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ES2053462T3 - PROCEDURE FOR THE PRODUCTION OF NITROETHANE DERIVATIVES. - Google Patents

PROCEDURE FOR THE PRODUCTION OF NITROETHANE DERIVATIVES.

Info

Publication number
ES2053462T3
ES2053462T3 ES87105064T ES87105064T ES2053462T3 ES 2053462 T3 ES2053462 T3 ES 2053462T3 ES 87105064 T ES87105064 T ES 87105064T ES 87105064 T ES87105064 T ES 87105064T ES 2053462 T3 ES2053462 T3 ES 2053462T3
Authority
ES
Spain
Prior art keywords
procedure
production
preparation
nitroethane derivatives
nitroethane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87105064T
Other languages
Spanish (es)
Inventor
Dr Peter Dipl Chem Morsdorf
Dr Helmut Dipl Ch Schickaneder
Dr Kurt Henning Ahrens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heumann Pharma GmbH and Co
Original Assignee
Heumann Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma GmbH and Co filed Critical Heumann Pharma GmbH and Co
Application granted granted Critical
Publication of ES2053462T3 publication Critical patent/ES2053462T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA PREPARACION DE LOS NITROETERDERIVADOS RANITIDINO Y NIZATIDINO, QUE LLEGA SOBRE NUEVOS PRODUCTOS INTERMEDIOS Y QUE PERMITE QUE SE PREPAREN LAS COMBINACIONES MENCIONADOS CON PUREZA MAS ALTA. UNA VANTAJA ADICIONAL EXISTE DENTRO QUE, NO SE LIBRA UN METIL MERCAPTANO MALOLIENTE Y ALTAMENTE TOXICO, A LO CONTRARIO, DE LOS PROCEDIMIENTO CONOCIDOS.A NEW PROCEDURE FOR THE PREPARATION OF THE RANITIDINE AND NIZATIDINE NITROETERIVES IS DESCRIBED. IT COMES ON NEW INTERMEDIATE PRODUCTS AND ALLOWS THE PREPARATION OF THE MENTIONED COMBINATIONS WITH HIGHER PURITY. AN ADDITIONAL ADVANTAGE EXISTS WITHIN WHICH A MALOORLY AND HIGHLY TOXIC METHYL MERCAPTAN IS NOT DELIVERED, OTHERWISE, FROM THE KNOWN PROCEDURES.

ES87105064T 1987-04-06 1987-04-06 PROCEDURE FOR THE PRODUCTION OF NITROETHANE DERIVATIVES. Expired - Lifetime ES2053462T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87105064A EP0285681B1 (en) 1987-04-06 1987-04-06 Process for the preparation of nitroethylene derivatives

Publications (1)

Publication Number Publication Date
ES2053462T3 true ES2053462T3 (en) 1994-08-01

Family

ID=8196897

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87105064T Expired - Lifetime ES2053462T3 (en) 1987-04-06 1987-04-06 PROCEDURE FOR THE PRODUCTION OF NITROETHANE DERIVATIVES.

Country Status (17)

Country Link
US (1) US4968808A (en)
EP (1) EP0285681B1 (en)
JP (1) JP2755385B2 (en)
KR (1) KR940010179B1 (en)
AR (1) AR245116A1 (en)
AT (1) ATE86619T1 (en)
AU (1) AU597159B2 (en)
CA (1) CA1321594C (en)
DE (1) DE3784698D1 (en)
DK (1) DK155488A (en)
ES (1) ES2053462T3 (en)
GR (1) GR3007314T3 (en)
HU (1) HU200760B (en)
IE (1) IE61744B1 (en)
IL (1) IL85706A (en)
NZ (1) NZ223844A (en)
PT (1) PT87116B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds
IN181698B (en) * 1994-05-13 1998-09-05 Ranbaxy Lab Ltd
EP0697411B1 (en) * 1994-06-24 1998-07-01 Ranbaxy Laboratories Limited Process for the manufacture of pharmaceutical grade ranitidine base
US5470865A (en) * 1994-08-30 1995-11-28 Eli Lilly And Company Pharmaceutical composition
US6069256A (en) * 1996-09-11 2000-05-30 Knoll Aktiengesellschaft Process for the preparation of nizatidine
IT1299198B1 (en) * 1998-03-05 2000-02-29 Nicox Sa NITRATED SALTS OF ANTI-ULCER DRUGS
EP1140066A4 (en) 1998-11-17 2005-11-09 Nitromed Inc Nitrosated and nitrosylated h2 receptor antagonist compounds, compositions and methods of use
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US9457011B2 (en) * 2014-02-25 2016-10-04 Muslim D. Shahid Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
US4233302A (en) * 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
ES8206506A1 (en) * 1981-11-16 1982-08-16 Pharmedical Sa Lab PROCEDURE FOR THE PREPARATION OF AMINO ALCOSI FURANOS OR TIOPHENES.
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
US4625025A (en) * 1983-08-25 1986-11-25 Ube Industries, Ltd. Process for producing a 2H-1,3-thiazolidine, 2H-tetrahydro-1,3-thiazine, or 2H-hexahydro-1,3-thiazepine derivative substituted at the 2 position by a nitromethylene group derivative
EP0224612A1 (en) * 1985-12-05 1987-06-10 HEUMANN PHARMA GMBH & CO Process for the preparation of N-cyano-N'-methyl-N''[2-(5-methylimidazol-4-ylmethylthio)-ethyl]-guanidine
US4777260A (en) * 1985-12-18 1988-10-11 Eli Lilly And Company Synthesis of nizatidine intermediate

Also Published As

Publication number Publication date
AU1313488A (en) 1988-10-06
JPS63258861A (en) 1988-10-26
JP2755385B2 (en) 1998-05-20
IE61744B1 (en) 1994-11-30
IL85706A0 (en) 1988-08-31
IL85706A (en) 1992-06-21
IE880977L (en) 1988-10-06
GR3007314T3 (en) 1993-07-30
DE3784698D1 (en) 1993-04-15
PT87116B (en) 1992-07-31
EP0285681B1 (en) 1993-03-10
ATE86619T1 (en) 1993-03-15
AR245116A1 (en) 1993-12-30
KR880012579A (en) 1988-11-28
DK155488D0 (en) 1988-03-22
EP0285681A1 (en) 1988-10-12
US4968808A (en) 1990-11-06
PT87116A (en) 1988-04-01
NZ223844A (en) 1989-12-21
DK155488A (en) 1988-10-07
HU200760B (en) 1990-08-28
KR940010179B1 (en) 1994-10-22
AU597159B2 (en) 1990-05-24
CA1321594C (en) 1993-08-24

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