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ES2062941B1 - Nuevos derivados de azol activos por via oral. - Google Patents

Nuevos derivados de azol activos por via oral.

Info

Publication number
ES2062941B1
ES2062941B1 ES09300537A ES9300537A ES2062941B1 ES 2062941 B1 ES2062941 B1 ES 2062941B1 ES 09300537 A ES09300537 A ES 09300537A ES 9300537 A ES9300537 A ES 9300537A ES 2062941 B1 ES2062941 B1 ES 2062941B1
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
azol
hydrogen
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09300537A
Other languages
English (en)
Other versions
ES2062941A1 (es
Inventor
Javier Bartroli
Manuel Anguita
Enric Turmo
Elena Carceller
Carmen Almansa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09300537A priority Critical patent/ES2062941B1/es
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to AT94104007T priority patent/ATE171175T1/de
Priority to CA002129455A priority patent/CA2129455C/en
Priority to EP94104007A priority patent/EP0617031B1/en
Priority to ES94104007T priority patent/ES2124332T3/es
Priority to US08/213,208 priority patent/US5478826A/en
Priority to JP06993594A priority patent/JP3790276B2/ja
Priority to DK94104007T priority patent/DK0617031T3/da
Priority to DE69413281T priority patent/DE69413281T2/de
Publication of ES2062941A1 publication Critical patent/ES2062941A1/es
Application granted granted Critical
Publication of ES2062941B1 publication Critical patent/ES2062941B1/es
Priority to US08/542,680 priority patent/US5646294A/en
Priority to US08/839,980 priority patent/US5760245A/en
Priority to JP2005364733A priority patent/JP4652223B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPUESTOS DE FORMULA 1, EN FORMA DE RACEMICOS O EN FORMA DE SU ENANTIOMEROS BIOLOGICAMENTE ACTIVOS PUROS (R,R), Y SUS SALES Y SOLVATOS, EN DONDE X ES CH O N; AR ES UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO POR HALOGENO O TRIFLUORMETILO; RSI3 SC ES LA O JUNTO CON RSI1 SC FORMA UN ANILLO DE SEIS MIEMBROS DE FORMULA III, DONDE B ES O O OH; RSI1 SC JUNTO CON RSI3 SC FORMA EL ANILLO III O BIEN ES CN, COSI2 SCH O CHSI2 SCY, SIENDO Y UN GRUPO HIDROXILO, ETER, ESTER, AMINO O CARBAMATO; RSI2 SC ES UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO, NAFTILO O UN HETEROCICLO; Y P ES 0 O 1. DICHOS COMPUESTOS SON UTILES COMO ANTIFUNGICOS. LA PRESENTE INVENCION DESCRIBE TAMBIEN PROCEDIMIENTOS PARA SU OBTENCION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES09300537A 1993-03-15 1993-03-15 Nuevos derivados de azol activos por via oral. Expired - Fee Related ES2062941B1 (es)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ES09300537A ES2062941B1 (es) 1993-03-15 1993-03-15 Nuevos derivados de azol activos por via oral.
DE69413281T DE69413281T2 (de) 1993-03-15 1994-03-15 Oral aktive Azolderivate
EP94104007A EP0617031B1 (en) 1993-03-15 1994-03-15 Orally active azole derivates
ES94104007T ES2124332T3 (es) 1993-03-15 1994-03-15 Derivados de azol activos por via oral.
US08/213,208 US5478826A (en) 1993-03-15 1994-03-15 Orally active azole derivatives
JP06993594A JP3790276B2 (ja) 1993-03-15 1994-03-15 新規な経口活性を有するアゾール誘導体
AT94104007T ATE171175T1 (de) 1993-03-15 1994-03-15 Oral aktive azolderivate
CA002129455A CA2129455C (en) 1993-03-15 1994-03-15 Orally active azole derivatives
DK94104007T DK0617031T3 (da) 1993-03-15 1994-03-15 Oralt aktive azolderivater
US08/542,680 US5646294A (en) 1993-03-15 1995-10-13 Orally active azole derivatives
US08/839,980 US5760245A (en) 1993-03-15 1997-04-24 Homochiral intermediates for preparation of orally active azole derivatives
JP2005364733A JP4652223B2 (ja) 1993-03-15 2005-12-19 新規な経口活性を有するアゾール誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09300537A ES2062941B1 (es) 1993-03-15 1993-03-15 Nuevos derivados de azol activos por via oral.

Publications (2)

Publication Number Publication Date
ES2062941A1 ES2062941A1 (es) 1994-12-16
ES2062941B1 true ES2062941B1 (es) 1995-10-01

Family

ID=8281134

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09300537A Expired - Fee Related ES2062941B1 (es) 1993-03-15 1993-03-15 Nuevos derivados de azol activos por via oral.
ES94104007T Expired - Lifetime ES2124332T3 (es) 1993-03-15 1994-03-15 Derivados de azol activos por via oral.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES94104007T Expired - Lifetime ES2124332T3 (es) 1993-03-15 1994-03-15 Derivados de azol activos por via oral.

