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EP4501235A1 - Structure composite d'électrode neuronale flexible et son procédé de fabrication et d'implantation, et ensemble d'implantation auxiliaire - Google Patents

Structure composite d'électrode neuronale flexible et son procédé de fabrication et d'implantation, et ensemble d'implantation auxiliaire Download PDF

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Publication number
EP4501235A1
EP4501235A1 EP23778418.6A EP23778418A EP4501235A1 EP 4501235 A1 EP4501235 A1 EP 4501235A1 EP 23778418 A EP23778418 A EP 23778418A EP 4501235 A1 EP4501235 A1 EP 4501235A1
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EP
European Patent Office
Prior art keywords
auxiliary
implantation
flexible neural
flexible
electrode composite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23778418.6A
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German (de)
English (en)
Other versions
EP4501235A4 (fr
Inventor
Ying Fang
Huihui TIAN
Runjiu FANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Bciflex Medical Technology Co Ltd
Original Assignee
Beijing Bciflex Medical Technology Co Ltd
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Publication date
Application filed by Beijing Bciflex Medical Technology Co Ltd filed Critical Beijing Bciflex Medical Technology Co Ltd
Publication of EP4501235A1 publication Critical patent/EP4501235A1/fr
Publication of EP4501235A4 publication Critical patent/EP4501235A4/fr
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/294—Bioelectric electrodes therefor specially adapted for particular uses for nerve conduction study [NCS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A61B5/293—Invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/251—Means for maintaining electrode contact with the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0462—Apparatus with built-in sensors
    • A61B2560/0468—Built-in electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/262—Needle electrodes

Definitions

  • the present disclosure relates to a technical field of neuroscience, in particular to a flexible neural electrode composite structure, a manufacturing method and an implantation method thereof, a composite structure assembly and an implantation method thereof, and an auxiliary implantation assembly.
  • implantable neural electrodes have been developed rapidly.
  • traditional implantable neural electrodes are rigid and are not matched with the mechanical properties of the brain tissue, there will be a relative movement between the neural electrode and the brain tissue under the influence of breathing and movement after the neural electrode is implanted in the brain, which will result in considerable damage to the brain tissue around the electrode and further cause inflammatory reactions.
  • the recorded signals of brain electrodes will be continuously weakened until failed.
  • the flexible neural electrode Compared with the rigid neural electrode, the flexible neural electrode has mechanical properties more matched with the nerve tissue, which can reduce immune damage to the brain tissue, thus improving the stability of detection of nerve signals and can be used for long-term recording of electroencephalogram (EEG) signals.
  • EEG electroencephalogram
  • Embodiments of the present disclosure provide a flexible neural electrode composite structure, a manufacturing method and an implantation method thereof, a composite structure assembly and an implantation method thereof, and an auxiliary implantation assembly.
  • a flexible neural electrode composite structure includes a plurality of flexible neural electrodes, each of which includes an implant part and an auxiliary structure provided on the implant part; an auxiliary implantation assembly including a plurality of auxiliary implantation needles in one-to-one correspondence with the plurality of flexible neural electrodes, wherein each of the plurality of auxiliary implantation needles includes an auxiliary implantation end located close to one end of a corresponding flexible neural electrode, and the auxiliary implantation end is configured to be assembled with the auxiliary structure; and a fixture configured to fix the auxiliary implantation end and the auxiliary structure which have been assembled.
  • a manufacturing method of a flexible neural electrode composite structure includes: providing a plurality of flexible neural electrodes, wherein each of the plurality of flexible neural electrodes includes an implant part and an auxiliary structure formed on the implant part; forming an auxiliary implantation assembly, wherein the auxiliary implantation assembly includes a plurality of auxiliary implantation needles, and each of the plurality of auxiliary implantation needles includes an auxiliary implantation end located at one side close to the plurality of flexible neural electrodes; assembling the auxiliary implantation end with the auxiliary structure; and fixing the auxiliary implantation end and the auxiliary structure which have been assembled.
  • an implantation method of flexible neural electrodes adopting the aforementioned flexible neural electrode composite structure includes: moving the flexible neural electrode composite structure to drive the implant parts of the plurality of flexible neural electrodes to move to a surface of a target tissue; melting or dissolving the fixture, so that the auxiliary implantation end and the auxiliary structure are in a separable state; moving the auxiliary implantation assembly towards the target tissue so as to drive a plurality of implant parts of the plurality of flexible neural electrodes to move to the target tissue; and removing the auxiliary implantation assembly and leaving the plurality of flexible neural electrodes at the target tissue.
  • a composite structure assembly includes the aforementioned flexible neural electrode composite structure.
  • an implantation method of flexible neural electrodes adopting the aforementioned composite structure assembly includes: implanting a plurality of groups of flexible neural electrodes into a target tissue by utilizing a plurality of flexible neural electrode composite structures, wherein each group of flexible neural electrodes includes a plurality of flexible neural electrodes.
  • an auxiliary implantation assembly includes an auxiliary fixing member including at least one auxiliary fixing plate; and a plurality of auxiliary implantation needles configured to be connected with the at least one auxiliary fixing plate, wherein an extension direction of the plurality of auxiliary implantation needles is not parallel to a plane where the at least one auxiliary fixing plate is located.
  • the embodiments of the present disclosure provide a flexible neural electrode composite structure, a manufacturing method and an implantation method thereof, a composite structure assembly and an implantation method thereof, and an auxiliary implantation assembly.
  • the flexible neural electrode composite structure with auxiliary implantation assembly to realize high-throughput implantation, the implantation difficulty is reduced, and the operation time is shortened.
