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ES2058449T3 - Nuevas piperazinilalquil-3(2h)-piridazinonas, procedimiento para su obtencion y su empleo como agentes reductores de la presion sanguinea. - Google Patents

Nuevas piperazinilalquil-3(2h)-piridazinonas, procedimiento para su obtencion y su empleo como agentes reductores de la presion sanguinea.

Info

Publication number
ES2058449T3
ES2058449T3 ES89121681T ES89121681T ES2058449T3 ES 2058449 T3 ES2058449 T3 ES 2058449T3 ES 89121681 T ES89121681 T ES 89121681T ES 89121681 T ES89121681 T ES 89121681T ES 2058449 T3 ES2058449 T3 ES 2058449T3
Authority
ES
Spain
Prior art keywords
hydrogen
replaced
alkyl
substituted
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89121681T
Other languages
English (en)
Inventor
Heinz Dr Blaschke
Heimo Dr Stroissnig
Harald Dr Fellier
Rita Dr Enzenhofer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hafslund Nycomed Pharma AG
Original Assignee
Hafslund Nycomed Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hafslund Nycomed Pharma AG filed Critical Hafslund Nycomed Pharma AG
Application granted granted Critical
Publication of ES2058449T3 publication Critical patent/ES2058449T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

EL INVENTO SE REFIERE A UNA NUEVA PIPARACINILOALQUILO-3(2H)- PIRIDAZIMINA DE FORMULA (I) Y SUS SALES FARMACEUTICAS; TRATA DE UN PROCEDIMIENTO PARA SU PRODUCCION Y DESCRIBE SU APLICACION COMO MEDICAMENTO PARA EL TRATAMIENTO DE LA HIPERTONA, INSUFICIENCIA CARDIACA Y PERTURBACIONES DEL SISTEMA CIRCULATORIO SANGUINEO. SIENDO R HIDROGENO, FENILO, BENCILO, MORFOLINO O PIPERIDINO NO SUSTITUIDO O SUSTITUIDO UNA O VARIAS VECES A TRAVES DE HIDROXI O UN GRUPO NR4R5; R2 Y R3 HIDROGENO, HALOGENO, ALCOXI DE C 1 A 6, ALQUILO DE C 1 A 6; R4 Y R5 IGUALES O DIFERENTES PUEDEN SER HIDROGENO, METILO, ETILO SUSTITUIDO O NO SUSTITUIDO POR ALQUILO DE C 1 A 6 ; R6 HIDROGENO ALQUILO DE C 1 A 4, FLUILO, BENCILO, O FENILOETILO; R8 Y R9 IGUALES O DIFERENTES HIDROGENO O ALQUILO DE C 1 A 6; (B) ALQUILENO DE C 1 A 7 NO SUSTITUIDO O SUSTITUIDO UNA O VARIAS VECES A BASES DE HIDROXI, ALQUILO DE C 1 A 4 O EL GRUPO NR4R5 Y QUE FORMA UN ANILLO DE CUATRO A SIETE MIEMBROS Y 2 FENILO, NAFTILO, PIRIDILO O TIACOLILO NO SUSTITUIDOO SUSTITUIDO A BASES DE ALQUILO DE C1 A 6 BENCILOXI, TRIFLIOROMETILO, HALOGENO, NITRO, CICLOALCOXI DE C3 A 7, ALQUITRO DE C 1 A 4 ITRIGLUOROMETUHO O NR4R5.
ES89121681T 1988-12-06 1989-11-23 Nuevas piperazinilalquil-3(2h)-piridazinonas, procedimiento para su obtencion y su empleo como agentes reductores de la presion sanguinea. Expired - Lifetime ES2058449T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT299188 1988-12-06

Publications (1)

Publication Number Publication Date
ES2058449T3 true ES2058449T3 (es) 1994-11-01

Family

ID=3543605

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89121681T Expired - Lifetime ES2058449T3 (es) 1988-12-06 1989-11-23 Nuevas piperazinilalquil-3(2h)-piridazinonas, procedimiento para su obtencion y su empleo como agentes reductores de la presion sanguinea.

Country Status (28)

