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ES2059321T3 - Heparinas, fracciones y fragmentos de heparinas libres de edta, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Heparinas, fracciones y fragmentos de heparinas libres de edta, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2059321T3
ES2059321T3 ES87106784T ES87106784T ES2059321T3 ES 2059321 T3 ES2059321 T3 ES 2059321T3 ES 87106784 T ES87106784 T ES 87106784T ES 87106784 T ES87106784 T ES 87106784T ES 2059321 T3 ES2059321 T3 ES 2059321T3
Authority
ES
Spain
Prior art keywords
heparines
edta
free
fractions
fragments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87106784T
Other languages
English (en)
Inventor
Benito Casu
Pasqua Oreste
Annamaria Naggi
Giangiacomo Torri
Giorgio Zoppetti
Giancarlo Sportoletti
Santis Francesco De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elf Sanofi SA
Italfarmaco SpA
Original Assignee
Elf Sanofi SA
Italfarmaco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26327543&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2059321(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IT8620462A external-priority patent/IT1213093B/it
Priority claimed from IT21901/86A external-priority patent/IT1197482B/it
Application filed by Elf Sanofi SA, Italfarmaco SpA filed Critical Elf Sanofi SA
Application granted granted Critical
Publication of ES2059321T3 publication Critical patent/ES2059321T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

HEPARINAS, FRACCIONES DE HEPARINA Y FRAGMENTOS DE HEPARINA, OPCIONELMENTE SALIFICADAS CON CATIONES FARMACEUTICAMENTE ACEPTABLES, QUE TIENEN PESOS MOLECULARES QUE OSCILAN ENTRE 1000 Y 30000 D, CARACTERIZADAS POR UN CONTENIDO EDTA INFERIOR AL 0,1%, POR LA AUSENCIA, EN LOS ESPECTROS 1 H-RMN, DE LAS SEÑALES DEBIDAS AL EDTA ENTRE 2,54,00 PPM, Y SUSTANCIALMENTE EXENTAS DE EFECTO DE SANGRADO Y OPCIONALMENTE EXENTAS DE SEÑALES, EN EL ESPECTRO 13 C-RMN, DE 80 A 86 PPM.
ES87106784T 1986-05-16 1987-05-11 Heparinas, fracciones y fragmentos de heparinas libres de edta, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2059321T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8620462A IT1213093B (it) 1986-05-16 1986-05-16 Eparine purificate frazioni e frammenti eparinici purificati, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono come principi attivi.
IT21901/86A IT1197482B (it) 1986-10-03 1986-10-03 Eparine, frazioni e frammenti eparinici esenti da edta, procedimenti per la loro preparazione e composizioni farmaceutiche che li contengono come principi attivi

Publications (1)

Publication Number Publication Date
ES2059321T3 true ES2059321T3 (es) 1994-11-16

Family

ID=26327543

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87106784T Expired - Lifetime ES2059321T3 (es) 1986-05-16 1987-05-11 Heparinas, fracciones y fragmentos de heparinas libres de edta, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (5)

Country Link
US (1) US5110918A (es)
EP (1) EP0245813B2 (es)
JP (1) JP2628507B2 (es)
DE (1) DE3787996T2 (es)
ES (1) ES2059321T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2102207A1 (en) * 1991-05-02 1992-11-03 Irun R. Cohen Compositions for the prevention and/or treatment of patholigical processes
GB2266239B (en) * 1992-03-25 1996-03-06 Jevco Ltd Wound healing compositions containing chondroitin sulphate oligosaccharides
US5639469A (en) * 1994-06-15 1997-06-17 Minnesota Mining And Manufacturing Company Transmucosal delivery system
WO2000065521A2 (en) 1999-04-23 2000-11-02 Massachusetts Institute Of Technology System and method for polymer notation
ITMI20032498A1 (it) 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
CA2478700C (en) 2002-03-11 2012-10-16 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
EP1513880B1 (en) * 2002-06-18 2010-10-20 Glycores 2000 S.r.l. Epimerized derivatives of k5 polysaccharide with a very high degree of sulfation
US8513407B2 (en) * 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
ES2817779T3 (es) * 2010-01-19 2021-04-08 Momenta Pharmaceuticals Inc Evaluación de preparaciones de heparina
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
KR20220005441A (ko) 2019-04-26 2022-01-13 라보라토리오스 파마슈티코스 로비, 에스.아. 접선유동여과법에 의해 저분자량 헤파린을 얻는 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5446809A (en) * 1977-08-08 1979-04-13 Choay Sa Purifying of heparine
GB2027728B (en) * 1978-08-08 1983-03-30 Choay Sa Physiologically acceptable heparin
US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
GB2071127B (en) * 1980-02-29 1984-07-25 Italfarmaco Spa Process for the purification of glucosaninoglucans
US4396762A (en) * 1981-08-24 1983-08-02 Massachusetts Institute Of Technology Heparinase derived anticoagulants
DE3244214A1 (de) * 1982-11-30 1984-05-30 B. Braun Melsungen Ag, 3508 Melsungen Verfahren zur reinigung und fraktionierung von heparin

Also Published As

Publication number Publication date
EP0245813A2 (en) 1987-11-19
DE3787996T2 (de) 1994-03-03
DE3787996D1 (de) 1993-12-09
JPS6322801A (ja) 1988-01-30
EP0245813B2 (en) 2000-03-22
EP0245813A3 (en) 1988-09-21
US5110918A (en) 1992-05-05
EP0245813B1 (en) 1993-11-03
JP2628507B2 (ja) 1997-07-09

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