  • At least one embodiment of the present disclosure provides a flexible neural electrode composite structure, which includes: a plurality of flexible neural electrodes, wherein each flexible neural electrode includes an implant part and an auxiliary structure provided on the implant part; an auxiliary implantation assembly including a plurality of auxiliary implantation needles in one-to-one correspondence with the plurality of flexible neural electrodes, wherein each auxiliary implantation needle includes an auxiliary implantation end located close to one end of the corresponding flexible neural electrode, and the auxiliary implantation end is configured to be assembled with the auxiliary structure; and a fixture configured to fix the auxiliary implantation end and the auxiliary structure which have been assembled.
  • the auxiliary implantation end and the auxiliary structure are fixed by the fixture, so that the auxiliary implantation assembly and the plurality of flexible neural electrodes are fixed together. In this way, a plurality of flexible neural electrodes can be implanted into the target tissue at the same time during the implantation process of the flexible neural electrodes.
  • the flexible neural electrodes and the auxiliary implantation assembly having been assembled are fixed or connected together by a fixture, so that the operation of on-site assembling the flexible neural electrodes with the auxiliary implantation assembly during implantation is omitted, the implantation efficiency is improved, and the operation time is shortened; in addition, because the flexible neural electrodes and the auxiliary implantation assembly have been assembled into an integrated structure, it is convenient for transportation and usage.
  • "a plurality of " refers to two or more.
  • a plurality of flexible neural electrodes can be arranged in one or more rows, thereby forming a flexible neural electrode array.
  • a plurality of auxiliary implantation needles can also be arranged in one or more rows, thereby forming an auxiliary implantation needle array.
  • the auxiliary implantation needle array is an optical fiber array, tungsten wire array, a platinum-iridium alloy wire array and a nickel-chromium alloy wire array obtained by three-dimensionally spatial arrangement; or a silicon needle array prepared by using a micro-electro-mechanical system (MEMS); or a comb-shaped array obtained by deep silicon etching; or a needle-like array obtained by MEMS processing.
  • MEMS micro-electro-mechanical system
  • Fig. 1 is a schematic perspective view of a flexible neural electrode composite structure provided by an embodiment of the present disclosure.
  • a flexible neural electrode composite structure 100 includes a plurality of flexible neural electrodes 1 (i.e., a flexible neural electrode array), an auxiliary implantation assembly 2 and a fixture 3.
  • each flexible neural electrode 1 includes an implant part 10 and an auxiliary structure 11 provided on the implant part 10.
  • the implant part 10 is configured to be implanted into a target tissue, such as brain tissue of a human or an animal, under the action of an external force.
  • Fig. 2 is a schematic cross-sectional view of the flexible neural electrode composite structure of Fig. 1 taken along the dashed plane a.
  • Fig. 3 is a partially enlarged view of the flexible neural electrode composite structure in Fig. 2 .
  • the implant part 10 of the flexible neural electrode 1 includes, for example, a flexible insulating layer 101 and at least one conductive layer 102 buried in the flexible insulating layer 101.
  • the conductive layer 102 includes a plurality of conductive wires 103.
  • the plurality of conductive wires 103 are insulated from each other by the flexible insulating layer 101.
  • the implant part 10 is provided with a plurality of electrode sites 104, which are connected with the plurality of conductive wires 103 in one-to-one correspondence for nerve recording or regulation.
  • the electrode sites 104 are formed by removing part of the flexible insulating layer 101 to expose the conductive wires 103.
  • Each implant part 10 in Figs. 3 and 4A only illustrates ten electrode sites 104 and ten conductive wires 103 connected thereto. It can be understood that in other embodiments of the present disclosure, the number of the electrode sites 104 and the number of the conductive wires 103 of each implant part 10 can be determined according to actual needs, which is not limited in the embodiment of the present disclosure.
  • the plurality of implant parts 10 of the plurality of flexible neural electrodes 1 can be arranged in various ways.
  • Fig. 4B is a top view of a plurality of flexible neural electrodes of Fig. 1 .
  • the plurality of implant parts 10 are arranged in a 4x3 array.
  • the embodiment of the present disclosure is not limited thereto, and the plurality of implant parts 10 can also be arranged in m rows and n columns, where m is greater than or equal to 1 and n is greater than or equal to 1.
  • each spiral structure is about 1 mm.
  • the width of each flexible neural electrode is about 15 ⁇ m, and each flexible neural electrode is distributed with 10 detection sites (electrode sites 104).
  • the implant part is divided into five layers (insulating layer/conductive layer/insulating layer/conductive layer/insulating layer).
  • the overall thickness of the flexible neural electrode is about 2.5 ⁇ m.
  • the implant part 10 is located at a front end of each flexible neural electrode 1, and a rear end of each flexible neural electrode 1 is provided with a pad corresponding to each electrode site 104, and the pad is connected to an external circuit.
  • the implant part 10 is provided with an auxiliary structure 11 configured to be connected with the auxiliary implantation assembly 2.
  • the auxiliary structure 11 and the auxiliary implantation assembly 2 are connected with each other by way of plugging-in.
  • the auxiliary implantation assembly 2 includes, for example, a plurality of auxiliary implantation needles 20 in one-to-one correspondence with the plurality of flexible neural electrodes 1, and each auxiliary implantation needle 20 includes an auxiliary implantation end 201 and a fixing end 202, wherein the auxiliary implantation end 201 is located at one end of the auxiliary implantation needle 20 close to the flexible neural electrode 1, and the fixing end 202 is located at the other end of the auxiliary implantation needle 20 away from the flexible neural electrode 1.
  • the auxiliary implantation end 201 is configured to be assembled with the auxiliary structure 11, so that the flexible neural electrode 1 and the auxiliary implantation assembly 2 can be assembled together.
  • the plurality of flexible neural electrodes 1 are connected with the auxiliary implantation assembly 2 by using the auxiliary implantation end 201 and the auxiliary structure 11 having been well assembled, which is beneficial to the batch implantation of a plurality of flexible neural electrodes 1 through the auxiliary implantation assembly 2, thereby realizing electrode implantation in a high-throughput and high-coverage way.