Country Status (8)

Country Link
US (3) US5478826A (es)
EP (1) EP0617031B1 (es)
JP (2) JP3790276B2 (es)
AT (1) ATE171175T1 (es)
CA (1) CA2129455C (es)
DE (1) DE69413281T2 (es)
DK (1) DK0617031T3 (es)
ES (2) ES2062941B1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10507205A (ja) * 1995-08-02 1998-07-14 ホータ．ウリアッヒ イ シイア．エセ．アー． 抗真菌活性を有する新規カルボンアミド
ES2112774B1 (es) * 1995-10-20 1999-05-16 Uriach & Cia Sa J Nuevos derivados azolicos con actividad antifungica.
US6696426B2 (en) 2000-08-22 2004-02-24 Pharmacia Corporation Preservative free ophthalmic oxazolidinone antibiotic drug delivery systems
PE20020300A1 (es) * 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
AU2002321068B2 (en) * 2001-06-26 2007-11-15 Basilea Pharmaceutica Ag Intermediate halophenyl derivatives and their use in a process for preparing azole derivatives
KR100572996B1 (ko) * 2003-08-12 2006-04-25 한국화학연구원 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법
US20080044326A1 (en) * 2006-07-04 2008-02-21 Esencia Co., Ltd. Sterilizer for baby products
CN101768126B (zh) * 2009-12-10 2012-05-02 中国人民解放军第二军医大学 一种三氮唑类抗真菌化合物及其盐类
CN104292214B (zh) * 2014-09-24 2017-04-05 南京华威医药科技开发有限公司 艾氟康唑及其中间体的合成方法
CN105801500B (zh) * 2014-12-31 2018-08-24 四川科伦药物研究院有限公司 拆分艾沙康唑中间化合物消旋体的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
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EP0046633A1 (en) * 1980-08-22 1982-03-03 Imperial Chemical Industries Plc Heterocyclic compounds useful as pesticides and processes for making them
CA1162540A (en) * 1980-12-24 1984-02-21 Ikutaro Saji Imidazolylpropanol compounds and their acid addition salts, and production and use thereof
JPS5862163A (ja) * 1981-10-09 1983-04-13 Sumitomo Chem Co Ltd イミダゾリルカルボン酸誘導体
US4482558A (en) * 1982-06-18 1984-11-13 Pfizer Inc. Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydroxyprop-1-yl)-1H-1,2,4-triazoles
ZA837220B (en) * 1982-09-30 1984-08-29 Pfizer Triazole antifungal agents
DE3307218A1 (de) * 1983-03-02 1984-09-06 Bayer Ag, 5090 Leverkusen Substituierte diazolylalkyl-carbinole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
GB8332788D0 (en) * 1983-12-08 1984-01-18 Ici Plc Antifungal triazole compound
US4758262A (en) * 1985-02-08 1988-07-19 E. I. Du Pont De Nemours And Company Herbicidal propylene oxide derivatives
NO171272C (no) * 1988-03-04 1993-02-17 Sankyo Co Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,4-triazolforbindelser
EP0352352B1 (en) * 1988-07-28 1991-10-16 J. URIACH &amp; CIA. S.A. 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
CA2031892C (en) * 1989-12-25 2000-08-01 Minoru Tokizawa Triazole derivatives
TW211006B (es) * 1990-08-24 1993-08-11 Mochida Pharm Co Ltd
ES2024332A6 (es) * 1990-10-08 1992-02-16 Uriach & Cia Sa J Procedimiento para la obtencion de nuevas sulfonamidas.
GB9107055D0 (en) * 1991-04-04 1991-05-22 Pfizer Ltd Triazole antifungal agents
KR920019763A (ko) * 1991-04-26 1992-11-19 모리다 가즈라 아졸 화합물, 그의 제조방법 및 용도
EP0548553A1 (en) * 1991-11-25 1993-06-30 Takeda Chemical Industries, Ltd. Optically active azole compounds, their production and use
JP3471831B2 (ja) * 1991-12-09 2003-12-02 富山化学工業株式会社 新規なトリアゾール誘導体およびその塩

Also Published As

Publication number Publication date
EP0617031B1 (en) 1998-09-16
ATE171175T1 (de) 1998-10-15
US5760245A (en) 1998-06-02
DK0617031T3 (da) 1999-06-14
DE69413281D1 (de) 1998-10-22
US5478826A (en) 1995-12-26
ES2124332T3 (es) 1999-02-01
US5646294A (en) 1997-07-08
EP0617031A1 (en) 1994-09-28
DE69413281T2 (de) 1999-05-06
JPH072788A (ja) 1995-01-06
ES2062941A1 (es) 1994-12-16
CA2129455C (en) 2005-01-25
JP2006124397A (ja) 2006-05-18
JP4652223B2 (ja) 2011-03-16
CA2129455A1 (en) 1994-09-16
JP3790276B2 (ja) 2006-06-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010604