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ES2053618T3 - Metodo para separar la endotoxina de la tos ferina, un toxoide de la tos ferina y su produccion. - Google Patents

Metodo para separar la endotoxina de la tos ferina, un toxoide de la tos ferina y su produccion.

Info

Publication number
ES2053618T3
ES2053618T3 ES88108004T ES88108004T ES2053618T3 ES 2053618 T3 ES2053618 T3 ES 2053618T3 ES 88108004 T ES88108004 T ES 88108004T ES 88108004 T ES88108004 T ES 88108004T ES 2053618 T3 ES2053618 T3 ES 2053618T3
Authority
ES
Spain
Prior art keywords
endotoxin
whole cough
toxoid
production
cough
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88108004T
Other languages
English (en)
Inventor
Isao Fujita
Hideo Watanabe
Masatoshi Miyamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2053618T3 publication Critical patent/ES2053618T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Abstract

LA PRESENTE INVENCION OFRECE UN METODO CLARO Y EFICIENTE PARA ELIMINAR LA ENDOTOXINA DE LA TOS FERINA CARACTERIZADO PORQUE A UN FLUIDO QUE CONTIENE LA FRACCION ANTIINFECCIOSA Y LA ENDOTOXINA DE CEPAS DE BORDOTELLA PERTOSSIS FASE I SE LE APORTA ION CALCIO EN PRESENCIA DE UN EXCESO DE ION FOSFATO ANTES DE LA CENTRIFUGACION POR ZONAS. TAMBIEN SE PRESENTA UN TOXOIDE DE TOS FERINA CUYO CONTENIDO DE ENDOTOXINA POR CADA MICROGRAMO DE NITROGENO PROTEINICO NO ES MAYOR DE 0,5 NG. TAMBIEN SE PRESENTA SU METODO DE OBTENCION.
ES88108004T 1987-05-22 1988-05-19 Metodo para separar la endotoxina de la tos ferina, un toxoide de la tos ferina y su produccion. Expired - Lifetime ES2053618T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12639487 1987-05-22

Publications (1)

Publication Number Publication Date
ES2053618T3 true ES2053618T3 (es) 1994-08-01

Family

ID=14934054

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88108004T Expired - Lifetime ES2053618T3 (es) 1987-05-22 1988-05-19 Metodo para separar la endotoxina de la tos ferina, un toxoide de la tos ferina y su produccion.

Country Status (15)

Country Link
US (1) US5101019A (es)
EP (1) EP0291968B1 (es)
JP (1) JPH0834742B2 (es)
KR (1) KR970002614B1 (es)
CN (1) CN1019979C (es)
AT (1) ATE84971T1 (es)
CA (1) CA1326444C (es)
DE (1) DE3877818T2 (es)
DK (1) DK273588A (es)
ES (1) ES2053618T3 (es)
GR (1) GR3007238T3 (es)
HU (1) HU200194B (es)
NO (1) NO178423C (es)
RU (1) RU2089216C1 (es)
UA (1) UA12647A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0669971T3 (da) * 1991-11-15 2003-04-22 Pfizer Fremgangsmåde til fremstilling af Gram-negative bakterielle vacciner
CN1147259A (zh) * 1994-04-28 1997-04-09 武田药品工业株式会社 分离百日咳杆菌保护性组分的方法
RU2130778C1 (ru) * 1998-07-31 1999-05-27 Акционерное общество закрытого типа НПК "Комбиотех Лтд" Комбинированная вакцина для иммунопрофилактики вирусного гепатита в, столбняка, дифтерии и коклюша
SE0003958D0 (sv) 2000-10-31 2000-10-31 Biogaia Fermentation Ab Method for growth of microorganisms
CA2759280C (en) * 2009-04-28 2016-09-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
DE102009043932A1 (de) 2009-09-02 2011-03-10 Stükerjürgen, Ferdinand Wickelrohr mit erhöhter Stabilität
GB201011968D0 (en) * 2010-07-16 2010-09-01 Secr Defence Toxoiding method
CN103454235B (zh) * 2013-09-13 2016-04-20 广州康盛生物科技有限公司 一种超声辅助测定血浆中细菌内毒素含量的方法
CN104017792A (zh) * 2014-06-26 2014-09-03 上海第一生化药业有限公司 一种去除胰蛋白酶中的内毒素的方法
CN104017793A (zh) * 2014-06-26 2014-09-03 上海第一生化药业有限公司 一种去除糜蛋白酶中的内毒素的方法
CN104031900A (zh) * 2014-06-26 2014-09-10 上海第一生化药业有限公司 一种去除多肽中的内毒素的方法
US20190177588A1 (en) * 2017-12-12 2019-06-13 Xotramorphic LLC Compositions, Methods, and Systems For Producing Flocculent Materials for Special Effects

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1604134A (es) * 1967-09-26 1971-07-12
US3978209A (en) * 1975-03-24 1976-08-31 Merck & Co., Inc. Endotoxin free meningococcus polysaccharides
US4220717A (en) * 1977-12-22 1980-09-02 American Cyanamid Company Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.
JPS5750925A (en) * 1980-09-12 1982-03-25 Takeda Chem Ind Ltd Preparation of pertussis toxoid
US4705686A (en) * 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
CA1337859C (en) * 1987-04-24 1996-01-02 Masashi Chazono Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine

Also Published As

Publication number Publication date
DE3877818T2 (de) 1993-05-27
HU200194B (en) 1990-04-28
DK273588D0 (da) 1988-05-19
HUT47602A (en) 1989-03-28
DK273588A (da) 1988-11-23
JPS6452726A (en) 1989-02-28
KR970002614B1 (ko) 1997-03-06
NO882208L (no) 1988-11-23
ATE84971T1 (de) 1993-02-15
HU896222D0 (en) 1990-02-28
CN88103075A (zh) 1988-12-21
CN1019979C (zh) 1993-03-03
CA1326444C (en) 1994-01-25
EP0291968A1 (en) 1988-11-23
US5101019A (en) 1992-03-31
DE3877818D1 (de) 1993-03-11
RU2089216C1 (ru) 1997-09-10
GR3007238T3 (es) 1993-07-30
UA12647A1 (uk) 1997-02-28
NO178423B (no) 1995-12-18
NO178423C (no) 1996-03-27
EP0291968B1 (en) 1993-01-27
JPH0834742B2 (ja) 1996-03-29
NO882208D0 (no) 1988-05-20
KR880013573A (ko) 1988-12-21

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