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EP4626518A1 - Tige de piston de seringue, cylindre de seringue et seringue - Google Patents

Tige de piston de seringue, cylindre de seringue et seringue

Info

Publication number
EP4626518A1
EP4626518A1 EP23813103.1A EP23813103A EP4626518A1 EP 4626518 A1 EP4626518 A1 EP 4626518A1 EP 23813103 A EP23813103 A EP 23813103A EP 4626518 A1 EP4626518 A1 EP 4626518A1
Authority
EP
European Patent Office
Prior art keywords
syringe
needle
barrel
sealing plug
press
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23813103.1A
Other languages
German (de)
English (en)
Inventor
Per Knutsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Krui Medical AB
Original Assignee
Krui Medical AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krui Medical AB filed Critical Krui Medical AB
Publication of EP4626518A1 publication Critical patent/EP4626518A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31516—Piston or piston-rod constructions, e.g. connection of piston with piston-rod reducing dead-space in the syringe barrel after delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31521—Pistons with a forward extending skirt at their front end

Definitions

  • the present invention relates to a syringe plunger rod, a syringe barrel, and a syringe comprising a syringe plunger rod and a syringe barrel.
  • Injections are among the most common health care procedures, with as much as 22 billion injections administered globally each year. During 2021, the Covid- 19 mass vaccination will require even further vast amounts of syringes to conduct the injections.
  • Syringes known in the art may be pre-filled syringes, delivered already holding a medicament/vaccine, or conventional syringes which are empty and filled on site with the drug to be administered to the patient.
  • Pre-filled syringes are made from either glass or polymeric materials. However, they are not manufacturing process is not cost effective. Further, the glass syringes are even more expensive than the polymeric syringe.
  • the present invention preferably seeks to mitigate, alleviate or eliminate one or more of the above-identified deficiencies in the art and disadvantages singly or in any combination and solves at least the above mentioned problems by proposing a syringe plunger rod extending along a longitudinal central axis comprising: a distal plunger top, having a sealing plug for sealing engagement with a syringe barrel; a proximal elongated shaft comprising a proximal end adapted to receive an applied force along an axis; wherein the sealing plug is made of an elastic material and wherein a sealing plug distal surface comprises concentric steps, wherein the concentric steps are climbing laterally.
  • a syringe barrel is also provided, said syringe barrel extending along a longitudinal central axis and comprising: a barrel cylinder defining a volume adapted to contain a drug, the barrel cylinder having a distal plunger socket wall and a tubular wall extending proximally from said distal plunger socket wall, a needle hub extending distally from the barrel cylinder, a hollow needle extending distally from the needle hub, wherein the needle hub is provided with longitudinal needle press-fit channel, wherein the press-fit channel is flush with the distal plunger socket wall, such that the press-fit channel extends proximally into the volume, wherein the hollow needle is press fitted in the press-fit channel.
  • a syringe comprising such syringe plunger rod and syringe barrel is also provided.
  • Fig. l is a longitudinal section of a syringe
  • Fig. 2 shows details of the syringe and sections of use positions of the syringe according to the present invention.
  • a syringe plunger rod 100 is disclosed.
  • the syringe plunger rod 100 extends along a longitudinal central axis A.
  • the syringe plunger rod 100 comprises a distal plunger top 101.
  • the distal plunger top 101 comprises a sealing plug 102.
  • the sealing plug 102 seals against a syringe barrel 200, upon use, to form a syringe 300.
  • Proximally of the sealing plug 102 an elongated shaft 103 is provided.
  • a push plate 104 At the proximal end of the elongated shaft 103 there is provided a push plate 104.
  • the push plate 104 extends substantially transversally to the longitudinal axis A.
  • the push plate 104 is adapted to receive an applied force along the axis A, upon use, such that the syringe plunger rod 100 is displaced in relation to the barrel 200.
  • the present invention also provides a syringe barrel 200.
  • the syringe barrel 200 extends along a longitudinal axis A.
  • the syringe barrel 200 comprises a barrel cylinder 201 defining a volume V adapted to contain a drug.
  • the barrel cylinder 201 has a distal plunger socket wall 202 and a tubular wall 203, extending proximally from said distal plunger socket wall 202.
  • a needle hub 204 extends distally from the barrel cylinder 201.
  • a hollow needle 205 extends distally from the needle hub 204.
  • the needle hub 204 is provided with longitudinal needle press-fit channel 206.
  • the press-fit channel 206 is flush with the distal plunger socket wall 202, such that the press-fit channel 206 extends proximally to the volume V, such that the press-fit channel 206 and falls out in volume V.
  • the hollow needle 205 is press fitted in the press-fit channel 206.
  • the wall thickness of the needle hub 204 around the press-fit channel 206 is preferably 0.5 to 1.5 mm, which provides stretch and flexibility properties during the needle mounting process. Further, the length of the press-fit channel 206 in the longitudinal direction is preferably 1.5 to 4.5 mm. The relatively thin thickness increases the seal between the hollow needle 205 and the needle hub 204, and decreases irregularities and weaknesses therein.
  • the sealing plug 102 is made of an elastic material. At the distal end of the sealing plug 102 a sealing plug distal surface 105 is arranged.