  • the extension direction of the plurality of auxiliary implantation needles 20 is not parallel to the extension direction of the plurality of implant parts 10 of the plurality of flexible neural electrodes 1.
  • the extension direction of the plurality of auxiliary implantation needles 20 is spatially crossed with the extension direction of the plurality of implant parts 10 of the plurality of flexible neural electrodes 1, that is, they may or may not intersect with each other.
  • the plurality of auxiliary implantation needles 20 are parallel to each other and extend in the z direction.
  • the implant part 10 of each flexible neural electrode 1 is, for example, a stretchable spiral structure, and the plane where the spiral structure is located is the xy plane.
  • the extension direction z of the auxiliary implantation needle 20 is not parallel to the xy plane where the spiral structure is located, for example, they are perpendicular to each other.
  • Figs. 1 and 2 only illustrate the case where the extension direction of the auxiliary implantation needle 20 is perpendicular to the extension direction of the implant part 10 of the flexible neural electrode. It can be understood that in other embodiments of the present disclosure, the extension direction of the auxiliary implantation needle 20 may have a certain inclination angle with respect to the xy plane where the spiral structure is located, for example, the inclination angle is greater than 0 degree and less than or equal to 90 degree, which is also beneficial to controlling the implantation depth of the flexible neural electrodes and is not limited in the embodiment of the present disclosure.
  • each flexible neural electrode 1 has a stretchable spiral structure
  • the spiral structure when the thickness of the spiral structure in the z direction is ignored, the spiral structure may be a two-dimensional planar structure as illustrated in Fig. 1 , or a three-dimensional structure, that is, in a three-dimensional shape by spiralling along the z direction, which is not limited in the present disclosure.
  • the spiral structure when the spiral structure is a two-dimensional planar structure as illustrated in Fig. 1 , the spiral structure has the shape of, for example, a circle, a triangle, a quadrilateral, a polygon, or a rounded triangle, a rounded quadrilateral, a rounded polygon, etc.
  • the spiral structure has the shape of a circle, which can be formed as a semicircle (i.e.
  • the auxiliary structure 11 is located at the end of the spiral structure, that is, the terminal end of the implant part 10, which is beneficial to drawing or pulling the spiral structure to be unfolded more easily during the implantation of the flexible neural electrode. It can be understood that in other embodiments of the present disclosure, the auxiliary structure 11 can also be located at other positions at the end of the implant part 10 (for example, the C1 position between the two electrode sites 104 in Fig. 4A ), or at a portion of the implant part 10 away from the terminal end (for example, the C2 position in Fig. 4A ), which also enables the flexible neural electrode to be stretched or unfolded. Therefore, the position of the auxiliary structure 11 is not limited in the embodiment of the present disclosure.
  • Figs. 1 and 2 only illustrate that the implant part 10 is a stretchable spiral structure, and it can be understood that the implant part 10 can also have other shapes in some other embodiments of the present disclosure, such as a linear structure or a wavy structure.
  • the implant part 10 may be one or more of a spiral structure, a wavy structure and a linear structure.
  • the auxiliary implantation end 201 and the auxiliary structure 11 are detachably assembled together, for example, by way of plugging-in, which is convenient for assembly and disassembly.
  • the auxiliary implantation end 201 and the auxiliary structure 11 are assembled together by way of plugging-in.
  • the auxiliary structure 11 is, for example, a through hole 111 located on the implant part 10.
  • the auxiliary implantation end 201 includes a tip 203, and the diameter of the tip 203 is smaller than or equal to that of the auxiliary implantation needle 20.
  • the tip 203 has a cross section that gradually decreases towards the auxiliary structure 11, for example, cone shape as illustrated in the figure, which may be a circular cone or a pyramid.
  • the tip 203 can serve for guiding, which is beneficial to quickly inserting the auxiliary structure 11 for assembling.
  • the tip 203 may also be flat-headed, and the shape of the tip 203 is not specifically limited in the embodiment of the present disclosure.
  • Fig. 4A only illustrates the case where the auxiliary structure 11 is a through hole.
  • the auxiliary structure 11 can also be a groove or a protrusion, and any structure that can be plugged-in with the auxiliary implantation end 201 is included in the embodiment of the present disclosure.
  • the auxiliary implantation end 201 is partially or completely inserted into the auxiliary structure 11.
  • the firmness after assembling can be improved;
  • the auxiliary implantation end 201 is partially inserted into the auxiliary structure 11, the separation of the flexible neural electrode 1 from the auxiliary implantation assembly 2 after the flexible neural electrode 1 has been implanted can be facilitated.
  • the auxiliary implantation end 201 is partially inserted into the through hole 111, which means that the tip 203 is inserted into the through hole 111.
  • the shape of the cross-section of each auxiliary implantation needle 20 includes one of a triangle, a rectangle, a circle, an ellipse and a regular polygon.
  • the shape of the cross-section of the auxiliary implantation needle 20 refers to the shape of the cross-section in the xy plane of the auxiliary implantation needle 20 in Fig. 1 .
  • the shape of the cross-section is a circle or an ellipse, it can reduce the damage to brain tissue and hence is preferred.
  • the material of each auxiliary implantation needle 20 includes one or more of metal, alloy and nonmetal.
  • the metal includes, for example, tungsten.
  • the nonmetal includes silicon or silicon dioxide, for example.
  • the alloy includes, for example, platinum-iridium alloy or nickel-chromium alloy, or the like.
  • the auxiliary implantation needle 20 is, for example, a rigid micro-wire, which is obtained by processing an optical fiber or a tungsten wire with good collimation; or a silicon-based needle-like array obtained by deep silicon etching through micro-electro-mechanical system (MEMS) technology; or a SU-8 needle-like array structure with high aspect ratio which is obtained by MEMS technology.
