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ES2051371T3 - Inhalador de aerosoles. - Google Patents

Inhalador de aerosoles.

Info

Publication number
ES2051371T3
ES2051371T3 ES89309756T ES89309756T ES2051371T3 ES 2051371 T3 ES2051371 T3 ES 2051371T3 ES 89309756 T ES89309756 T ES 89309756T ES 89309756 T ES89309756 T ES 89309756T ES 2051371 T3 ES2051371 T3 ES 2051371T3
Authority
ES
Spain
Prior art keywords
holding chamber
rigid holding
patient
flow meter
compact
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89309756T
Other languages
English (en)
Inventor
Bart Joseph Zoltan
Beth Louise Laube
George Kenneth Adams Iii
Clarke F Bow
Ralph J Devito
Walter Harrington
Louis S Hoffman
Charles B Sanders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Application granted granted Critical
Publication of ES2051371T3 publication Critical patent/ES2051371T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

APARATO COMPACTO Y PERFECCIONADO, PARA UTILIZAR EN LA INHALACION DE AEROSOLES FARMACEUTICOS. EL APARATO AUMENTA LA DEPOSICION DEL AEROSOL A LOS BRONQUIOLOS, LIMITANDO LA DEPOSICION A LA LARINGE. EL RITMO DEL FLUJO VOLUMETRICO SE LIMITA POR EL USO DE ORIFICIOS EN EL EXTREMO DISTANTE DE LA CAMARA RIGIDA DE RETENCION. LA INVENCION ESTA TAMBIEN IDEADA PARA QUE RESULTE MAS FACIL AL PACIENTE LA INHALACION DE LA MEDICACION EN EL PUNTO ADECUADO DE SU CICLO RESPIRATORIO. ADEMAS DE LA CAMARA RIGIDA DE RETENCION, EL APARATO DE LA INVENCION UTILIZA UN FLUJOMETRO INTEGRADO, UNICO Y COMPACTO, PARA LA ENTREGA AL PACIENTE DE UN VOLUMEN DE AIRE AMBIENTE NO MEDICADO, ANTES DE LA INHALACION DEL AEROSOL CONTENIENDO LA MEDICINA. CUANDO NO SE ESTA UTILIZANDO EL APARATO, SE PLIEGA, CON LO QUE PARTE DEL APARATO DE FLUJOMETRO INTEGRADO, Y LA EMBOCADURA, ESTAN LOCALIZADOS EN EL INTERIOR DE LA CAMARA RIGIDA DE RETENCION, REDUCIENDO AL MINIMO ASI EL TAMAÑO DEL DISPOSITIVO.
ES89309756T 1988-10-04 1989-09-26 Inhalador de aerosoles. Expired - Lifetime ES2051371T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25303988A 1988-10-04 1988-10-04

Publications (1)

Publication Number Publication Date
ES2051371T3 true ES2051371T3 (es) 1994-06-16

Family

ID=22958578

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89309756T Expired - Lifetime ES2051371T3 (es) 1988-10-04 1989-09-26 Inhalador de aerosoles.

Country Status (7)

