) 1991-09-25
YU47907B (en) 1996-05-20
JPH02231457A (en) 1990-09-13
DE68918207T2 (en) 1995-05-11
NO892861L (en) 1990-01-15
CA1338672C (en) 1996-10-22
NO892861D0 (en) 1989-07-11
KR960004185B1 (en) 1996-03-27
AR248267A1 (en) 1995-07-12
IT1226902B (en) 1991-02-21
ZA895255B (en) 1990-04-25
KR900001641A (en) 1990-02-27
IE65956B1 (en) 1995-11-29
IE892227L (en) 1990-01-12
PT91144B (en) 1995-01-31
FI893368A0 (en) 1989-07-11
IT8821322A0 (en) 1988-07-12
JP2507069B2 (en) 1996-06-12
AU3805789A (en) 1990-01-25
FI893368L (en) 1990-01-13
HU203318B (en) 1991-07-29
NO174293C (en) 1994-04-13
FI101534B (en) 1998-07-15
FI101534B1 (en) 1998-07-15
PT91144A (en) 1990-02-08
EP0357565B1 (en) 1994-09-14
DE68918207D1 (en) 1994-10-20
DD284674A5 (en) 1990-11-21
IL90844A0 (en) 1990-02-09
NO174293B (en) 1994-01-03
HUT51596A (en) 1990-05-28
DK342489D0 (en) 1989-07-11
DK172106B1 (en) 1997-10-27
PL160103B1 (en) 1993-02-26
NZ229910A (en) 1991-04-26
US4962223A (en) 1990-10-09
AU615083B2 (en) 1991-09-19
ATE111439T1 (en) 1994-09-15

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