  • MEMS micro-electro-mechanical system
  • SU-8 needle-like array structure with high aspect ratio which is obtained by MEMS technology.
  • the diameter (the diameter D illustrated in Fig. 3 ) of the auxiliary implantation needle 20 is 5 ⁇ m to 200 ⁇ m, for example, it may be 5 ⁇ m, 10 ⁇ m, 50 ⁇ m, 100 ⁇ m, 150 ⁇ m, and 200 ⁇ m. If the diameter D is larger, the damage to brain tissue is greater. In one example, the diameter D is 50 ⁇ m to 150 ⁇ m, for example, it may be 50 ⁇ m, 75 ⁇ m, 100 ⁇ m, 125 ⁇ m and 150 ⁇ m; further, it is, for example, 75 ⁇ m to 100 ⁇ m.
  • the auxiliary implantation needle 20 is formed by an etching process, for example.
  • the maximum diameter d of the tip of the auxiliary implantation needle 20 is 1 ⁇ m to 100 ⁇ m, for example, it may be 1 ⁇ m, 10 ⁇ m, 50 ⁇ m and 100 ⁇ m. In one example, the maximum diameter d is 10 ⁇ m to 100 ⁇ m, e.g., 10 ⁇ m, 20 ⁇ m, 50 ⁇ m and 100 ⁇ m; further, it is, for example, 20 ⁇ m to 50 ⁇ m.
  • the difference between the diameter of the tip 203 of the auxiliary implantation needle 20 and diameter of the auxiliary implantation needle 201 is 20 ⁇ m to 50 ⁇ m.
  • the diameter of the through hole 111 is 1 ⁇ m to 100 ⁇ m, for example, it may be 1 ⁇ m, 10 ⁇ m, 50 ⁇ m and 100 ⁇ m. In one example, the diameter of the through hole 111 is 5 ⁇ m to 100 ⁇ m, e.g., 5 ⁇ m, 10 ⁇ m, 20 ⁇ m, 50 ⁇ m and 100 ⁇ m; further, it is, for example, 20 ⁇ m to 50 ⁇ m. In the embodiment of the present disclosure, in order to ensure the fitting between the tip 203 and the through hole 111, the diameter of the through hole 111 is greater than or equal to the diameter d of the tip, and is less than or equal to the diameter D of the auxiliary implantation needle.
  • the fixture 3 is configured to fix the auxiliary implantation end 201 and the auxiliary structure 11 which have been assembled.
  • the fixture 3 is located between the auxiliary implantation end 201 and the auxiliary structure 11 to maintain the relative position between the auxiliary implantation end 201 and the auxiliary structure 11, which can ensure that the flexible neural electrode 1 and the auxiliary implantation assembly 3 will not move relative to each other during transportation.
  • the flexible neural electrode 1 and the auxiliary implantation assembly 3 having been assembled are fixed or connected together by using the fixture 3, so that the operation of on-site assembling the flexible neural electrode 1 with the auxiliary implantation assembly 3 during implantation is omitted, the implantation efficiency is improved, and the operation time is shortened; in addition, because the flexible neural electrodes 1 and the auxiliary implantation assembly 3 are assembled into an integrated structure, it is convenient for transportation and usage.
  • the fixture 3 is configured such that its physical state changes with the change of external conditions.
  • at least one physical parameter, such as volume, for characterizing the physical state is changed with the change of external conditions.
  • the fixture 3 can be changed from a solid state to a liquid state by changing the illumination or the ambient temperature, which results in the change of volume.
  • a specific liquid is dropped onto the fixture 3, although the fixture 3 remains solid, its volume is changed from small to large (that is, the swelling phenomenon occurs).
  • the auxiliary implantation assembly 2 and the flexible neural electrode 1 are no longer bound together by the fixture 3 but are separable, which is convenient for the subsequent operation of implanting the flexible neural electrode.
  • the fixture 3 includes one or more of a photo-meltable material, a thermal-meltable material, a liquid-swellable material and a liquid-dissolvable material.
  • the photo-meltable material includes positive photosensitive resin, such as diazonaphthaquinone-based photosensitive resin, the working principle of which is that the exposed part of the photosensitive film is decomposed and denitrified upon being exposed to light, and generates acid with water through rearrangement reaction of molecules.
  • positive photosensitive resin such as diazonaphthaquinone-based photosensitive resin
  • the thermal-meltable material includes thermal-meltable polymer, such as one or more of polyethylene glycol (PEG) and polylactic acid-glycolic acid copolymer-polyethylene glycol (PLGA-PEG).
  • thermal-meltable polymer such as one or more of polyethylene glycol (PEG) and polylactic acid-glycolic acid copolymer-polyethylene glycol (PLGA-PEG).
  • the liquid-swellable material includes water-swellable polymer, such as one or more of poly (ethylene glycol) alginate diacrylate (PEGDA) and polyacrylamide-alginate (PAAm).
  • PEGDA poly(ethylene glycol) alginate diacrylate
  • PAAm polyacrylamide-alginate
  • the liquid-dissolvable material includes water-dissolvable polymer, such as one or more of polyvinyl alcohol (PVA), silk protein, polyethylene glycol (PEG), polylactic acid-glycolic acid copolymer-polyethylene glycol (PLGA-PEG) and gelatin;
  • the liquid includes one or more of ultrapure water, physiological saline and phosphate buffer solution (PBS).
  • PVA solution the concentration of PVA solution is 2% ⁇ 10%, such as 2%, 5%, 10%, etc., for example 5%.
  • the fixture 3 takes the form of a film, for example, a plurality of auxiliary implantation ends 201 and a plurality of auxiliary structures 11 are fixed together by the film.