  • the sealing plug distal surface 105 comprises concentric steps 106.
  • the term “concentric” refers to an extension around the central axis A, and not necessarily with same step length, same step height, exact circles, exact same centre, at the circumference etc., while these are not excluded. In the embodiment disclosed in Fig. 2, this means that the different steps 106 are arranged at different radial distance from the central axis A and extends around the central axis A.
  • the number of concentric steps is five. However, this number may vary dependent on the size of the syringe in which the syringe plunger rod 100 is to be arranged and/or the medicament to be injected.
  • the number of steps 106 may be from 2 to 50, such as for example two, three, four, five, six, seven, eight, nine, or ten in number.
  • the steps 106 are climbing laterally, i.e. towards the circumference of the sealing plug 102.
  • the sealing plug distal surface 105 will abut the distal plunger socket wall 202 of the barrel 200.
  • the sealing plug 102 slides against the tubular wall 203 of the barrel 200. Since the steps 106 are climbing laterally, the most lateral step 106 will abut the distal plunger wall 202 first, squeezing the liquid to be injected centrally.
  • the sealing plug 102 will deform upon additional force in the distal direction, whereby the step centrally of the most lateral step 106 will be displaced in relation to the barrel 200 to abut the distal plunger socket wall 202. In this way the liquid to be injected is pushed further centrally. For each step 106 the same relative movement in relation to the barrel 200 is repeated to push the liquid centrally, and into the hollow needle 205 of the barrel 200. In this way, the amount of trapped air in the interface of the sealing plug 102 and the plunger socket wall 202 may be decreased.
  • the height of each step may be 0.01 mm to 1 mm.
  • the number of steps 106 may vary from 2 to 50.
  • the parameters regulating the step height and the number of steps may be the inner diameter of the barrel 200, the E module of the sealing plug 102.
  • the width of the steps 106 may also vary.
  • the sealing plug distal surface 105 Centrally, i.e. underneath the hollow needle 205, the sealing plug distal surface 105 is provided with a central plateau 107, from which the concentric steps climb laterally. The central plateau 107 is thus placed proximally directly underneath the hollow needle 205. In this way, the sealing plug distal surface 105 is configured such that a minimal amount of fluid to be injected is trapped in the barrel 200, since the plateau 107 may be arranged flush to the proximal end of the hollow needle 205.
  • the sealing plug distal surface 105 is generally conical, such that the most lateral concentric step 106 is arranged proximally a distal end point of the sealing plug 102, such as the plateau 107. This further helps the fluid to be injected to be pushed into the needle 205, since there will be a distal force component from the distally directed injection force.
  • the needle hub 204 comprises a distal needle hub opening 207 which is tapered in the proximal direction, towards the longitudinal central axis A and a centre of the needle hub opening 207.
  • the hollow needle 205 has a needle proximal end 208 with an external taper or rounding, tapered/rounded towards the longitudinal central axis A.
  • a proximal needle end 208 of the hollow needle 205 is substantially flush with the distal plunger socket wall 202.
  • the proximal end 208 of the hollow needle 205 is engaged in a needle hub 204.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention propose une tige de piston de seringue (100) s'étendant le long d'un axe central longitudinal (A). La tige de piston de seringue (100) comprend un bouchon d'étanchéité distal (102) pour une mise en prise étanche avec un cylindre de seringue (200), et un arbre allongé proximal (103) comprenant une extrémité proximale (104) conçue pour recevoir une force appliquée le long de l'axe longitudinal (A). Le bouchon d'étanchéité (102) est constitué d'un matériau élastique et une surface distale de bouchon d'étanchéité (105) comprend des étapes concentriques (106), les étapes concentriques (106) montant latéralement. L'invention propose également un cylindre de seringue (200). Le cylindre de seringue (200) comprend une embase d'aiguille (204) pourvue d'un canal à ajustement par pression d'aiguille longitudinale (206). Le canal à ajustement par pression (206) affleure la paroi d'emboîture de piston distale (202), de telle sorte que le canal à ajustement par pression (206) s'étend de manière proximale dans le volume (V). Une aiguille creuse (205) est ajustée par pression dans le canal à ajustement par pression (206).
EP23813103.1A 2022-11-29 2023-11-10 Tige de piston de seringue, cylindre de seringue et seringue Pending EP4626518A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE2251387 2022-11-29
PCT/SE2023/051139 WO2024117957A1 (fr) 2022-11-29 2023-11-10 Tige de piston de seringue, cylindre de seringue et seringue

Publications (1)

Publication Number Publication Date
EP4626518A1 true EP4626518A1 (fr) 2025-10-08

Family

ID=91324509

Family Applications (1)

Application Number Title Priority Date Filing Date
EP23813103.1A Pending EP4626518A1 (fr) 2022-11-29 2023-11-10 Tige de piston de seringue, cylindre de seringue et seringue

Country Status (4)

Country Link
EP (1) EP4626518A1 (fr)
JP (1) JP2025537393A (fr)
CN (1) CN120265344A (fr)
WO (1) WO2024117957A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285110B2 (en) * 2003-06-10 2007-10-23 P. Rowan Smith, Jr. Retractable hypodermic safety syringe
US9295788B2 (en) * 2011-03-04 2016-03-29 Anestaweb, Inc. Syringe with integrated cannula
KR102267308B1 (ko) * 2021-01-18 2021-06-21 (주)풍림파마텍 루어락 체결형 주사바늘 허브

Also Published As

Publication number Publication date
CN120265344A (zh) 2025-07-04
WO2024117957A1 (fr) 2024-06-06
JP2025537393A (ja) 2025-11-14

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