Country Link
US (1) US5034391A (es)
EP (1) EP0372305B1 (es)
JP (1) JPH02200676A (es)
KR (1) KR900009626A (es)
CN (1) CN1022565C (es)
AT (1) ATE92487T1 (es)
AU (1) AU622501B2 (es)
CA (1) CA2004298A1 (es)
DD (1) DD290885A5 (es)
DE (1) DE58905151D1 (es)
DK (1) DK169102B1 (es)
ES (1) ES2058449T3 (es)
FI (1) FI93956C (es)
GR (1) GR3008659T3 (es)
HU (1) HU203748B (es)
IE (1) IE62890B1 (es)
IL (1) IL92442A0 (es)
LT (2) LTIP1615A (es)
LV (1) LV10273B (es)
MD (2) MD382C2 (es)
MY (1) MY106282A (es)
NO (1) NO173441C (es)
NZ (1) NZ231625A (es)
PT (1) PT92488B (es)
RU (2) RU1823874C (es)
UA (1) UA19756A1 (es)
YU (1) YU229289A (es)
ZA (1) ZA899320B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162321A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie 1-naphthyl piperazines useful as 5-HT1A receptor ligands
DK0482208T3 (da) * 1990-04-25 2000-09-18 Nissan Chemical Ind Ltd Pyridazinonderivat
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
US6960597B2 (en) * 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
HU225955B1 (en) * 2001-07-26 2008-01-28 Egis Gyogyszergyar Nyilvanosan Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HU227237B1 (en) * 2001-09-27 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
CA2474239A1 (en) * 2002-01-18 2003-07-24 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
US20050176755A1 (en) * 2003-10-31 2005-08-11 Dyatkin Alexey B. Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
EP1725538B1 (en) * 2004-02-10 2007-08-29 Janssen Pharmaceutica N.V. Pyridazinone ureas as antagonists of a4 integrins
EP1720839A1 (en) * 2004-02-10 2006-11-15 Janssen Pharmaceutica N.V. Pyridazinones as antagonists of a4 integrins
JP2013518907A (ja) * 2010-02-08 2013-05-23 アラーガン インコーポレイテッド カンナビノイド−２作動薬として有用なピリダジン誘導体

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1086238B (de) * 1959-02-03 1960-08-04 Basf Ag Verfahren zur Herstellung von (4, 5)-Dihalogenpyridazonen-(6)
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
BE755015A (fr) * 1969-08-20 1971-02-01 Byk Gulden Lomberg Chem Fab Piperazinyl-alcoylamino-uraciles substitues par un groupe aryle, leurs ethers et thioethers, ainsi que leur procede de preparation
FR2124164A1 (en) * 1971-02-10 1972-09-22 Ferlux Phenyl pyridazonyl piperazines - analgesics hypotensives sedatives and antibacterials
DE2334009A1 (de) * 1973-07-04 1975-01-23 Boehringer Mannheim Gmbh Purin-derivate sowie verfahren zu ihrer herstellung
FR2261756A1 (en) * 1974-02-27 1975-09-19 Roussel Uclaf 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity
LU74319A1 (es) * 1976-02-09 1977-08-19
JPS5742679A (en) * 1980-08-29 1982-03-10 Otsuka Pharmaceut Co Ltd Preparation of phenylpiperazine derivative
JPH0641454B2 (ja) * 1985-02-27 1994-06-01 日産化学工業株式会社 ピリダジノン誘導体
US4892947A (en) * 1985-04-27 1990-01-09 Nissan Chemical Industries Ltd. 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it
YU134686A (en) * 1985-07-30 1988-02-29 Nissan Chemical Ind Ltd Process for preparing new derivatives 3-(2h)-pyridazinone
HU195645B (en) * 1985-10-30 1988-06-28 Gyogyszerkutato Intezet Process for preparing novel 3(2h)-pyridazinone derivatives and pharmaceutical compositions comprising the same
US4859672A (en) * 1986-10-29 1989-08-22 Rorer Pharmaceutical Corporation Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
US4978665A (en) * 1987-01-20 1990-12-18 Nissan Chemical Industries Ltd. 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones

Also Published As

Publication number Publication date
PT92488B (pt) 1995-08-09
DD290885A5 (de) 1991-06-13
MY106282A (en) 1995-04-29
NO894856D0 (no) 1989-12-05
HUT52094A (en) 1990-06-28
HU203748B (en) 1991-09-30
IE62890B1 (en) 1995-03-08
RU2024517C1 (ru) 1994-12-15
FI93956B (fi) 1995-03-15
AU622501B2 (en) 1992-04-09
CA2004298A1 (en) 1990-06-06
US5034391A (en) 1991-07-23
LT3945B (en) 1996-05-27
RU1823874C (ru) 1993-06-23
DK169102B1 (da) 1994-08-15
FI93956C (fi) 1995-06-26
NZ231625A (en) 1991-02-26
LTIP1615A (en) 1995-07-25
ZA899320B (en) 1991-02-27
NO173441B (no) 1993-09-06
NO894856L (no) 1990-06-07
YU229289A (en) 1991-10-31
PT92488A (pt) 1990-06-29
IE893721L (en) 1990-06-06
LTIP1808A (en) 1995-08-25
LV10273A (lv) 1994-10-20
DE58905151D1 (de) 1993-09-09
JPH02200676A (ja) 1990-08-08
UA19756A1 (uk) 1997-12-25
EP0372305A1 (de) 1990-06-13
DK611789D0 (da) 1989-12-05
KR900009626A (ko) 1990-07-05
IL92442A0 (en) 1990-08-31
DK611789A (da) 1990-06-07
CN1022565C (zh) 1993-10-27
EP0372305B1 (de) 1993-08-04
AU4589889A (en) 1990-06-14
CN1043129A (zh) 1990-06-20
ATE92487T1 (de) 1993-08-15
LV10273B (en) 1995-04-20
GR3008659T3 (es) 1993-11-30
FI895824A0 (fi) 1989-12-05
NO173441C (no) 1993-12-15
MD382C2 (ro) 1996-06-30
MD383C2 (ro) 1996-06-30

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