  • the process of forming the fixture 3 can be simplified, that is, a plurality of auxiliary implantation ends 201 and a plurality of auxiliary structures 11 may be fixed together by one-step film forming process.
  • at least a plurality of joints between a plurality of auxiliary implantation ends 201 and a plurality of auxiliary structures 11 can be fixed together through the film. This can reduce the usage amount of the fixing material and reduce the influence on the target tissue due to larger usage amount.
  • the thickness of the film is greater than the width of the joint in the z direction, for example, the range of the thickness is 30 ⁇ m to 50 ⁇ m.
  • the auxiliary implantation assembly 2 further includes an auxiliary fixing member 21, which is provided at one side of the plurality of auxiliary implantation needles 20 away from the plurality of flexible neural electrodes 1 and is configured to fix the plurality of auxiliary implantation needles 20.
  • the plurality of flexible neural electrodes 1 may be connected to the same object, so that a surgeon can move or implant the plurality of flexible neural electrodes 1, as a whole, by grasping the auxiliary fixing member during the implantation.
  • Fig. 5 is a schematic structural diagram of an auxiliary implantation assembly provided by an embodiment of the present disclosure.
  • the auxiliary fixing member 21 includes two auxiliary fixing plates 211, the plane where the auxiliary fixing plates 211 are located is a xy plane, and the extension direction of the plurality of auxiliary implantation needles 20 is a z direction, and thus the xy plane where the auxiliary fixing plates 211 are located is perpendicular to the extension direction z of the plurality of auxiliary implantation needles 20.
  • the plane where the auxiliary fixing plates 211 are located and the extension direction of the plurality of auxiliary implantation needles 20 it is beneficial to controlling the implantation depth of the flexible neural electrode conveniently in the process of implanting the flexible neural electrode.
  • Fig. 5 only illustrates the case in which the plane where the auxiliary fixing plates 211 are located is perpendicular to the extension direction of the plurality of auxiliary implantation needles 20. It would be understood that in some other embodiments of the present disclosure, the extension direction of the plurality of auxiliary implantation needles 20 may not be parallel to the xy plane where the auxiliary fixing plates 211 are located.
  • the extension direction of the plurality of auxiliary implantation needles 20 has a certain inclination angle relative to the xy plane, and the inclination angle is, for example, more than 0 degree and less than or equal to 90 degree, which is also beneficial to controlling the implantation depth of the flexible neural electrode, and the embodiment of the present disclosure is not limited thereto.
  • the auxiliary fixing plate 211 is detachably or fixedly connected with a plurality of auxiliary implantation needles 20.
  • a detachable connection is adopted, the number and positions of the auxiliary implantation needles 20 fixed to the auxiliary fixing plate 211 can be selected according to actual needs.
  • a fixed connection is adopted, the stability of the whole flexible neural electrode composite structure can be improved.
  • Fig. 6 is a schematic cross-sectional view of an auxiliary implantation assembly according to another embodiment of the present disclosure.
  • the auxiliary fixing plate 211 is provided with openings 212, and the plurality of auxiliary implantation needles 20 each include a fixing end 202 away from the auxiliary implantation end 201 along the extension direction of the auxiliary implantation needle, and the fixing end 202 is configured to pass through the openings 212 to be connected with the auxiliary fixing plate 211.
  • the openings 212 in the auxiliary fixing plate 211 it is beneficial to realizing the detachable connection between the auxiliary implantation needles 20 and the auxiliary fixing plate 211.
  • the auxiliary implantation assembly 2 further includes an adhesive 22, and at least part of the adhesive 22 is located between the auxiliary fixing plate 211 and the plurality of auxiliary implantation needles 20 so that the auxiliary fixing plate 211 is bonded with the plurality of auxiliary implantation needles 20.
  • the adhesive 22 By providing the adhesive 22, the firmness between the auxiliary fixing plate 211 and the plurality of auxiliary implantation needles 20 can be improved, and the auxiliary implantation needles 20 can be prevented from falling off or deviating during the movement of the flexible neural electrode composite structure which may affect the implantation effect.
  • Fig. 6 illustrates the case where two auxiliary fixing plates 211 are provided, but it can be understood that the number of the auxiliary fixing plates 211 may also be one or more than two, which is not limited in the embodiment of the present disclosure.
  • the two auxiliary fixing plates 211 are provided with a gap therebetween, which can further ensure the collimation of the auxiliary implantation needles, and further improve the firmness between the auxiliary fixing plates 211 and the plurality of auxiliary implantation needles 20.
  • a plurality of auxiliary implantation needles 20 can be arranged in various ways.
  • the plurality of auxiliary implantation needles 20 are arranged in an array.
  • the arrangement of the plurality of auxiliary implantation needles 20 may be determined depending on the arrangement of the plurality of flexible neural electrodes.
  • the auxiliary implantation needle array can also be presented as a circle, a square or a polygon so that the auxiliary implantation needles can be in one-to-one correspondence with the plurality of flexible neural electrodes 1.
  • Fig. 7 is a schematic structural diagram of a flexible neural electrode composite structure provided by another embodiment of the present disclosure.
  • the flexible neural electrode composite structure 100a includes four flexible neural electrodes 1a, an auxiliary implantation assembly 2a and a fixture (not illustrated).
  • the four flexible neural electrodes 1a are arranged in a 2x2 array.
  • each flexible neural electrode 1a includes an implant part 10a and an auxiliary structure 11a provided on the implant part 10a.
  • the implant part 10a is configured to be implanted into a target tissue under the action of an external force.
  • specific structure of the implant part 10a of the flexible neural electrode 1a reference can be made to the description of the previous embodiment, which will not be repeated here.