Country Link
US (1) US5027806A (es)
EP (1) EP0363060B1 (es)
JP (1) JP2927836B2 (es)
AT (1) ATE104867T1 (es)
CA (1) CA1327299C (es)
DE (1) DE68914932T2 (es)
ES (1) ES2051371T3 (es)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5507281A (en) * 1990-08-30 1996-04-16 Boehringer Ingelheim Kg Device for initiating a mechanical switching operation in synchronism with the breathing
DE4027391A1 (de) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
DE4133274A1 (de) * 1991-08-22 1993-02-25 Boehringer Ingelheim Kg Vorrichtung zum atemzugsynchronen ausloesen eines mechanischen schaltvorganges
CA2112674C (en) 1991-07-02 2005-10-04 John S. Patton Method and device for delivering aerosolized medicaments
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
US5320094A (en) * 1992-01-10 1994-06-14 The Johns Hopkins University Method of administering insulin
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US7448375B2 (en) 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US5318016A (en) * 1993-03-30 1994-06-07 We Pharmaceuticals, Inc. Inhalation device
US5752502A (en) * 1993-12-16 1998-05-19 King; Russell Wayne General purpose aerosol inhalation apparatus
SE502268C2 (sv) * 1994-01-26 1995-09-25 Aga Ab Sätt, användning och beredning av aerosol för läkemedelsdistribution innehållande helium och/eller neon
ATE264096T1 (de) 1994-03-07 2004-04-15 Nektar Therapeutics Verfahren und mittel zur verabreichung von insulin über die lunge
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
CZ289029B6 (cs) 1994-09-21 2001-10-17 Inhale Therapeutic Systems Způsob aerosolizace práąku, zejména práąkového léku a zařízení k provádění tohoto způsobu
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
WO1998006426A1 (en) * 1996-08-14 1998-02-19 Gram Joergen Brodersen Use of a plasminogen activator for the treatment of pulmonary disorders
US5906202A (en) * 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
DE19734022C2 (de) * 1997-08-06 2000-06-21 Pari Gmbh Inhalationstherapiegerät mit einem Ventil zur Begrenzung des Inspirationsflusses
US5855564A (en) * 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
NZ504021A (en) * 1997-10-17 2003-04-29 Systemic Pulmonary Delivery Lt Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication
DE69918267T2 (de) 1998-01-16 2005-07-28 1263152 Ontario Inc., London Anzeigevorrichtung zur verwendung mit einer abgabevorrichtung
EP1066074A1 (en) * 1998-03-16 2001-01-10 Inhale Therapeutic Systems, Inc. Aerosolized active agent delivery
US6082358A (en) 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
US6257233B1 (en) * 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
UA73924C2 (en) * 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
GB9825118D0 (en) * 1998-11-16 1999-01-13 Minnesota Mining & Mfg Breath-actuated aerosol dispensers
GB2344534B (en) * 1998-12-11 2000-10-18 Bespak Plc Inhalation apparatus
US6223744B1 (en) 1999-03-16 2001-05-01 Multi-Vet Ltd. Wearable aerosol delivery apparatus
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6606992B1 (en) * 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
US7305986B1 (en) * 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
AU2001234005B2 (en) * 2000-02-28 2006-01-19 Pharmakodex Limited Improvements in or relating to the delivery of oral drugs
US6453900B1 (en) * 2000-06-09 2002-09-24 Pulmonary Services, Inc. Inhaler device
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
AU2003220125B2 (en) 2002-03-20 2006-06-15 Mannkind Corporation Inhalation apparatus
US7004164B2 (en) 2002-03-21 2006-02-28 Trudell Medical International Indicating device for aerosol container
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US7185651B2 (en) * 2002-06-18 2007-03-06 Nektar Therapeutics Flow regulator for aerosol drug delivery and methods
US7621273B2 (en) 2003-10-28 2009-11-24 Trudell Medical International Indicating device with warning dosage indicator
US7100530B2 (en) 2003-12-15 2006-09-05 Trudell Medical International, Inc. Dose indicating device
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
EP2314298B1 (en) 2004-08-23 2015-05-27 MannKind Corporation Microparticles comprising diketopiperazine salts for drug delivery
US7543582B2 (en) 2004-09-20 2009-06-09 Trudell Medical International Dose indicating device with display elements attached to container
JP5189369B2 (ja) 2005-01-20 2013-04-24 トルーデル メディカル インターナショナル 分与装置
DK1901749T3 (en) 2005-05-18 2016-10-24 Raptor Pharmaceuticals Inc Aerosolized fluoroquinolones AND USES THEREOF
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
AU2006290870B2 (en) 2005-09-14 2013-02-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
DK1986679T3 (da) 2006-02-22 2017-11-20 Mannkind Corp Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof
US8141550B2 (en) 2006-08-01 2012-03-27 Trudell Medical International Dispensing device
WO2009079078A1 (en) 2007-12-14 2009-06-25 Labogroup S.A.S. Delivering aerosolizable food products
AU2009228074B2 (en) * 2008-03-27 2015-01-22 Mannkind Corporation A dry powder inhalation system
US8082873B2 (en) 2008-05-05 2011-12-27 Trudell Medical International Drive mechanism for an indicating device
US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
CN103252007B (zh) 2008-06-13 2016-06-22 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
WO2010008523A1 (en) 2008-07-13 2010-01-21 Map Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
CA2739893C (en) 2008-10-07 2016-10-04 Mpex Pharmaceuticals, Inc. Inhalation of levofloxacin for reducing lung inflammation
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
EP2179760B1 (en) 2008-10-22 2013-02-27 Trudell Medical International Modular Aerosol Delivery System
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2676695A3 (en) 2009-03-11 2017-03-01 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
KR101875969B1 (ko) 2009-06-12 2018-07-06 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
EP3569235A1 (en) 2009-09-04 2019-11-20 Horizon Orphan LLC Use of aerosolized levofloxacin for treating cystic fibrosis
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
JP6021117B2 (ja) 2011-01-31 2016-11-02 ジェノア ファーマシューティカルズ，インク． エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
SG11201500218VA (en) 2012-07-12 2015-03-30 Mannkind Corp Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
EP2970149B1 (en) 2013-03-15 2019-08-21 MannKind Corporation Microcrystalline diketopiperazine compositions and methods
CN105451716A (zh) 2013-07-18 2016-03-30 曼金德公司 热稳定性干粉药物组合物和方法
US20150044288A1 (en) 2013-07-31 2015-02-12 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
EP4491180A1 (en) 2014-01-10 2025-01-15 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof
WO2024134330A1 (en) * 2022-12-19 2024-06-27 G.D S.P.A Device for inhaling a product, in particular a pharmaceutical product

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US733027A (en) * 1903-02-28 1903-07-07 Frederick Tagliavia Tanini Inhaler.
US1695930A (en) * 1924-11-15 1928-12-18 Alexander Bernhard Drager Inhaling device for administering gases and the like
FR773018A (fr) * 1933-08-09 1934-11-10 Perfectionnements aux appareils inhalateurs de gaz ou vapeurs
DE1045049B (de) * 1953-11-24 1958-11-27 Dr Med Karl Seidl Inhalationsgeraet fuer gasfoermige Stoffe und zur Atemgymnastik
GB1479283A (en) * 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
US3960148A (en) * 1974-10-15 1976-06-01 Dryden Gale E Apparatus for high flow anesthesia
US4077404A (en) * 1975-09-17 1978-03-07 H. B. W. Medical Instruments Manufacturing Company, Inc. Breathing equipment such as resuscitators
US4534343A (en) * 1984-01-27 1985-08-13 Trutek Research, Inc. Metered dose inhaler
FI69963C (fi) * 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
NZ209900A (en) * 1984-10-16 1989-08-29 Univ Auckland Automatic inhaler
US4790305A (en) * 1986-06-23 1988-12-13 The Johns Hopkins University Medication delivery system

Also Published As

Publication number Publication date
JP2927836B2 (ja) 1999-07-28
EP0363060A2 (en) 1990-04-11
US5027806A (en) 1991-07-02
EP0363060A3 (en) 1991-01-02
ATE104867T1 (de) 1994-05-15
EP0363060B1 (en) 1994-04-27
CA1327299C (en) 1994-03-01
JPH02243164A (ja) 1990-09-27
DE68914932T2 (de) 1994-08-11
DE68914932D1 (de) 1994-06-01

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