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ES2044881T3 - PROCEDURE FOR THE PREPARATION OF A STRUCTURAL PHOSPHOPROTEIN (PP 150) OF THE HUMAN CYTOMEGALOVIRUS. - Google Patents

PROCEDURE FOR THE PREPARATION OF A STRUCTURAL PHOSPHOPROTEIN (PP 150) OF THE HUMAN CYTOMEGALOVIRUS.

Info

Publication number
ES2044881T3
ES2044881T3 ES87111726T ES87111726T ES2044881T3 ES 2044881 T3 ES2044881 T3 ES 2044881T3 ES 87111726 T ES87111726 T ES 87111726T ES 87111726 T ES87111726 T ES 87111726T ES 2044881 T3 ES2044881 T3 ES 2044881T3
Authority
ES
Spain
Prior art keywords
human cytomegalovirus
procedure
preparation
immunogenous
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87111726T
Other languages
Spanish (es)
Inventor
Gerhard Dr Jahn
Birgit-Christine Scholl
Michael Dr Broker
Michael Dr Mach
Bernard Prof Fleckenstein
Bernd Traupe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2044881T3 publication Critical patent/ES2044881T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA PROTEINA ESTRUCTURAL FOSFORILADA, DE PESO MOLECULAR DE UNOS 150 KD (PP 150) DEL CITOMEGALOVIRUS HUMANO (HCMV) ES FUERTEMENTE INMUNOGENA Y LOS ANTISUEROS HUMANOS LA RECONOCEN DE FORMA FIABLE. ESTA PROTEINA, UNA VEZ REFERIDA AL GENOMA DE HCMV, PUEDE OBTENERSE POR IGENIERIA GENETICA EN FORMA COMPLETA O EN ZONAS INMUNOGENAS PARCIALES. ESTAS PROTEINAS SON ADECUADAS COMO REACTIVO, POR EJEMPLO EN EL ENSAYO ELISA, Y COMO COMPONENTES DE VACUNASTHE PHOSPHORILATED STRUCTURAL PROTEIN, OF A MOLECULAR WEIGHT OF ABOUT 150 KD (PP 150) OF THE HUMAN CYTOMEGALOVIRUS (HCMV) IS STRONGLY IMMUNOGENOUS AND RECOGNIZED BY THE HUMAN ANTIWERS. THIS PROTEIN, ONCE REFERRED TO THE HCMV GENOME, MAY BE OBTAINED BY FULL GENETIC GENETICS OR IN PARTIAL IMMUNOGENOUS AREAS. THESE PROTEINS ARE SUITABLE AS A REAGENT, FOR EXAMPLE IN THE ELISA TEST, AND AS VACCINE COMPONENTS

ES87111726T 1986-06-12 1987-06-05 PROCEDURE FOR THE PREPARATION OF A STRUCTURAL PHOSPHOPROTEIN (PP 150) OF THE HUMAN CYTOMEGALOVIRUS. Expired - Lifetime ES2044881T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3619718 1986-06-12

Publications (1)

Publication Number Publication Date
ES2044881T3 true ES2044881T3 (en) 1994-01-16

Family

ID=6302829

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87111726T Expired - Lifetime ES2044881T3 (en) 1986-06-12 1987-06-05 PROCEDURE FOR THE PREPARATION OF A STRUCTURAL PHOSPHOPROTEIN (PP 150) OF THE HUMAN CYTOMEGALOVIRUS.

Country Status (8)

Country Link
US (2) US5728578A (en)
EP (1) EP0252531B1 (en)
JP (2) JP2732840B2 (en)
AT (1) ATE82985T1 (en)
AU (1) AU605155B2 (en)
DE (1) DE3782867D1 (en)
ES (1) ES2044881T3 (en)
GR (1) GR3007031T3 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE132533T1 (en) * 1988-02-24 1996-01-15 Behringwerke Ag STRUCTURAL PHOSPHOPROTEIN (PP28) OF HUMAN CYTOMEGALOVIRUS (HCMV), ITS PRODUCTION AND USE
US5591439A (en) * 1989-03-24 1997-01-07 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
EP0389286B1 (en) * 1989-03-24 1996-07-10 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
US5552143A (en) * 1989-03-24 1996-09-03 The Wistar Institute Of Anatomy & Biology Recombinant cytomegalovirus vaccine
GB9014652D0 (en) * 1990-07-02 1990-08-22 Wellcome Found Antigen
DE4128684A1 (en) * 1991-08-29 1993-03-04 Behringwerke Ag HCMV-SPECIFIC PEPTIDES, MEDIUM IN THIS AND THEIR USE
US5744298A (en) * 1991-08-29 1998-04-28 Behringwerke Aktiengesellschaft DNA sequences which encode immunoreactive HCMV-specific peptides
WO1997040165A1 (en) * 1996-04-23 1997-10-30 The Wistar Institute Of Anatomy And Biology Novel human cytomegalovirus dna constructs and uses therefor
AU2002214624A1 (en) * 2000-10-20 2002-05-06 City Of Hope Immunoreactive peptide ctl epitopes of human cytomegalovirus pp150
WO2004076645A2 (en) * 2003-02-27 2004-09-10 University Of Massachusetts Compositions and methods for cytomegalovirus treatment
GB0716992D0 (en) * 2007-08-31 2007-10-10 Immune Targeting Systems Its L Influenza antigen delivery vectors and constructs
GB0408164D0 (en) * 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
JP5833565B2 (en) 2009-12-23 2015-12-16 ４−アンティボディ・アクチェンゲゼルシャフト４−Ａｎｔｉｂｏｄｙ Ａｇ Binding member for human cytomegalovirus
CN104569387B (en) * 2015-01-13 2017-06-16 必欧瀚生物技术（合肥）有限公司 A kind of ELISA detects human serum HCMV pp150 IgM antibody kits

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4769331A (en) * 1981-09-16 1988-09-06 University Patents, Inc. Recombinant methods and materials
US4554159A (en) * 1981-11-12 1985-11-19 Institute Merieux Vaccine and method of immunizing against herpes simplex virus (types 1 and 2)
US4762780A (en) * 1984-04-17 1988-08-09 The Regents Of The University Of California Method and composition for screening and diagnosing "HCMV"
GB8404368D0 (en) * 1984-02-20 1984-03-28 Cogent Ltd Monoclonal antibodies to human cytomegalovirus
US4743562A (en) * 1984-08-21 1988-05-10 The Board Of Trustees Of The Leland Stanford Junior University Purified human cytomegalovirus protein
US4689225A (en) * 1984-11-02 1987-08-25 Institut Merieux Vaccine for cytomegalovirus
US4808518A (en) * 1985-02-11 1989-02-28 University Of Tennessee Research Corporation Recovery of cytomegalovirus antigen and use thereof in an assay

Also Published As

Publication number Publication date
DE3782867D1 (en) 1993-01-14
GR3007031T3 (en) 1993-07-30
US5728578A (en) 1998-03-17
AU605155B2 (en) 1991-01-10
JP3272641B2 (en) 2002-04-08
EP0252531A1 (en) 1988-01-13
JPH10113190A (en) 1998-05-06
JPS62296893A (en) 1987-12-24
US5846733A (en) 1998-12-08
AU7412887A (en) 1987-12-17
EP0252531B1 (en) 1992-12-02
ATE82985T1 (en) 1992-12-15
JP2732840B2 (en) 1998-03-30

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