  • the implant part 10a is provided with eight electrode sites 104a, and the eight electrode sites 104a are connected with eight conductive wires 103a in one-to-one correspondence for nerve recording or regulation.
  • the electrode sites 104a in Fig. 7 are distributed at both sides of the implant part 10a, so that the number of electrode sites can be increased in a unit area, and more signals can be recorded or regulated.
  • each implant part 10a has a linear structure
  • the extension direction of a plurality of auxiliary implantation needles 20 is the z direction
  • the extension direction of a plurality of linear structures is the x direction
  • the extension direction of the plurality of auxiliary implantation needles 20a is perpendicular to the extension direction of the plurality of linear structures.
  • Fig. 7 only illustrates the case where the extension direction of the auxiliary implantation needle 20a is perpendicular to the extension direction of the implant part 10a of the flexible neural electrode 1a, but it can be understood that in some other embodiments of the present disclosure, the extension direction of the auxiliary implantation needle 20a may have a certain inclination angle with respect to the extension direction of the linear structure, for example, the inclination angle is greater than 0 degree and less than or equal to 90 degree, which is also beneficial to controlling the implantation depth of the flexible neural electrode and is not limited in the embodiment of the present disclosure.
  • a plurality of flexible neural electrodes 1 may include a plurality of implant parts 10; some of these implant parts are linear structures as illustrated in Fig. 7 , and some others of these implant parts are stretchable spiral structures as illustrated in Fig. 1 . In this way, different requirements for implanted electrodes can be satisfied during the surgery.
  • the shape of the implant part can be varied, only the linear structure and the spiral structure are illustrated above, and other structures such as spring structure and net structure can also be included.
  • the shape of the spiral structure is not limited to the circle illustrated above, but also may be a triangle, a quadrangle, a polygon or a rounded triangle, a rounded quadrangle, a rounded polygon, and the like.
  • the flexible neural electrode composite structure 100 may further include a support assembly 4.
  • the support assembly 4 is connected with a plurality of implant parts of a plurality of flexible neural electrodes 1 and serves for supporting, thereby facilitating overall transfer of the plurality of flexible neural electrodes 1.
  • the support assembly 4 includes a first support member 41 and a second support member 42 connected to the first support member 41, wherein the first support member 41 includes the flexible insulating layer 101 and the conductive layer 102 of the flexible neural electrode 1.
  • the second support member 42 only includes the flexible insulating layer 101, and serves for insulating.
  • At least one embodiment of the present disclosure also provides a manufacturing method of the flexible neural electrode composite structure.
  • Fig. 8 is a flowchart of the manufacturing method of the flexible neural electrode composite structure provided by the embodiment of the present disclosure. As illustrated in Fig. 8 , the manufacturing method of the flexible neural electrode composite structure 100 of Fig. 1 provided by the embodiment of the present disclosure includes the following steps:
  • the plurality of flexible neural electrodes can be implanted into the target tissue at the same time during the implantation process of the flexible neural electrodes.
  • the flexible neural electrodes and the auxiliary implantation assembly Compared with the implantation method in which the electrodes are implanted individually one by one, on the one hand, it shortens the implantation time and reduces the implantation difficulty, thus realizing the implantation of a flexible neural electrode array in a high-throughput and high-coverage manner; on the other hand, before the flexible neural electrodes are implanted, the flexible neural electrodes and the auxiliary implantation assembly having been assembled are fixed or connected together by a fixture, so that the operation of on-site assembling the flexible neural electrodes with the auxiliary implantation assembly during implantation is omitted, the implantation efficiency is improved, and the operation time is shortened; in addition, because the flexible neural electrodes and the auxiliary implantation assembly have been assembled into an integrated structure, it is convenient for transportation and usage.
  • step S100 there are various methods for forming the flexible neural electrode 1, such as photolithography, micro-electro-mechanical system (MEMS) and the like.
  • MEMS micro-electro-mechanical system
  • the preparation method of a plurality of flexible neural electrodes includes the following steps: S101: cleaning and drying a base substrate.
  • the base substrate is a silicon wafer, which is cleaned by ultrasonic wave and blow-dried by nitrogen gas, and then is cleaned by plasma.
  • S102 forming a plurality of grooves on the base substrate, wherein the plurality of grooves correspond to a plurality of auxiliary structures 11 on a plurality of implant parts 10 of a plurality of flexible neural electrodes 1.
  • the auxiliary structure 11 may be a through hole, a groove or a protrusion.
  • the plurality of grooves it is convenient to provide an accommodation space for the auxiliary implantation end 201 passing through a through hole when the auxiliary implantation needle 20 is inserted into the through hole, facilitating the transfer of electrodes.
  • the sacrificial layer is formed on the base substrate, which is beneficial to releasing the flexible neural electrode array formed on the base substrate.
  • PMMA polymethyl methacrylate
  • Al aluminum
  • Ni nickel
  • the sacrificial layer is adopted for the sacrificial layer.
  • the flexible neural electrode array is formed on the sacrificial layer.
  • S104 forming a flexible neural electrode array on the base substrate formed with the sacrificial layer.
  • the flexible neural electrode array includes a plurality of flexible neural electrodes 1.
  • the flexible neural electrode 1 includes a flexible insulating layer 101 and a conductive layer 102, wherein the conductive layer 102 includes a plurality of conductive wires 103; the flexible neural electrode 1 further includes an implant part 1 and an auxiliary structure 11 located on the implant part 1.
  • An electrode site 104 is formed by removing part of the flexible insulating layer 101 to expose part of the conductive wire 103.
  • the conductive layer 102 may be formed by a photolithography process.
  • the photolithography process includes, but is not limited to, coating a photoresist, exposing with a mask, developing, etching, lifting off the remaining photoresist, and the like.
  • the conductive layer 102 may be a single-layer structure or a multi-layer structure, and each conductive layer 102 may be provided with a plurality of conductive wires 103, and adjacent conductive layers 102 are insulated from each other.
