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ES2059679T3 - Derivados de carbapenem. - Google Patents

Derivados de carbapenem.

Info

Publication number
ES2059679T3
ES2059679T3 ES89120631T ES89120631T ES2059679T3 ES 2059679 T3 ES2059679 T3 ES 2059679T3 ES 89120631 T ES89120631 T ES 89120631T ES 89120631 T ES89120631 T ES 89120631T ES 2059679 T3 ES2059679 T3 ES 2059679T3
Authority
ES
Spain
Prior art keywords
group
alkyl group
chem
nitrogen
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89120631T
Other languages
English (en)
Inventor
Makoto Daiichi Pharma Takemura
Toshiyuki Daiichi Pharma Nishi
Hiroshi Daiichi Pharmac Susaki
Youhei Daiichi Pharmace Ishida
Hiroko Daiichi Pharmaceut Koda
Takeshi Daiichi Pharmac Hayano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2059679T3 publication Critical patent/ES2059679T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

DERIVADOS DE CARBAPENO DE FORMULA (I): EN DONDE (A) R1 ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO DE 1 A 6 ATOMOS DE CARBONO, UN GRUPO HIDROXIALQUILO INFERIOR O UN GRUPO PROTEGIDO HIDROXI- ALQUILO INFERIOR DE 1 A 6 ATOMOS DE CARBONO EN SU MITAD ALQUILO, (B) COOR2 ES UN GRUPO CARBOXILO, UN ANION CARBOXILADO O UN GRUPO CARBOXILO PROTEGIDO, (C) R3 ES UN GRUPO ALQUILO DE 1 A 6 ATOMOS DE CARBONO Y (D) R4 ES UN GRUPO HETEROBICICLICO SUSTITUIDO O NO SUSTITUIDO DE FORMULA (II): EN LA CUAL LA ESTRUCTURA PARCIAL ES UN SATURADO O NO SATURADO HETEROCICLICO CONTENIENDO NITROGENO DE 5- O 6- MIEMBRO, CONTENIENDO DE 1 A 4 ATOMOS HETERO SELECCIONADO CADA UNO DEL GRUPO COMPUESTO POR OXIGENO, AZUFRE Y NITROGENO, SIENDO NITROGENO AL MENOS UNO DE LOS HETERO ATOMOS, Y ES TAL QUE R5 Y R6 SON CADA UNO UN ATOMO DE HIDROGENO O UN SUSTITUYENTE APROPIADO, ALGUN ISOMERO DE ELLOS, O SALES FARMACEUTICAMENTE ACEPTABLES DE ELLOS SON POTENTES Y ESTABLES AGENTES ANTI-MICROBIANOS.
ES89120631T 1988-11-08 1989-11-07 Derivados de carbapenem. Expired - Lifetime ES2059679T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP28179888 1988-11-08

Publications (1)

Publication Number Publication Date
ES2059679T3 true ES2059679T3 (es) 1994-11-16

Family

ID=17644130

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89120631T Expired - Lifetime ES2059679T3 (es) 1988-11-08 1989-11-07 Derivados de carbapenem.

Country Status (7)

Country Link
US (1) US5583218A (es)
EP (1) EP0368259B1 (es)
AT (1) ATE108798T1 (es)
CA (1) CA2002551C (es)
DE (1) DE68916908T2 (es)
ES (1) ES2059679T3 (es)
HU (1) HU211267A9 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8923844D0 (en) * 1989-10-23 1989-12-13 Fujisawa Pharmaceutical Co Carbapenem compounds
US5602118A (en) * 1993-03-16 1997-02-11 American Cyanamid Company 2-thiosubstituted carbapenems
US5707987A (en) * 1994-02-25 1998-01-13 Banyu Pharmaceutical Co., Ltd. Carbapenem derivatives
KR100945706B1 (ko) * 2001-11-05 2010-03-05 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규 카르바페넴 화합물
JPWO2004089954A1 (ja) 2003-04-08 2006-07-06 大日本住友製薬株式会社 新規なカルバペネム化合物
JPWO2006025475A1 (ja) * 2004-09-03 2008-05-08 大日本住友製薬株式会社 新規なカルバペネム化合物
JPWO2006103999A1 (ja) * 2005-03-25 2008-09-04 大日本住友製薬株式会社 新規なカルバペネム化合物
US20110021469A1 (en) * 2007-06-13 2011-01-27 Meythaler Jay M baclofen solution for low-volume therapeutic delivery
US20100210604A1 (en) * 2007-06-13 2010-08-19 Meythaler Jay M Zwitterion solution for low-volume therapeutic delivery
WO2014070774A1 (en) * 2012-10-29 2014-05-08 Southern Methodist University Methods of generating beta-lactamase resistant carbapenem compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
ES514240A0 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
IE851586L (en) * 1984-07-02 1986-01-02 Interchem Internat S A I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
CA1285940C (en) * 1984-07-02 1991-07-09 Merck & Co., Inc. Carbapenems having a 2-quaternary heteroarylalkylthio substituent
PH24782A (en) * 1985-10-24 1990-10-30 Sankyo Co Composition containing a penem or carbapenem antibiotic and the use of the same
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative

Also Published As

Publication number Publication date
DE68916908T2 (de) 1994-12-01
EP0368259B1 (en) 1994-07-20
HU211267A9 (en) 1995-11-28
US5583218A (en) 1996-12-10
EP0368259A1 (en) 1990-05-16
ATE108798T1 (de) 1994-08-15
CA2002551C (en) 1999-04-06
DE68916908D1 (de) 1994-08-25
CA2002551A1 (en) 1990-05-08

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