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ES2059467T3 - Derivados de aminometil-oxooxazolidinil-etenilbenceno utiles como agentes antibacterianos. - Google Patents

Derivados de aminometil-oxooxazolidinil-etenilbenceno utiles como agentes antibacterianos.

Info

Publication number
ES2059467T3
ES2059467T3 ES88117304T ES88117304T ES2059467T3 ES 2059467 T3 ES2059467 T3 ES 2059467T3 ES 88117304 T ES88117304 T ES 88117304T ES 88117304 T ES88117304 T ES 88117304T ES 2059467 T3 ES2059467 T3 ES 2059467T3
Authority
ES
Spain
Prior art keywords
derivatives
useful
oxooxazolidinil
etenilbenceno
aminometil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88117304T
Other languages
English (en)
Inventor
David Ross Brittelli
Walter Adelman Gregory
Peter Franklin Corless
Chung-Ho Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Application granted granted Critical
Publication of ES2059467T3 publication Critical patent/ES2059467T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

DERIVADOS DEL ETEMILBENCENO OXOOXAZOLIDIMIL AMINOMETIL, INCLUYENDO LOS NITRILOS, SULFOXIDOS, ACETAMIDAS Y NITROCOMPUESTOS, TALES COMO L-N-[3-[4-(E-1-METIL-2-CIANOETENIL)FENIL]-2-OXOOZAHIDIN-5-ILMETIL]ACETAMIDA POSEEN UNA UTIL ACTIVIDAD ANTIBACTERIAL.
ES88117304T 1987-10-21 1988-10-18 Derivados de aminometil-oxooxazolidinil-etenilbenceno utiles como agentes antibacterianos. Expired - Lifetime ES2059467T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11083787A 1987-10-21 1987-10-21

Publications (1)

Publication Number Publication Date
ES2059467T3 true ES2059467T3 (es) 1994-11-16

Family

ID=22335197

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88117304T Expired - Lifetime ES2059467T3 (es) 1987-10-21 1988-10-18 Derivados de aminometil-oxooxazolidinil-etenilbenceno utiles como agentes antibacterianos.

Country Status (18)

Country Link
EP (1) EP0316594B1 (es)
JP (1) JPH01135777A (es)
KR (1) KR890006603A (es)
AT (1) ATE95176T1 (es)
AU (1) AU617697B2 (es)
CA (1) CA1317594C (es)
DE (1) DE3884563T2 (es)
DK (1) DK584188A (es)
ES (1) ES2059467T3 (es)
FI (1) FI884849A7 (es)
HU (1) HU201915B (es)
IL (1) IL88107A (es)
MY (1) MY103433A (es)
NO (1) NO884676L (es)
NZ (1) NZ226631A (es)
PT (1) PT88811B (es)
RU (1) RU1801109C (es)
ZA (1) ZA887853B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032605A (en) * 1987-10-09 1991-07-16 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US5036093A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
CA2119556C (en) * 1991-11-01 2004-07-06 Michael Robert Barbachyn Substituted aryl- and heteroaryl-phenyloxazolidinones
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
NZ257031A (en) * 1992-12-08 1996-07-26 Upjohn Co Tropone substituted phenyloxazolidinone derivatives and anti-bacterial medicaments thereof
TW299332B (es) * 1992-12-08 1997-03-01 Upjohn Co
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
CA2174107C (en) * 1993-11-22 2005-04-12 Steven J. Brickner Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones
CN1068325C (zh) * 1994-10-26 2001-07-11 法玛西雅厄普约翰美国公司 苯基噁唑烷酮抗菌剂
ATE233766T1 (de) * 1994-11-15 2003-03-15 Upjohn Co Antibakterielle bizyklische oxazin und thiazin- oxazolidinone
ES2163004T3 (es) * 1995-02-03 2002-01-16 Upjohn Co Feniloxazolidinona sustituida por un anillo heteroaromatico como agente antimicrobiano.
FI974180A0 (fi) * 1995-05-11 1997-11-10 Upjohn Co Spirosyklisiä ja bisyklisiä diatsinyyli- ja karbatsinyylioksatsolidinoneja
US5883093A (en) * 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
AU729247B2 (en) 1996-08-12 2001-01-25 Celgene Corporation Novel immunotherapeutic agents and their use in the reduction of cytokine levels
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
AU739055B2 (en) * 1997-11-12 2001-10-04 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
EP1049682A1 (en) 1998-01-23 2000-11-08 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
EP1200416A1 (en) 1999-07-28 2002-05-02 Pharmacia & Upjohn Company Oxazolidinones and their use as antiinfectives
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
WO2002018354A1 (en) * 2000-08-31 2002-03-07 Abbott Laboratories Oxazolidinones and their use as antibacterial agents
WO2002020515A1 (en) * 2000-09-08 2002-03-14 Abbott Laboratories Oxazolidinone antibacterial agents
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
MXPA05009434A (es) 2003-03-05 2005-11-23 Celgene Corp Compuestos de difeniletileno y usos de los mismos.
US7470723B2 (en) 2003-03-05 2008-12-30 Celgene Corporation Diphenylethylene compounds and uses thereof
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
CA2578789A1 (en) 2004-09-03 2006-03-16 Celgene Corporation Substituted heterocyclic compounds and uses thereof
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
RU2578602C2 (ru) 2005-10-04 2016-03-27 Байер Интеллектуэль Проперти Гмбх Способ получения 5-хлор-n-(5s)-2-оксо-3-[4-(3-оксо-морфолинил)-фенил]-1,3-оксазолидин-5-ил}-метил)-2-тиофенкарбоксамида в модификации ii (варианты)
CN101965353B (zh) 2008-03-26 2014-12-17 丹诺医药(苏州）有限公司 共价连接到取代苯基噁唑烷酮的双环硝基咪唑类
EP3498273A1 (en) * 2017-12-14 2019-06-19 Universität Wien Pharmaceutical composition for modulating the response of a gaba-a receptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1222708A (en) * 1968-10-22 1971-02-17 Delalande Sa Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
NO884676L (no) 1989-04-24
IL88107A (en) 1993-02-21
ZA887853B (en) 1990-06-27
DE3884563T2 (de) 1994-02-17
MY103433A (en) 1993-06-30
FI884849A0 (fi) 1988-10-20
PT88811B (pt) 1993-04-30
ATE95176T1 (de) 1993-10-15
HUT52075A (en) 1990-06-28
HU201915B (en) 1991-01-28
EP0316594B1 (en) 1993-09-29
FI884849A7 (fi) 1989-04-22
RU1801109C (ru) 1993-03-07
AU2404388A (en) 1989-04-27
DK584188D0 (da) 1988-10-20
AU617697B2 (en) 1991-12-05
NZ226631A (en) 1991-01-29
DE3884563D1 (de) 1993-11-04
CA1317594C (en) 1993-05-11
NO884676D0 (no) 1988-10-20
KR890006603A (ko) 1989-06-14
EP0316594A1 (en) 1989-05-24
JPH01135777A (ja) 1989-05-29
IL88107A0 (en) 1989-06-30
DK584188A (da) 1989-04-22

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