  • Fig. 9 is a schematic structural diagram of a flexible neural electrode formed in the manufacturing method of the flexible neural electrode composite structure provided by the embodiment of the present disclosure.
  • Fig. 10 is a schematic cross-sectional view taken along line AA of Fig. 9 .
  • a circular groove 320 with a diameter of 60 ⁇ m and a depth of 100 ⁇ m is formed in a silicon wafer 310 to accommodate an auxiliary implantation needle passing through an auxiliary structure 11b.
  • a PMMA sacrificial layer 330 is formed on the silicon wafer 310 where the circular groove 320 is formed.
  • a flexible neural electrode 1b is formed on the PMMA sacrificial layer 330.
  • the flexible neural electrode 1b includes an implant part 10b having a spiral structure.
  • the implant part 10b includes an auxiliary structure 11b (a through hole 111b as illustrated in the figure) and an electrode site 104a.
  • the flexible neural electrode 1b further includes a conductive wire 103b, which is connected to the electrode site 104a.
  • the diameter of the circular groove may be 5 ⁇ m to 100 ⁇ m, such as 5 ⁇ m, 10 ⁇ m, 20 ⁇ m, 25 ⁇ m, 30 ⁇ m, 40 ⁇ m, 50 ⁇ m, 100 ⁇ m, etc., for example, 40 ⁇ m to 60 ⁇ m;
  • the depth of the circular groove may be 1 ⁇ m to 200 ⁇ m, such as 0 ⁇ m, 5 ⁇ m, 10 ⁇ m, 15 ⁇ m, 25 ⁇ m, 30 ⁇ m, 40 ⁇ m, 50 ⁇ m, 100 ⁇ m, 150 ⁇ m, 200 ⁇ m, etc., for example, 100 ⁇ m to 150 ⁇ m.
  • the thickness of the sacrificial layer is 0 ⁇ m to 20 ⁇ m, such as 1 ⁇ m, 2 ⁇ m, 5 ⁇ m, 10 ⁇ m, 20 ⁇ m, etc., for example, 1 ⁇ m.
  • step S200 may further include:
  • Figs. 11 to 13 are schematic cross-sectional views of a manufacturing method of the auxiliary implantation assembly provided by the embodiment of the present disclosure.
  • Figs. 11 to 13 illustrate a manufacturing method of the auxiliary implantation assembly of Fig. 6 , including the following steps:
  • a tungsten wire may also be used as the auxiliary implantation needle.
  • the above step 4) can be replaced by the following step 4'):
  • the front end with a length of about 6 mm of the tungsten wire is immersed in 2 mol/L sodium hydroxide (NaOH) solution, and an electrochemical etching process is carried out under a constant potential mode of Chenhua Electrochemical Workstation (CHI660) with an overpotential of 5.0 V to etch the tungsten wire until it has a diameter of about 100 ⁇ m; then the tip of the tungsten wire is lifted, and only a portion with a length of about 2 mm of the tip of the tungsten wire is immersed in the NaOH solution for further etching until the meniscus is broken, so as to obtain tungsten wire with a flat tip; finally, the auxiliary implantation assembly illustrated in Fig. 6 is also obtained.
  • CHI660 Chenhua Electrochemical Workstation
  • the manufacturing method further includes: S500: aligning the auxiliary implantation end 201 with the auxiliary structure 11.
  • At least one auxiliary implantation end 201 among a plurality of auxiliary implantation ends 201 is aligned with at least one auxiliary structure 11 among a plurality of auxiliary structures 11, which is beneficial to assembling the auxiliary implantation end 201 with the auxiliary structure 11 more quickly.
  • the auxiliary implantation assembly 2 is pre-fixed by using a stereo locator, and the array of flexible neural electrodes 1 is placed on a rotary stage and adjusted to be aligned with the auxiliary implantation assembly 2.
  • the rotary stage is, for example, a multi-axis precision air-floated rotary stage that can rotate at multiple angles.
  • the step S400 may further include: forming a fixture 3 at least at the joint between the auxiliary implantation end 201 and the auxiliary structure 11, as illustrated in Figs. 2 and 3 .
  • the fixture 3 is at least filled between the tip 203 of the auxiliary implantation end 201 and the through hole 111, so as to maintain the relative position between the tip 203 and the through hole 111 unchanged.
  • the fixture 3 is formed as a film that connects the plurality of auxiliary implantation ends 201 and the plurality of auxiliary structures 11 together.
  • the specific material of the fixture 3 can refer to the description of the previous embodiments, and will not be described here.
  • the following steps are performed:
  • At least one embodiment of the present disclosure also provides a composite structure assembly including a plurality of flexible neural electrode composite structures described in any of the previous embodiments.
  • Fig. 14 is a schematic structural diagram of a composite structure assembly provided by an embodiment of the present disclosure.
  • the composite structure assembly 40 includes a plurality of flexible neural electrode composite structures 410 (for example, three flexible neural electrode composite structures as illustrated in the figure), and each flexible neural electrode composite structure 410 has the same configuration as the flexible neural electrode composite structure 100 illustrated in Fig. 1 .
  • the composite structure assembly 40 further includes a connection part 420 having a plurality of conductive wires. Each conductive wire is connected between the electrode site of the flexible neural electrode and the pad (not illustrated) to realize signal transmission.
  • the auxiliary implantation end and the auxiliary structure are fixed by the fixture for each flexible neural electrode composite structure, the auxiliary implantation assembly and the plurality of flexible neural electrodes are fixed together. In this way, a plurality of flexible neural electrodes can be implanted into the target tissue at the same time during the implantation process of the flexible neural electrodes.
  • the flexible neural electrodes and the auxiliary implantation assembly Compared with the implantation method in which the electrodes are implanted individually one by one, on the one hand, it shortens the implantation time and reduces the implantation difficulty, thus realizing the implantation of a flexible neural electrode array in a high-throughput and high-coverage manner; on the other hand, before the flexible neural electrodes are implanted, the flexible neural electrodes and the auxiliary implantation assembly having been assembled are fixed or connected together by a fixture, so that the operation of on-site assembling the flexible neural electrodes with the auxiliary implantation assembly during implantation is omitted, the implantation efficiency is improved, and the operation time is shortened; in addition, since the flexible neural electrodes and the auxiliary implantation assembly have been assembled into an integrated structure, it is convenient for transportation and usage.
  • At least one embodiment of the present disclosure also provides an implantation method of flexible neural electrodes adopting the flexible neural electrode composite structure described in any of the previous embodiments.
  • Fig. 15 is an implantation method of flexible neural electrodes adopting the flexible neural electrode composite structure of Fig. 1 as provided by an embodiment of the present disclosure.
  • the above implantation method includes:
  • the auxiliary implantation assembly 2 when moving the auxiliary implantation assembly 2 toward the target tissue, the plurality of implant parts 10 of the plurality of flexible neural electrodes 1 are moved to the target tissue at the same time.
  • the auxiliary implantation assembly 2 can be lifted so as to be separated from the flexible neural electrode(s) 1 left on the target tissue, so that the auxiliary implantation assembly 2 can be reused or directly discarded.
  • the flexible neural electrode(s) left at the target tissue may be part or all of the plurality of flexible neural electrodes 1. When all the flexible neural electrodes 1 are left at the target tissue, more electrode sites may be provided on the target tissue.
  • the auxiliary structure 11 is located on the stretchable spiral structure.
  • the auxiliary implantation end 201 can be utilized to push the auxiliary structure 11 downwardly, so that the stretchable spiral structure can be unfolded in the z direction.
  • each implant part 10a has a linear structure, and the auxiliary structure 11a is located on the linear structure.
  • the auxiliary implantation end 201a can be utilized to push the auxiliary structure 11a downwardly to drive the linear structure to move to the target tissue.
  • a plurality of flexible neural electrodes can be implanted into the target tissue at the same time.
  • the flexible neural electrodes and the auxiliary implantation assembly having been assembled are fixed or connected together by a fixture, so that the operation of on-site assembling the flexible neural electrodes with the auxiliary implantation assembly during implantation is omitted, the implantation efficiency is improved, and the operation time is shortened; in addition, since the flexible neural electrodes and the auxiliary implantation assembly have been assembled into an integrated structure, it is convenient for transportation and usage.
  • the implantation method of flexible neural electrodes includes the following steps:
  • At least one embodiment of the present disclosure also provides an implantation method of flexible neural electrodes adopting the composite structure assembly described in the previous embodiment, which includes: implanting a plurality of groups of flexible neural electrodes into a target tissue by using a plurality of flexible neural electrode composite structures, and each group of flexible neural electrodes includes a plurality of flexible neural electrodes.
  • the implantation method includes: sequentially implanting a first group of flexible neural electrodes 431, a second group of flexible neural electrodes 432 and a third group of flexible neural electrodes 433 into a target tissue by using a plurality of flexible neural electrode composite structures 410.
  • Each group of flexible neural electrodes includes, for example, twelve flexible neural electrodes.
  • the first group of flexible neural electrodes 431, the second group of flexible neural electrodes 432 and the third group of flexible neural electrodes 433 may also be implanted into the target tissue at the same time by using a plurality of flexible neural electrode composite structures 410.
  • the auxiliary implantation assembly 2 includes an auxiliary fixing member 21 including at least one auxiliary fixing plate 211; and a plurality of auxiliary implantation needles 20 configured to be connected with the at least one auxiliary fixing plate 211.
  • the extension direction (the z direction as illustrated in the figure) of the plurality of auxiliary implantation needles 20 is not parallel to the plane (the xy plane as illustrated in the figure) where the at least one auxiliary fixing plate 211 is located.
  • At least one auxiliary fixing plate 211 is detachably or fixedly connected with a plurality of auxiliary implantation needles 20.
  • the at least one auxiliary fixing plate 211 is provided with an opening 212
  • the plurality of auxiliary implantation needles 20 each include a fixing end 202 arranged in opposite to the auxiliary implantation end 201, and the fixing end 202 is configured to pass through the opening 212 to be connected with the at least one auxiliary fixing plate 211.
  • the auxiliary implantation assembly 2 further includes an adhesive 22, and at least a part of the adhesive 22 is located between the at least one auxiliary fixing plate and the plurality of auxiliary implantation needles 20.
  • the implantable flexible neural electrode array can be transferred and implanted as a whole.
  • the implantation and transfer method of electrode array can greatly improve the efficiency of transfer, release and implantation, reduce the time consumption of implantation, and provide a simple and efficient method for large-scale implantation of implantable flexible neural electrode array.
  • the implantation speed is 1 ⁇ 200 ⁇ m/s (micron/s), such as 1 ⁇ m/s, 5 ⁇ m/s, 10 ⁇ m/s, 15 ⁇ m/s, 20 ⁇ m/s, 30 ⁇ m/s, 50 ⁇ m/s, 100 ⁇ m/s and 200 ⁇ m, for example, 10 ⁇ m/s ⁇ 20 ⁇ m/s.

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EP23778418.6A 2022-04-02 2023-03-31 Structure composite d'électrode neuronale flexible et son procédé de fabrication et d'implantation, et ensemble d'implantation auxiliaire Pending EP4501235A4 (fr)

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EP4652933A1 (fr) * 2024-05-21 2025-11-26 ETH Zurich Agencement pour l'insertion d'un dispositif d'implant dans un tissu biologique
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